1 Table of Contents 1 Table of Contents 4 1.1 List of Tables 5 1.2 List of Figures 7 2 Introduction 8 2.1 Swine and Avian Influenza Report Coverage 8 2.2 Influenza A Virus, H5N1 Subtype Infections – Overview 8 2.3 Influenza A Virus, H1N1 Subtype Infections – Overview 8 3 Therapeutics Development 9 3.1 Influenza A Virus, H5N1 Subtype Infections 9 3.2 Influenza A Virus, H1N1 Subtype Infections 18 4 Therapeutics Assessment 30 4.1 Influenza A Virus, H5N1 Subtype Infections 30 4.2 Influenza A Virus, H1N1 Subtype Infections 36 5 Companies Involved in Therapeutics Development 43 5.1 Influenza A Virus, H5N1 Subtype Infections 43 5.2 Influenza A Virus, H1N1 Subtype Infections 58 6 Dormant Projects 81 6.1 Influenza A Virus, H5N1 Subtype Infections 81 6.2 Influenza A Virus, H1N1 Subtype Infections 86 7 Discontinued Products 90 7.1 Influenza A Virus, H5N1 Subtype Infections 90 7.2 Influenza A Virus, H1N1 Subtype Infections 90 8 Product Development Milestones 91 8.1 Influenza A Virus, H5N1 Subtype Infections 91 8.2 Influenza A Virus, H1N1 Subtype Infections 103 9 Appendix 118 9.1 Methodology 118 9.2 Coverage 118 9.3 Secondary Research 118 9.4 Primary Research 118 9.5 Expert Panel Validation 118 9.6 Contact Us 119 9.7 Disclaimer 119

1.1 List of Tables Table 1: Number of Products under Development for Influenza A Virus, H5N1 Subtype Infections 9 Table 2: Number of Products under Development by Companies Influenza A Virus, H5N1 Subtype Infections 11 Table 3: Number of Products under Development by Universities/Institutes Influenza A Virus, H5N1 Subtype Infections 13 Table 4: Products under Development by Companies Influenza A Virus, H5N1 Subtype Infections 14 Table 5: Products under Development by Universities/Institutes Influenza A Virus, H5N1 Subtype Infections 17 Table 6: Number of Products under Development for Influenza A Virus, H1N1 Subtype Infections 18 Table 7: Number of Products under Development by Companies Influenza A Virus, H1N1 Subtype Infections 20 Table 8: Number of Products under Development by Universities/Institutes Influenza A Virus, H1N1 Subtype Infections 22 Table 9: Products under Development by Companies Influenza A Virus, H1N1 Subtype Infections 23 Table 10: Products under Development by Universities/Institutes Influenza A Virus, H1N1 Subtype Infections 28 Table 11: Number of Products by Stage and Target Influenza A Virus, H5N1 Subtype Infections 31 Table 12: Number of Products by Stage and Mechanism of Action Influenza A Virus, H5N1 Subtype Infections 32 Table 13: Number of Products by Stage and Route of Administration Influenza A Virus, H5N1 Subtype Infections 34 Table 14: Number of Products by Stage and Molecule Type Influenza A Virus, H5N1 Subtype Infections 35 Table 15: Number of Products by Stage and Target Influenza A Virus, H1N1 Subtype Infections 37 Table 16: Number of Products by Stage and Mechanism of Action Influenza A Virus, H1N1 Subtype Infections 39 Table 17: Number of Products by Stage and Route of Administration Influenza A Virus, H1N1 Subtype Infections 41 Table 18: Number of Products by Stage and Molecule Type Influenza A Virus, H1N1 Subtype Infections 42 Table 19: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Akshaya Bio Inc 43 Table 20: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Altimmune Inc 43 Table 21: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Antigen Express Inc 44 Table 22: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Aphios Corp 44 Table 23: Influenza A Virus, H5N1 Subtype Infections – Pipeline by BiondVax Pharmaceuticals Ltd 45 Table 24: Influenza A Virus, H5N1 Subtype Infections – Pipeline by CEL-SCI Corp 45 Table 25: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Cocrystal Pharma Inc 46 Table 26: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Curevac AG 46 Table 27: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Gemmus Pharma Inc 47 Table 28: Influenza A Virus, H5N1 Subtype Infections – Pipeline by GlaxoSmithKline Plc 47 Table 29: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Hemispherx Biopharma Inc 48 Table 