1. Executive Summary 2. United States Proton Therapy Market Analysis 2.1 United States Proton Therapy - Actual and Potential Market (2009 - 2022) 2.1.1 United States -Actual Proton Therapy Market and Forecast 2.1.2 United States - Potential Proton Therapy Market and Forecast 2.2 United States Proton Therapy Patients Number - Actual and Potential (2009 - 2022) 2.2.1 United States - Patients Treated with Proton Therapy Actual Number and Forecast 2.2.2 United States - Potential Candidate for Proton Therapy Number and Forecast 3. United States - List of Proton Therapy Centers, Start of Treatment, Patient Treated 4. United States Proton Therapy - Company Analysis 4.1 IBA Proton Therapy 4.1.1 IBA Proton Therapy Sales and Forecast (2007 - 2022) 4.1.2 The Proton Therapy Centers Developed by IBA 4.2 Optivus Proton Therapy 4.2.1 The Proton Therapy Centers Developed by Optivus 4.3 Hitachi Proton Therapy 4.3.1 The Proton Therapy Centers Developed by Hitachi 4.4 Mevion Proton Therapy 4.4.1 The Proton Therapy Centers Developed by Mevion 4.5 Varian Proton Therapy 4.5.1 The Proton Therapy Centers Developed by Varian 5. United States – Number of Patients Treated at Proton Therapy Centers 5.1 UC Davis Crocker Lab, Davis, CA - Number of Patients Treated (2007 – 2015) 5.2 Loma Linda (LLUMC) Proton Therapy Center, Loma Linda, CA – Number of Patients Treated (2006 – 2014) 5.3 Francis H. Burr Proton Center (formerly NPTC) at Massachusetts General Hospital (MGH), Boston, MA – Number of Patients Treated (2007 – 2015) 5.4 Indiana University Health Proton Therapy Center, Bloomington, IN - Number of Patients Treated, (2013 – 2014) 5.5 U Florida Proton Therapy Institute, Jacksonville, FL - Number of Patients Treated (2007 – 2015) 5.6 M. D. Anderson Cancer Center, Houston, TX - Number of Patients Treated (2007 – 2015) 5.7 ProCure Proton Therapy Center, Oklahoma City, OK - Number of Patients Treated (2013 – 2015) 5.8 CDH Proton Center, A ProCure Center, Warrenville - Number of Patients Treated (2013 – 2015) 5.9 Roberts Proton Therapy Center at Penn Medicine, Philadelphia, PA - Number of Patients Treated (2013 – 2015) 5.10 Hampton University Proton Therapy Institute, Hampton, VA - Number of Patients Treated (2013 – 2015) 5.11 ProCure Proton Therapy Center, Somerset, NJ - Number of Patients Treated (2013 – 2015) 5.12 S. Lee Kling Proton Therapy Center (Siteman Cancer Center), Missouri - Number of Patients Treated (2013 – 2015) 5.13 ProCure Proton Therapy Center, Seattle, WA - Number of Patients Treated (2013 – 2015) 5.14 Provision Center for Proton Therapy, Tennessee - Number of Patients Treated (2014 – 2015) 5.15 Scripps Proton Therapy Center, San Diego - Number of Patients Treated (2014 – 2015) 5.16 Willis-Knighton Cancer Center, Shreveport, Louisiana - Number of Patients Treated (2014 – 2015) 5.17 St. Jude Children's Research Hospital, Memphis, TN - Number of Patients Treated (2015) 5.18 Texas Center for Proton Therapy, Irvin, Texas - Number of Patients Treated (2015) 5.19 Robert Wood Johnson University Hospital (The Laurie Proton Therapy Center), New Brunswick, NJ - Number of Patients Treated (2015) 5.20 Mayo Clinic Proton Beam Therapy Program, Minnesota - Number of Patients Treated (March 2016) 6. Current Radiation Therapies 6.1 Third Dimensional Conformal Therapy (CRT) 6.2 Image Guided Radiotherapy (IGRT) 6.3 Intensity Modulated Radiotherapy (IMRT) 6.4 Stereotactic Radiotherapy 6.5 Neutron Therapy 6.6 Heavy Ion Radiotherapy 6.7 Proton Therapy 7. Components of a Standard Proton Therapy Center 7.1 Proton Accelerator 7.2 Beam Transport System 7.3 Beam Delivery System 7.3.1 The Passive Scattering Technique 7.3.2 Beam Scanning 7.4 Nozzle 7.4.1 Single Scattering 7.4.2 Double Scattering 7.4.3 Uniform Scanning Nozzle 7.4.4 Pencil Scanning Nozzle 7.5 Treatment Planning System 7.6 Image Viewers 7.7 Patient Positioning System (PPS) 7.8 Human Resource 8. Proton Therapy - Driving Factors 8.1 Technology Advancement 8.2 Growing Incidence of Cancer Patients 8.3 Proton Therapy Provides Enormous Benefits 9. Proton Therapy - Challenges 9.1 Requires Huge Investment 9.2 Operations Challenges 9.3 More Clinical Evidence Is Needed

