1 Table of Contents 1 Table of Contents 5 1.1 List of Tables 7 1.2 List of Figures 8 2 Introduction 10 2.1 Disease Introduction 10 2.2 Epidemiology 10 2.3 Symptoms 11 2.4 Etiology and Pathophysiology 12 2.4.1 Pathophysiology 15 2.5 Diagnosis 16 2.5.1 Diagnostic Algorithm for Chronic HF 16 2.5.2 Diagnostic Algorithm for Acute HF 19 2.6 Disease Classification 20 2.6.1 Co-morbidities and Complications 22 2.7 Prognosis 23 2.8 Treatment Options and Treatment Algorithm 24 2.8.1 Treatment Options 24 2.8.2 Treatment Algorithm 26 2.8.3 Non-pharmacological Treatments 31 3 Marketed Products 32 3.1 Overview 32 3.1.1 Entresto (sacubitril plus valsartan) - Novartis 33 3.1.2 Procoralan (ivabradine) - Les Laboratoires Servier 35 3.1.3 Angiotensin-Converting Enzyme Inhibitors 36 3.1.4 Angiotensin Receptor Blockers 37 3.1.5 Diuretics 38 3.1.6 Beta Blockers 39 3.1.7 Mineralocorticoid Receptor Antagonists 40 3.1.8 Digoxin 41 3.2 Comparative Efficacy and Safety of Marketed Products 42 4 Pipeline Analysis 44 4.1 Pipeline by Stage of Development, Molecule Type, Route of Administration and Program Type 44 4.2 Pipeline by Molecular Target 47 4.3 Promising Pipeline Candidates 49 4.3.1 Omecamtiv mecarbil (CK-1827452/AMG-423) - Cynokinetics 49 4.3.2 Vericiguat - Bayer/Merck & Co. 50 4.4 Comparative Efficacy and Safety of Pipeline Products 52 4.5 Product Competitiveness Framework 53 5 Clinical Trial Analysis 54 5.1 Failure Rate 54 5.1.1 Overall Failure Rate 54 5.1.2 Failure Rate by Phase and Molecule Type 56 5.1.3 Failure Rate by Phase and Molecular Target 57 5.2 Clinical Trial Size 58 5.2.1 Patient Enrollment per Product by Molecule Type and Stage of Development 58 5.2.2 Patient Enrollment per Product by Molecular Target and Stage of Development 59 5.2.3 Patient Enrollment per Trial by Molecule Type and Stage of Development 60 5.2.4 Patient Enrollment per Trial by Molecular Target and Stage of Development 61 5.3 Clinical Trial Duration 62 5.3.1 Trial Duration by Molecule Type and Stage of Development 62 5.3.2 Trial Duration by Molecular Target and Stage of Development 63 5.4 Summary of Clinical Trial Metrics 64 6 Multi-scenario Forecast 65 6.1 Geographical Markets 65 6.2 Asia-Pacific Market 65 6.3 India 67 6.3.1 Treatment Usage Patterns 67 6.3.2 Annual Cost of Therapy 68 6.3.3 Market Size 69 6.4 China 70 6.4.1 Treatment Usage Patterns 70 6.4.2 Annual Cost of Therapy 71 6.4.3 Market Size 73 6.5 Australia 74 6.5.1 Treatment Usage Patterns 74 6.5.2 Annual Cost of Therapy 75 6.5.3 Market Size 76 6.6 South Korea 77 6.6.1 Treatment Usage Patterns 77 6.6.2 Annual Cost of Therapy 78 6.6.3 Market Size 79 6.7 Japan 80 6.7.1 Treatment Usage Patterns 80 6.7.2 Annual Cost of Therapy 81 6.7.3 Market Size 82 7 Drivers and Barriers 84 7.1 Drivers 84 7.1.1 Rising Prevalence and Growing Awareness of the Disease to Drive Market Growth 84 7.1.2 Promising Pipeline Products that Target Unmet Needs for HF 84 7.1.3 Increasing Awareness and Diversified Healthcare Reform to Boost Market Growth 84 7.1.4 Launch of Entresto and its Label Expansion will Drive Market Growth 85 7.2 Barriers 85 7.2.1 Market Access for New Therapies as well as Crowded and Cheap Generic Market 85 7.2.2 Lack of Development of Acute HF Pipeline Products 85 7.2.3 Reluctance of Cardiologists to Adopt New Therapies 86 8 Deals and Strategic Consolidations 87 8.1 Licensing Deals 87 8.1.1 Deals by Region and Value 87 8.1.2 Number of Disclosed and Undisclosed Deals by Year, Aggregate Deal Value 89 8.1.3 Deal Value by Stage of Development, Molecule Type, and Molecular Target 90 8.1.4 Key Licensing Deals 92 8.2 Co-development Deals 95 8.2.1 Deals by Region and Value 95 8.2.2 Number of Disclosed and Undisclosed Deals by Year, Aggregate Deal Value 96 8.2.3 Deal Value by Stage of Development, Molecule Type, and Molecular Target 97 8.2.4 Key Co-development Deals 99 9 Appendix 101 9.1 All Pipeline Drugs by Stage of Development 101 9.1.1 Discovery 101 9.1.2 Preclinical 102 9.1.3 IND/CTA-filed 106 9.1.4 Phase I 106 9.1.5 Phase II 107 9.1.6 Phase III 109 9.1.7 Pre-registration 109 9.2 Summary of Multi-scenario Market Forecasts to 2024 110 9.2.1 Asia-Pacific 110 9.2.2 India 110 9.2.3 China 111 9.2.4 Australia 111 9.2.5 South Korea 112 9.2.6 Japan 112 9.3 Bibliography 112 9.4 Abbreviations 118 9.5 Research Methodology 119 9.5.1 Secondary Research 120 9.5.2 Marketed Product Profiles 120 9.5.3 Late-Stage Pipeline Candidates 121 9.5.4 Comparative Efficacy and Safety Heat Map for Marketed and Pipeline Products 121 9.5.5 Product Competitiveness Framework 121 9.5.6 Pipeline Analysis 121 9.5.7 Forecasting Model 122 9.5.8 Deals Data Analysis 123 9.6 Contact Us 123 9.7 Disclaimer 123