30: Influenza A Virus, H5N1 Subtype Infections – Pipeline by iBio Inc 48 Table 31: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Inovio Pharmaceuticals Inc 49 Table 32: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Johnson & Johnson 49 Table 33: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Kineta Inc 50 Table 34: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Lakewood-Amedex Inc 50 Table 35: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Medicago Inc 51 Table 36: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Medigen Vaccine Biologics Corp 51 Table 37: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Microbiotix Inc 52 Table 38: Influenza A Virus, H5N1 Subtype Infections – Pipeline by NanoBio Corp 52 Table 39: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Nanotherapeutics Inc 53 Table 40: Influenza A Virus, H5N1 Subtype Infections – Pipeline by NanoViricides Inc 53 Table 41: Influenza A Virus, H5N1 Subtype Infections – Pipeline by OPKO Health Inc 54 Table 42: Influenza A Virus, H5N1 Subtype Infections – Pipeline by PaxVax Inc 54 Table 43: Influenza A Virus, H5N1 Subtype Infections – Pipeline by PeptiDream Inc 55 Table 44: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Shionogi & Co Ltd 56 Table 45: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Takeda Pharmaceutical Company Ltd 56 Table 46: Influenza A Virus, H5N1 Subtype Infections – Pipeline by TechnoVax Inc 56 Table 47: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Vaxart Inc 57 Table 48: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Vaxine Pty Ltd 57 Table 49: Influenza A Virus, H5N1 Subtype Infections – Pipeline by Visterra Inc 58 Table 50: Influenza A Virus, H1N1 Subtype Infections – Pipeline by AbbVie Inc 58 Table 51: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Adimmune Corp 59 Table 52: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Akshaya Bio Inc 59 Table 53: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Altimmune Inc 60 Table 54: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Antigen Express Inc 60 Table 55: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Beijing Minhai Biotechnology Co Ltd 61 Table 56: Influenza A Virus, H1N1 Subtype Infections – Pipeline by BioCryst Pharmaceuticals Inc 61 Table 57: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Cadila Healthcare Ltd 62 Table 58: Influenza A Virus, H1N1 Subtype Infections – Pipeline by CEL-SCI Corp 62 Table 59: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Cilian AG 63 Table 60: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Cocrystal Pharma Inc 63 Table 61: Influenza A Virus, H1N1 Subtype Infections – Pipeline by ContraFect Corp 64 Table 62: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Curevac AG 64 Table 63: Influenza A Virus, H1N1 Subtype Infections – Pipeline by EpiVax Inc 65 Table 64: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Etubics Corp 65 Table 65: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Gemmus Pharma Inc 66 Table 66: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Genentech Inc 66 Table 67: Influenza A Virus, H1N1 Subtype Infections – Pipeline by iBio Inc 67 Table 68: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Inovio Pharmaceuticals Inc 67 Table 69: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Jiangsu Kanion Pharmaceutical Co Ltd 68 Table 70: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Johnson & Johnson 69 Table 71: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Kineta Inc 69 Table 72: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Kyowa Hakko Kirin Co Ltd 70 Table 73: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Lakewood-Amedex Inc 70 Table 74: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Medicago Inc 71 Table 75: Influenza A Virus, H1N1 Subtype Infections – Pipeline by MedImmune LLC 71 Table 76: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Microbiotix Inc 72 Table 77: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Mucosis BV 72 Table 78: Influenza A Virus, H1N1 Subtype Infections – Pipeline by NanoViricides Inc 73 Table 79: Influenza A Virus, H1N1 Subtype Infections – Pipeline by NewLink Genetics Corp 73 Table 80: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Novavax Inc 74 Table 81: Influenza A Virus, H1N1 Subtype Infections – Pipeline by OPKO Health Inc 74 Table 82: Influenza A Virus, H1N1 Subtype Infections – Pipeline by PeptiDream Inc 75 Table 83: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Recce Ltd 75 Table 84: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Sanofi 75 Table 85: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Sanofi Pasteur SA 76 Table 86: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Sarepta Therapeutics Inc 77 Table 87: Influenza A Virus, H1N1 Subtype Infections – Pipeline by SK Chemicals Co Ltd 77 Table 88: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Takeda Pharmaceutical Company Ltd 78 Table 89: Influenza A Virus, H1N1 Subtype Infections – Pipeline by TechnoVax Inc 78 Table 90: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Touchlight Genetics Ltd 78 Table 91: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Vaccibody AS 79 Table 92: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Vaxart Inc 79 Table 93: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Vironova AB 80 Table 94: Influenza A Virus, H1N1 Subtype Infections – Pipeline by Visterra Inc 80 Table 95: Influenza A Virus, H5N1 Subtype Infections – Dormant Projects 81 Table 96: Influenza A Virus, H1N1 Subtype Infections – Dormant Projects 86 Table 97: Influenza A Virus, H5N1 Subtype Infections – Discontinued Products 90 Table 98: Influenza A Virus, H1N1 Subtype Infections – Discontinued Products 90 1.2 List of Figures Figure 1: Number of Products under Development for Influenza A Virus, H5N1 Subtype Infections 9 Figure 2: Number of Products under Development by Companies Influenza A Virus, H5N1 Subtype Infections 10 Figure 3: Number of Products under Development by Universities/Institutes Influenza A Virus, H5N1 Subtype Infections 13 Figure 4: Number of Products under Development for Influenza A Virus, H1N1 Subtype Infections 18 Figure 5: Number of Products under Development by Companies Influenza A Virus, H1N1 Subtype Infections 19 Figure 6: Number of Products under Development by Universities/Institutes Influenza A Virus, H1N1 Subtype Infections 22 Figure 7: Number of Products by Top 10 Targets Influenza A Virus, H5N1 Subtype Infections 30 Figure 8: Number of Products by Stage and Top 10 Targets Influenza A Virus, H5N1 Subtype Infections 30 Figure 9: Number of Products by Top 10 Mechanism of Actions Influenza A Virus, H5N1 Subtype Infections 31 Figure 10: Number of Products by Stage and Top 10 Mechanism of Actions Influenza A Virus, H5N1 Subtype Infections 32 Figure 11: Number of Products by Top 10 Routes of Administration Influenza A Virus, H5N1 Subtype Infections 33 Figure 12: Number of Products by Stage and Top 10 Routes of Administration Influenza A Virus, H5N1 Subtype Infections 33 Figure 13: Number of Products by Top 10 Molecule Types Influenza A Virus, H5N1 Subtype Infections 34 Figure 14: Number of Products by Stage and Top 10 Molecule Types Influenza A Virus, H5N1 Subtype Infections 35 Figure 15: Number of Products by Top 10 Targets Influenza A Virus, H1N1 Subtype Infections 36 Figure 16: Number of Products by Stage and Top 10 Targets Influenza A Virus, H1N1 Subtype Infections 36 Figure 17: Number of Products by Top 10 Mechanism of Actions Influenza A Virus, H1N1 Subtype Infections 38 Figure 18: Number of Products by Stage and Top 10 Mechanism of Actions Influenza A Virus, H1N1 Subtype Infections 38 Figure 19: Number of Products by Top 10 Routes of Administration Influenza A Virus, H1N1 Subtype Infections 40 Figure 20: Number of Products by Stage and Top 10 Routes of Administration Influenza A Virus, H1N1 Subtype Infections 40 Figure 21: Number of Products by Top 10 Molecule Types Influenza A Virus, H1N1 Subtype Infections 41 Figure 22: Number of Products by Stage and Top 10 Molecule Types Influenza A Virus, H1N1 Subtype Infections 42