1 Table of Contents 1 Table of Contents 4 1.1 List of Tables 5 1.2 List of Figures 8 2 Introduction 10 2.1 Influenza A Viral Infections Report Coverage 10 2.2 Influenza A Virus, H3N2 Subtype Infections – Overview 10 2.3 Influenza A Virus, H1N1 Subtype Infections – Overview 10 2.4 Influenza A Virus, H5N1 Subtype Infections – Overview 10 2.5 Influenza A Virus, H7N9 Subtype Infections – Overview 10 3 Therapeutics Development 11 3.1 Influenza A Virus, H3N2 Subtype Infections 11 3.2 Influenza A Virus, H1N1 Subtype Infections 19 3.3 Influenza A Virus, H5N1 Subtype Infections 31 3.4 Influenza A Virus, H7N9 Subtype Infections 41 4 Therapeutics Assessment 48 4.1 Influenza A Virus, H3N2 Subtype Infections 48 4.2 Influenza A Virus, H1N1 Subtype Infections 55 4.3 Influenza A Virus, H5N1 Subtype Infections 62 4.4 Influenza A Virus, H7N9 Subtype Infections 69 5 Companies Involved in Therapeutics Development 75 5.1 Influenza A Virus, H3N2 Subtype Infections 75 5.2 Influenza A Virus, H1N1 Subtype Infections 89 5.3 Influenza A Virus, H5N1 Subtype Infections 114 5.4 Influenza A Virus, H7N9 Subtype Infections 130 6 Dormant Projects 140 6.1 Influenza A Virus, H3N2 Subtype Infections 140 6.2 Influenza A Virus, H1N1 Subtype Infections 142 6.3 Influenza A Virus, H5N1 Subtype Infections 146 6.4 Influenza A Virus, H7N9 Subtype Infections 151 7 Discontinued Products 152 7.1 Influenza A Virus, H3N2 Subtype Infections 152 7.2 Influenza A Virus, H1N1 Subtype Infections 153 7.3 Influenza A Virus, H5N1 Subtype Infections 153 8 Product Development Milestones 154 8.1 Influenza A Virus, H3N2 Subtype Infections 154 8.2 Influenza A Virus, H1N1 Subtype Infections 160 8.3 Influenza A Virus, H5N1 Subtype Infections 174 8.4 Influenza A Virus, H7N9 Subtype Infections 185 9 Appendix 187 9.1 Methodology 187 9.2 Coverage 187 9.3 Secondary Research 187 9.4 Primary Research 187 9.5 Expert Panel Validation 187 9.6 Contact Us 188 9.7 Disclaimer 188

1.1 List of Tables Table 1: Number of Products under Development for Influenza A Virus, H3N2 Subtype Infections 11 Table 2: Number of Products under Development by Companies Influenza A Virus, H3N2 Subtype Infections 12 Table 3: Number of Products under Development by Universities/Institutes Influenza A Virus, H3N2 Subtype Infections 14 Table 4: Products under Development by Companies Influenza A Virus, H3N2 Subtype Infections 15 Table 5: Products under Development by Universities/Institutes Influenza A Virus, H3N2 Subtype Infections 18 Table 6: Number of Products under Development for Influenza A Virus, H1N1 Subtype Infections 19 Table 7: Number of Products under Development by Companies, Influenza A Virus, H1N1 Subtype Infections 21 Table 8: Number of Products under Development by Universities/Institutes, Influenza A Virus, H1N1 Subtype Infections 23 Table 9: Products under Development by Companies, Influenza A Virus, H1N1 Subtype Infections 24 Table 10: Products under Development by Universities/Institutes, Influenza A Virus, H1N1 Subtype Infections 30 Table 11: Number of Products under Development for Influenza A Virus, H5N1 Subtype Infections 32 Table 12: Number of Products under Development by Companies, Influenza A Virus, H5N1 Subtype Infections 34 Table 13: Number of Products under Development by Universities/Institutes, Influenza A Virus, H5N1 Subtype Infections 36 Table 14: Products under Development by Companies, Influenza A Virus, H5N1 Subtype Infections 37 Table 15: Products under Development by