1 Table of Contents 1 Table of Contents 4 1.1 List of Tables 5 1.2 List of Figures 8 2 Introduction 9 2.1 Pain Report Coverage 9 2.2 Post-Operative Pain - Overview 9 2.3 Fibromyalgia - Overview 9 2.4 Complex Regional Pain Syndrome - Overview 9 2.5 Visceral Pain - Overview 9 3 Therapeutics Development 10 3.1 Post-Operative Pain 10 3.2 Fibromyalgia 18 3.3 Complex Regional Pain Syndrome 22 3.4 Visceral Pain 25 4 Therapeutics Assessment 32 4.1 Post-Operative Pain 32 4.2 Fibromyalgia 42 4.3 Complex Regional Pain Syndrome 49 4.4 Visceral Pain 54 5 Companies Involved in Therapeutics Development 62 5.1 Post-Operative Pain 62 5.2 Fibromyalgia 85 5.3 Complex Regional Pain Syndrome 91 5.4 Visceral Pain 93 6 Dormant Projects 103 6.1 Post-Operative Pain 103 6.2 Fibromyalgia 106 6.3 Complex Regional Pain Syndrome 107 6.4 Visceral Pain 108 7 Discontinued Products 111 7.1 Post-Operative Pain 111 7.2 Fibromyalgia 112 7.3 Visceral Pain 112 8 Product Development Milestones 114 8.1 Post-Operative Pain 114 8.2 Fibromyalgia 127 8.3 Complex Regional Pain Syndrome 138 8.4 Visceral Pain 141 9 Appendix 147 9.1 Methodology 147 9.2 Coverage 147 9.3 Secondary Research 147 9.4 Primary Research 147 9.5 Expert Panel Validation 147 9.6 Contact Us 148 9.7 Disclaimer 148

1.1 List of Tables Table 1: Number of Products under Development for Post-Operative Pain 10 Table 2: Number of Products under Development by Companies, Post-Operative Pain 12 Table 3: Number of Products under Development by Universities/Institutes, Post-Operative Pain 14 Table 4: Products under Development by Companies, Post-Operative Pain 15 Table 5: Products under Development by Universities/Institutes, Post-Operative Pain 18 Table 6: Number of Products under Development for Fibromyalgia 19 Table 7: Number of Products under Development by Companies, Fibromyalgia 20 Table 8: Number of Products under Development by Universities/Institutes, Fibromyalgia 20 Table 9: Products under Development by Companies, Fibromyalgia 21 Table 10: Products under Development by Universities/Institutes, Fibromyalgia 22 Table 11: Number of Products under Development for Complex Regional Pain Syndrome 22 Table 12: Number of Products under Development by Companies, Complex Regional Pain Syndrome 23 Table 13: Number of Products under Development by Universities/Institutes, Complex Regional Pain Syndrome 24 Table 14: Products under Development by Companies, Complex Regional Pain Syndrome 24 Table 15: Products under Development by Universities/Institutes, Complex Regional Pain Syndrome 24 Table 16: Number of Products under Development for Visceral Pain 25 Table 17: Number of Products under Development by Companies, Visceral Pain 27 Table 18: Number of Products under Development by Universities/Institutes, Visceral Pain 28 Table 19: Products under Development by Companies, Visceral Pain 29 Table 20: Products under Development by Universities/Institutes, Visceral Pain 31 Table 21: Number of Products by Stage and Target, Post-Operative Pain 33 Table 22: Number of Products by Stage and Mechanism of Action, Post-Operative Pain 36 Table 23: Number of Products by Stage and Route of Administration, Post-Operative Pain 39 Table 24: Number of Products by Stage and Molecule Type, Post-Operative Pain 41 Table 25: Number of Products by Stage and Target, Fibromyalgia 43 Table 26: Number of Products by Stage and Mechanism of Action, Fibromyalgia 45 Table 27: Number of Products by Stage and Route of Administration, Fibromyalgia 47 Table 28: Number of Products by Stage and Molecule Type, Fibromyalgia 48 Table 29: Number of Products by Stage and Target, Complex Regional Pain Syndrome 50 Table 30: Number of Products by Stage and Mechanism of Action, Complex Regional Pain