1 Table of Contents 1 Table of Contents 4 1.1 List of Tables 5 1.2 List of Figures 6 2 Introduction 7 2.1 Diarrhea and Constipation Report Coverage 7 2.2 Constipation - Overview 7 2.3 Diarrhea - Overview 7 3 Therapeutics Development 8 3.1 Constipation 8 3.2 Diarrhea 13 4 Therapeutics Assessment 20 4.1 Constipation 20 4.2 Diarrhea 26 5 Companies Involved in Therapeutics Development 33 5.1 Constipation 33 5.2 Diarrhea 41 6 Dormant Projects 57 6.1 Constipation 57 6.2 Diarrhea 58 7 Discontinued Products 61 7.1 Constipation 61 7.2 Diarrhea 61 8 Product Development Milestones 62 8.1 Constipation 62 8.2 Diarrhea 78 9 Appendix 92 9.1 Methodology 92 9.2 Coverage 92 9.3 Secondary Research 92 9.4 Primary Research 92 9.5 Expert Panel Validation 92 9.6 Contact Us 93 9.7 Disclaimer 93

1.1 List of Tables Table 1: Number of Products under Development for Constipation 8 Table 2: Number of Products under Development by Companies, Constipation 10 Table 3: Number of Products under Development by Universities/Institutes, Constipation 11 Table 4: Products under Development by Companies, Constipation 12 Table 5: Products under Development by Universities/Institutes, Constipation 13 Table 6: Number of Products under Development for Diarrhea 13 Table 7: Number of Products under Development by Companies, Diarrhea 14 Table 8: Number of Products under Development by Universities/Institutes, Diarrhea 16 Table 9: Products under Development by Companies, Diarrhea 17 Table 10: Products under Development by Universities/Institutes, Diarrhea 19 Table 11: Number of Products by Stage and Target, Constipation 21 Table 12: Number of Products by Stage and Mechanism of Action, Constipation 22 Table 13: Number of Products by Stage and Route of Administration, Constipation 24 Table 14: Number of Products by Stage and Molecule Type, Constipation 25 Table 15: Number of Products by Stage and Target, Diarrhea 27 Table 16: Number of Products by Stage and Mechanism of Action, Diarrhea 29 Table 17: Number of Products by Stage and Route of Administration, Diarrhea 31 Table 18: Number of Products by Stage and Molecule Type, Diarrhea 32 Table 19: Constipation - Pipeline by Allergan Plc 33 Table 20: Constipation - Pipeline by Ardelyx Inc 33 Table 21: Constipation - Pipeline by Braintree Laboratories Inc 34 Table 22: Constipation - Pipeline by Dong-A ST Co Ltd 34 Table 23: Constipation - Pipeline by EA Pharma Co Ltd 35 Table 24: Constipation - Pipeline by Ironwood Pharmaceuticals Inc 35 Table 25: Constipation - Pipeline by Johnson & Johnson 36 Table 26: Constipation - Pipeline by MallInckrodt Plc 37 Table 27: Constipation - Pipeline by NGM Biopharmaceuticals Inc 37 Table 28: Constipation - Pipeline by RaQualia Pharma Inc 38 Table 29: Constipation - Pipeline by Sanwa Kagaku Kenkyusho Co Ltd 38 Table 30: Constipation - Pipeline by SK Biopharmaceuticals Co Ltd 38 Table 31: Constipation - Pipeline by Sumitomo Dainippon Pharma Co Ltd 39 Table 32: Constipation - Pipeline by Synthetic Biologics Inc 39 Table 33: Constipation - Pipeline by Vanda Pharmaceuticals Inc 40 Table 34: Constipation - Pipeline by Yuhan Corp 40 Table 35: Constipation - Pipeline by Zensun (Shanghai) Sci & Tech Co Ltd 41 Table 36: Diarrhea - Pipeline by Aegis Therapeutics LLC 41 Table 37: Diarrhea - Pipeline by Akthelia Pharmaceuticals Ltd 42 Table 38: Diarrhea - Pipeline by Albireo Pharma Inc 42 Table 39: Diarrhea - Pipeline by Allergan Plc 43 Table 40: Diarrhea - Pipeline by Ardelyx Inc 43 Table 41: Diarrhea - Pipeline by AzurRx BioPharma Inc 43 Table 42: Diarrhea - Pipeline by Bharat Biotech Ltd 44 Table 43: Diarrhea - Pipeline by Chongqing Zhifei