1 Table of Contents 1 Table of Contents 4 1.1 List of Tables 5 1.2 List of Figures 7 2 Introduction 8 2.1 Respiratory Tract Infections Report Coverage 8 2.2 Tuberculosis - Overview 8 2.3 Diphtheria - Overview 8 2.4 Pertussis (Whooping Cough) - Overview 8 3 Therapeutics Development 9 3.1 Tuberculosis 9 3.2 Diphtheria 25 3.3 Pertussis (Whooping Cough) 32 4 Therapeutics Assessment 40 4.1 Tuberculosis 40 4.2 Diphtheria 49 4.3 Pertussis (Whooping Cough) 53 5 Companies Involved in Therapeutics Development 58 5.1 Tuberculosis 58 5.2 Diphtheria 86 5.3 Pertussis (Whooping Cough) 94 6 Dormant Projects 105 6.1 Tuberculosis 105 6.2 Diphtheria 112 6.3 Pertussis (Whooping Cough) 114 7 Discontinued Products 117 7.1 Tuberculosis 117 7.2 Diphtheria 117 7.3 Pertussis (Whooping Cough) 117 8 Product Development Milestones 118 8.1 Tuberculosis 118 8.2 Diphtheria 129 8.3 Pertussis (Whooping Cough) 138 9 Appendix 152 9.1 Methodology 152 9.2 Coverage 152 9.3 Secondary Research 152 9.4 Primary Research 152 9.5 Expert Panel Validation 152 9.6 Contact Us 153 9.7 Disclaimer 153

1.1 List of Tables Table 1: Number of Products under Development for Tuberculosis 9 Table 2: Number of Products under Development by Companies Tuberculosis 11 Table 3: Number of Products under Development by Universities/Institutes Tuberculosis 14 Table 4: Products under Development by Companies Tuberculosis 16 Table 5: Products under Development by Universities/Institutes Tuberculosis 21 Table 6: Number of Products under Development for Diphtheria 25 Table 7: Number of Products under Development by Companies Diphtheria 27 Table 8: Number of Products under Development by Universities/Institutes Diphtheria 28 Table 9: Products under Development by Companies Diphtheria 29 Table 10: Products under Development by Universities/Institutes Diphtheria 31 Table 11: Number of Products under Development for Pertussis (Whooping Cough) 32 Table 12: Number of Products under Development by Companies Pertussis (Whooping Cough) 34 Table 13: Number of Products under Development by Universities/Institutes Pertussis (Whooping Cough) 35 Table 14: Products under Development by Companies Pertussis (Whooping Cough) 36 Table 15: Products under Development by Universities/Institutes Pertussis (Whooping Cough) 39 Table 16: Number of Products by Stage and Target Tuberculosis 41 Table 17: Number of Products by Stage and Mechanism of Action Tuberculosis 44 Table 18: Number of Products by Stage and Route of Administration Tuberculosis 47 Table 19: Number of Products by Stage and Molecule Type Tuberculosis 48 Table 20: Number of Products by Stage and Target Diphtheria 50 Table 21: Number of Products by Stage and Route of Administration Diphtheria 51 Table 22: Number of Products by Stage and Molecule Type Diphtheria 53 Table 23: Number of Products by Stage and Target Pertussis (Whooping Cough) 54 Table 24: Number of Products by Stage and Mechanism of Action Pertussis (Whooping Cough) 54 Table 25: Number of Products by Stage and Route of Administration Pertussis (Whooping Cough) 56 Table 26: Number of Products by Stage and Molecule Type Pertussis (Whooping Cough) 57 Table 27: Tuberculosis - Pipeline by Abera Bioscience AB 58 Table 28: Tuberculosis - Pipeline by AGILeBiotics BV 58 Table 29: Tuberculosis - Pipeline by Akshaya Bio Inc 59 Table 30: Tuberculosis - Pipeline by Archivel Farma SL 59 Table 31: Tuberculosis - Pipeline by AstraZeneca Plc 60 Table 32: Tuberculosis - Pipeline by Aucta Pharmaceuticals LLC 60 Table 33: Tuberculosis - Pipeline by BioLingus AG 61 Table 34: Tuberculosis - Pipeline by Bioversys AG 61 Table 35: Tuberculosis - Pipeline by Celgene Corp 62 Table 36: Tuberculosis - Pipeline by Chongqing Zhifei Biological Products Co Ltd 62 Table 37: Tuberculosis - Pipeline by Consegna Pharma Inc 63 Table 38: Tuberculosis - Pipeline by Crestone Inc 63 Table 39: Tuberculosis - Pipeline by Daiichi Sankyo Co Ltd 64 Table 40: Tuberculosis - Pipeline by Demuris Ltd 64 Table 41: Tuberculosis - Pipeline by Eisai Co Ltd 65 Table 42: Tuberculosis - Pipeline by Eli Lilly and Co 65 Table 43: Tuberculosis - Pipeline by EpiVax Inc 66 Table 44: Tuberculosis - Pipeline by Evotec AG 66 Table 45: Tuberculosis - Pipeline by FIT Biotech Oy 67 Table 46: Tuberculosis - Pipeline by GangaGen Inc 67 Table 47: Tuberculosis - Pipeline by GC Pharma 68 Table 48: Tuberculosis - Pipeline by GlaxoSmithKline Plc 68 Table 49: Tuberculosis - Pipeline by Globeimmune Inc 69 Table 50: Tuberculosis - Pipeline by Hager Biosciences LLC 69 Table 51: Tuberculosis - Pipeline by Hsiri Therapeutics LLC 70 Table 52: Tuberculosis - Pipeline by Immodulon Therapeutics Ltd 70 Table 53: Tuberculosis - Pipeline by Immunitor Inc 711.2 List of Figures Figure 1: Number of Products under Development for Tuberculosis 9 Figure 2: Number of Products under Development by Companies Tuberculosis 10 Figure 3: Number of Products under Development by Universities/Institutes Tuberculosis 13 Figure 4: Number of Products under Development for Diphtheria 25 Figure 5: Number of Products under Development by Companies Diphtheria 26 Figure 6: Number of Products under Development by Universities/Institutes Diphtheria 28 Figure 7: Number of Products under Development for Pertussis (Whooping Cough) 32 Figure 8: Number of Products under Development by Companies Pertussis (Whooping Cough) 33 Figure 9: Number of Products under Development by Universities/Institutes Pertussis (Whooping Cough) 35 Figure 10: Number of Products by Top 10 Targets Tuberculosis 40 Figure 11: Number of Products by Stage and Top 10 Targets Tuberculosis 40 Figure 12: Number of Products by Top 10 Mechanism of Actions Tuberculosis 43 Figure 13: Number of Products by Stage and Top 10 Mechanism of Actions Tuberculosis 43 Figure 14: Number of Products by Routes of Administration Tuberculosis 46 Figure 15: Number of Products by Stage and Routes of Administration Tuberculosis 46 Figure 16: Number of Products by Top 10 Molecule Types Tuberculosis 47 Figure 17: Number of Products by Stage and Top 10 Molecule Types Tuberculosis 48 Figure 18: Number of Products by Targets Diphtheria 49 Figure 19: Number of Products by Stage and Targets Diphtheria 49 Figure 20: Number of Products by Routes of Administration Diphtheria 50 Figure 21: Number of Products by Stage and Routes of Administration Diphtheria 51 Figure 22: Number of Products by Molecule Types Diphtheria 52 Figure 23: Number of Products by Stage and Molecule Types Diphtheria 52 Figure 24: Number of Products by Targets Pertussis (Whooping Cough) 53 Figure 25: Number of Products by Stage and Targets Pertussis (Whooping Cough) 54 Figure 26: Number of Products by Routes of Administration Pertussis (Whooping Cough) 55 Figure 27: Number of Products by Stage and Routes of Administration Pertussis (Whooping Cough) 55 Figure 28: Number of Products by Top 10 Molecule Types Pertussis (Whooping Cough) 56 Figure 29: Number of Products by Stage and Molecule Types Pertussis (Whooping Cough) 57

Abera Bioscience AB AGILeBiotics BV Akshaya Bio Inc Archivel Farma SL AstraZeneca Plc Aucta Pharmaceuticals LLC Beijing Minhai Biotechnology Co Ltd Bharat Biotech Ltd BioLingus AG Biological E Ltd Bioversys AG BlueWillow Biologics Boryung Pharmaceutical Co Ltd Cadila Healthcare Ltd Celgene Corp Chongqing Zhifei Biological Products Co Ltd Consegna Pharma Inc Crestone Inc Daiichi Sankyo Co Ltd DBV Technologies SA Demuris Ltd Diphtheria Eisai Co Ltd Eli Lilly and Co EpiVax Inc Evotec AG FIT Biotech Oy GangaGen Inc GC Pharma GlaxoSmithKline Plc Globeimmune Inc Hager Biosciences LLC Hsiri Therapeutics LLC Immodulon Therapeutics Ltd Immunitor Inc ImmunoBiology Ltd Indian Immunologicals Ltd Innovare R & D SA De CV Inovio Pharmaceuticals Inc Johnson & Johnson Kaketsuken LegoChem Biosciences Inc LG Chem Ltd Matinas BioPharma Holdings Inc Merck & Co Inc Microbiotix Inc Novartis AG NovoBiotic Pharmaceuticals LLC Otsuka Holdings Co Ltd Panacea Biotec Ltd Pertussis (Whooping Cough) Pfizer Inc QureTech Bio AB Qurient Co Ltd Recce Ltd Rodos BioTarget GmbH Sanofi Sanofi Pasteur SA Sequella Inc Serum Institute of India Ltd Shantha Biotechnics Pvt Ltd Shionogi & Co Ltd Synthetic Biologics Inc Takeda Pharmaceutical Co Ltd Target Medicals LLC Theravectys SA TVAX Biomedical Inc Vaccibody AS Vakzine Projekt Management GmbH Vaxil Bio Therapeutics Ltd Vaxine Pty Ltd Vichem Chemie Research Ltd Wockhardt Ltd