1. Key Insights 2. Cystinuria: Patient Overview at a Glance 2.1. Patient Share (%) Distribution of Cystinuria in 2017 2.2. Patient Share (%) Distribution of Cystinuria in 2028 3. Disease Overview: Cystinuria 3.1. Introduction 3.2. Classification 3.3. Clinical features 3.4. Genetics 3.5. Pathophysiology 3.6. Diagnosis 4. Epidemiology and Patient Population 4.1. Key Findings 4.2. 7MM Total Prevalent Patient Population of Cystinuria 4.3. Country Wise-Epidemiology of Cystinuria 4.4. United States 4.4.1. Assumptions and Rationale 4.4.2. Prevalent Cases of Cystinuria in the United States 4.4.3. Gender-Specific Cases of Cystinuria in the United States 4.4.4. Age-Specific Cases of Cystinuria in the United States 4.4.5. Diagnosed Cases of Cystinuria in the United States 4.4.6. Type-Specific Cases of Cystinuria in the United States 4.5. EU5 4.5.1. Assumptions and Rationale 4.6. Germany 4.6.1. Prevalent Cases of Cystinuria in Germany 4.6.2. Gender-Specific Cases of Cystinuria in Germany 4.6.3. Age-Specific Cases of Cystinuria in Germany 4.6.4. Diagnosed Cases of Cystinuria in Germany 4.6.5. Type-Specific Diagnosed Cases of Cystinuria in Germany 4.7. France 4.7.1. Prevalent Cases of Cystinuria in France 4.7.2. Gender-Specific Cases of Cystinuria in France 4.7.3. Age-Specific Cases of Cystinuria in France 4.7.4. Diagnosed Cases of Cystinuria in France 4.7.5. Type-Specific Cases of Cystinuria in France 4.8. Italy 4.8.1. Prevalent Cases of Cystinuria in Italy 4.8.2. Gender-Specific Cases of Cystinuria in Italy 4.8.3. Age-Specific Cases of Cystinuria in Italy 4.8.4. Diagnosed Cases of Cystinuria in Italy 4.8.5. Type-Specific Cases of Cystinuria in Italy 4.9. Spain 4.9.1. Prevalent Cases of Cystinuria in Spain 4.9.2. Gender-Specific Cases of Cystinuria in Spain 4.9.3. Age-Specific Cases of Cystinuria in Spain 4.9.4. Diagnosed Cases of Cystinuria in Spain 4.9.5. Type-Specific Cases of Cystinuria in Spain 4.10. United Kingdom 4.10.1. Prevalent Cases of Cystinuria in United Kingdom 4.10.2. Gender-Specific Cases of Cystinuria in the United Kingdom 4.10.3. Age-Specific Cases of Cystinuria in the United Kingdom 4.10.4. Diagnosed Cases of Cystinuria in the United Kingdom 4.10.5. Type-Specific Diagnosed Cases of Cystinuria in the United Kingdom 4.11. Japan 4.11.1. Assumptions and Rationale 4.11.2. Prevalent Cases of Cystinuria in Japan 4.11.3. Gender-Specific Cases of Cystinuria in Japan 4.11.4. Age-Specific Cases of Cystinuria in Japan 4.11.5. Diagnosed Cases of Cystinuria in Japan 4.11.6. Type-Specific Diagnosed Cases of Cystinuria in Japan 5. Unmet Needs 6. Market Drivers 7. Market Barriers 8. Appendix 8.1 Report Methodology 9. DelveInsight Capabilities 10. Disclaimer 11. About DelveInsight

Table 1: Phenotypic classification of cystinuria based on parental (heterozygote) findings Table 2: Urinary cystine concentration Table 3: Genotypic classification of Cystinuria Table 4: Most common Cystinuria-associated mutations in rBAT*, SLC3A1, b0,+AT‡, and SLC7A9 Table 5: Prevalent Patient Population of Cystinuria in 7MM (2017–2028) Table 6: Prevalent Cases of Cystinuria in the United States (2017–2028) Table 7: Gender-Specific Cases of Cystinuria in the United States (2017–2028) Table 8: Age-Specific Cases of Cystinuria in the United States (2017–2028) Table 9: Diagnosed Cases of Cystinuria in the United States (2017–2028) Table 10: Type-Specific Cases of Cystinuria in the United States (2017–2028) Table 11: Prevalent Cases of Cystinuria in Germany (2017–2028) Table 12: Gender-Specific Cases of Cystinuria in Germany (2017–2028) Table 13: Age-Specific Cases of Cystinuria in Germany (2017–2028) Table 14: Diagnosed Cases of Cystinuria in Germany (2017–2028) Table 15: Type-Specific Cases of Cystinuria in Germany (2017–2028) Table 16: Prevalent Cases of Cystinuria in France (2017–2028) Table 17: Gender-Specific Cases of Cystinuria in France (2017–2028) Table 18: Age-Specific Cases of Cystinuria in France (2017–2028) Table 19: Diagnosed Cases of Cystinuria in France (2017–2028) Table 20: Type-Specific Cases of Cystinuria in France (2017–2028) Table 21: Prevalent Cases of Cystinuria in Italy (2017–2028) Table 22: