Table of Contents Table of Contents 2 Introduction 14 Pancreatic Cancer - Overview 15 Pancreatic Cancer - Therapeutics Development 16 Pancreatic Cancer - Therapeutics Assessment 94 Pancreatic Cancer - Companies Involved in Therapeutics Development 135 Pancreatic Cancer - Drug Profiles 289 Pancreatic Cancer - Dormant Projects 2665 Pancreatic Cancer - Discontinued Products 2694 Pancreatic Cancer - Product Development Milestones 2700 Appendix 2711

List of Tables Number of Products under Development for Pancreatic Cancer, H2 2018 91 Number of Products under Development by Companies, H2 2018 93 Number of Products under Development by Universities/Institutes, H2 2018 118 Products under Development by Companies, H2 2018 123 Products under Development by Universities/Institutes, H2 2018 163 Number of Products by Stage and Target, H2 2018 170 Number of Products by Stage and Mechanism of Action, H2 2018 188 Number of Products by Stage and Route of Administration, H2 2018 206 Number of Products by Stage and Molecule Type, H2 2018 209 Pancreatic Cancer - Pipeline by 3-V Biosciences Inc, H2 2018 210 Pancreatic Cancer - Pipeline by 4P-Pharma SAS, H2 2018 210 Pancreatic Cancer - Pipeline by 4SC AG, H2 2018 211 Pancreatic Cancer - Pipeline by AB Science SA, H2 2018 211 Pancreatic Cancer - Pipeline by AbbVie Inc, H2 2018 212 Pancreatic Cancer - Pipeline by AbGenomics International Inc, H2 2018 212 Pancreatic Cancer - Pipeline by Ability Pharmaceuticals SL, H2 2018 213 Pancreatic Cancer - Pipeline by Aclaris Therapeutics Inc, H2 2018 213 Pancreatic Cancer - Pipeline by Actuate Therapeutics Inc, H2 2018 214 Pancreatic Cancer - Pipeline by Adamed Sp z oo, H2 2018 214 Pancreatic Cancer - Pipeline by ADC Therapeutics SA, H2 2018 214 Pancreatic Cancer - Pipeline by Aduro BioTech Inc, H2 2018 215 Pancreatic Cancer - Pipeline by Advanced BioDesign, H2 2018 215 Pancreatic Cancer - Pipeline by Advantagene Inc, H2 2018 216 Pancreatic Cancer - Pipeline by Advanz Pharmaceutical Corp , H2 2018 216 Pancreatic Cancer - Pipeline by Advenchen Laboratories LLC, H2 2018 217 Pancreatic Cancer - Pipeline by Agency for Science, Technology and Research, H2 2018 217 Pancreatic Cancer - Pipeline by AGV Discovery SAS, H2 2018 217 Pancreatic Cancer - Pipeline by AIMM Therapeutics BV, H2 2018 218 Pancreatic Cancer - Pipeline by Alissa Pharma, H2 2018 218 Pancreatic Cancer - Pipeline by Alligator Bioscience AB, H2 2018 219 Pancreatic Cancer - Pipeline by Allinky Biopharma SL, H2 2018 219 Pancreatic Cancer - Pipeline by Almac Discovery Ltd, H2 2018 219 Pancreatic Cancer - Pipeline by Altor BioScience Corp, H2 2018 220 Pancreatic Cancer - Pipeline by ALX Oncology Inc, H2 2018 220 Pancreatic Cancer - Pipeline by Ambrx Inc, H2 2018 220 Pancreatic Cancer - Pipeline by amcure GmbH, H2 2018 221 Pancreatic Cancer - Pipeline by Amgen Inc, H2 2018 221 Pancreatic Cancer - Pipeline by Amplia Therapeutics Ltd, H2 2018 222 Pancreatic Cancer - Pipeline by Anavex Life Sciences Corp, H2 2018 222 Pancreatic Cancer - Pipeline by Andarix Pharmaceuticals Inc, H2 2018 223 Pancreatic Cancer - Pipeline by ANP Technologies Inc, H2 2018 223 Pancreatic Cancer - Pipeline by AntiCancer Inc, H2 2018 223 Pancreatic Cancer - Pipeline by APEIRON Biologics AG, H2 2018 224 Pancreatic Cancer - Pipeline by Apexigen Inc, H2 2018 224 Pancreatic Cancer - Pipeline by Aphios Corp, H2 2018 224 Pancreatic Cancer - Pipeline by Aposense