Table of Contents Hearing Implants Biomaterials Market Driving Forces 12 Surgical Cochlear Implantation Is By And Large Safe 13 Hearing Implant Market Shares 15 Hearing Implant Biomaterials Market Forecasts 18 1. Biomaterials for Hearing Implants: Market Description and Market Dynamics 21 1.1 Use Of Cochlear Implants 21 1.2 Ear Description 25 1.2.1 Cochlear Implant (CI) System 26 1.2.2 Biomaterial As A Substance 27 1.3 Bilateral CI Fitting 30 1.4 Cochlear Implants Biomaterials 30 1.4.1 Silicone 31 1.4.2 Platinum 33 1.4.3 Titanium 33 1.4.4 Ceramics 35 1.5 Biomaterials in Hearing Implant 36 2. Hearing Implants and Biomaterials Market Shares and Forecasts 41 2.1 Hearing Implants and Biomaterials Market Driving Forces 41 2.1.1 Surgical Cochlear Implantation Is By And Large Safe 42 2.2 Hearing Implant Market Shares 44 2.2.1 Cochlear 48 2.2.2 Advanced Bionics AG 49 2.2.3 Med-EL EAS 50 2.3 Biomaterials Market Forecasts 50 2.3.1 Biomaterial Hearing Implant Segments, Children, Adults Age 19 to 50, Adults 51 to 64, Adults Over 65, Market Forecasts 56 2.3.2 Biomaterial Hearing Implant Market Installed Base Forecasts 59 2.4 Global Biomaterials Market 60 2.4.1 Optimizing the Biocompatibility Properties Of The Hearing Implant 64 2.4.2 Biofilms 66 2.4.3 Teflon for Cochlear Implants 67 2.4.4 Electrically Conducting Polymers 67 2.4.5 Polyimides 68 2.4.6 Silicon Electrodes 68 2.4.7 Physical Functionalization Of Surfaces 69 2.4.8 Drug Delivery In The Inner Ear (Neurotrophic Effects) 70 2.4.9 BioMaterial Nanoparticles 70 2.4.10 Nanoparticles And Cochlear Implants 71 2.4.11 Biomaterials Market Overview 71 2.5 Cochlear (CI) Implant Technical Specifications 77 2.5.1 Advanced Bionics Technical Specifications 77 2.5.2 Cochlear Technical Specifications 78 2.6 Biomaterials Pricing 79 2.7 Biomaterials Regional Segment Analysis 79 2.7.1 United States 81 2.7.2 Europe 83 2.7.3 Rapid Development of Middle Class in South America 84 3. Biomaterial Hearing Implants Product Description 91 3.1 Cochlear 91 3.1.1 Cochlear Kanso™ Sound Processor 95 3.1.2 Cochlear Nucleus® 6 Sound Processor 96 3.1.3 Cochlear Hearing Implant Specifications 97 3.1.4 Cochlear Implant Technical Specifications 101 3.2 Med-El GmbH’s Flex EAS 102 3.2.1 Med-EL EAS™ Hearing Implant System for Partial Mild To Moderate Deafness 102 3.2.2 Hearing Implant Advantages Of Bilateral Implantation 103 3.2.3 MedEL Implant Concerto 106 3.2.4 MedEL Implant Concerto Structure Preservation 107 3.2.1 MedEL Implant Concerto Complete Cochlear Coverage CCC 108 3.2.2 Med-EL Electrode Arrays 109 3.2.3 Med-EL FLEX Tip Technology 112 3.2.4 Med-EL Classic Series 114 3.2.5 Med-EL FLEX Series 114 3.2.6 FDA Approves the MED-EL Synchrony EAS Hearing Implant System 115 3.2.7 Med-EL Addresses Hearing Loss in the US 117 3.2.8 MED-EL Technical Specifications 118 3.3 Sonova / Advanced Bionics AG 119 3.3.1 Advanced Bionics Implant Specifications 120 4. Biomaterials Research and Technology 121 4.1 Medical Device Standards and Implant Standards - ASTM International 121 4.2 Metalic Implants 122 4.2.1 Unalloyed Titanium 123 4.2.2 Titanium Alloy 123 4.3 Hearing Implant Prosthesis