Gender-Specific Cases of Cystinuria in Italy (2017–2028) Table 23: Age-Specific Cases of Cystinuria in Italy (2017–2028) Table 24: Diagnosed Cases of Cystinuria in Italy (2017–2028) Table 25: Type-Specific Cases of Cystinuria in Italy (2017–2028) Table 26: Prevalent Cases of Cystinuria in Spain (2017–2028) Table 27: Gender-Specific Cases of Cystinuria in Spain (2017–2028) Table 28: Age-Specific Cases of Cystinuria in Spain (2017–2028) Table 29: Diagnosed Cases of Cystinuria in Spain (2017–2028) Table 30: Type-Specific Cases of Cystinuria in Spain (2017–2028) Table 31: Prevalent Cases of Cystinuria in the United Kingdom (2017–2028) Table 32: Gender-Specific Cases of Cystinuria in the United Kingdom (2017–2028) Table 33: Age-Specific Cases of Cystinuria in the United Kingdom (2017–2028) Table 34: Diagnosed Cases of Cystinuria in the United Kingdom (2017–2028) Table 35: Type-Specific Cases of Cystinuria in the United Kingdom (2017–2028) Table 36: Prevalent Cases of Cystinuria in Japan (2017–2028) Table 37: Gender-Specific Cases of Cystinuria in Japan (2017–2028) Table 38: Age-Specific Cases of Cystinuria in Japan (2017–2028) Table 39: Diagnosed Cases of Cystinuria in Japan (2017–2028) Table 40: Type-Specific Cases of Cystinuria in Japan (2017–2028) Figure 1: Cellular localization and function of rBAT (SLC3A1) and b0,+AT (SLC7A9) Figure 2: Genomic structure and putative function of the encoded protein regions of the Cystinuria genes Figure 3: Trafficking of cystine and dibasic amino acids in epithelial cells of the renal proximal tubule or small intestine Figure 4: Diagnostic algorithm of Cystinuria Figure 5: Prevalent Patient Population of Cystinuria in 7MM (2017–2028) Figure 6: Prevalent Cases of Cystinuria in the United States (2017–2028) Figure 7: Gender-Specific Cases of Cystinuria in the United States (2017–2028) Figure 8: Age-Specific Cases of Cystinuria in the United States (2017–2028) Figure 9: Diagnosed Cases of Cystinuria in the United States (2017–2028) Figure 10: Type-Specific Cases of Cystinuria in the United States (2017–2028) Figure 11: Prevalent Cases of Cystinuria Germany (2017–2028) Figure 12: Gender-Specific Cases of Cystinuria in Germany (2017–2028) Figure 13: Age-Specific Cases of Cystinuria in Germany (2017–2028) Figure 14: Diagnosed Cases of Cystinuria in Germany (2017–2028) Figure 15: Type-Specific Cases of Cystinuria in Germany (2017–2028) Figure 16: Prevalent Cases of Cystinuria in France (2017–2028) Figure 17: Gender-Specific Cases of Cystinuria in France (2017–2028) Figure 18: Age-Specific Cases of Cystinuria in France (2017–2028) Figure 19: Diagnosed Cases of Cystinuria in France (2017–2028) Figure 20: Type-Specific Cases of Cystinuria in France (2017–2028) Figure 21: Prevalent Cases of Cystinuria in Italy (2017–2028) Figure 22: Gender-Specific Cases of Cystinuria in Italy (2017–2028) Figure 23: Age-Specific Cases of Cystinuria in Italy (2017–2028) Figure 24: Diagnosed Cases of Cystinuria in Italy (2017–2028) Figure 25: Type-Specific Cases of Cystinuria in Italy (2017–2028) Figure 26: Prevalent Cases of Cystinuria in Spain (2017–2028) Figure 27: Gender-Specific Cases of Cystinuria in Spain (2017–2028) Figure 28: Age-Specific Cases of Cystinuria in Spain (2017–2028) Figure 29: Diagnosed Cases of Cystinuria in Spain (2017–2028) Figure 30: Type-Specific of Cystinuria in Spain (2017–2028) Figure 31: Prevalent Cases of Cystinuria in the United Kingdom (2017–2028) Figure 32: Gender-Specific Cases of Cystinuria in the United Kingdom (2017–2028) Figure 33: Age-Specific Cases of Cystinuria in the United Kingdom (2017–2028) Figure 34: Diagnosed Cases of Cystinuria in the United Kingdom (2017–2028) Figure 35: Type-Specific Cases of Cystinuria in the United Kingdom (2017–2028) Figure 36: Prevalent Cases of Cystinuria in Japan (2017–2028) Figure 37: Gender-Specific Cases of Cystinuria in Japan (2017–2028) Figure 38: Age-Specific Cases of Cystinuria in Japan (2017–2028) Figure 39: Diagnosed Cases of Cystinuria in Japan (2017–2028) Figure 40: Type-Specific Cases of Cystinuria in Japan (2017–2028) Figure 41: Unmet Needs Figure 42: Market Drivers Figure 43: Market Barriers