1.1 List of Tables Table 1: Heart Failure Therapeutics Market, Symptoms 12 Table 2: Heart Failure Therapeutics Market, New York Heart Association Classification of HF 13 Table 3: Heart Failure Therapeutics Market, Etiologies of HF 14 Table 4: Heart Failure Therapeutics Market, Key Diagnostic and Prognostic Biomarkers in HF 19 Table 5: Heart Failure Therapeutics Market, Definition of HF with Preserved (HFpEF), Mid-range (HFmrEF) and Reduced Ejection Fraction (HFrEF) 21 Table 6: Heart Failure Therapeutics Market, Importance of Co-morbidities in Patients with HF 22 Table 7: Heart Failure Therapeutics Market, Drugs Used in HF with Reduced Left Ventricular Ejection Fraction 27 Table 8: Heart Failure Therapeutics Market, Global, Licensing Deals Value, 2007-2018 94 Table 9: Heart Failure Therapeutics Market, Global, Co-development Deals Value, 2007-2018 100 Table 10: Heart Failure Therapeutics Market, Global, All Pipeline Products, Discovery, 2018 101 Table 11: Heart Failure Therapeutics Market, Global, All Pipeline Products, Preclinical, 2018 102 Table 12: Heart Failure Therapeutics Market, Global, All Pipeline Products, IND/CTA-filed, 2018 106 Table 13: Heart Failure Therapeutics Market, Global, All Pipeline Products, Phase I, 2018 106 Table 14: Heart Failure Therapeutics Market, Global, All Pipeline Products, Phase II, 2018 107 Table 15: Heart Failure Therapeutics Market, Global, All Pipeline Products, Phase III, 2018 109 Table 16: Heart Failure Therapeutics Market, Global, All Pipeline Products, Phase III, 2018 109 Table 17: Heart Failure Therapeutics Market, APAC, Market Forecast, 2017-2024 110 Table 18: Heart Failure Therapeutics Market, India, Market Forecast, 2017-2024 110 Table 19: Heart Failure Therapeutics Market, China, Market Forecast, 2017-2024 111 Table 20: Heart Failure Therapeutics Market, Australia, Market Forecast, 2017-2024 111 Table 21: Heart Failure Therapeutics Market, South Korea, Market Forecast, 2017-2024 112 Table 22: Heart Failure Therapeutics Market, Japan, Market Forecast, 2017-2024 1121.2 List of Figures Figure 1: Heart Failure Therapeutics Market, Western Australia, Prevalence of HF Due to Risk factors (%) 11 Figure 2: Heart Failure Therapeutics Market, Types of HF 13 Figure 3: Heart Failure Therapeutics Market, Pathophysiology of HF 16 Figure 4: Heart Failure Therapeutics Market, Diagnostic Algorithm for Chronic HF 17 Figure 5: Heart Failure Therapeutics Market, Diagnosis Algorithm of Acute HF 19 Figure 6: Heart Failure Therapeutics Market, Stages of HF 20 Figure 7: Heart Failure Therapeutics Market, Approach to Management of HF with Reduced Ejection Fraction 28 Figure 8: Heart Failure Therapeutics Market, Management of Patients with Acute HF Based on Clinical Profile During an Early Phase 30 Figure 9: Heart Failure Therapeutics Market, Comparative Efficacy and Safety Heatmap for Marketed Products for Heart Failure Treatment, 2018 43 Figure 10: Heart Failure Therapeutics Market, Global, Pipeline, 2018 46 Figure 11: Heart Failure Therapeutics Market, Global, Pipeline by Molecular Target, 2018 48 Figure 12: Heart Failure Therapeutics Market, APAC, Omecamtiv Mecarbil Forecast ($m), 2022-2024 50 Figure 13: Heart Failure Therapeutics Market, APAC, Vericiguat Forecast ($m), 2021-2024 52 Figure 14: Heart Failure Therapeutics Market, Comparative Efficacy and Safety Heatmap for Pipeline Products for Heart Failure Treatment 52 Figure 15: Heart Failure Therapeutics, Global, Average Clinical Trial Failure Rate (%), 2007-2017 55 Figure 16: Heart Failure