Biomaterials 125 5. Ear Implant Biomaterials Company Profiles 127 5.1 Cochlear 127 5.1.1 Cochlear Revenue 129 5.2 Med-EL Maestro 143 5.2.1 Med-EL Hearing Implant Concerto 145 5.2.2 Med-EL Revenue 146 5.2.3 Med-EL Implantable Solutions 146 5.3 Nurotron Biotechnology Co., Ltd. (China) 147 5.3.1 Nurotron Biomaterials Positioning 149 5.3.2 Nurotron Biotechnology Thin, Ergonomic, Titanium Implant Package 149 5.3.3 Nurotron Biotechnology Expands Facilities, Staff Ten-Fold 151 5.3.4 Nurotron Biotechnology Co., Ltd. (http://en.nurotron.com) 151 5.4 Sonova / Advanced Bionics AG 152 5.4.1 Sonova Group Revenue / Advanced Bionics 153 5.4.2 Sonova / Advanced Bionics 155 5.5 William Demant / Oticon Medical / Neurelec 156

List of Figures Figure 1. Hearing Implant Market Leaders Worldwide 15 Figure 2. Biomaterial Hearing Implant Market, Shares, Dollars, Worldwide, 2016 16 Figure 3. Biomaterial Hearing Implant Market Shares, Dollars, Worldwide, 201617 Figure 4. Hearing Implants Market Forecasts, Dollars, Worldwide, 2017-2023 19 Figure 5. Cochlear Implant 22 Figure 6. Implantable Portion Of The Cochlear Implant: 23 Figure 7. Components of the Ear 26 Figure 8. Biomaterials Clinical Disciplines Underpin The Design 28 Figure 9. Biomaterials Sciences 28 Figure 10. Biomaterials Uses in Clinical Diagnosis And Therapy 29 Figure 11. Biomaterials in Hearing Implant 36 Figure 12. Biomaterials for Receiver 37 Figure 13. Electrode Array Biomaterials 38 Figure 14. Electrode Contacts Biomaterials Requirement 39 Figure 15. Cocolear Implant CI Biocompatibilty Issues 40 Figure 16. Hearing Implant Market Leaders Worldwide 44 Figure 17. Biomaterial Hearing Implant Market Shares, Dollars, Worldwide, 2016 45 Figure 18. Biomaterial Hearing Implant Market Shares, Dollars, Worldwide, 2016 46 Figure 19. Hearing Loss Implant Reliability of Leading Three Vendors 47 Figure 20. Advanced Bionics Cochlear Implant 49 Figure 21. Hearing Implants Market Forecasts, Dollars, Worldwide, 2017-2023 51 Figure 22. Biomaterials Hearing Implant Market Forecasts, Units, Worldwide, 2017-2023 52 Figure 23. Biomaterial Hearing Implant Market Forecasts, Dollars and Units, Worldwide, 2017-2023 53 Figure 24. Hearing Loss Market Metrics 54 Figure 25. Biomaterial Hearing Implant Segments, Children, Adults Age 19 to 50, Adults 51 to 64, Adults Over 65, Market Forecasts Dollars, Worldwide, 2017-2023 56 Figure 26. Biomaterial Hearing Implant Segments, Children, Adults Age 19 to 50, Adults 51 to 64, Adults Over 65, Market Forecasts, Percent, Worldwide, 2017-2023 57 Figure 27. Biomaterial Hearing Implant Market Installed Base Forecasts, Units, Worldwide, 2017-2023 59 Figure 28. Biomaterial Hearing Implant Market Penetration Forecasts, Units, Worldwide, 2017-2023 60 Figure 29. Application Segments Of Biomaterials 61 Figure 30. Surface Structuring Physical Functionalization Aspects 65 Figure 31. Major Players In The Global Biomaterials Market 72 Figure 32. Hyaluronic Acid-based Biomaterials Manufacturers 73 Figure 33. Biomaterials Market, by Type of Material 74 Figure 34. Biomaterials Market, by Application 76 Figure 35. Cochlear Technical