Table of Contents Table of Contents 2 Introduction 5 Diabetic Foot Ulcers - Overview 6 Diabetic Foot Ulcers - Therapeutics Development 7 Diabetic Foot Ulcers - Therapeutics Assessment 17 Diabetic Foot Ulcers - Companies Involved in Therapeutics Development 25 Diabetic Foot Ulcers - Drug Profiles 37 Diabetic Foot Ulcers - Dormant Projects 118 Diabetic Foot Ulcers - Discontinued Products 122 Diabetic Foot Ulcers - Product Development Milestones 123 Appendix 132

List of Tables Number of Products under Development for Diabetic Foot Ulcers, H2 2018 12 Number of Products under Development by Companies, H2 2018 14 Number of Products under Development by Universities/Institutes, H2 2018 17 Products under Development by Companies, H2 2018 18 Products under Development by Universities/Institutes, H2 2018 21 Number of Products by Stage and Target, H2 2018 23 Number of Products by Stage and Mechanism of Action, H2 2018 25 Number of Products by Stage and Route of Administration, H2 2018 27 Number of Products by Stage and Molecule Type, H2 2018 29 Diabetic Foot Ulcers - Pipeline by Anterogen Co Ltd, H2 2018 30 Diabetic Foot Ulcers - Pipeline by CardioVascular BioTherapeutics Inc, H2 2018 30 Diabetic Foot Ulcers - Pipeline by Celularity Inc, H2 2018 31 Diabetic Foot Ulcers - Pipeline by Cynata Therapeutics Ltd, H2 2018 31 Diabetic Foot Ulcers - Pipeline by CytoTools AG, H2 2018 32 Diabetic Foot Ulcers - Pipeline by Energenesis Biomedical Co Ltd, H2 2018 32 Diabetic Foot Ulcers - Pipeline by EyeGene Inc, H2 2018 32 Diabetic Foot Ulcers - Pipeline by Factor Therapeutics Ltd, H2 2018 33 Diabetic Foot Ulcers - Pipeline by FirstString Research Inc, H2 2018 33 Diabetic Foot Ulcers - Pipeline by Genentech Inc, H2 2018 34 Diabetic Foot Ulcers - Pipeline by Human Stem Cells Institute, H2 2018 34 Diabetic Foot Ulcers - Pipeline by Lakewood-Amedex Inc, H2 2018 34 Diabetic Foot Ulcers - Pipeline by MallInckrodt Plc, H2 2018 35 Diabetic Foot Ulcers - Pipeline by MediWound Ltd, H2 2018 35 Diabetic Foot Ulcers - Pipeline by NovaLead Pharma Pvt Ltd, H2 2018 36 Diabetic Foot Ulcers - Pipeline by OliX Pharmaceuticals Inc, H2 2018 36 Diabetic Foot Ulcers - Pipeline by Oneness Biotech Co Ltd, H2 2018 37 Diabetic Foot Ulcers - Pipeline by Pherecydes Pharma SA, H2 2018 37 Diabetic Foot Ulcers - Pipeline by ProMetic Life Sciences Inc, H2 2018 38 Diabetic Foot Ulcers - Pipeline by Promore Pharma AB, H2 2018 38 Diabetic Foot Ulcers - Pipeline by Shionogi & Co Ltd, H2 2018 38 Diabetic Foot Ulcers - Pipeline by Stempeutics Research Pvt Ltd, H2 2018 39 Diabetic Foot Ulcers - Pipeline by SynDermix AG, H2 2018 39 Diabetic Foot Ulcers - Pipeline by TechnoPhage SA, H2 2018 40 Diabetic Foot Ulcers - Pipeline by Topadur Pharma AG, H2 2018 40 Diabetic Foot Ulcers - Pipeline by USV Pvt Ltd, H2 2018 40 Diabetic Foot Ulcers - Pipeline by ViroMed Co Ltd, H2 2018 41 Diabetic Foot Ulcers - Pipeline by ZZ Biotech LLC, H2 2018 41 Diabetic Foot Ulcers - Dormant Projects, H2 2018 123 Diabetic Foot Ulcers - Discontinued Products, H2 2018 127List of Figures Number of Products under Development for Diabetic Foot Ulcers, H2 2018 12 Number of Products under Development by Companies, H2 2018 13 Number of Products by Top 10 Targets, H2 2018 22 Number of Products by Stage and Top 10 Targets, H2 2018 22 Number of Products by Top 10 Mechanism of Actions, H2 2018 24 Number of Products by Stage and Top 10 Mechanism of Actions, H2 2018 24 Number of Products by Routes of Administration, H2 2018 26 Number of Products by Stage and Routes of Administration, H2 2018 26 Number of Products by Top 10 Molecule Types, H2 2018 28 Number of Products by Stage and Top 10 Molecule Types, H2 2018 28

Anterogen Co Ltd CardioVascular BioTherapeutics Inc Celularity Inc Cynata Therapeutics Ltd CytoTools AG Energenesis Biomedical Co Ltd EyeGene Inc Factor Therapeutics Ltd FirstString Research Inc Genentech Inc Human Stem Cells Institute Lakewood-Amedex Inc MallInckrodt Plc MediWound Ltd NovaLead Pharma Pvt Ltd OliX Pharmaceuticals Inc Oneness Biotech Co Ltd Pherecydes Pharma SA ProMetic Life Sciences Inc Promore Pharma AB Shionogi & Co Ltd Stempeutics Research Pvt Ltd SynDermix AG TechnoPhage SA Topadur Pharma AG USV Pvt Ltd ViroMed Co Ltd ZZ Biotech LLC