Table of Contents Table of Contents 2 Introduction 13 Colorectal Cancer - Overview 14 Colorectal Cancer - Therapeutics Development 15 Colorectal Cancer - Therapeutics Assessment 83 Colorectal Cancer - Companies Involved in Therapeutics Development 115 Colorectal Cancer - Drug Profiles 257 Colorectal Cancer - Dormant Projects 2439 Colorectal Cancer - Discontinued Products 2462 Colorectal Cancer - Product Development Milestones 2468 Appendix 2479

List of Tables Number of Products under Development for Colorectal Cancer, H2 2018 83 Number of Products under Development by Companies, H2 2018 85 Number of Products under Development by Universities/Institutes, H2 2018 106 Products under Development by Companies, H2 2018 110 Products under Development by Universities/Institutes, H2 2018 146 Number of Products by Stage and Target, H2 2018 152 Number of Products by Stage and Mechanism of Action, H2 2018 166 Number of Products by Stage and Route of Administration, H2 2018 180 Number of Products by Stage and Molecule Type, H2 2018 182 Colorectal Cancer - Pipeline by 3-V Biosciences Inc, H2 2018 183 Colorectal Cancer - Pipeline by 3SBio Inc, H2 2018 183 Colorectal Cancer - Pipeline by 4SC AG, H2 2018 184 Colorectal Cancer - Pipeline by Aadi Bioscience Inc, H2 2018 184 Colorectal Cancer - Pipeline by AB Science SA, H2 2018 185 Colorectal Cancer - Pipeline by AbbVie Inc, H2 2018 185 Colorectal Cancer - Pipeline by AbGenomics International Inc, H2 2018 186 Colorectal Cancer - Pipeline by Abpro, H2 2018 186 Colorectal Cancer - Pipeline by Aclaris Therapeutics Inc, H2 2018 186 Colorectal Cancer - Pipeline by Adamed Sp z oo, H2 2018 187 Colorectal Cancer - Pipeline by ADC Therapeutics SA, H2 2018 187 Colorectal Cancer - Pipeline by Adhera Therapeutics, H2 2018 188 Colorectal Cancer - Pipeline by Aduro BioTech Inc, H2 2018 188 Colorectal Cancer - Pipeline by Advanced Accelerator Applications SA, H2 2018 189 Colorectal Cancer - Pipeline by Advanced BioDesign, H2 2018 189 Colorectal Cancer - Pipeline by Advenchen Laboratories LLC, H2 2018 189 Colorectal Cancer - Pipeline by Agency for Science, Technology and Research, H2 2018 190 Colorectal Cancer - Pipeline by Agenus Inc, H2 2018 190 Colorectal Cancer - Pipeline by AlfaSigma SpA, H2 2018 191 Colorectal Cancer - Pipeline by Alkermes Plc, H2 2018 191 Colorectal Cancer - Pipeline by Alligator Bioscience AB, H2 2018 192 Colorectal Cancer - Pipeline by Allinky Biopharma SL, H2 2018 192 Colorectal Cancer - Pipeline by Almac Discovery Ltd, H2 2018 192 Colorectal Cancer - Pipeline by Alpine Immune Sciences Inc, H2 2018 193 Colorectal Cancer - Pipeline by ALX Oncology Inc, H2 2018 193 Colorectal Cancer - Pipeline by Amarin Corp Plc, H2 2018 194 Colorectal Cancer - Pipeline by amcure GmbH, H2 2018 194 Colorectal Cancer - Pipeline by Amgen Inc, H2 2018 195 Colorectal Cancer - Pipeline by APEIRON Biologics AG, H2 2018 195 Colorectal Cancer - Pipeline by Apexigen Inc, H2 2018 195 Colorectal Cancer - Pipeline by Aphios Corp, H2 2018 196 Colorectal Cancer - Pipeline by Apogenix AG, H2 2018 196 Colorectal Cancer - Pipeline by Aposense Ltd, H2 2018 197 Colorectal Cancer - Pipeline by Arcus Biosciences Inc, H2 2018 197 Colorectal Cancer - Pipeline by Array BioPharma Inc, H2 2018 198 Colorectal Cancer - Pipeline by Arvinas Inc, H2 2018 198 Colorectal Cancer - Pipeline by Asana BioSciences LLC, H2 2018 199 Colorectal Cancer - Pipeline by Ascelia Pharma AB, H2 2018 199 Colorectal Cancer - Pipeline by Aslan Pharmaceuticals Pte Ltd, H2 2018 199 Colorectal Cancer - Pipeline by Astellas Pharma Inc, H2 2018 200 Colorectal Cancer - Pipeline by Astex Pharmaceuticals Inc, H2 2018 200 Colorectal Cancer - Pipeline by AstraZeneca Plc, H2 2018 201 Colorectal