Syndrome 51 Table 31: Number of Products by Stage and Route of Administration, Complex Regional Pain Syndrome 53 Table 32: Number of Products by Stage and Molecule Type, Complex Regional Pain Syndrome 53 Table 33: Number of Products by Stage and Target, Visceral Pain 55 Table 34: Number of Products by Stage and Mechanism of Action, Visceral Pain 57 Table 35: Number of Products by Stage and Route of Administration, Visceral Pain 59 Table 36: Number of Products by Stage and Molecule Type, Visceral Pain 61 Table 37: Post-Operative Pain - Pipeline by Abide Therapeutics Inc 62 Table 38: Post-Operative Pain - Pipeline by AcelRx Pharmaceuticals Inc 62 Table 39: Post-Operative Pain - Pipeline by Adynxx Inc 63 Table 40: Post-Operative Pain - Pipeline by AngioChem Inc 63 Table 41: Post-Operative Pain - Pipeline by Aoxing Pharmaceutical Company Inc 64 Table 42: Post-Operative Pain - Pipeline by Apsen Farmaceutica SA 64 Table 43: Post-Operative Pain - Pipeline by Cadila Healthcare Ltd 65 Table 44: Post-Operative Pain - Pipeline by Camurus AB 65 Table 45: Post-Operative Pain - Pipeline by Cara Therapeutics Inc 66 Table 46: Post-Operative Pain - Pipeline by Center Laboratories Inc 66 Table 47: Post-Operative Pain - Pipeline by CerSci Therapeutics Inc 67 Table 48: Post-Operative Pain - Pipeline by Colby Pharmaceutical Co 67 Table 49: Post-Operative Pain - Pipeline by Dompe Farmaceutici SpA 68 Table 50: Post-Operative Pain - Pipeline by Eupraxia Pharmaceuticals Inc 68 Table 51: Post-Operative Pain - Pipeline by EyeGate Pharmaceuticals Inc 69 Table 52: Post-Operative Pain - Pipeline by Fujimoto Pharmaceutical Corp 69 Table 53: Post-Operative Pain - Pipeline by GW Pharmaceuticals Plc 70 Table 54: Post-Operative Pain - Pipeline by Heron Therapeutics Inc 70 Table 55: Post-Operative Pain - Pipeline by Immupharma Plc 71 Table 56: Post-Operative Pain - Pipeline by Innocoll AG 71 Table 57: Post-Operative Pain - Pipeline by Insys Therapeutics Inc 72 Table 58: Post-Operative Pain - Pipeline by Ionis Pharmaceuticals Inc 72 Table 59: Post-Operative Pain - Pipeline by iX Biopharma Ltd 73 Table 60: Post-Operative Pain - Pipeline by Jiangsu Hengrui Medicine Co Ltd 73 Table 61: Post-Operative Pain - Pipeline by Lipocure Ltd 74 Table 62: Post-Operative Pain - Pipeline by Liquidia Technologies Inc 74 Table 63: Post-Operative Pain - Pipeline by Lumosa Therapeutics Co Ltd 74 Table 64: Post-Operative Pain - Pipeline by Medtronic Plc 751.2 List of Figures Figure 1: Number of Products under Development for Post-Operative Pain 10 Figure 2: Number of Products under Development by Companies, Post-Operative Pain 11 Figure 3: Number of Products under Development by Universities/Institutes, Post-Operative Pain 14 Figure 4: Number of Products under Development for Fibromyalgia 18 Figure 5: Number of Products under Development by Companies, Fibromyalgia 19 Figure 6: Number of Products under Development for Complex Regional Pain Syndrome 22 Figure 7: Number of Products under Development by Companies, Complex Regional Pain Syndrome 23 Figure 8: Number of Products under Development for Visceral Pain 25 Figure 9: Number of Products under Development by Companies, Visceral Pain 26 Figure 10: Number of Products under Development by Universities/Institutes, Visceral Pain 28 Figure 11: Number of Products by Top 10 Targets, Post-Operative Pain 32 Figure 12: Number of Products by Stage and Top 10 Targets, Post-Operative Pain 32 Figure 13: Number of Products by Top 10 Mechanism of Actions, Post-Operative Pain 35 Figure 14: Number of Products by Stage and Top 10 Mechanism of Actions, Post-Operative Pain 35 Figure 15: Number of Products by Top 10 Routes of Administration, Post-Operative Pain 38 Figure 16: Number of Products by