Table of Contents Table of Contents 2 Introduction 12 Melanoma - Overview 13 Melanoma - Therapeutics Development 14 Melanoma - Therapeutics Assessment 80 Melanoma - Companies Involved in Therapeutics Development 114 Melanoma - Drug Profiles 240 Melanoma - Dormant Projects 2161 Melanoma - Discontinued Products 2195 Melanoma - Product Development Milestones 2200 Appendix 2213

List of Tables Number of Products under Development for Melanoma, H2 2018 85 Number of Products under Development by Companies, H2 2018 87 Number of Products under Development by Universities/Institutes, H2 2018 108 Products under Development by Companies, H2 2018 113 Products under Development by Universities/Institutes, H2 2018 144 Number of Products by Stage and Target, H2 2018 152 Number of Products by Stage and Mechanism of Action, H2 2018 167 Number of Products by Stage and Route of Administration, H2 2018 182 Number of Products by Stage and Molecule Type, H2 2018 184 Melanoma - Pipeline by 4D Pharma PLC, H2 2018 185 Melanoma - Pipeline by 4P-Pharma SAS, H2 2018 185 Melanoma - Pipeline by 4SC AG, H2 2018 186 Melanoma - Pipeline by AB Science SA, H2 2018 186 Melanoma - Pipeline by AbbVie Inc, H2 2018 187 Melanoma - Pipeline by Abivax SA, H2 2018 187 Melanoma - Pipeline by Adaptimmune Therapeutics Plc, H2 2018 188 Melanoma - Pipeline by Aduro BioTech Inc, H2 2018 188 Melanoma - Pipeline by Advanced BioDesign, H2 2018 189 Melanoma - Pipeline by Advenchen Laboratories LLC, H2 2018 189 Melanoma - Pipeline by Aeglea BioTherapeutics Inc, H2 2018 190 Melanoma - Pipeline by Afecta Pharmaceuticals Inc, H2 2018 190 Melanoma - Pipeline by Affichem SA, H2 2018 190 Melanoma - Pipeline by Agenus Inc, H2 2018 191 Melanoma - Pipeline by AGV Discovery SAS, H2 2018 191 Melanoma - Pipeline by AIMM Therapeutics BV, H2 2018 192 Melanoma - Pipeline by AiVita Biomedical Inc, H2 2018 192 Melanoma - Pipeline by Alkermes Plc, H2 2018 193 Melanoma - Pipeline by Allergy Therapeutics Plc, H2 2018 193 Melanoma - Pipeline by Alligator Bioscience AB, H2 2018 194 Melanoma - Pipeline by Altor BioScience Corp, H2 2018 194 Melanoma - Pipeline by Amgen Inc, H2 2018 195 Melanoma - Pipeline by Angimmune LLC, H2 2018 195 Melanoma - Pipeline by Antibe Therapeutics Inc, H2 2018 196 Melanoma - Pipeline by APEIRON Biologics AG, H2 2018 196 Melanoma - Pipeline by Apexigen Inc, H2 2018 196 Melanoma - Pipeline by Aphios Corp, H2 2018 197 Melanoma - Pipeline by Aposense Ltd, H2 2018 197 Melanoma - Pipeline by Aprea AB, H2 2018 198 Melanoma - Pipeline by Aptose Biosciences Inc, H2 2018 198 Melanoma - Pipeline by Arcus Biosciences Inc, H2 2018 199 Melanoma - Pipeline by ArQule Inc, H2 2018 199 Melanoma - Pipeline by Array BioPharma Inc, H2 2018 200 Melanoma - Pipeline by Asana BioSciences LLC, H2 2018 200 Melanoma - Pipeline by Ascentage Pharma Group Corp Ltd, H2 2018 201 Melanoma - Pipeline by Astex Pharmaceuticals Inc, H2 2018 201 Melanoma - Pipeline by Atreca Inc, H2 2018 201 Melanoma - Pipeline by aTyr Pharma Inc, H2 2018 202 Melanoma - Pipeline by Aurigene Discovery Technologies Ltd, H2 2018 202 Melanoma - Pipeline by Autolus Therapeutics Plc, H2 2018 