Table of Contents Table of Contents 2 Introduction 8 Age Related Macular Degeneration - Overview 9 Age Related Macular Degeneration - Therapeutics Development 10 Age Related Macular Degeneration - Therapeutics Assessment 47 Age Related Macular Degeneration - Companies Involved in Therapeutics Development 59 Age Related Macular Degeneration - Drug Profiles 111 Age Related Macular Degeneration - Dormant Projects 478 Age Related Macular Degeneration - Discontinued Products 496 Age Related Macular Degeneration - Product Development Milestones 499 Appendix 507

List of Tables Number of Products under Development for Age Related Macular Degeneration, H1 2018 Number of Products under Development by Companies, H1 2018 Number of Products under Development by Companies, H1 2018 (Contd..1), H1 2018 Number of Products under Development by Companies, H1 2018 (Contd..2), H1 2018 Number of Products under Development by Companies, H1 2018 (Contd..3), H1 2018 Number of Products under Development by Companies, H1 2018 (Contd..4), H1 2018 Number of Products under Development by Companies, H1 2018 (Contd..5), H1 2018 Number of Products under Development by Companies, H1 2018 (Contd..6), H1 2018 Number of Products under Development by Companies, H1 2018 (Contd..7), H1 2018 Number of Products under Development by Universities/Institutes, H1 2018 Products under Development by Companies, H1 2018 Products under Development by Companies, H1 2018 (Contd..1), H1 2018 Products under Development by Companies, H1 2018 (Contd..2), H1 2018 Products under Development by Companies, H1 2018 (Contd..3), H1 2018 Products under Development by Companies, H1 2018 (Contd..4), H1 2018 Products under Development by Companies, H1 2018 (Contd..5), H1 2018 Products under Development by Companies, H1 2018 (Contd..6), H1 2018 Products under Development by Companies, H1 2018 (Contd..7), H1 2018 Products under Development by Companies, H1 2018 (Contd..8), H1 2018 Products under Development by Companies, H1 2018 (Contd..9), H1 2018 Products under Development by Companies, H1 2018 (Contd..10), H1 2018 Products under Development by Companies, H1 2018 (Contd..11), H1 2018 Products under Development by Companies, H1 2018 (Contd..12), H1 2018 Products under Development by Universities/Institutes, H1 2018 Number of Products by Stage and Target, H1 2018 Number of Products by Stage and Target, H1 2018 (Contd..1), H1 2018 Number of Products by Stage and Target, H1 2018 (Contd..2), H1 2018 Number of Products by Stage and Mechanism of Action, H1 2018 Number of Products by Stage and Mechanism of Action, H1 2018 (Contd..1), H1 2018 Number of Products by Stage and Mechanism of Action, H1 2018 (Contd..2), H1 2018 Number of Products by Stage and Route of Administration, H1 2018 Number of Products by Stage and Molecule Type, H1 2018 Age Related Macular Degeneration - Pipeline by 3SBio Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Abzena Plc, H1 2018 Age Related Macular Degeneration - Pipeline by Achillion Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Aciont Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Acucela Inc, H1 2018 Age Related Macular Degeneration - Pipeline by AdAlta Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Adverum Biotechnologies Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Aerie Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Aldeyra Therapeutics Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Alimera Sciences Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Alkeus Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Allergan Plc, H1 2018 Age Related Macular Degeneration - Pipeline by Allgenesis Biotherapeutics Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Allinky Biopharma, H1 2018 Age Related Macular Degeneration - Pipeline by Alteogen Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Amarna Therapeutics BV, H1 2018 Age Related Macular Degeneration - Pipeline by AngioGenex Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Apellis Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Apexigen Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Applied Genetic Technologies Corp, H1 2018 Age Related Macular Degeneration - Pipeline by Astellas Pharma Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Benitec Biopharma Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Biokine Therapeutics Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by BioMAS Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Biomics Biotechnologies Co Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Biophytis SA, H1 2018 Age Related Macular Degeneration - Pipeline by Catalyst Biosciences Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Cell Cure Neurosciences Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Cell Medica Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Celon Pharma SA, H1 2018 Age Related Macular Degeneration - Pipeline by Charlesson LLC, H1 2018 Age Related Macular Degeneration - Pipeline by Chong Kun Dang Pharmaceutical Corp, H1 2018 Age Related Macular Degeneration - Pipeline by CJ HealthCare Corp, H1 2018 Age