Ltd, H2 2018 225 Pancreatic Cancer - Pipeline by Aravive Inc, H2 2018 225 Pancreatic Cancer - Pipeline by ArQule Inc, H2 2018 226 Pancreatic Cancer - Pipeline by Array BioPharma Inc, H2 2018 226List of Figures Number of Products under Development for Pancreatic Cancer, H2 2018 91 Number of Products under Development by Companies, H2 2018 92 Number of Products under Development by Universities/Institutes, H2 2018 118 Number of Products by Top 10 Targets, H2 2018 169 Number of Products by Stage and Top 10 Targets, H2 2018 169 Number of Products by Top 10 Mechanism of Actions, H2 2018 187 Number of Products by Stage and Top 10 Mechanism of Actions, H2 2018 187 Number of Products by Top 10 Routes of Administration, H2 2018 205 Number of Products by Stage and Top 10 Routes of Administration, H2 2018 205 Number of Products by Top 10 Molecule Types, H2 2018 208 Number of Products by Stage and Top 10 Molecule Types, H2 2018 208

3-V Biosciences Inc 4P-Pharma SAS 4SC AG AB Science SA AbbVie Inc AbGenomics International Inc Ability Pharmaceuticals SL Aclaris Therapeutics Inc Actuate Therapeutics Inc Adamed Sp z oo ADC Therapeutics SA Aduro BioTech Inc Advanced BioDesign Advantagene Inc Advanz Pharmaceutical Corp Advenchen Laboratories LLC Agency for Science, Technology and Research AGV Discovery SAS AIMM Therapeutics BV Alissa Pharma Alligator Bioscience AB Allinky Biopharma SL Almac Discovery Ltd Altor BioScience Corp ALX Oncology Inc Ambrx Inc amcure GmbH Amgen Inc Amplia Therapeutics Ltd Anavex Life Sciences Corp Andarix Pharmaceuticals Inc ANP Technologies Inc AntiCancer Inc APEIRON Biologics AG Apexigen Inc Aphios Corp Aposense Ltd Aravive Inc ArQule Inc Array BioPharma Inc Asana BioSciences LLC Ascelia Pharma AB Astellas Pharma Inc AstraZeneca Plc Aurigene Discovery Technologies Ltd AVEO Pharmaceuticals Inc Axcentua Pharmaceuticals AB Basilea Pharmaceutica Ltd Batu Biologics Inc Bavarian Nordic A/S Bayer AG BeiGene Ltd Bellicum Pharmaceuticals Inc Berg LLC BerGenBio ASA Bexion Pharmaceuticals LLC BeyondSpring Inc Bio-Path Holdings Inc BioAtla LLC Biokine Therapeutics Ltd BioLineRx Ltd BioMoti Ltd Biomunex Pharmaceuticals Biothera Pharmaceutical Inc Biouniversa srl BioXcel Therapeutics Inc BLR Bio LLC Boehringer Ingelheim GmbH Boston Biomedical Inc BriaCell Therapeutics Corp Bristol-Myers Squibb Co Cancer Prevention Pharmaceuticals Inc Canget BioTekpharma LLC Cantargia AB Cantex Pharmaceuticals Inc CARsgen Therapeutics Ltd CBM BioPharma Inc CBT Pharmaceuticals Inc CCRP Therapeutics GmbH Celgene Corp Celldex Therapeutics Inc Cellectar Biosciences Inc Celleron Therapeutics Ltd Cellular Biomedicine Group Inc Celprogen Inc Celyad SA Centrose LLC ChemoCentryx Inc Chugai Pharmaceutical Co Ltd Clovis Oncology Inc COARE Biotechnology Inc Codiak BioSciences Inc Corcept Therapeutics Inc Cotinga Pharmaceuticals Inc CPL Biologicals Pvt Ltd CrystalGenomics Inc CTI BioPharma Corp Cyclacel Pharmaceuticals Inc CytImmune Sciences Inc Cytori Therapeutics Inc CyTuVax BV Daiichi Sankyo Co Ltd DEKK-TEC Inc Delta-Fly Pharma Inc Denceptor Therapeutics Ltd Diffusion Pharmaceuticals Inc Eisai Co Ltd Eleison Pharmaceuticals LLC Eli Lilly and Co Endor Technologies SL Enterome Bioscience SA Erytech Pharma SA Esperance Pharmaceuticals Inc Etubics Corp Exelixis Inc F. Hoffmann-La Roche Ltd Faron Pharmaceuticals Oy Felicitex Therapeutics Inc FibroGen Inc Forbius Formosa Laboratories Inc