List of Figures: Figure 2-1: United States – Actual Proton Therapy Market (Million US$), 2009 - 2016 Figure 2-2: United States - Forecast for Actual Proton Therapy Market (Million US$), 2017 - 2022 Figure 2-3: United States - Potential Proton Therapy Market (Million US$), 2009 - 2016 Figure 2-4: United States - Forecast for Potential Proton Therapy Market (Million US$), 2017 - 2022 Figure 2-5: United States - Actual Patient Treated with Proton Therapy (Number), 2009 - 2016 Figure 2-6: United States - Forecast for Actual Patient Treated with Proton Therapy (Number), 2017 - 2022 Figure 2-7: United States - Potential Candidate for Proton Therapy (Number), 2009 - 2016 Figure 2-8: United States - Forecast for Potential Candidate for Proton Therapy (Number), 2017 - 2022 Figure 4-1: United States - IBA Proton Therapy Sales (Million US$), 2007 - 2016 Figure 4-2: United States – Forecast for IBA Proton Therapy Sales (Million US$), 2017 - 2022 Figure 5-1: UC Davis Crocker Lab – Total Patients Treated (Number), 2007 – 2015 Figure 5-2: Loma Linda (LLUMC) Proton Therapy Center – Total Patients Treated (Number), 2006– 2014 Figure 5-3: Francis H. Burr Proton Center (formerly NPTC) at MGH – Total Patients Treated (Number), 2007 – 2015 Figure 5-4: Indiana University Health Proton Therapy Center - Total Patients Treated (Number), 2013 – 2014 Figure 5-5: U Florida Proton Therapy Institute - Total Patients Treated (Number), 2007 – 2015 Figure 5-6: M. D. Anderson Cancer Center - Total Patients Treated (Number), 2007 – 2015 Figure 5-7: ProCure Proton Therapy Center, Oklahoma City, OK - Total Patients Treated (Number), 2013 – 2015 Figure 5-8: CDH Proton Center, A ProCure Center - Total Patients Treated (Number), 2013 – 2015 Figure 5-9: Roberts Proton Therapy Center at Penn Medicine - Total Patients Treated (Number), 2013 – 2015 Figure 5-10: Hampton University Proton Therapy Institute - Total Patients Treated (Number), 2013 – 2015 Figure 5-11: ProCure Proton Therapy Center, Somerset, NJ - Total Patients Treated (Number), 2013 – 2015 Figure 5-12: S. Lee Kling Proton Therapy Center - Total Patients Treated (Number), 2013 – 2015 Figure 5-13: ProCure Proton Therapy Center - Total Patients Treated (Number), 2013 – 2015 Figure 5-14: Provision Center for Proton Therapy - Total Patients Treated (Number), 2014 – 2015 Figure 5-15: Scripps Proton Therapy Center - Total Patients Treated (Number), 2014 – 2015 Figure 5-16: Willis-Knighton Cancer Center - Total Patients Treated (Number), 2014 – 2015 Figure 8-1: United States - Number of Patient Diagnosed with Cancer (Million), 2009 - 2016 Figure 8-2: United States - Forecast for Number of Patient Diagnosed with Cancer (Million), 2017 - 2022 List of Tables: Table 3-1: United States - List of Proton Therapy Centers Operational, Under Construction and Planned Table 4-1: United States - IBA Proton Therapy Centers Operational and Planned Table 4-2: United States - Hitachi Proton Therapy Centers Operational and Planned Table 4-3: United States - Mevion Proton Therapy Centers Operational and Planned Table 4-4: United States - Varian Proton Therapy Centers Operational and Planned

IBA, Mevion, Varian, Hitachi, Optivus