Universities/Institutes, Influenza A Virus, H5N1 Subtype Infections 40 Table 16: Number of Products under Development for Influenza A Virus, H7N9 Subtype Infections 41 Table 17: Number of Products under Development by Companies, Influenza A Virus, H7N9 Subtype Infections 43 Table 18: Number of Products under Development by Universities/Institutes, Influenza A Virus, H7N9 Subtype Infections 44 Table 19: Products under Development by Companies, Influenza A Virus, H7N9 Subtype Infections 45 Table 20: Products under Development by Universities/Institutes, Influenza A Virus, H7N9 Subtype Infections 47 Table 21: Number of Products by Stage and Target, Influenza A Virus, H3N2 Subtype Infections 49 Table 22: Number of Products by Stage and Mechanism of Action, Influenza A Virus, H3N2 Subtype Infections 51 Table 23: Number of Products by Stage and Route of Administration, Influenza A Virus, H3N2 Subtype Infections 53 Table 24: Number of Products by Stage and Molecule Type, Influenza A Virus, H3N2 Subtype Infections 55 Table 25: Number of Products by Stage and Target, Influenza A Virus, H3N2 Subtype Infections 56 Table 26: Number of Products by Stage and Mechanism of Action, Influenza A Virus, H3N2 Subtype Infections 58 Table 27: Number of Products by Stage and Route of Administration, Influenza A Virus, H3N2 Subtype Infections 60 Table 28: Number of Products by Stage and Molecule Type, Influenza A Virus, H3N2 Subtype Infections 62 Table 29: Number of Products by Stage and Target, Influenza A Virus, H5N1 Subtype Infections 63 Table 30: Number of Products by Stage and Mechanism of Action, Influenza A Virus, H5N1 Subtype Infections 65 Table 31: Number of Products by Stage and Route of Administration, Influenza A Virus, H5N1 Subtype Infections 67 Table 32: Number of Products by Stage and Molecule Type, Influenza A Virus, H5N1 Subtype Infections 68 Table 33: Number of Products by Stage and Target, Influenza A Virus, H7N9 Subtype Infections 70 Table 34: Number of Products by Stage and Mechanism of Action, Influenza A Virus, H7N9 Subtype Infections 71 Table 35: Number of Products by Stage and Route of Administration, Influenza A Virus, H7N9 Subtype Infections 73 Table 36: Number of Products by Stage and Molecule Type, Influenza A Virus, H7N9 Subtype Infections 74 Table 37: Influenza A Virus, H3N2 Subtype Infections – Pipeline by AbbVie Inc 75 Table 38: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Adimmune Corp 76 Table 39: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Aphios Corp 76 Table 40: Influenza A Virus, H3N2 Subtype Infections – Pipeline by AusBio Ltd 77 Table 41: Influenza A Virus, H3N2 Subtype Infections – Pipeline by BioCryst Pharmaceuticals Inc 77 Table 42: Influenza A Virus, H3N2 Subtype Infections – Pipeline by BiondVax Pharmaceuticals Ltd 78 Table 43: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Cadila Healthcare Ltd 78 Table 44: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Celltrion Inc 79 Table 45: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Emergent BioSolutions Inc 80 Table 46: Influenza A Virus, H3N2 Subtype Infections – Pipeline by FluGen Inc 80 Table 47: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Inovio Pharmaceuticals Inc 81 Table 48: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Jiangsu Kanion Pharmaceutical Co Ltd 81 Table 49: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Johnson & Johnson 82 Table 50: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Medicago