Table of Contents Table of Contents 2 Introduction 8 Asthma - Overview 9 Asthma - Therapeutics Development 10 Asthma - Therapeutics Assessment 37 Asthma - Companies Involved in Therapeutics Development 55 Asthma - Drug Profiles 108 Asthma - Dormant Projects 524 Asthma - Discontinued Products 549 Asthma - Product Development Milestones 555 Appendix 566

List of Tables Table 1: Number of Products under Development for Asthma, H1 2018 Table 2: Number of Products under Development by Companies, H1 2018 Table 3: Number of Products under Development by Companies, H1 2018 (Contd..1), H1 2018 Table 4: Number of Products under Development by Companies, H1 2018 (Contd..2), H1 2018 Table 5: Number of Products under Development by Companies, H1 2018 (Contd..3), H1 2018 Table 6: Number of Products under Development by Companies, H1 2018 (Contd..4), H1 2018 Table 7: Number of Products under Development by Companies, H1 2018 (Contd..5), H1 2018 Table 8: Number of Products under Development by Companies, H1 2018 (Contd..6), H1 2018 Table 9: Number of Products under Development by Companies, H1 2018 (Contd..7), H1 2018 Table 10: Number of Products under Development by Universities/Institutes, H1 2018 Table 11: Products under Development by Companies, H1 2018 Table 12: Products under Development by Companies, H1 2018 (Contd..1), H1 2018 Table 13: Products under Development by Companies, H1 2018 (Contd..2), H1 2018 Table 14: Products under Development by Companies, H1 2018 (Contd..3), H1 2018 Table 15: Products under Development by Companies, H1 2018 (Contd..4), H1 2018 Table 16: Products under Development by Companies, H1 2018 (Contd..5), H1 2018 Table 17: Products under Development by Companies, H1 2018 (Contd..6), H1 2018 Table 18: Products under Development by Companies, H1 2018 (Contd..7), H1 2018 Table 19: Products under Development by Companies, H1 2018 (Contd..8), H1 2018 Table 20: Products under Development by Companies, H1 2018 (Contd..9), H1 2018 Table 21: Products under Development by Companies, H1 2018 (Contd..10), H1 2018 Table 22: Products under Development by Companies, H1 2018 (Contd..11), H1 2018 Table 23: Products under Development by Universities/Institutes, H1 2018 Table 24: Products under Development by Universities/Institutes, H1 2018 (Contd..1), H1 2018 Table 25: Number of Products by Stage and Target, H1 2018 Table 26: Number of Products by Stage and Target, H1 2018 (Contd..1), H1 2018 Table 27: Number of Products by Stage and Target, H1 2018 (Contd..2), H1 2018 Table 28: Number of Products by Stage and Target, H1 2018 (Contd..3), H1 2018 Table 29: Number of Products by Stage and Target, H1 2018 (Contd..4), H1 2018 Table 30: Number of Products by Stage and Target, H1 2018 (Contd..5), H1 2018 Table 31: Number of Products by Stage and Mechanism of Action, H1 2018 Table 32: Number of Products by Stage and Mechanism of Action, H1 2018 (Contd..1), H1 2018 Table 33: Number of Products by Stage and Mechanism of Action, H1 2018 (Contd..2), H1 2018 Table 34: Number of Products by Stage and Mechanism of Action, H1 2018 (Contd..3), H1 2018 Table 35: Number of Products by Stage and Mechanism of Action, H1 2018 (Contd..4), H1 2018 Table 36: Number of Products by Stage and Mechanism of Action, H1 2018 (Contd..5), H1 2018 Table 37: Number of Products by Stage and Route of Administration, H1 2018 Table 38: Number of Products by Stage and Molecule Type, H1 2018 Table 39: Asthma - Pipeline by 4D Pharma PLC, H1 2018 Table 40: Asthma - Pipeline by AB Science SA, H1 2018 Table 41: Asthma - Pipeline by AbbVie Inc, H1 2018 Table 42: Asthma - Pipeline by Abeome Corp, H1 2018 Table 43: Asthma - Pipeline by Accolade Pharmaceuticals LLC, H1 2018 Table 44: Asthma - Pipeline by Adamis Pharmaceuticals Corp, H1 2018 Table 45: Asthma - Pipeline by ALK-Abello AS, H1 2018 Table 46: Asthma - Pipeline by Allergan Plc, H1 2018 Table 47: Asthma - Pipeline by Allergopharma GmbH & Co KG, H1 2018 Table 48: Asthma - Pipeline by Almirall SA, H1 2018 Table 49: Asthma - Pipeline by Amgen Inc, H1 2018 Table 50: Asthma - Pipeline by Amphastar Pharmaceuticals Inc, H1 2018 Table 51: Asthma - Pipeline by AnaptysBio Inc, H1 2018 Table 52: Asthma - Pipeline by AnGes Inc, H1 2018 Table 53: Asthma - Pipeline by Antisense Therapeutics Ltd, H1 2018 