Related Macular Degeneration - Pipeline by Clanotech AB, H1 2018 Age Related Macular Degeneration - Pipeline by Coherus BioSciences Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Colby Pharmaceutical Co, H1 2018 Age Related Macular Degeneration - Pipeline by Crinetics Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Daiichi Sankyo Co Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Dong-A Socio Holdings Co Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Elasmogen Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Elsalys Biotech SA, H1 2018 Age Related Macular Degeneration - Pipeline by Enzene Biosciences Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Exonate Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by EyeGate Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by EyePoint Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Eyevensys SAS, H1 2018 Age Related Macular Degeneration - Pipeline by F. Hoffmann-La Roche Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by FirstString Research Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Foamix Pharmaceuticals Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Formycon AG, H1 2018 Age Related Macular Degeneration - Pipeline by Gene Signal International SA, H1 2018 Age Related Macular Degeneration - Pipeline by Gene Techno Science Co Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Genentech Inc, H1 2018 Age Related Macular Degeneration - Pipeline by GenSight Biologics SA, H1 2018 Age Related Macular Degeneration - Pipeline by Graybug Vision Inc, H1 2018 Age Related Macular Degeneration - Pipeline by HanAll Biopharma Co Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Huabo Biopharm Co Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Iconic Therapeutics Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Ildong Pharmaceutical Co Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Immupharma Plc, H1 2018 Age Related Macular Degeneration - Pipeline by Inception Sciences Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Innovent Biologics Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Ionis Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Isarna Therapeutics GmbH, H1 2018 Age Related Macular Degeneration - Pipeline by Jeil Pharmaceutical Co Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Johnson & Johnson, H1 2018 Age Related Macular Degeneration - Pipeline by Kala Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Kodiak Sciences Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Lead Discovery Center GmbH, H1 2018 Age Related Macular Degeneration - Pipeline by Lee's Pharmaceutical Holdings Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Lin Bioscience Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Lupin Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by M's Science Corp, H1 2018 Age Related Macular Degeneration - Pipeline by Mabion SA, H1 2018 Age Related Macular Degeneration - Pipeline by MacuCLEAR Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Mitotech SA, H1 2018 Age Related Macular Degeneration - Pipeline by Mitsubishi Tanabe Pharma Corp, H1 2018 Age Related Macular Degeneration - Pipeline by Mor Research Application Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Neovacs SA, H1 2018 Age Related Macular Degeneration - Pipeline by NGM Biopharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Novartis AG, H1 2018 Age Related Macular Degeneration - Pipeline by NovelMed Therapeutics Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Ocular Therapeutix Inc, H1 2018 Age Related Macular Degeneration - Pipeline by OcuNexus Therapeutics Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Ohr Pharmaceutical Inc, H1 2018 Age Related Macular Degeneration - Pipeline by OliX Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Omeros Corp, H1 2018 Age Related Macular Degeneration - Pipeline by Ophthotech Corp, H1 2018 Age Related Macular Degeneration - Pipeline by Oxford BioMedica Plc, H1 2018 Age Related Macular Degeneration - Pipeline by Oxstem Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by PanOptica Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Paras Biopharmaceuticals Finland Oy, H1 2018 Age Related Macular Degeneration - Pipeline by Pfizer Inc, H1 2018 Age Related Macular Degeneration - Pipeline by PlantForm Corp, H1 2018 Age Related Macular Degeneration - Pipeline by Profarma, H1 2018 Age Related Macular Degeneration - Pipeline by Promedior Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Ra Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Regeneron Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by RegenxBio Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Reliance Life Sciences Pvt Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by RheinCell Therapeutics GmbH, H1 2018 Age Related Macular Degeneration - Pipeline by Ribomic Inc, H1 2018 Age Related Macular Degeneration - Pipeline by RXi Pharmaceuticals Corp, H1 2018 Age Related Macular Degeneration - Pipeline by SanBio Inc, H1 2018 Age Related Macular Degeneration - Pipeline by SciFluor Life Sciences LLC, H1 