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Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic acid is particularly important during phases of rapid cell division, such as infancy, pregnancy, and erythropoiesis, and plays a protective factor in the development of cancer. As humans are unable to synthesize folic acid endogenously, diet and supplementation is necessary to prevent deficiencies. For example, folic acid is present in green vegetables, beans, avocado, and some fruits.
In order to function within the body, folic acid must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted by anti-metabolite therapies such as Methotrexate as they function as DHFR inhibitors to prevent DNA synthesis in rapidly dividing cells, and therefore prevent the formation of DHF and THF. When used in high doses such as for cancer therapy, or in low doses such as for Rheumatoid Arthritis or psoriasis, Methotrexate impedes the body's ability to create folic acid. This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects. As a result, supplementation with 1-5mg of folic acid is recommended to prevent deficiency and a number of side effects associated with MTX therapy including mouth ulcers and gastrointestinal irritation. Leucovorin (also known as folinic acid) supplementation is typically used for high-dose MTX regimens for the treatment of cancer. Levoleucovorin and leucovorin are analogs of tetrahydrofolate (THF) and are able to bypass DHFR reduction to act as a cellular replacement for the co-factor THF.
Market Analysis and Insights: Global Folic Acid Tablets Market
The global Folic Acid Tablets market was valued at US$ XX in 2020 and will reach US$ XX million by the end of 2027, growing at a CAGR of XX% during 2022-2027.
Global Folic Acid Tablets Scope and Market Size
The global Folic Acid Tablets market is segmented by company, region (country), by Type, and by Application. Players, stakeholders, and other participants in the global Folic Acid Tablets market will be able to gain the upper hand as they use the report as a powerful resource. The segmental analysis focuses on sales, revenue and forecast by region (country), by Type and by Application for the period 2016-2027.
Segment by Type
1mg
5mg
Other
Segment by Application
Pregnancy Lady
Pregnant Lady
Lactating Lady
Child
Men
General
Other
The Folic Acid Tablets market is analysed and market size information is provided by regions (countries). Segment by Application, the Folic Acid Tablets market is segmented into North America, Europe, China, Japan, Southeast Asia, India and Other Regions.
By Company
Bayer
A＆Z Pharmaceutical
Endo International
Cardinal Health
Leading Pharma, LLC
Meiaojian
Sunota
Scrianen
Fishburg
Meydunlg
Elevit
Natures Bounty
Forceval
Nutrilite
Osteroform
Ferguson
By-Health
Lisheng Pharmaceutical
Renhe Pharmacy
SAN JIU ENTERPRISE GROUP
In order to function within the body, folic acid must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted by anti-metabolite therapies such as Methotrexate as they function as DHFR inhibitors to prevent DNA synthesis in rapidly dividing cells, and therefore prevent the formation of DHF and THF. When used in high doses such as for cancer therapy, or in low doses such as for Rheumatoid Arthritis or psoriasis, Methotrexate impedes the body's ability to create folic acid. This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects. As a result, supplementation with 1-5mg of folic acid is recommended to prevent deficiency and a number of side effects associated with MTX therapy including mouth ulcers and gastrointestinal irritation. Leucovorin (also known as folinic acid) supplementation is typically used for high-dose MTX regimens for the treatment of cancer. Levoleucovorin and leucovorin are analogs of tetrahydrofolate (THF) and are able to bypass DHFR reduction to act as a cellular replacement for the co-factor THF.
Market Analysis and Insights: Global Folic Acid Tablets Market
The global Folic Acid Tablets market was valued at US$ XX in 2020 and will reach US$ XX million by the end of 2027, growing at a CAGR of XX% during 2022-2027.
Global Folic Acid Tablets Scope and Market Size
The global Folic Acid Tablets market is segmented by company, region (country), by Type, and by Application. Players, stakeholders, and other participants in the global Folic Acid Tablets market will be able to gain the upper hand as they use the report as a powerful resource. The segmental analysis focuses on sales, revenue and forecast by region (country), by Type and by Application for the period 2016-2027.
Segment by Type
1mg
5mg
Other
Segment by Application
Pregnancy Lady
Pregnant Lady
Lactating Lady
Child
Men
General
Other
The Folic Acid Tablets market is analysed and market size information is provided by regions (countries). Segment by Application, the Folic Acid Tablets market is segmented into North America, Europe, China, Japan, Southeast Asia, India and Other Regions.
By Company
Bayer
A＆Z Pharmaceutical
Endo International
Cardinal Health
Leading Pharma, LLC
Meiaojian
Sunota
Scrianen
Fishburg
Meydunlg
Elevit
Natures Bounty
Forceval
Nutrilite
Osteroform
Ferguson
By-Health
Lisheng Pharmaceutical
Renhe Pharmacy
SAN JIU ENTERPRISE GROUP
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