Table of Contents Table of Contents 2 Introduction 5 Chronic Kidney Disease (Chronic Renal Failure) - Overview 6 Chronic Kidney Disease (Chronic Renal Failure) - Therapeutics Development 7 Chronic Kidney Disease (Chronic Renal Failure) - Therapeutics Assessment 19 Chronic Kidney Disease (Chronic Renal Failure) - Companies Involved in Therapeutics Development 29 Chronic Kidney Disease (Chronic Renal Failure) - Drug Profiles 47 Chronic Kidney Disease (Chronic Renal Failure) - Dormant Projects 198 Chronic Kidney Disease (Chronic Renal Failure) - Discontinued Products 202 Chronic Kidney Disease (Chronic Renal Failure) - Product Development Milestones 203 Appendix 212

List of Tables Table 1: Number of Products under Development for Chronic Kidney Disease (Chronic Renal Failure), H1 2018 Table 2: Number of Products under Development by Companies, H1 2018 Table 3: Number of Products under Development by Companies, H1 2018 (Contd..1), H1 2018 Table 4: Number of Products under Development by Companies, H1 2018 (Contd..2), H1 2018 Table 5: Number of Products under Development by Universities/Institutes, H1 2018 Table 6: Products under Development by Companies, H1 2018 Table 7: Products under Development by Companies, H1 2018 (Contd..1), H1 2018 Table 8: Products under Development by Companies, H1 2018 (Contd..2), H1 2018 Table 9: Products under Development by Companies, H1 2018 (Contd..3), H1 2018 Table 10: Products under Development by Universities/Institutes, H1 2018 Table 11: Number of Products by Stage and Target, H1 2018 Table 12: Number of Products by Stage and Target, H1 2018 (Contd..1), H1 2018 Table 13: Number of Products by Stage and Mechanism of Action, H1 2018 Table 14: Number of Products by Stage and Mechanism of Action, H1 2018 (Contd..1), H1 2018 Table 15: Number of Products by Stage and Route of Administration, H1 2018 Table 16: Number of Products by Stage and Molecule Type, H1 2018 Table 17: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Allena Pharmaceuticals Inc, H1 2018 Table 18: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Angion Biomedica Corp, H1 2018 Table 19: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by apceth Biopharma GmbH, H1 2018 Table 20: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Astellas Pharma Inc, H1 2018 Table 21: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by AstraZeneca Plc, H1 2018 Table 22: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Bayer AG, H1 2018 Table 23: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Boehringer Ingelheim GmbH, H1 2018 Table 24: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Boryung Pharmaceutical Co Ltd, H1 2018 Table 25: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Cellmid Ltd, H1 2018 Table 26: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Chugai Pharmaceutical Co Ltd, H1 2018 Table 27: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Corvidia Therapeutics, H1 2018 Table 28: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by CTI BioPharma Corp, H1 2018 Table 29: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by DURECT Corp, H1 2018 Table 30: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Evotec AG, H1 2018 Table 31: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Gilead Sciences Inc, H1 2018 Table 32: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by GNI Group Ltd, H1 2018 Table 33: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Lupin Ltd, H1 2018 Table 34: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Navya Biologicals Pvt Ltd, H1 2018 Table 35: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Novartis AG, H1 2018 Table 36: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by OPKO Health Inc, H1 2018 Table 37: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Otsuka Holdings Co Ltd, H1 2018 Table 38: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Prolong Pharmaceuticals LLC, H1 2018 Table 39: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by ProMetic Life Sciences Inc, H1 2018 Table 40: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Reata Pharmaceuticals Inc, H1 2018 Table 41: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Relypsa Inc, H1 2018 Table 42: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Resverlogix Corp, H1 2018 Table 43: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Rockwell Medical Inc, H1 2018 Table 44: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Sanwa Kagaku Kenkyusho Co Ltd, H1 2018 Table 45: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Sarfez Pharmaceuticals Inc, H1 2018 Table 46: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Taisho Pharmaceutical Holdings Co Ltd, H1 2018 Table 47: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Toray Industries Inc, H1 2018 Table 48: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Tricida Inc, H1 2018 Table 49: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Unity Biotechnology Inc, H1 2018 Table 50: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Vascular BioSciences, H1 2018 Table 51: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by VESSL Therapeutics Ltd, H1 2018 Table 52: Chronic Kidney Disease (Chronic Renal Failure) - Pipeline by Vicore Pharma AB, H1 2018 Table 53: Chronic Kidney Disease (Chronic Renal Failure) - Dormant Projects, H1 2018 Table 54: Chronic Kidney Disease (Chronic Renal Failure) - Dormant Projects, H1 2018 (Contd..1), H1 2018 Table 55: Chronic Kidney Disease (Chronic Renal Failure) - Dormant Projects, H1 2018 (Contd..2), H1 2018 Table 56: Chronic Kidney Disease (Chronic Renal Failure) - Discontinued Products, H1 2018 List of Figures Figure 1: Number of Products under Development for Chronic Kidney Disease (Chronic Renal Failure), H1 2018 Figure 2: Number of Products under Development by Companies, H1 2018 Figure 3: Number of Products under Development by Universities/Institutes, H1 2018 Figure 4: Number of Products by Top 10 Targets, H1 2018 Figure 5: Number of Products by Stage and Top 10 Targets, H1 2018 Figure 6: Number of Products by Top 10 Mechanism of Actions, H1 2018 Figure 7: Number of Products by Stage and Top 10 Mechanism of Actions, H1 2018 Figure 8: Number of Products by Top 10 Routes of Administration, H1 2018 Figure 9: Number of Products by Stage and Top 10 Routes of Administration, H1 2018 Figure 10: Number of Products by Top 10 Molecule Types, H1 2018 Figure 11: Number of Products by Stage and Top 10 Molecule Types, H1 2018

Allena Pharmaceuticals Inc Angion Biomedica Corp apceth Biopharma GmbH Astellas Pharma Inc AstraZeneca Plc Bayer AG Boehringer Ingelheim GmbH Boryung Pharmaceutical Co Ltd Cellmid Ltd Chugai Pharmaceutical Co Ltd Corvidia Therapeutics CTI BioPharma Corp DURECT Corp Evotec AG Gilead Sciences Inc GNI Group Ltd Lupin Ltd Navya Biologicals Pvt Ltd Novartis AG OPKO Health Inc Otsuka Holdings Co Ltd Prolong Pharmaceuticals LLC ProMetic Life Sciences Inc Reata Pharmaceuticals Inc Relypsa Inc Resverlogix Corp Rockwell Medical Inc Sanwa Kagaku Kenkyusho Co Ltd Sarfez Pharmaceuticals Inc Taisho Pharmaceutical Holdings Co Ltd Toray Industries Inc Tricida Inc Unity Biotechnology Inc Vascular BioSciences VESSL Therapeutics Ltd Vicore Pharma AB