1 Table of Contents 1 Table of Contents 4 1.1 List of Tables 5 1.2 List of Figures 11 2 Introduction 12 2.1 Diabetes and Associated Metabolic Conditions Report Coverage 12 2.2 Type1 diabetes (Juvenile Diabetes) - Overview 12 2.3 Hyperinsulinemia - Overview 12 2.4 Hyperglycemia - Overview 12 3 Therapeutics Development 13 3.1 Type1 diabetes (Juvenile Diabetes) 13 3.2 Type2 diabetes 34 3.3 Hyperinsulinemia 71 3.4 Hyperglycemia 75 4 Therapeutics Assessment 78 4.1 Type1 diabetes (Juvenile Diabetes) 78 4.2 Type2 diabetes 89 4.3 Hyperinsulinemia 107 4.4 Hyperglycemia 114 5 Companies Involved in Therapeutics Development 119 5.1 Type1 diabetes (Juvenile Diabetes) 119 5.2 Type2 diabetes 168 5.3 Hyperinsulinemia 264 5.4 Hyperglycemia 266 6 Dormant Projects 267 6.1 Type1 diabetes (Juvenile Diabetes) 267 6.2 Type2 diabetes 277 6.3 Hyperinsulinemia 302 6.4 Hyperglycemia 302 7 Discontinued Products 303 7.1 Type1 diabetes (Juvenile Diabetes) 303 7.2 Type2 diabetes 305 7.3 Hyperglycemia 312 8 Product Development Milestones 313 8.1 Type1 diabetes (Juvenile Diabetes) 313 8.2 Type2 diabetes 324 8.3 Hyperinsulinemia 336 9 Appendix 343 9.1 Methodology 343 9.2 Coverage 343 9.3 Secondary Research 343 9.4 Primary Research 343 9.5 Expert Panel Validation 343 9.6 Contact Us 344 9.7 Disclaimer 344

Adocia SAS Aegis Therapeutics LLC AFFiRiS AG AiCuris GmbH & Co KG Akcea Therapeutics Inc Allist Shanghai Pharmaceutical Technology Co Ltd Amarantus Bioscience Holdings Inc Amarna Therapeutics BV Amgen Inc apceth Biopharma GmbH Aphios Corp Apodemus AB Arecor Ltd Arena Pharmaceuticals Inc Astellas Pharma Inc AstraZeneca Plc Atlantic Bio Sci LLC AusBio Ltd Avadel Pharmaceuticals Plc Axxam SpA Bayer AG Beta-Cell NV Betagenon AB Betta Pharmaceuticals Co Ltd Biocon Ltd BioLineRx Ltd BioLingus AG BioRestorative Therapies Inc Biozeus BirchBioMed Inc Biscayne Pharmaceuticals Inc Boehringer Ingelheim GmbH Boston Therapeutics Inc Braasch Biotech LLC Bristol-Myers Squibb Co BTB Pharma AB C4X Discovery Holdings PLC Cadila Healthcare Ltd Cadila Pharmaceuticals Ltd Caelus Health Caladrius Biosciences Inc Cancer Prevention Pharmaceuticals Inc Cardax Inc Carmot Therapeutics Inc Cellix Bio Pvt Ltd Celon Pharma SA Center Laboratories Inc Chipscreen Biosciences Ltd Chong Kun Dang Pharmaceutical Corp Cinnagen Co CJ HealthCare Corp CohBar Inc Compugen Ltd Concenter BioPharma Silkim Ltd CymaBay Therapeutics Inc Daewoong Pharmaceutical Co Ltd Daiichi Sankyo Co Ltd Dance Biopharm Inc DanDrit Biotech A/S Delpor Inc Denceptor Therapeutics Ltd Diabetology (Products) Ltd Diamyd Medical AB Diasome Pharmaceuticals Inc DiaVacs Inc DiscoveryBiomed Inc DNJ Pharma Inc Dompe Farmaceutici SpA Dong-A Socio Holdings Co Ltd Elcelyx Therapeutics Inc Eli Lilly and Co Eloxx Pharmaceuticals Inc Energenesis Biomedical Co Ltd Ensol Biosciences Inc Enteris BioPharma Inc Enzene Biosciences Ltd Enzo Biochem Inc Epichem Pty Ltd EpiVax Inc Eternygen GmbH Evotec AG F. Hoffmann-La Roche Ltd Fate Therapeutics Inc Generex Biotechnology Corp GeNeuro SA Genexine Inc Genfit SA Genmedica Therapeutics SL Genovate Biotechnology Co LTD Geropharm