Inc 83 Table 51: Influenza A Virus, H3N2 Subtype Infections – Pipeline by MedImmune LLC 83 Table 52: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Mucosis BV (Inactive) 84 Table 53: Influenza A Virus, H3N2 Subtype Infections – Pipeline by NanoViricides Inc 84 Table 54: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Novavax Inc 85 Table 55: Influenza A Virus, H3N2 Subtype Infections – Pipeline by OPKO Health Inc 85 Table 56: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Sanofi 86 Table 57: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Sanofi Pasteur SA 87 Table 58: Influenza A Virus, H3N2 Subtype Infections – Pipeline by Sarepta Therapeutics Inc 87 Table 59: Influenza A Virus, H3N2 Subtype Infections – Pipeline by SK Chemicals Co Ltd 88 Table 60: Influenza A Virus, H3N2 Subtype Infections – Pipeline by VBI Vaccines Inc 88 Table 61: Influenza A Virus, H1N1 Subtype Infections – Pipeline by AbbVie Inc 891.2 List of Figures Figure 1: Number of Products under Development for Influenza A Virus, H3N2 Subtype Infections 11 Figure 2: Number of Products under Development by Companies, Influenza A Virus, H3N2 Subtype Infections 12 Figure 3: Number of Products under Development by Universities/Institutes Influenza A Virus, H3N2 Subtype Infections 14 Figure 4: Number of Products under Development for Influenza A Virus, H1N1 Subtype Infections 19 Figure 5: Number of Products under Development by Companies, Influenza A Virus, H1N1 Subtype Infections 20 Figure 6: Number of Products under Development by Universities/Institutes, Influenza A Virus, H1N1 Subtype Infections 23 Figure 7: Number of Products under Development for Influenza A Virus, H5N1 Subtype Infections 31 Figure 8: Number of Products under Development by Companies, Influenza A Virus, H5N1 Subtype Infections 33 Figure 9: Number of Products under Development by Universities/Institutes, Influenza A Virus, H5N1 Subtype Infections 36 Figure 10: Number of Products under Development for Influenza A Virus, H7N9 Subtype Infections 41 Figure 11: Number of Products under Development by Companies, Influenza A Virus, H7N9 Subtype Infections 42 Figure 12: Number of Products under Development by Universities/Institutes, Influenza A Virus, H7N9 Subtype Infections 44 Figure 13: Number of Products by Top 10 Targets, Influenza A Virus, H3N2 Subtype Infections 48 Figure 14: Number of Products by Stage and Top 10 Targets, Influenza A Virus, H3N2 Subtype Infections 48 Figure 15: Number of Products by Top 10 Mechanism of Actions, Influenza A Virus, H3N2 Subtype Infections 50 Figure 16: Number of Products by Stage and Top 10 Mechanism of Actions, Influenza A Virus, H3N2 Subtype Infections 50 Figure 17: Number of Products by Routes of Administration, Influenza A Virus, H3N2 Subtype Infections 52 Figure 18: Number of Products by Stage and Routes of Administration, Influenza A Virus, H3N2 Subtype Infections 52 Figure 19: Number of Products by Top 10 Molecule Types, Influenza A Virus, H3N2 Subtype Infections 54 Figure 20: Number of Products by Stage and Top 10 Molecule Types, Influenza A Virus, H3N2 Subtype Infections 54 Figure 21: Number of Products by Top 10 Targets, Influenza A Virus, H3N2 Subtype Infections 55 Figure 22: Number of Products by Stage and Top 10 Targets, Influenza A Virus, H3N2 Subtype Infections 56 Figure 23: Number of Products by Top 10 Mechanism of Actions, Influenza A Virus, H3N2 Subtype Infections 57 Figure 24: Number of Products