PART 01: EXECUTIVE SUMMARY PART 02: SCOPE OF THE REPORT PART 03: RESEARCH METHODOLOGY PART 04: MARKET LANDSCAPE • Market ecosystem • Market characteristics • Market segmentation analysis PART 05: MARKET SIZING • Market definition • Market sizing 2017 • Market size and forecast 2017-2022 PART 06: FIVE FORCES ANALYSIS • Bargaining power of buyers • Bargaining power of suppliers • Threat of new entrants • Threat of substitutes • Threat of rivalry • Market condition PART 07: MARKET SEGMENTATION BY PRODUCT • Segmentation by product • Comparison by product • Transcatheter heart valves – Market size and forecast 2017-2022 • Tissue heart valves – Market size and forecast 2017-2022 • Mechanical heart valves – Market size and forecast 2017-2022 • Market opportunity by product PART 08: CUSTOMER LANDSCAPE PART 09: MARKET SEGMENTATION BY END-USER • Comparison by end-user • Hospitals • ASCs • Specialty cardiac centers PART 10: REGIONAL LANDSCAPE • Geographical segmentation • Regional comparison • Americas – Market size and forecast 2017-2022 • EMEA – Market size and forecast 2017-2022 • APAC – Market size and forecast 2017-2022 • Market opportunity PART 11: DECISION FRAMEWORK PART 12: DRIVERS AND CHALLENGES • Market drivers • Market challenges PART 13: MARKET TRENDS • Emergence of MRI-conditional heart valves • Growing popularity of sutureless aortic valve replacement • New product launch coupled with R&D activities • Advances in technology • Growing number of M&A • Emergence of two-in-one valve solutions PART 14: VENDOR LANDSCAPE • Overview • Landscape disruption • Competitive landscape • Other prominent vendors PART 15: VENDOR ANALYSIS • Vendors covered • Vendor classification • Market positioning of vendors • Abbott • Boston Scientific • Edwards Lifesciences • LivaNova • Lepu Medical Technology • Medtronic PART 16: APPENDIX • List of abbreviations Exhibit 01: Parent market Exhibit 02: Global cardiac prosthetic devices market Exhibit 03: Market characteristics Exhibit 04: Market segments Exhibit 05: Market definition - Inclusions and exclusions checklist Exhibit 06: Market size 2017 Exhibit 07: Validation techniques employed for market sizing 2017 Exhibit 08: Global – Market size and forecast 2017-2022 ($ mn) Exhibit 09: Global – Year-over-year growth 2018-2022 (%) Exhibit 10: Five forces analysis 2017 Exhibit 11: Five forces analysis 2022 Exhibit 12: Bargaining power of buyers Exhibit 13: Bargaining power of suppliers Exhibit 14: Threat of new entrants Exhibit 15: Threat of substitutes Exhibit 16: Threat of rivalry Exhibit 17: Market condition - Five forces 2017 Exhibit 18: Product – Market share 2017-2022 (%) Exhibit 19: Comparison by product Exhibit 20: Transcatheter heart valves – Market size and forecast 2017-2022 ($ mn) Exhibit 21: Transcatheter heart valves – Year-over-year growth 2018-2022 (%) Exhibit 22: Tissue heart valves – Market size and forecast 2017-2022 ($ mn) Exhibit 23: Tissue heart valves – Year-over-year growth 2018-2022 (%) Exhibit 24: Mechanical heart valves – Market size and forecast 2017-2022 ($ mn) Exhibit 25: Mechanical heart valves – Year-over-year growth 2018-2022 (%) Exhibit 26: Market opportunity by product Exhibit 27: Customer landscape Exhibit 28: Global prosthetic heart valves market by end-user – Market share 2017 (%) Exhibit 29: Global – Market share by geography 2017-2022 (%) Exhibit 30: Regional comparison Exhibit 31: Americas – Market size and forecast 2017-2022 ($ mn) Exhibit 32: Americas – Year-over-year growth 2018-2022 (%) Exhibit 33: Top three countries in Americas Exhibit 34: EMEA – Market size and forecast 2017-2022 ($ mn) Exhibit 35: EMEA – Year-over-year growth 2018-2022 (%) Exhibit 36: Top three countries in EMEA Exhibit 37: APAC – Market size and forecast 2017-2022 ($ mn) Exhibit 38: APAC – Year-over-year growth 2018-2022 (%) Exhibit 39: Top three countries in APAC Exhibit 40: Market opportunity Exhibit 41: Product recalls in global prosthetic heart valves market 2015-2017 Exhibit 42: New product launches in 2016-2017 Exhibit 43: Major M&A deals during 2015-2017 Exhibit 44: Vendor landscape Exhibit 45: Landscape disruption Exhibit 46: Vendors covered Exhibit 47: Vendor classification Exhibit 48: Market positioning of vendors Exhibit 49: Abbott – Overview Exhibit 50: Abbott – Business segments Exhibit 51: Abbott – Organizational developments Exhibit 52: Abbott – Geographic focus Exhibit 53: Abbott – Segment focus Exhibit 54: Abbott – Key offerings Exhibit 55: Abbott – Key customers Exhibit 56: Boston Scientific – Overview Exhibit 57: Boston Scientific – Business segments Exhibit 58: Boston Scientific – Organizational developments Exhibit 59: Boston Scientific – Geographic focus Exhibit 60: Boston Scientific – Segment focus Exhibit 61: Boston Scientific – Key offerings Exhibit 62: Boston Scientific – Key customers Exhibit 63: Edwards Lifesciences – Overview Exhibit 64: Edwards Lifesciences – Business segments Exhibit 65: Edwards Lifesciences – Organizational developments Exhibit 66: Edwards Lifesciences – Geographic focus Exhibit 67: Edwards Lifesciences – Segment focus Exhibit 68: Edwards Lifesciences – Key offerings Exhibit 69: Edwards Lifesciences – Key customers Exhibit 70: LivaNova overview Exhibit 71: LivaNova – Business segments Exhibit 72: LivaNova – Organizational developments Exhibit 73: LivaNova – Geographic focus Exhibit 74: LivaNova – Segment focus Exhibit 75: LivaNova – Key offerings Exhibit 76: LivaNova – Key customers Exhibit 77: Lepu Medical Technology – Overview Exhibit 78: Lepu Medical Technology – Products categories Exhibit 79: Lepu Medical Technology – Organizational developments Exhibit 80: Lepu Medical Technology – Geographic focus Exhibit 81: Lepu Medical Technology – Segment focus Exhibit 82: Lepu Medical Technology – Key offerings Exhibit 83: Lepu Medical Technology – Key customers Exhibit 84: Medtronic – Overview Exhibit 85: Medtronic: Business segments Exhibit 86: Medtronic: Organizational developments Exhibit 87: Medtronic: Geographic focus Exhibit 88: Medtronic: Segment focus Exhibit 89: Medtronic: Key offerings Exhibit 90: Medtronic: Key customers

Abbott, Boston Scientific, Edwards Lifesciences, LivaNova, Lepu Medical Technology, Medtronic