Liver is a vital organ that performs several important bodily functions including bile production for digestion, protein production, synthesis of blood clotting factors, storage of glucose (sugar) in the form glycogen, and detoxification. Also, the liver cells have a remarkable ability to regenerate themselves after any damage. Due to this unique capability, the liver tissues have fascinated the researchers. True understanding of molecular and cellular connectivity and functions of the liver tissues in an in-vivo as well as in-vitro setting is very important from the viewpoint of discovery science and clinical application. Development of liver models that can provide a virtual ecosystem that mimics the molecular processes of a liver factory can help understand molecular interactions to network dynamics and whole organ functions. These advanced liver models are mini-organs or organoids that are expected to replicate human liver physiology, anatomy, and functions from molecular layer upward. The formation of these living models is a fairly new area of science that has the potential to replace animal models. The human liver models offer several advantages over animal models that are not always accurate and pose ethical issues. The human liver models or organoids have been used to screen new drugs for liver toxicity. These models are also being deeply studied to build a functional model of human liver development. The process of making a human liver model starts with a fetal liver progenitor cell, an immature cell that transforms into a specialized liver cell. The fetal liver progenitor cell is allowed to self-assemble in a small disc. These discs are composed of ferret liver cells that are pre-processed to remove all cells of the ferret. The resultant mini-organ models the actual human liver development. These models have been observed to generate hepatocytes, the basic functional cells of the liver, which is expected to produce the functional bioengineered liver tissues for transplantation into patients in the near future.
North American segment accounted for the largest share of the market in 2018. The human liver market for North America is driven by the presence of a well-established life sciences industry, growing awareness about the organoids technology, increasing government funding, growing incidence of NAFLD, and unavailability of livers for transplantation, increasing investments on research, rising focus on tissue culture-based clinical diagnostics, and the availability of skilled professionals.

Market Analysis and Insights: Global Human Liver Models Market
The global Human Liver Models market is valued at 1444.6 million US$ in 2020 is expected to reach 3026.5 million US$ by the end of 2026, growing at a CAGR of 11.0% during 2021-2026.
Global Human Liver Models Market: Drivers and Restrains
The research report has incorporated the analysis of different factors that augment the market’s growth. It constitutes trends, restraints, and drivers that transform the market in either a positive or negative manner. This section also provides the scope of different segments and applications that can potentially influence the market in the future. The detailed information is based on current trends and historic milestones. This section also provides an analysis of the volume of production about the global market and also about each type from 2015 to 2026. This section mentions the volume of production by region from 2015 to 2026. Pricing analysis is included in the report according to each type from the year 2015 to 2026, manufacturer from 2015 to 2020, region from 2015 to 2020, and global price from 2015 to 2026.
A thorough evaluation of the restrains included in the report portrays the contrast to drivers and gives room for strategic planning. Factors that overshadow the market growth are pivotal as they can be understood to devise different bends for getting hold of the lucrative opportunities that are present in the ever-growing market. Additionally, insights into market expert’s opinions have been taken to understand the market better.
Market Segment Analysis
The research report includes specific segments by Type and by Application. Each type provides information about the production during the forecast period of 2015 to 2026. Application segment also provides consumption during the forecast period of 2015 to 2026. Understanding the segments helps in identifying the importance of different factors that aid the market growth.
Segment by Type
Liver Organoids
Liver-on-a-chip
2D Models
3D Bioprinting
Others

Segment by Application
Drug Discovery
Education
Others

Global Human Liver Models Market: Regional Analysis
The report offers in-depth assessment of the growth and other aspects of the Human Liver Models market in important regions, including the U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, Taiwan, Southeast Asia, Mexico, and Brazil, etc. Key regions covered in the report are North America, Europe, Asia-Pacific and Latin America.
The report has been curated after observing and studying various factors that determine regional growth such as economic, environmental, social, technological, and political status of the particular region. Analysts have studied the data of revenue, production, and manufacturers of each region. This section analyses region-wise revenue and volume for the forecast period of 2015 to 2026. These analyses will help the reader to understand the potential worth of investment in a particular region.
Global Human Liver Models Market:

Competitive Landscape

This section of the report identifies various key manufacturers of the market. It helps the reader understand the strategies and collaborations that players are focusing on combat competition in the market. The comprehensive report provides a significant microscopic look at the market. The reader can identify the footprints of the manufacturers by knowing about the global revenue of manufacturers, the global price of manufacturers, and production by manufacturers during the forecast period of 2015 to 2019.
The major players in the market include Emulate, Ascendance Bio, InSphero, CN Bio, Organovo, Cyfuse Biomedical, Mimetas, etc.