by Stage and Top 10 Mechanism of Actions, Influenza A Virus, H3N2 Subtype Infections 57 Figure 25: Number of Products by Top 10 Routes of Administration, Influenza A Virus, H3N2 Subtype Infections 59 Figure 26: Number of Products by Stage and Top 10 Routes of Administration, Influenza A Virus, H3N2 Subtype Infections 59 Figure 27: Number of Products by Top 10 Molecule Types, Influenza A Virus, H3N2 Subtype Infections 61 Figure 28: Number of Products by Stage and Top 10 Molecule Types, Influenza A Virus, H3N2 Subtype Infections 61 Figure 29: Number of Products by Top 10 Targets, Influenza A Virus, H5N1 Subtype Infections 62 Figure 30: Number of Products by Stage and Top 10 Targets, Influenza A Virus, H5N1 Subtype Infections 63 Figure 31: Number of Products by Top 10 Mechanism of Actions, Influenza A Virus, H5N1 Subtype Infections 64 Figure 32: Number of Products by Stage and Top 10 Mechanism of Actions, Influenza A Virus, H5N1 Subtype Infections 64 Figure 33: Number of Products by Routes of Administration, Influenza A Virus, H5N1 Subtype Infections 66 Figure 34: Number of Products by Stage and Routes of Administration, Influenza A Virus, H5N1 Subtype Infections 66 Figure 35: Number of Products by Top 10 Molecule Types, Influenza A Virus, H5N1 Subtype Infections 67 Figure 36: Number of Products by Stage and Top 10 Molecule Types, Influenza A Virus, H5N1 Subtype Infections 68 Figure 37: Number of Products by Targets, Influenza A Virus, H7N9 Subtype Infections 69 Figure 38: Number of Products by Stage and Targets, Influenza A Virus, H7N9 Subtype Infections 69 Figure 39: Number of Products by Mechanism of Actions, Influenza A Virus, H7N9 Subtype Infections 70 Figure 40: Number of Products by Stage and Mechanism of Actions, Influenza A Virus, H7N9 Subtype Infections 71 Figure 41: Number of Products by Routes of Administration, Influenza A Virus, H7N9 Subtype Infections 72 Figure 42: Number of Products by Stage and Routes of Administration, Influenza A Virus, H7N9 Subtype Infections 72 Figure 43: Number of Products by Molecule Types, Influenza A Virus, H7N9 Subtype Infections 73 Figure 44: Number of Products by Stage and Molecule Types, Influenza A Virus, H7N9 Subtype Infections 74

AbbVie Inc Adimmune Corp Akshaya Bio Inc Altimmune Inc Antigen Express Inc Aphios Corp AusBio Ltd Beijing Minhai Biotechnology Co Ltd BioCryst Pharmaceuticals Inc BiondVax Pharmaceuticals Ltd Cadila Healthcare Ltd Celltrion Inc CEL-SCI Corp Cilian AG Cocrystal Pharma Inc ContraFect Corp Curevac AG Emergent BioSolutions Inc EpiVax Inc Etubics Corp FluGen Inc Gemmus Pharma Inc Genentech Inc GlaxoSmithKline Plc Hemispherx Biopharma Inc iBio Inc Influenza A Virus, H1N1 Subtype Infections Influenza A Virus, H3N2 Subtype Infections Influenza A Virus, H5N1 Subtype Infections Influenza A Virus, H7N9 Subtype Infections Inovio Pharmaceuticals Inc Jiangsu Kanion Pharmaceutical Co Ltd Johnson & Johnson Karyopharm Therapeutics Inc Kineta Inc Kyowa Hakko Kirin Co Ltd Lakewood-Amedex Inc Medicago Inc Medigen Vaccine Biologics Corp MedImmune LLC Microbiotix Inc Moderna Therapeutics Inc Mucosis BV (Inactive) NanoBio Corp NanoViricides Inc Novavax Inc Ology Bioservices Inc OPKO Health Inc PaxVax Inc PeptiDream Inc Recce Ltd Sanofi Sanofi Pasteur SA Sarepta Therapeutics Inc Shionogi & Co Ltd SK Chemicals Co Ltd TechnoVax Inc Touchlight Genetics Ltd Vaccibody AS Vaxart Inc Vaxine Pty Ltd VBI Vaccines Inc VirionHealth Ltd Visterra Inc Vivaldi Biosciences Inc