1 Table of Contents 1 Table of Contents 4 1.1 List of Tables 5 1.2 List of Figures 6 2 Introduction 7 2.1 Menopausal Disorders Report Coverage 7 2.2 Post Menopausal Osteoporosis - Overview 7 2.3 Vaginal Atrophy (Atrophic Vaginitis) - Overview 7 2.4 Vasomotor Symptoms of Menopause (Hot Flashes) - Overview 7 3 Therapeutics Development 8 3.1 Post Menopausal Osteoporosis 8 3.2 Vaginal Atrophy (Atrophic Vaginitis) 12 3.3 Vasomotor Symptoms of Menopause (Hot Flashes) 15 4 Therapeutics Assessment 18 4.1 Post Menopausal Osteoporosis 18 4.2 Vaginal Atrophy (Atrophic Vaginitis) 24 4.3 Vasomotor Symptoms of Menopause (Hot Flashes) 29 5 Companies Involved in Therapeutics Development 35 5.1 Post Menopausal Osteoporosis 35 5.2 Vaginal Atrophy (Atrophic Vaginitis) 41 5.3 Vasomotor Symptoms of Menopause (Hot Flashes) 43 6 Dormant Projects 46 6.1 Post Menopausal Osteoporosis 46 6.2 Vaginal Atrophy (Atrophic Vaginitis) 47 6.3 Vasomotor Symptoms of Menopause (Hot Flashes) 48 7 Discontinued Products 49 7.1 Post Menopausal Osteoporosis 49 7.2 Vasomotor Symptoms of Menopause (Hot Flashes) 49 8 Product Development Milestones 50 8.1 Post Menopausal Osteoporosis 50 8.2 Vaginal Atrophy (Atrophic Vaginitis) 65 8.3 Vasomotor Symptoms of Menopause (Hot Flashes) 68 9 Appendix 83 9.1 Methodology 83 9.2 Coverage 83 9.3 Secondary Research 83 9.4 Primary Research 83 9.5 Expert Panel Validation 83 9.6 Contact Us 84 9.7 Disclaimer 84

Amgen Inc EndoCeutics Inc Enteris BioPharma Inc GL Pharm Tech Corp Intas Pharmaceuticals Ltd Ipsen SA Ligand Pharmaceuticals Inc Lupin Ltd Luye Pharma Group Ltd Medinova AG MenoGeniX Inc Mithra Pharmaceuticals SA NIBEC Ogeda SA Oncobiologics Inc Paras Biopharmaceuticals Finland Oy Pherin Pharmaceuticals Inc TherapeuticsMD Inc Uni-Bio Science Group Ltd