1. Executive Summary 2. Research Methodology 3. Human Growth Hormone 3.1 Overview 3.2 The Pathophysiology of Growth Hormone 3.2.1 Molecular Basis of GH Action 3.2.2 Metabolic Effects of GH 3.3 Growth Hormone Deficiency 3.3.1 Pediatric GHD 3.3.2 Adult GHD 3.3.3 Other Diorders 3.4 Recombinant HGH 3.4.1 Inclusion Body Technology 3.4.2 Protein Secretion Technology 3.4.3 Mouse-Cell Technology 4. Human Growth Hormone Market Analysis 4.1 Market Sizing 4.1.1 Market Size by Value (Actual & Forecasted) 4.1.2 Market Size by Volume (Actual & Forecasted) 4.1.3 Market Share by Region 4.2 HGH Market by Segment 4.2.1 Market Share 4.2.2 Pediatric GHD market 4.2.3 Adult GHD market 5. GH Deficiency Therapy 5.1 Diagnosis 5.2 Therapy for Various GHDs 5.3 Treatment Options 5.3.1 HGH Injections 5.3.2 HGH Releasers 5.3.3 Homeopathic HGH 5.3.4 Others 5.4 Human Growth Hormone (HGH) Replacement 5.4.1 Overview 5.4.2 Benefits of HGH Replacement 6. Global HGH Market Regional/Country Analysis 6.1 Europe 6.1.1 Overview 6.1.2 rhGH Market Sizing (Actual & Forecasted) 6.1.1 Pediatric rhGH Market Sizing (Actual & Forecasted) 6.2 The US 6.2.1 Overview 6.2.2 rhGH Market Sizing (Actual & Forecasted) 6.2.1 Pediatric rhGH Market Sizing (Actual & Forecasted) 6.3 Japan 6.3.1 Overview 6.3.2 rhGH Market Sizing (Actual & Forecasted) 6.3.1 Pediatric rhGH Market Sizing (Actual & Forecasted) 7. Global HGH Market Dynamics 7.1 Industry Trends & Developments 7.1.1 Advent of Long-acting rhGH 7.1.2 Use of HGH as Performance Enhancers 7.1.3 Products Under Development 7.2 Growth Drivers 7.2.1 Prevalence of Pituitary Dysfunction 7.2.2 Low Market Penetration 7.2.3 Growing Geriatric Population 7.2.4 Rising Healthcare Expenditure and Affordability 7.3 Challenges 7.3.1 High Treatment Cost 7.3.2 Adverse Side-effects of rhGH 7.3.3 Illicit Uses of HGH 7.3.4 Reimbursement Issues for Patients 7.3.5 Poor Adherence to Therapy by Patient 7.3.6 Stringent Regulatory Approvals 8. Competitive Landscape 8.1 Brand Analysis 8.2 Drugs by Disorders 8.3 Market Share by Competitors 9. Company Profiles 9.1 Merck Serono 9.2 Novo Nordisk 9.3 Pfizer 9.4 Eli Lilly 9.5 F. Hoffmann-La Roche Ltd. List of Charts Figure 1: Rockville Research – Research Methodology Figure 2: Regulation of GH Secretion Table 1: Regulation of the GH/IGF-I Axis Figure 3. Multiple Sites of Growth Hormone Action Table 2: Approved Doses for GHD by Nations Figure 4: Global Human Growth Hormone (rhGH) Market Size by Value, 2012-16 (US$ Billions) Figure 5: Global Human Growth Hormone (rhGH) Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 6: Global Human Growth Hormone (rhGH) Market Size by Volume, 2012-16 (US$ Billions) Figure 7: Global Human Growth Hormone (rhGH) Market Size by Volume Forecasted, 2017E-22E (US$ Billions) Figure 8: Global HGH Market Share by Region (2015) Figure 9: Global HGH Market Share by Segment (2015) Table 3: Benefits of GH Therapy for Established Indications Figure 10. Diagnostic Approach to Short Stature Diagnosis Standard Therapies Table 4: Various Tests for Diagnosis of Growth Hormone Deficiency Figure 11: Europe rhGH Market Size by Value, 2012-16E (US$ Billions) Figure 12: Europe rhGH Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 13: Europe Pediatric rhGH Market Size by Value, 2012-16E (US$ Billions) Figure 14: Europe Pediatric rhGH Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 16: The US rhGH Market Size by Value, 2012-16E (US$ Billions) Figure 17: The US rhGH Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 18: The US Pediatric rhGH Market Size by Value, 2012-16E (US$ Billions) Figure 19: The US Pediatric rhGH Market Size by Value Forecasted, 2017E-22E (US$ Billions) Table 5: rhGH Current Dose & Regimen Approved in Japan Figure 20: Japan rhGH Market Size by Value, 2012-16E (US$ Billions) Figure 21: Japan rhGH Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 22: Japan Pediatric rhGH Market Size by V0alue, 2012-16E (US$ Billions) Figure 23: Japan Pediatric rhGH Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 24: Somavartan rhGH Sequence Table 6: Comparison of Somavartan with Daily rhGh Table 7: Year 2 – Somavartan Efficacy Comparison with daily rhGH Table 8: Sports Enhancement Products Figure 25: Prevalence of Anterior Pituitary Hormone Deficiencies Figure 26: Market Penetration of rHGH Across Nations Figure 27: Decline of HGH Levels with Age Figure 28: Global Ageing Population, 2010-50 Figure 29: Global Healthcare Expenditure, 2005-16E (US$ Trillion) Figure 30: Global Gross National Income, 2005-15 (US$ Billion) Table 9: Prices for Popular Recombinant Human Growth Hormones Table 10: Adverse Effects of GH Therapy Figure 31: Poor Compliance with Daily rhGH Injections (Percent Skipping Injections) Table 11: FDA-Approved Growth Hormone Deficiency Indications by Product Table 12: Leading HGH Brands by Company Table 13: List of Growth Hormones Generics by Indication & Dosage Table 14: Drugs for Paeder Will Syndrome (PWS) Table 15: Drugs for Turner’s Syndrome Table 16: Drugs for Idiopathic Short Stature (ISS) Table 17: Drugs for Small for Gestational Age (SGA) Figure 32: Global rhGH Market Value Share by Competitors (2016) Figure 33: Global rhGH Market Volume Share by Competitors (2016) Figure 34: Merck Serono Revenue by Business Segment (FY2016) Figure 35: Merck Serono Revenue by Business Segment (FY2016) Figure 36: Novo Nordisk Human Growth Hormone Sales, FY2012-FY2016 (US$ Billion) Table 18: Novo Nordisk – Growth Disorder R&D Pipeline Table 19: Pfizer – Growth Hormone Deficiency Pipeline (as of 31st January, 2017) Figure 37: Roche Revenue by Busisness Segment (FY2016) Figure 38: Roche Ltd. Sales, FY2012-FY2016 (US$ Billions)

Figure 1: Rockville Research – Research Methodology Figure 2: Regulation of GH Secretion Figure 3. Multiple Sites of Growth Hormone Action Figure 4: Global Human Growth Hormone (rhGH) Market Size by Value, 2012-16 (US$ Billions) Figure 5: Global Human Growth Hormone (rhGH) Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 6: Global Human Growth Hormone (rhGH) Market Size by Volume, 2012-16 (US$ Billions) Figure 7: Global Human Growth Hormone (rhGH) Market Size by Volume Forecasted, 2017E-22E (US$ Billions) Figure 8: Global HGH Market Share by Region (2015) Figure 9: Global HGH Market Share by Segment (2015) Figure 10. Diagnostic Approach to Short Stature Diagnosis Standard Therapies Figure 11: Europe rhGH Market Size by Value, 2012-16E (US$ Billions) Figure 12: Europe rhGH Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 13: Europe Pediatric rhGH Market Size by Value, 2012-16E (US$ Billions) Figure 14: Europe Pediatric rhGH Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 16: The US rhGH Market Size by Value, 2012-16E (US$ Billions) Figure 17: The US rhGH Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 18: The US Pediatric rhGH Market Size by Value, 2012-16E (US$ Billions) Figure 19: The US Pediatric rhGH Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 20: Japan rhGH Market Size by Value, 2012-16E (US$ Billions) Figure 21: Japan rhGH Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 22: Japan Pediatric rhGH Market Size by V0alue, 2012-16E (US$ Billions) Figure 23: Japan Pediatric rhGH Market Size by Value Forecasted, 2017E-22E (US$ Billions) Figure 24: Somavartan rhGH Sequence Figure 25: Prevalence of Anterior Pituitary Hormone Deficiencies Figure 26: Market Penetration of rHGH Across Nations Figure 27: Decline of HGH Levels with Age m,Figure 28: Global Ageing Population, 2010-50 Figure 29: Global Healthcare Expenditure, 2005-16E (US$ Trillion) Figure 30: Global Gross National Income, 2005-15 (US$ Billion) Figure 31: Poor Compliance with Daily rhGH Injections (Percent Skipping Injections) Figure 32: Global rhGH Market Value Share by Competitors (2016) Figure 33: Global rhGH Market Volume Share by Competitors (2016) Figure 34: Merck Serono Revenue by Business Segment (FY2016) Figure 35: Merck Serono Revenue by Business Segment (FY2016) Figure 36: Novo Nordisk Human Growth Hormone Sales, FY2012-FY2016 (US$ Billion) Figure 37: Roche Revenue by Busisness Segment (FY2016) Figure 38: Roche Ltd. Sales, FY2012-FY2016 (US$ Billions)

Novo Nordisk, Pfizer, Eli Lilly and Company, Merck KGaA and F. Hoffmann-La Roche Ltd.