Table 54: Asthma - Pipeline by Apollo Endosurgery Inc, H1 2018 Table 55: Asthma - Pipeline by ARA Healthcare Pvt Ltd, H1 2018 Table 56: Asthma - Pipeline by ASIT Biotech SA, H1 2018 Table 57: Asthma - Pipeline by Aslan Pharmaceuticals Pte Ltd, H1 2018 Table 58: Asthma - Pipeline by Astellas Pharma Inc, H1 2018 Table 59: Asthma - Pipeline by AstraZeneca Plc, H1 2018 Table 60: Asthma - Pipeline by Aurigene Discovery Technologies Ltd, H1 2018 Table 61: Asthma - Pipeline by Biotec Pharmacon ASA, H1 2018 Table 62: Asthma - Pipeline by Boehringer Ingelheim GmbH, H1 2018 Table 63: Asthma - Pipeline by Cellular Biomedicine Group Inc, H1 2018 Table 64: Asthma - Pipeline by Celon Pharma SA, H1 2018 Table 65: Asthma - Pipeline by Chiesi Farmaceutici SpA, H1 2018 Table 66: Asthma - Pipeline by Circassia Pharmaceuticals Plc, H1 2018 Table 67: Asthma - Pipeline by Cognosci Inc, H1 2018 Table 68: Asthma - Pipeline by Crossject SA, H1 2018 Table 69: Asthma - Pipeline by CrystalGenomics Inc, H1 2018 Table 70: Asthma - Pipeline by CSL Ltd, H1 2018 List of Figures Figure 1: Number of Products under Development for Asthma, H1 2018 Figure 2: Number of Products under Development by Companies, H1 2018 Figure 3: Number of Products under Development by Universities/Institutes, H1 2018 Figure 4: Number of Products by Top 10 Targets, H1 2018 Figure 5: Number of Products by Stage and Top 10 Targets, H1 2018 Figure 6: Number of Products by Top 10 Mechanism of Actions, H1 2018 Figure 7: Number of Products by Stage and Top 10 Mechanism of Actions, H1 2018 Figure 8: Number of Products by Top 10 Routes of Administration, H1 2018 Figure 9: Number of Products by Stage and Top 10 Routes of Administration, H1 2018 Figure 10: Number of Products by Top 10 Molecule Types, H1 2018 Figure 11: Number of Products by Stage and Top 10 Molecule Types, H1 2018

4D Pharma PLC AB Science SA AbbVie Inc Abeome Corp Accolade Pharmaceuticals LLC Adamis Pharmaceuticals Corp ALK-Abello AS Allergan Plc Allergopharma GmbH & Co KG Almirall SA Amgen Inc Amphastar Pharmaceuticals Inc AnaptysBio Inc AnGes Inc Antisense Therapeutics Ltd Apollo Endosurgery Inc ARA Healthcare Pvt Ltd ASIT Biotech SA Aslan Pharmaceuticals Pte Ltd Astellas Pharma Inc AstraZeneca Plc Aurigene Discovery Technologies Ltd Biotec Pharmacon ASA Boehringer Ingelheim GmbH Cellular Biomedicine Group Inc Celon Pharma SA Chiesi Farmaceutici SpA Circassia Pharmaceuticals Plc Cognosci Inc Crossject SA CrystalGenomics Inc CSL Ltd Cumberland Pharmaceuticals Inc Cynata Therapeutics Ltd Cytokinetics Inc Daiichi Sankyo Co Ltd Denceptor Therapeutics Ltd Energenesis Biomedical Co Ltd Enterprise Therapeutics Ltd F. Hoffmann-La Roche Ltd Fountain Biopharma Inc Genentech Inc GlaxoSmithKline Plc Glenmark Pharmaceuticals Ltd Griffin Discoveries BV Han Wha Pharma Co Ltd Hydra Biosciences Inc iCeutica Inc iCo Therapeutics Inc. Icure Pharmaceutical Inc Idorsia Ltd InKemia IUCT Group SA Inspyr Therapeutics Inc Intech Biopharm Ltd Invion Ltd Jiangsu Hansoh Pharmaceutical Group Co Ltd Kissei Pharmaceutical Co Ltd Knopp Biosciences LLC Kyowa Hakko Kirin Co Ltd Laboratorios LETI SL Lead Discovery Center GmbH LG Chem Ltd Longevity Biotech Inc Medicenna Therapeutics Corp MedImmune LLC Merck & Co Inc Mitsubishi Tanabe Pharma Corp Mycenax Biotech Inc NAL Pharmaceuticals Ltd NeoPharm Co Ltd Novartis AG Omeros Corp Ono Pharmaceutical Co Ltd OPKO Health Inc Orbis Biosciences Inc Orchid Pharma Ltd Orion Corporation Oxagen Ltd Paradigm Biopharmaceuticals Ltd Pfizer Inc Pharmaxis Ltd Pieris Pharmaceuticals Inc Polyphor Ltd Progenra Inc Promedior Inc Prommune Inc Pulmagen Therapeutics LLP Pulmatrix Inc Pulmokine Inc Pulmotect Inc Qu Biologics Inc Qurient Co Ltd Re-Pharm Ltd Regeneron Pharmaceuticals Inc Reliance Life Sciences Pvt Ltd Respiratorius AB ReveraGen BioPharma Inc Saje Pharma LLC SolAeroMed Inc Sterna biologicals GmbH & Co KG Sumitomo Chemical Co Ltd Sumitomo Dainippon Pharma Co Ltd Sun Pharmaceutical Industries Ltd Swecure AB Synermore Biologics Co Ltd TaiwanJ Pharmaceuticals Co Ltd Teva Pharmaceutical Industries Ltd The Geneva Biotech Center SA Therabron Therapeutics Inc Theravance Biopharma Inc Tolerys SA United BioPharma Inc Vectura Group Plc Verona Pharma Plc WhanIn Pharmaceutical Co Ltd Xencor Inc Zai Lab Ltd