203 Melanoma - Pipeline by Basilea Pharmaceutica Ltd, H2 2018 203 Melanoma - Pipeline by Batu Biologics Inc, H2 2018 204 Melanoma - Pipeline by Bayer AG, H2 2018 204 Melanoma - Pipeline by BeiGene Ltd, H2 2018 205 Melanoma - Pipeline by Beijing Kawin Technology Share-Holding Co Ltd, H2 2018 205 Melanoma - Pipeline by Bellicum Pharmaceuticals Inc, H2 2018 206 Melanoma - Pipeline by BerGenBio ASA, H2 2018 206List of Figures Number of Products under Development for Melanoma, H2 2018 85 Number of Products under Development by Companies, H2 2018 86 Number of Products under Development by Universities/Institutes, H2 2018 107 Number of Products by Top 10 Targets, H2 2018 151 Number of Products by Stage and Top 10 Targets, H2 2018 151 Number of Products by Top 10 Mechanism of Actions, H2 2018 166 Number of Products by Stage and Top 10 Mechanism of Actions, H2 2018 166 Number of Products by Routes of Administration, H2 2018 181 Number of Products by Stage and Routes of Administration, H2 2018 181 Number of Products by Top 10 Molecule Types, H2 2018 183 Number of Products by Stage and Top 10 Molecule Types, H2 2018 183

4D Pharma PLC 4P-Pharma SAS 4SC AG AB Science SA AbbVie Inc Abivax SA Adaptimmune Therapeutics Plc Aduro BioTech Inc Advanced BioDesign Advenchen Laboratories LLC Aeglea BioTherapeutics Inc Afecta Pharmaceuticals Inc Affichem SA Agenus Inc AGV Discovery SAS AIMM Therapeutics BV AiVita Biomedical Inc Alkermes Plc Allergy Therapeutics Plc Alligator Bioscience AB Altor BioScience Corp Amgen Inc Angimmune LLC Antibe Therapeutics Inc APEIRON Biologics AG Apexigen Inc Aphios Corp Aposense Ltd Aprea AB Aptose Biosciences Inc Arcus Biosciences Inc ArQule Inc Array BioPharma Inc Asana BioSciences LLC Ascentage Pharma Group Corp Ltd Astex Pharmaceuticals Inc Atreca Inc aTyr Pharma Inc Aurigene Discovery Technologies Ltd Autolus Therapeutics Plc Basilea Pharmaceutica Ltd Batu Biologics Inc Bayer AG BeiGene Ltd Beijing Kawin Technology Share-Holding Co Ltd Bellicum Pharmaceuticals Inc BerGenBio ASA Biocad Bio-Cancer Treatment International Ltd Biogazelle NV Biogen Inc Biohaven Pharmaceutical Holding Company Ltd BioLineRx Ltd Bionomics Ltd BioNTech AG Biosion Inc Biothera Pharmaceutical Inc BioVaxys LLC Biovista Inc BioXcel Therapeutics Inc Boehringer Ingelheim GmbH Boston Biomedical Inc BrightPath Biotherapeutics Co Ltd Bristol-Myers Squibb Co Calithera Biosciences Inc Can-Fite BioPharma Ltd CBT Pharmaceuticals Inc Celdara Medical LLC Celgene Corp Celldex Therapeutics Inc Cellestia Biotech AG Celprogen Inc Celyad SA Checkmate Pharmaceuticals Inc Checkpoint Therapeutics Inc Chipscreen Biosciences Ltd Chugai Pharmaceutical Co Ltd Constellation Pharmaceuticals Inc Corvus Pharmaceuticals Inc Cue Biopharma Inc Curevac AG CytomX Therapeutics Inc Cytori Therapeutics Inc CytoVac AS CyTuVax BV CZ BioMed Corp Daiichi Sankyo Co Ltd Debiopharm International SA Deciphera Pharmaceuticals LLC DEKK-TEC Inc DNAtrix Inc Dynavax Technologies Corp Eisai Co Ltd Eli Lilly and Co Elsalys Biotech SA Emcure Pharmaceuticals Ltd EntreChem SL eTheRNA Immunotherapies NV Evelo Biosciences Inc Evotec AG Exelixis Inc