Cancer - Pipeline by Aurigene Discovery Technologies Ltd, H2 2018 202 Colorectal Cancer - Pipeline by Aurobindo Pharma Ltd, H2 2018 202 Colorectal Cancer - Pipeline by B Cell Design SAS, H2 2018 203 Colorectal Cancer - Pipeline by Basilea Pharmaceutica Ltd, H2 2018 203 Colorectal Cancer - Pipeline by Batu Biologics Inc, H2 2018 203 Colorectal Cancer - Pipeline by Bavarian Nordic A/S, H2 2018 204 Colorectal Cancer - Pipeline by Bayer AG, H2 2018 205 Colorectal Cancer - Pipeline by BeiGene Ltd, H2 2018 205List of Figures Number of Products under Development for Colorectal Cancer, H2 2018 83 Number of Products under Development by Companies, H2 2018 84 Number of Products under Development by Universities/Institutes, H2 2018 106 Number of Products by Top 10 Targets, H2 2018 151 Number of Products by Stage and Top 10 Targets, H2 2018 151 Number of Products by Top 10 Mechanism of Actions, H2 2018 165 Number of Products by Stage and Top 10 Mechanism of Actions, H2 2018 165 Number of Products by Top 10 Routes of Administration, H2 2018 179 Number of Products by Stage and Top 10 Routes of Administration, H2 2018 179 Number of Products by Top 10 Molecule Types, H2 2018 181 Number of Products by Stage and Top 10 Molecule Types, H2 2018 181

3SBio Inc 3-V Biosciences Inc 4SC AG Aadi Bioscience Inc AB Science SA AbbVie Inc AbGenomics International Inc Abpro Aclaris Therapeutics Inc Adamed Sp z oo ADC Therapeutics SA Adhera Therapeutics Aduro BioTech Inc Advanced Accelerator Applications SA Advanced BioDesign Advenchen Laboratories LLC Agency for Science, Technology and Research Agenus Inc AlfaSigma SpA Alkermes Plc Alligator Bioscience AB Allinky Biopharma SL Almac Discovery Ltd Alpine Immune Sciences Inc ALX Oncology Inc Amarin Corp Plc amcure GmbH Amgen Inc APEIRON Biologics AG Apexigen Inc Aphios Corp Apogenix AG Aposense Ltd Arcus Biosciences Inc Array BioPharma Inc Arvinas Inc Asana BioSciences LLC Ascelia Pharma AB Aslan Pharmaceuticals Pte Ltd Astellas Pharma Inc Astex Pharmaceuticals Inc AstraZeneca Plc Aurigene Discovery Technologies Ltd Aurobindo Pharma Ltd B Cell Design SAS Basilea Pharmaceutica Ltd Batu Biologics Inc Bavarian Nordic A/S Bayer AG BeiGene Ltd Beijing Hanmi Pharmaceutical Co Ltd BeyondSpring Inc Biocon Ltd BioLineRx Ltd Bionomics Ltd Bionovis SA Biosceptre International Ltd BioXpress Therapeutics SA Boehringer Ingelheim GmbH Boston Biomedical Inc Bristol-Myers Squibb Co Calithera Biosciences Inc CanBas Co Ltd Cancer Prevention Pharmaceuticals Inc Canget BioTekpharma LLC Cantargia AB Carna Biosciences Inc CaroGen Corp CBT Pharmaceuticals Inc CCRP Therapeutics GmbH Celgene Corp Celldex Therapeutics Inc Cellectar Biosciences Inc Celleron Therapeutics Ltd Cellestia Biotech AG Cellix Bio Pvt Ltd Celltrion Inc Celyad SA Checkmate Pharmaceuticals Inc Chengdu Kanghong Pharmaceuticals Group Co Chiome Bioscience Inc Chipscreen Biosciences Ltd ChoDang Pharm Co Ltd Chong Kun Dang Pharmaceutical Corp Chugai Pharmaceutical Co Ltd Cinnagen Co Cleveland BioLabs Inc COARE Biotechnology Inc Compugen Ltd Conatus Pharmaceuticals Inc Corvus Pharmaceuticals Inc Cotinga Pharmaceuticals Inc Cytlimic Inc Daiichi Sankyo Co Ltd Deciphera Pharmaceuticals LLC Dr. Reddy's Laboratories Ltd eFFECTOR Therapeutics Inc Eisai Co Ltd Eli Lilly and Co Endor Technologies SL Enochian Biosciences Inc EntreChem SL Enzene Biosciences Ltd Enzo Biochem Inc EpiThany Inc Etubics Corp Evelo Biosciences Inc Exelixis Inc Exicure Inc F. Hoffmann-La Roche Ltd Faron Pharmaceuticals Oy Fate Therapeutics Inc FLX Bio Inc Fog Pharmaceuticals Inc Forbius Formosa Laboratories Inc Forty Seven Inc Fresenius SE & Co KGaA F-star Biotechnology Ltd Fujifilm Holdings Corporation Fusion Antibodies plc