LLC Gilead Sciences Inc GlaxoSmithKline Plc Glucox Biotech AB Hanmi Pharmaceuticals Co Ltd Heptares Therapeutics Ltd HitGen LTD Hyundai Pharmaceutical Co Ltd ImCyse SA Immupharma Plc Immuron Ltd Inflazome Ltd Innovative Targeting Solutions Inc Inspyr Therapeutics Inc InStar Technologies AS Intarcia Therapeutics Inc Intas Pharmaceuticals Ltd Integral Molecular Inc Intercept Pharmaceuticals Inc Intrexon Corp Ionis Pharmaceuticals Inc Japan Tobacco Inc Jeil Pharmaceutical Co Ltd JHL Biotech Inc Jiangsu Hansoh Pharmaceutical Group Co Ltd Jiangsu Hengrui Medicine Co Ltd Johnson & Johnson Just Biotherapeutics Inc Kadimastem Ltd Kadmon Corp LLC Kamada Ltd Kasiak Research Pvt Ltd Kissei Pharmaceutical Co Ltd Kowa Co Ltd Laboratorios Silanes SA de CV Lead Discovery Center GmbH Leading BioSciences Inc Lexicon Pharmaceuticals Inc LG Chem Ltd LipimetiX Development Inc Longevity Biotech Inc Luye Pharma Group Ltd Magnus Life Ltd MannKind Corp Maruho Co Ltd Medesis Pharma SA MedImmune LLC Medlab Clinical Ltd Medtronic Plc Medy-Tox Inc Merck & Co Inc Meridigen Biotech Co Ltd Mesoblast Ltd Metabolic Solutions Development Company LLC Metabolys SAS Metacrine Inc Mitsubishi Chemical Holdings Corp Mitsubishi Tanabe Pharma Corp Naia Ltd Neovacs SA Neurimmune Holding AG NGM Biopharmaceuticals Inc Novapeutics LLC Novartis AG NovaTarg Therapeutics Inc Novo Nordisk AS Omeros Corp OPKO Biologics Ltd OPKO Health Inc Oramed Pharmaceuticals Inc Orgenesis Inc Original BioMedicals Co Ltd OSE Immunotherapeutics Palatin Technologies Inc Panacea Biotec Ltd Paras Biopharmaceuticals Finland Oy Parvus Therapeutics Inc Pathfinder Cell Therapy Inc Peptron Inc Pfizer Inc PharmaCyte Biotech Inc PharmaIN Corp Pharmasum Therapeutics AS Pila Pharma AB Poxel SA Prometheon Pharma LLC ProMetic Life Sciences Inc Prothena Corp Plc Purzer Pharmaceutical Co Ltd Reata Pharmaceuticals Inc RedHill Biopharma Ltd REGiMMUNE Corp Reliance Life Sciences Pvt Ltd reMYND NV Renova Therapeutics Inc Reset Therapeutics Inc Rezolute Inc Rubius Therapeutics Inc Saniona AB Sanofi Sanwa Kagaku Kenkyusho Co Ltd SATT Conectus Alsace SAS SBI Pharmaceuticals Co Ltd ScandiCure AB Semma Therapeutics Inc Seres Therapeutics Inc Serodus ASA Serometrix LLC Shenzhen HighTide Biopharmaceutical Ltd Shionogi & Co Ltd Sirona Biochem Corp SJT Molecular Research SL SK Chemicals Co Ltd Sotio AS Sprint Bioscience AB Sumitomo Dainippon Pharma Co Ltd Suzuken Co Ltd Taisho Pharmaceutical Holdings Co Ltd Takeda Pharmaceutical Co Ltd Teijin Pharma Ltd Tetragenetics Inc The Medicines Company Theracos Inc Thermalin Diabetes LLC Tiziana Life Sciences Plc Toleranzia AB Tolerion Inc Topas Therapeutics GmbH Toray Industries Inc Torrent Pharmaceuticals Ltd Transgene Biotek Ltd TTY Biopharm Company Ltd Twoxar Inc UCB SA Uni-Bio Science Group Ltd Unicyte AG Ventria Bioscience ViaCyte Inc Vichem Chemie Research Ltd Vicore Pharma AB Viking Therapeutics Inc Vivus Inc vTv Therapeutics Inc Vybion Inc XBiotech Inc XERIS Pharmaceuticals Inc XL-protein GmbH XOMA Corp XuanZhu Pharma Co Ltd Yabao Pharmaceutical Group Co Ltd Yuhan Corp Zafgen Inc Zealand Pharma AS