2018 Age Related Macular Degeneration - Pipeline by Senju Pharmaceutical Co Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Sesen Bio Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Stealth BioTherapeutics Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Sumitomo Dainippon Pharma Co Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Sun Pharma Advanced Research Company Ltd, H1 2018 Age Related Macular Degeneration - Pipeline by Sylentis SAU, H1 2018 Age Related Macular Degeneration - Pipeline by TRACON Pharmaceuticals Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Tyrogenex Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Unity Biotechnology Inc, H1 2018 Age Related Macular Degeneration - Pipeline by Wellstat Ophthalmics Corp, H1 2018 Age Related Macular Degeneration - Pipeline by Xbrane Biopharma AB, H1 2018 Age Related Macular Degeneration - Dormant Projects, H1 2018 Age Related Macular Degeneration - Dormant Projects, H1 2018 (Contd..1), H1 2018 Age Related Macular Degeneration - Dormant Projects, H1 2018 (Contd..2), H1 2018 Age Related Macular Degeneration - Dormant Projects, H1 2018 (Contd..3), H1 2018 Age Related Macular Degeneration - Dormant Projects, H1 2018 (Contd..4), H1 2018 Age Related Macular Degeneration - Dormant Projects, H1 2018 (Contd..5), H1 2018 Age Related Macular Degeneration - Dormant Projects, H1 2018 (Contd..6), H1 2018 Age Related Macular Degeneration - Dormant Projects, H1 2018 (Contd..7), H1 2018 Age Related Macular Degeneration - Dormant Projects, H1 2018 (Contd..8), H1 2018 Age Related Macular Degeneration - Dormant Projects, H1 2018 (Contd..9), H1 2018 Age Related Macular Degeneration - Dormant Projects, H1 2018 (Contd..10), H1 2018 Age Related Macular Degeneration - Dormant Projects, H1 2018 (Contd..11), H1 2018 Age Related Macular Degeneration - Discontinued Products, H1 2018 Age Related Macular Degeneration - Discontinued Products, H1 2018 (Contd..1), H1 2018List of Figures Number of Products under Development for Age Related Macular Degeneration, H1 2018 Number of Products under Development by Companies, H1 2018 Number of Products under Development by Universities/Institutes, H1 2018 Number of Products by Top 10 Targets, H1 2018 Number of Products by Stage and Top 10 Targets, H1 2018 Number of Products by Top 10 Mechanism of Actions, H1 2018 Number of Products by Stage and Top 10 Mechanism of Actions, H1 2018 Number of Products by Routes of Administration, H1 2018 Number of Products by Stage and Routes of Administration, H1 2018 Number of Products by Top 10 Molecule Types, H1 2018 Number of Products by Stage and Top 10 Molecule Types, H1 2018

3SBio Inc Abzena Plc Achillion Pharmaceuticals Inc Aciont Inc Acucela Inc AdAlta Ltd Adverum Biotechnologies Inc Aerie Pharmaceuticals Inc Aldeyra Therapeutics Inc Alimera Sciences Inc Alkeus Pharmaceuticals Inc Allergan Plc Allgenesis Biotherapeutics Inc Allinky Biopharma Alteogen Inc Amarna Therapeutics BV AngioGenex Inc Apellis Pharmaceuticals Inc Apexigen Inc Applied Genetic Technologies Corp Astellas Pharma Inc Benitec Biopharma Ltd Biokine Therapeutics Ltd BioMAS Ltd Biomics Biotechnologies Co Ltd Biophytis SA Catalyst Biosciences Inc Cell Cure Neurosciences Ltd Cell Medica Ltd Celon Pharma SA Charlesson LLC Chong Kun Dang Pharmaceutical Corp CJ HealthCare Corp Clanotech AB Coherus BioSciences Inc Colby Pharmaceutical Co Crinetics Pharmaceuticals Inc Daiichi Sankyo Co Ltd Dong-A Socio Holdings Co Ltd Elasmogen Ltd Elsalys Biotech SA Enzene Biosciences Ltd Exonate Ltd EyeGate Pharmaceuticals Inc EyePoint Pharmaceuticals Inc Eyevensys SAS F. Hoffmann-La Roche Ltd FirstString Research Inc Foamix Pharmaceuticals Ltd Formycon AG Gene Signal International SA Gene Techno Science Co Ltd Genentech Inc GenSight Biologics SA Graybug Vision Inc HanAll Biopharma Co Ltd Huabo Biopharm Co Ltd Iconic Therapeutics Inc Ildong Pharmaceutical Co Ltd Immupharma Plc Inception Sciences Inc Innovent Biologics Inc Ionis Pharmaceuticals Inc Isarna Therapeutics GmbH Jeil Pharmaceutical Co Ltd Johnson & Johnson Kala Pharmaceuticals Inc Kodiak Sciences Inc Lead Discovery Center GmbH Lee's Pharmaceutical Holdings Ltd Lin Bioscience Inc Lupin Ltd M's Science Corp Mabion SA MacuCLEAR Inc Mitotech SA Mitsubishi Tanabe Pharma Corp Mor Research Application Ltd Neovacs SA NGM Biopharmaceuticals Inc Novartis AG NovelMed Therapeutics Inc Ocular Therapeutix Inc OcuNexus Therapeutics Inc Ohr Pharmaceutical Inc OliX Pharmaceuticals Inc Omeros Corp Ophthotech Corp Oxford BioMedica Plc Oxstem Ltd PanOptica Inc Paras Biopharmaceuticals Finland Oy Pfizer Inc PlantForm Corp Profarma Promedior Inc Ra Pharmaceuticals Inc Regeneron Pharmaceuticals Inc RegenxBio Inc Reliance Life Sciences Pvt Ltd RheinCell Therapeutics GmbH Ribomic Inc RXi Pharmaceuticals Corp SanBio Inc SciFluor Life Sciences LLC Senju Pharmaceutical Co Ltd Sesen Bio Inc Stealth BioTherapeutics Inc Sumitomo Dainippon Pharma Co Ltd Sun Pharma Advanced Research Company Ltd Sylentis SAU TRACON Pharmaceuticals Inc Tyrogenex Inc Unity Biotechnology Inc Wellstat Ophthalmics Corp Xbrane Biopharma AB