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Amifostine (Ethiofos) is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents. It is marketed by Clinigen under the trade name Ethyol.
Amifostine is a pro-drug which is activated to the free thiol metabolite at the tissue site. The thiol metabolite is responsible for most of the cytoprotective and radioprotective properties of amifostine. It is readily taken up by cells where it binds to and detoxifies reactive metabolites of platinum and alkylating agents as well as scavenges free radicals. Other possible effects include inhibition of apoptosis, alteration of gene expression and modification of enzyme activity. Healthy cells are preferentially protected because amifostine and metabolites are present in healthy cells at 100-fold greater concentrations than in tumour cells.
Consumption of amifostine mainly concentrates in North America. In 2016, the region consumed 780 K Unit, holding about 52% market share globally. The follower is Asia-Pacific, with about 41% consumption share.
The market is relatively concentrated and there are just a few suppliers in the market, such as Clinigen , Sun Pharmaceutical, Merro Pharmaceutical and so on. Clinigen acquired the business from AstraZeneca in the year of 2014 and signed an agreement with Cumberland in the year of 2016. Under the agreement, Cumberland acquired the exclusive rights to commercialize Ethyol in the United States. Merro Pharmaceutical own the largest sales share in China.
Amifostine shows good effect in reducing harmful effects of cisplatin chemotherapy on kidneys in women treated for advanced ovarian cancer as well as relieving dry mouth problems (xerostomia) with head and neck cancer patients undergoing radiation treatment.
Market Analysis and Insights: Global Amifostine Market
The global Amifostine market was valued at US$ 53 in 2020 and will reach US$ 60 million by the end of 2027, growing at a CAGR of 2.2% during 2022-2027.
Global Amifostine Scope and Market Size
The global Amifostine market is segmented by company, region (country), by Type, and by Application. Players, stakeholders, and other participants in the global Amifostine market will be able to gain the upper hand as they use the report as a powerful resource. The segmental analysis focuses on sales, revenue and forecast by region (country), by Type and by Application for the period 2016-2027.
Segment by Type
400mg/Dose
500mg/Dose
Segment by Application
Head and Neck Cancer Adjuvant Therapy
Others
The Amifostine market is analysed and market size information is provided by regions (countries). Segment by Application, the Amifostine market is segmented into North America, Europe, China, Japan, Southeast Asia, India and Other Regions.
By Company
Clinigen
Sun Pharmaceutical
Taj Pharmaceuticals
Merro Pharmaceutical
Luye Pharma
Mingren Pharma
Amifostine is a pro-drug which is activated to the free thiol metabolite at the tissue site. The thiol metabolite is responsible for most of the cytoprotective and radioprotective properties of amifostine. It is readily taken up by cells where it binds to and detoxifies reactive metabolites of platinum and alkylating agents as well as scavenges free radicals. Other possible effects include inhibition of apoptosis, alteration of gene expression and modification of enzyme activity. Healthy cells are preferentially protected because amifostine and metabolites are present in healthy cells at 100-fold greater concentrations than in tumour cells.
Consumption of amifostine mainly concentrates in North America. In 2016, the region consumed 780 K Unit, holding about 52% market share globally. The follower is Asia-Pacific, with about 41% consumption share.
The market is relatively concentrated and there are just a few suppliers in the market, such as Clinigen , Sun Pharmaceutical, Merro Pharmaceutical and so on. Clinigen acquired the business from AstraZeneca in the year of 2014 and signed an agreement with Cumberland in the year of 2016. Under the agreement, Cumberland acquired the exclusive rights to commercialize Ethyol in the United States. Merro Pharmaceutical own the largest sales share in China.
Amifostine shows good effect in reducing harmful effects of cisplatin chemotherapy on kidneys in women treated for advanced ovarian cancer as well as relieving dry mouth problems (xerostomia) with head and neck cancer patients undergoing radiation treatment.
Market Analysis and Insights: Global Amifostine Market
The global Amifostine market was valued at US$ 53 in 2020 and will reach US$ 60 million by the end of 2027, growing at a CAGR of 2.2% during 2022-2027.
Global Amifostine Scope and Market Size
The global Amifostine market is segmented by company, region (country), by Type, and by Application. Players, stakeholders, and other participants in the global Amifostine market will be able to gain the upper hand as they use the report as a powerful resource. The segmental analysis focuses on sales, revenue and forecast by region (country), by Type and by Application for the period 2016-2027.
Segment by Type
400mg/Dose
500mg/Dose
Segment by Application
Head and Neck Cancer Adjuvant Therapy
Others
The Amifostine market is analysed and market size information is provided by regions (countries). Segment by Application, the Amifostine market is segmented into North America, Europe, China, Japan, Southeast Asia, India and Other Regions.
By Company
Clinigen
Sun Pharmaceutical
Taj Pharmaceuticals
Merro Pharmaceutical
Luye Pharma
Mingren Pharma
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