Stage and Top 10 Routes of Administration, Post-Operative Pain 38 Figure 17: Number of Products by Molecule Types, Post-Operative Pain 40 Figure 18: Number of Products by Stage and Molecule Types, Post-Operative Pain 40 Figure 19: Number of Products by Top 10 Targets, Fibromyalgia 42 Figure 20: Number of Products by Stage and Top 10 Targets, Fibromyalgia 42 Figure 21: Number of Products by Top 10 Mechanism of Actions, Fibromyalgia 44 Figure 22: Number of Products by Stage and Top 10 Mechanism of Actions, Fibromyalgia 44 Figure 23: Number of Products by Routes of Administration, Fibromyalgia 46 Figure 24: Number of Products by Stage and Routes of Administration, Fibromyalgia 46 Figure 25: Number of Products by Molecule Types, Fibromyalgia 47 Figure 26: Number of Products by Stage and Molecule Types, Fibromyalgia 48 Figure 27: Number of Products by Targets, Complex Regional Pain Syndrome 49 Figure 28: Number of Products by Stage and Targets, Complex Regional Pain Syndrome 49 Figure 29: Number of Products by Mechanism of Actions, Complex Regional Pain Syndrome 50 Figure 30: Number of Products by Stage and Mechanism of Actions, Complex Regional Pain Syndrome 51 Figure 31: Number of Products by Routes of Administration, Complex Regional Pain Syndrome 52 Figure 32: Number of Products by Stage and Top 10 Routes of Administration, Complex Regional Pain Syndrome 52 Figure 33: Number of Products by Stage and Molecule Types, Complex Regional Pain Syndrome 53 Figure 34: Number of Products by Top 10 Targets, Visceral Pain 54 Figure 35: Number of Products by Stage and Top 10 Targets, Visceral Pain 54 Figure 36: Number of Products by Top 10 Mechanism of Actions, Visceral Pain 56 Figure 37: Number of Products by Stage and Top 10 Mechanism of Actions, Visceral Pain 56 Figure 38: Number of Products by Routes of Administration, Visceral Pain 58 Figure 39: Number of Products by Stage and Routes of Administration, Visceral Pain 59 Figure 40: Number of Products by Molecule Types, Visceral Pain 60 Figure 41: Number of Products by Stage and Molecule Types, Visceral Pain 60

Abide Therapeutics Inc Abiogen Pharma SpA AcelRx Pharmaceuticals Inc Addex Therapeutics Ltd Adynxx Inc Anavex Life Sciences Corp AngioChem Inc Aoxing Pharmaceutical Company Inc Apsen Farmaceutica SA Aptinyx Inc Arena Pharmaceuticals Inc Artelo Biosciences Inc Astellas Pharma Inc Cadila Healthcare Ltd Camurus AB Cara Therapeutics Inc Center Laboratories Inc CerSci Therapeutics Inc Chromocell Corp Colby Pharmaceutical Co Daiichi Sankyo Co Ltd Dompe Farmaceutici SpA Echo Pharmaceuticals BV Eisai Co Ltd Eli Lilly and Co Eupraxia Pharmaceuticals Inc EyeGate Pharmaceuticals Inc Fujimoto Pharmaceutical Corp Grunenthal GmbH GW Pharmaceuticals Plc Heron Therapeutics Inc Idera Pharmaceuticals Inc Immupharma Plc Innocoll AG Innovative Med Concepts LLC Insys Therapeutics Inc Intec Pharma Ltd Ionis Pharmaceuticals Inc Ironwood Pharmaceuticals Inc iX Biopharma Ltd Jiangsu Hengrui Medicine Co Ltd Kyorin Pharmaceutical Co Ltd Kytogenics Pharmaceuticals Inc Lipella Pharmaceuticals Inc Lipocure Ltd Liquidia Technologies Inc Lumosa Therapeutics Co Ltd Luye Pharma Group Ltd Medtronic Plc Merck & Co Inc Mundipharma International Ltd Neumentum Inc Novartis AG Ocular Therapeutix Inc Pacira Pharmaceuticals Inc PainReform Ltd Pfizer Inc Pharmaleads SA PhytoHealth Corp Piramal Enterprises Ltd PixarBio Corp PolyPid Ltd Prismic Pharmaceuticals Inc RaQualia Pharma Inc Recro Pharma Inc Serina Therapeutics Inc SteadyMed Therapeutics Inc Taiwan Liposome Company Ltd Teikoku Pharma USA Inc Tetra Bio-Pharma Inc Trevena Inc UCB SA Urigen Pharmaceuticals Inc Virpax Pharmaceuticals Inc Vitality Biopharma Inc Xigen SA YiChang Humanwell Pharmaceutical Co Ltd