Therapeutics, Global, Clinical Trial Failure Rates by Molecule Type (%), 2007-2017 56 Figure 17: Heart Failure Therapeutics, Global, Clinical Trial Failure Rates by Molecular Target (%), 2007-2017 57 Figure 18: Heart Failure Therapeutics, Global, Clinical Trial Size per Product by Molecule Type (participants), 2007-2017 58 Figure 19: Heart Failure Therapeutics, Global, Clinical Trial Size per Product by Molecular Target (participants), 2007-2017 59 Figure 20: Heart Failure Therapeutics, Global, Clinical Trial Size per Trial by Molecule Type (participants), 2007-2017 60 Figure 21: Heart Failure Therapeutics, Global, Clinical Trial Size per Trial by Molecular Target (participants), 2007-2017 61 Figure 22: Heart Failure Therapeutics, Global, Clinical Trial Duration by Molecule Type (months), 2007-2017 62 Figure 23 Heart Failure Therapeutics, Global, Clinical Trial Duration by Molecular Target (months), 2007-2017 63 Figure 24: Heart Failure Therapeutics Market, Global, Comparison of Average Trial Metrics by Phase and Molecule Type 64 Figure 25: Heart Failure Therapeutics Market, Global, Comparison of Average Trial Metrics by Phase and Molecular Target 64 Figure 26: Heart Failure Therapeutics Market, APAC, Treatment Patterns (‘000), 2017-2024 66 Figure 27: Heart Failure Therapeutics Market, APAC, Market Size ($m), 2017-2024 66 Figure 28: Heart Failure Therapeutics Market, India, Treatment Patterns (‘000), 2017-2024 67 Figure 29: Heart Failure Therapeutics Market, India, Annual Cost of Therapy ($), 2017-2024 69 Figure 30: Heart Failure Therapeutics Market, India, Market Size ($m), 2017-2024 69 Figure 31: Heart Failure Therapeutics Market, China, Treatment Patterns (‘000), 2017-2024 71 Figure 32: Heart Failure Therapeutics Market, China, Annual Cost of Therapy ($), 2017-2024 72 Figure 33: Heart Failure Therapeutics Market, China, Market Size ($m), 2017-2024 73 Figure 34: Heart Failure Therapeutics Market, Australia, Treatment Patterns (‘000), 2017-2024 74 Figure 35: Heart Failure Therapeutics Market, Australia, Annual Cost of Therapy ($), 2017-2024 76 Figure 36: Heart Failure Therapeutics Market, Australia, Market Size ($m), 2017-2024 76 Figure 37: Heart Failure Therapeutics Market, South Korea, Treatment Patterns (‘000), 2017-2024 77 Figure 38: Heart Failure Therapeutics Market, South Korea, Annual Cost of Therapy ($), 2017-2024 79 Figure 39: Heart Failure Therapeutics Market, South Korea, Market Size ($m), 2017-2024 79 Figure 40: Heart Failure Therapeutics Market, Japan, Treatment Patterns (‘000), 2017-2024 80 Figure 41: Heart Failure Therapeutics Market, Japan, Annual Cost of Therapy ($), 2017-2024 82 Figure 42: Heart Failure Therapeutics Market, Japan, Market Size ($m), 2017-2024 82 Figure 43: Heart Failure Therapeutics Market, Global, Licensing Deals by Region and Value, 2007-2018 88 Figure 44: Herat Failure Therapeutics Market, Global, Number of Disclosed and Undisclosed Licensing Deals by Year, Aggregate Deal Value and Aggregate Upfront Payment Value, 2007-2018 89 Figure 45: Heart Failure Therapeutics Market, Global, Licensing Deals by Stage of Development, Deal Value and Upfront Payment Value, 2007-2018 90 Figure 46: Heart Failure Therapeutics Market, Global, Licensing Deals by Molecule Type and Stage of Development, 2007-2018 91 Figure 47: Heart Failure Therapeutics Market, Global, Licensing Deals by Molecular Targets and Aggregate Deal Value ($), 2007-2018 92 Figure 48: Heart Failure Therapeutics Market, Global, Co-development Deals by Region and Deal Value, 2007-2018 95 Figure 49: Heart Failure Therapeutics Market, Global, Number of Disclosed and Undisclosed Co-development Deals by Year, Aggregate Deal Value and Aggregate Upfront Payment Value, 2007-2018 96 Figure 50: Heart Failure Therapeutics Market, Global, Co-development Deals by Stage of Development, Deal Value and Upfront Payment Value, 2007-2018 97 Figure 51: Heart Failure Therapeutics Market, Global, Co-development Deals by Molecule Type and Stage of Development, 2007-2018 98 Figure 52: Heart Failure Therapeutics Market, Global, Co-development Deals by Molecular Target, 2007-2018 99