Biological Products Co Ltd 44 Table 44: Diarrhea - Pipeline by Cosmo Pharmaceuticals NV 45 Table 45: Diarrhea - Pipeline by DiscoveryBiomed Inc 45 Table 46: Diarrhea - Pipeline by Ferring International Center SA 46 Table 47: Diarrhea - Pipeline by GP Pharm SA 46 Table 48: Diarrhea - Pipeline by Kuhnil Pharmaceutical Co Ltd 47 Table 49: Diarrhea - Pipeline by Metacrine Inc 47 Table 50: Diarrhea - Pipeline by Miyarisan Pharmaceutical Company Ltd 48 Table 51: Diarrhea - Pipeline by Napo Pharmaceuticals Inc 48 Table 52: Diarrhea - Pipeline by Nippon Shinyaku Co Ltd 49 Table 53: Diarrhea - Pipeline by Novartis AG 49 Table 54: Diarrhea - Pipeline by Pfizer Inc 50 Table 55: Diarrhea - Pipeline by Prokarium Ltd 50 Table 56: Diarrhea - Pipeline by Protagonist Therapeutics Inc 51 Table 57: Diarrhea - Pipeline by RaQualia Pharma Inc 51 Table 58: Diarrhea - Pipeline by RedHill Biopharma Ltd 52 Table 59: Diarrhea - Pipeline by RxBio Inc 52 Table 60: Diarrhea - Pipeline by Scandinavian Biopharma Holding AB 531.2 List of Figures Figure 1: Number of Products under Development for Constipation 8 Figure 2: Number of Products under Development by Companies, Constipation 9 Figure 3: Number of Products under Development for Diarrhea 13 Figure 4: Number of Products under Development by Companies, Diarrhea 14 Figure 5: Number of Products under Development by Universities/Institutes, Diarrhea 16 Figure 6: Number of Products by Targets, Constipation 20 Figure 7: Number of Products by Stage and Targets, Constipation 20 Figure 8: Number of Products by Top 10 Mechanism of Actions, Constipation 21 Figure 9: Number of Products by Stage and Top 10 Mechanism of Actions, Constipation 22 Figure 10: Number of Products by Routes of Administration, Constipation 23 Figure 11: Number of Products by Stage and Routes of Administration, Constipation 23 Figure 12: Number of Products by Molecule Types, Constipation 24 Figure 13: Number of Products by Stage and Molecule Types, Constipation 25 Figure 14: Number of Products by Top 10 Targets, Diarrhea 26 Figure 15: Number of Products by Stage and Top 10 Targets, Diarrhea 26 Figure 16: Number of Products by Top 10 Mechanism of Actions, Diarrhea 28 Figure 17: Number of Products by Stage and Top 10 Mechanism of Actions, Diarrhea 28 Figure 18: Number of Products by Routes of Administration, Diarrhea 30 Figure 19: Number of Products by Stage and Routes of Administration, Diarrhea 30 Figure 20: Number of Products by Top 10 Molecule Types, Diarrhea 31 Figure 21: Number of Products by Stage and Top 10 Molecule Types, Diarrhea 32

Aegis Therapeutics LLC Akthelia Pharmaceuticals Ltd Albireo Pharma Inc Allergan Plc Ardelyx Inc AzurRx BioPharma Inc Bharat Biotech Ltd Braintree Laboratories Inc Chongqing Zhifei Biological Products Co Ltd Cosmo Pharmaceuticals NV Diarrhea DiscoveryBiomed Inc Dong-A ST Co Ltd EA Pharma Co Ltd Ferring International Center SA GP Pharm SA Ironwood Pharmaceuticals Inc Johnson & Johnson Kuhnil Pharmaceutical Co Ltd MallInckrodt Plc Metacrine Inc Miyarisan Pharmaceutical Company Ltd Napo Pharmaceuticals Inc NGM Biopharmaceuticals Inc Nippon Shinyaku Co Ltd Novartis AG Pfizer Inc Prokarium Ltd Protagonist Therapeutics Inc RaQualia Pharma Inc RedHill Biopharma Ltd RxBio Inc Sanwa Kagaku Kenkyusho Co Ltd Scandinavian Biopharma Holding AB SK Biopharmaceuticals Co Ltd Sublimity Therapeutics Ltd Sumitomo Dainippon Pharma Co Ltd Summit Therapeutics Plc Synthetic Biologics Inc Syntiron LLC Tasly Pharmaceutical Group Co Ltd Vanda Pharmaceuticals Inc Wuhan Institute of Biological Products Co Ltd Yuhan Corp Zealand Pharma AS Zensun (Shanghai) Sci & Tech Co Ltd