Specifications 78 Figure 36. Biomaterial Hearing Implant Regional Market Segments, Dollars, Worldwide, 2016 80 Figure 37. Hearing Implant and Biomaterials Regional Market Segments, Dollars, 2016 81 Figure 38. United States Hearing Implant Market Growth Drivers 82 Figure 39. United States Hearing Implant Nanotechnology Growth Drivers 83 Figure 40. Rapid Development of Middle Class in South America 85 Figure 41. SIze of the Middle Class in Latin America 86 Figure 42. Severe to Profound Hearing Loss in Latin America 87 Figure 43. CI Penetration in Latin America 88 Figure 44. Cochlear Staff in Latin America 89 Figure 45. Cochlear Expanding Reimbursement in Latin America 90 Figure 46. Cochlear Nucleus System 92 Figure 47. Cochlear Implant Functions 93 Figure 48. Cochlear Implant Hearing Improvement in Noisy Environments 94 Figure 49. Cochlear Kanso™ Sound Processor 95 Figure 50. Cochlear Nucleus® 6 Sound Processor 96 Figure 51. Cochlear Hearing Implant Functions 97 Figure 52. Cochlear Advantages Of Perimodiolar Electrodes 97 Figure 53. Cochlear Slim Modular Electrode 98 Figure 54. Cochlear Slim Modiolar Electrode Hearing Outcomes For Patients 99 Figure 55. Cochlear Electrode Placement 100 Figure 56. Cochlear Implant Technical Specifications 101 Figure 57. Med-EL Hearing Implant 103 Figure 58. MedEL MAESTRO Cochlear Implant System 105 Figure 59. MedEL MAESTRO consists of both an internal cochlear implant and an externally worn audio processor. 105 Figure 60. MedEL Implant Concerto 106 Figure 61. Med-EL Biomaterial Electrodes Features 108 Figure 62. Med-EL ASM Key Features 110 Figure 63. Med-EL FLEX Tip Technology Features 113 Figure 64. Med-EL Hearing Implant Electrode Array Featuring FLEX-Tip Technology 114 Figure 65. Med-EL Synchrony EAS Hearing Implant 115 Figure 66. MED-EL Technical Specifications Implant 118 Figure 67. Advanced Bionics Cochlear Implant 119 Figure 68. Advanced Bionics Technical Specifications 120 Figure 69. Cochlear Electrode Type Comparison 122 Figure 70. Cochlear Slim Straight Electrode 124 Figure 71. Cochlear Regional Presence in Americas and Europe 127 Figure 72. Cochlear Nucleus Implant Installed Base 128 Figure 73. Cochlear Regional Presence in Asia Pacific 129 Figure 74. Cochlear Leadership Position in Implantable Hearing Devices 130 Figure 75. Hearing Loss Market Opportunity Metrics 131 Figure 76. Cochlear Biomaterials Core Technology Positioning 132 Figure 77. Cochlear Positioning for Developing Growth Markets 133 Figure 78. Cochlear Growth of Services Revenue 135 Figure 79. Cochlear FY 2017 Financial Outlook 136 Figure 80. Cochlear Implant Market Awareness Opportunity 137 Figure 81. Cochlear Implant Services Revenue Components 138 Figure 82. Cochlear Slim Modiolar Electrode Array Image 139 Figure 83. Cochlear Nucleus Profile with Slim Modiolar Electrode Array – C1532 140 Figure 84. Cochlear Electrode Type Comparison 141 Figure 85. Cochlear Hearing Loss Implant Criteria for Electrode Choice 142 Figure 86. Med-EL Hearing Implant CONCERTO 145 Figure 87. Nurotron Biotechnology Venus Cochlear Implant System 148 Figure 88. Nurotron Biomaterials Positioning 149