Table of Contents Table of Contents 2 Introduction 5 High Affinity Nerve Growth Factor Receptor (Neurotrophic Tyrosine Kinase Receptor Type 1 or TRK1 Transforming Tyrosine Kinase Protein or Tropomyosin Related Kinase A or Tyrosine Kinase Receptor or gp140trk or p140 TrkA or NTRK1 or EC 2.7.10.1) - Overview 7 High Affinity Nerve Growth Factor Receptor (Neurotrophic Tyrosine Kinase Receptor Type 1 or TRK1 Transforming Tyrosine Kinase Protein or Tropomyosin Related Kinase A or Tyrosine Kinase Receptor or gp140trk or p140 TrkA or NTRK1 or EC 2.7.10.1) - Therapeutics Development 8 High Affinity Nerve Growth Factor Receptor (Neurotrophic Tyrosine Kinase Receptor Type 1 or TRK1 Transforming Tyrosine Kinase Protein or Tropomyosin Related Kinase A or Tyrosine Kinase Receptor or gp140trk or p140 TrkA or NTRK1 or EC 2.7.10.1) - Therapeutics Assessment 25 High Affinity Nerve Growth Factor Receptor (Neurotrophic Tyrosine Kinase Receptor Type 1 or TRK1 Transforming Tyrosine Kinase Protein or Tropomyosin Related Kinase A or Tyrosine Kinase Receptor or gp140trk or p140 TrkA or NTRK1 or EC 2.7.10.1) - Companies Involved in Therapeutics Development 31 High Affinity Nerve Growth Factor Receptor (Neurotrophic Tyrosine Kinase Receptor Type 1 or TRK1 Transforming Tyrosine Kinase Protein or Tropomyosin Related Kinase A or Tyrosine Kinase Receptor or gp140trk or p140 TrkA or NTRK1 or EC 2.7.10.1) - Drug Profiles 42 High Affinity Nerve Growth Factor Receptor (Neurotrophic Tyrosine Kinase Receptor Type 1 or TRK1 Transforming Tyrosine Kinase Protein or Tropomyosin Related Kinase A or Tyrosine Kinase Receptor or gp140trk or p140 TrkA or NTRK1 or EC 2.7.10.1) - Dormant Products 96 High Affinity Nerve Growth Factor Receptor (Neurotrophic Tyrosine Kinase Receptor Type 1 or TRK1 Transforming Tyrosine Kinase Protein or Tropomyosin Related Kinase A or Tyrosine Kinase Receptor or gp140trk or p140 TrkA or NTRK1 or EC 2.7.10.1) - Discontinued Products 99 High Affinity Nerve Growth Factor Receptor (Neurotrophic Tyrosine Kinase Receptor Type 1 or TRK1 Transforming Tyrosine Kinase Protein or Tropomyosin Related Kinase A or Tyrosine Kinase Receptor or gp140trk or p140 TrkA or NTRK1 or EC 2.7.10.1) - Product Development Milestones 101 Appendix 113

List of Tables Number of Products under Development by Stage of Development, H2 2018 Number of Products under Development by Therapy Areas, H2 2018 Number of Products under Development by Indications, H2 2018 Number of Products under Development by Indications, H2 2018 (Contd..1), H2 2018 Number of Products under Development by Indications, H2 2018 (Contd..2), H2 2018 Number of Products under Development by Indications, H2 2018 (Contd..3), H2 2018 Number of Products under Development by Companies, H2 2018 Number of Products under Development by Companies, H2 2018 (Contd..1) Products under Development by Companies, H2 2018 Products under Development by Companies, H2 2018 (Contd..1), H2 2018 Products under Development by Companies, H2 2018 (Contd..2), H2 2018 Products under Development by Companies, H2 2018 (Contd..3), H2 2018 Products under Development by Companies, H2 2018 (Contd..4), H2 2018 Products under Development by Companies, H2 2018 (Contd..5), H2 2018 Number of Products under Investigation by Universities/Institutes, H2 2018 Products under Investigation by Universities/Institutes, H2 2018 Number of Products by Stage and Mechanism of Actions, H2 2018 Number of Products by Stage and Route of Administration, H2 2018 Number of Products by Stage and Molecule Type, H2 2018 Pipeline by AlzeCure Pharma AB, H2 2018 Pipeline by Array BioPharma Inc, H2 2018 Pipeline by AstraZeneca Plc, H2 2018 Pipeline by Benevolentai Cambridge Ltd, H2 2018 Pipeline by Chugai Pharmaceutical Co Ltd, H2 2018 Pipeline by Daiichi Sankyo Co Ltd, H2 2018 Pipeline by Dompe Farmaceutici SpA, H2 2018 Pipeline by F. Hoffmann-La Roche Ltd, H2 2018 Pipeline by Genzyme Corp, H2 2018 Pipeline by Handok Inc, H2 2018 Pipeline by Loxo Oncology Inc, H2 2018 Pipeline by Merck & Co Inc, H2 2018 Pipeline by NMS Group SpA, H2 2018 Pipeline by Pfizer Inc, H2 2018 Pipeline by Plexxikon Inc, H2 2018 Pipeline by Purdue Pharma LP, H2 2018 Pipeline by Rottapharm Biotech Srl, H2 2018 Pipeline by Sienna Biopharmaceuticals Inc, H2 2018 Pipeline by Tiziana Life Sciences Plc, H2 2018 Dormant Products, H2 2018 Dormant Products, H2 2018 (Contd..1), H2 2018 Dormant Products, H2 2018 (Contd..2), H2 2018 Discontinued Products, H2 2018 Discontinued Products, H2 2018 (Contd..1), H2 2018List of Figures Number of Products under Development by Stage of Development, H2 2018 Number of Products under Development by Therapy Areas, H2 2018 Number of Products under Development by Top 10 Indications, H2 2018 Number of Products by Mechanism of Actions, H2 2018 Number of Products by Stage and Mechanism of Actions, H2 2018 Number of Products by Routes of Administration, H2 2018 Number of Products by Stage and Routes of Administration, H2 2018 Number of Products by Molecule Types, H2 2018 Number of Products by Stage and Molecule Types, H2 2018

AlzeCure Pharma AB Array BioPharma Inc AstraZeneca Plc Benevolentai Cambridge Ltd Chugai Pharmaceutical Co Ltd Daiichi Sankyo Co Ltd Dompe Farmaceutici SpA F. Hoffmann-La Roche Ltd Genzyme Corp Handok Inc Loxo Oncology Inc Merck & Co Inc NMS Group SpA Pfizer Inc Plexxikon Inc Purdue Pharma LP Rottapharm Biotech Srl Sienna Biopharmaceuticals Inc Tiziana Life Sciences Plc