1 Table of Contents 1 Table of Contents 4 1.1 List of Tables 5 1.2 List of Figures 9 2 Introduction 10 2.1 Gastric and Esophageal Cancer Report Coverage 10 2.2 Esophageal Cancer – Overview 10 2.3 Gastric Cancer – Overview 10 3 Therapeutics Development 11 3.1 Esophageal Cancer 11 3.2 Gastric Cancer 21 4 Therapeutics Assessment 45 4.1 Esophageal Cancer 45 4.2 Gastric Cancer 56 5 Companies Involved in Therapeutics Development 78 5.1 Esophageal Cancer 78 5.2 Gastric Cancer 109 6 Dormant Projects 187 6.1 Esophageal Cancer 187 6.2 Gastric Cancer 190 7 Discontinued Products 198 7.1 Esophageal Cancer 198 7.2 Gastric Cancer 199 8 Product Development Milestones 202 8.1 Esophageal Cancer 202 8.2 Gastric Cancer 218 9 Appendix 243 9.1 Methodology 243 9.2 Coverage 243 9.3 Secondary Research 243 9.4 Primary Research 243 9.5 Expert Panel Validation 243 9.6 Contact Us 244 9.7 Disclaimer 244

1.1 List of Tables Table 1: Number of Products under Development for Esophageal Cancer 11 Table 2: Number of Products under Development by Companies, Esophageal Cancer 13 Table 3: Number of Products under Development by Universities/Institutes, Esophageal Cancer 15 Table 4: Products under Development by Companies, Esophageal Cancer 16 Table 5: Products under Development by Universities/Institutes, Esophageal Cancer 20 Table 6: Number of Products under Development for Gastric Cancer 21 Table 7: Number of Products under Development by Companies, Gastric Cancer 23 Table 8: Number of Products under Development by Universities/Institutes, Gastric Cancer 30 Table 9: Products under Development by Companies, Gastric Cancer 31 Table 10: Products under Development by Universities/Institutes, Gastric Cancer 43 Table 11: Number of Products by Stage and Target, Esophageal Cancer 46 Table 12: Number of Products by Stage and Mechanism of Action, Esophageal Cancer 50 Table 13: Number of Products by Stage and Route of Administration, Esophageal Cancer 54 Table 14: Number of Products by Stage and Molecule Type, Esophageal Cancer 56 Table 15: Number of Products by Stage and Target, Gastric Cancer 58 Table 16: Number of Products by Stage and Mechanism of Action, Gastric Cancer 66 Table 17: Number of Products by Stage and Route of Administration, Gastric Cancer 75 Table 18: Number of Products by Stage and Molecule Type, Gastric Cancer 77 Table 19: Esophageal Cancer – Pipeline by Adaptimmune Therapeutics Plc 78 Table 20: Esophageal Cancer – Pipeline by ADC Therapeutics Sarl 78 Table 21: Esophageal Cancer – Pipeline by Aduro BioTech Inc 79 Table 22: Esophageal Cancer – Pipeline by Advenchen Laboratories LLC 79 Table 23: Esophageal Cancer – Pipeline by Almac Discovery Ltd 80 Table 24: Esophageal Cancer – Pipeline by Ambrx Inc 80 Table 25: Esophageal Cancer – Pipeline by Amgen Inc 81 Table 26: Esophageal Cancer – Pipeline by Aprea AB 81 Table 27: Esophageal Cancer – Pipeline by ArQule Inc 82 Table 28: Esophageal Cancer – Pipeline by Array BioPharma Inc 82 Table 29: Esophageal Cancer – Pipeline by Aslan Pharmaceuticals Pte Ltd 83 Table 30: Esophageal Cancer – Pipeline by Bayer AG 83 Table 31: Esophageal Cancer – Pipeline by BeiGene Ltd 84 Table 32: Esophageal Cancer – Pipeline by BioStar Pharmaceuticals Inc 84 Table 33: Esophageal Cancer – Pipeline by Boehringer Ingelheim GmbH 85 Table 34: Esophageal Cancer – Pipeline by Bristol-Myers Squibb Co 85 Table 35: Esophageal Cancer – Pipeline by Cascadian Therapeutics Inc 86 Table 36: Esophageal Cancer – Pipeline by CBT Pharmaceuticals Inc 86 Table 37: Esophageal Cancer – Pipeline by Celgene Corp 87 Table 38: Esophageal Cancer – Pipeline by Celldex Therapeutics Inc 87 Table 39: Esophageal Cancer – Pipeline by Cellectar Biosciences Inc 88 Table 40: Esophageal Cancer – Pipeline by Clovis Oncology Inc 88 Table 41: Esophageal Cancer – Pipeline by Cyclacel Pharmaceuticals Inc 89 Table 42: Esophageal Cancer – Pipeline by DAE HWA Pharmaceutical Co Ltd 89 Table 43: Esophageal Cancer – Pipeline by Eli Lilly and Co 90 Table 44: Esophageal Cancer – Pipeline by F. Hoffmann-La Roche Ltd 90 Table 45: Esophageal Cancer – Pipeline by Genmab A/S 91 Table 46: Esophageal Cancer – Pipeline by GlaxoSmithKline Plc 92 Table 47: Esophageal Cancer – Pipeline by Glycotope GmbH 92 Table 48: Esophageal Cancer – Pipeline by Hanmi Pharmaceuticals Co Ltd 92 Table 49: Esophageal Cancer – Pipeline by Hutchison MediPharma Ltd 93 Table 50: Esophageal Cancer – Pipeline by Ignyta Inc 93 Table 51: Esophageal Cancer – Pipeline by Immunocore Ltd 94 Table 52: Esophageal Cancer – Pipeline by ImmunoFrontier Inc 94 Table 53: Esophageal Cancer – Pipeline by Immunomedics Inc 95 Table 54: Esophageal Cancer – Pipeline by Incyte Corp 95 Table 55: Esophageal Cancer – Pipeline by Jiangsu Hengrui Medicine Co Ltd 96 Table 56: Esophageal Cancer – Pipeline by Johnson & Johnson 96 Table 57: Esophageal Cancer – Pipeline by Leap Therapeutics Inc 97 Table 58: Esophageal Cancer – Pipeline by Madrigal Pharmaceuticals Inc. 97 Table 59: Esophageal Cancer – Pipeline by MaxiVAX SA 98 Table 60: Esophageal Cancer – Pipeline by Mebiopharm Co Ltd 98 Table 61: Esophageal Cancer – Pipeline by MedImmune LLC 99 Table 62: Esophageal Cancer – Pipeline by Merck & Co Inc 99 Table 63: Esophageal Cancer – Pipeline by Merrimack Pharmaceuticals Inc 100 Table 64: Esophageal Cancer – Pipeline by Novartis AG 100 Table 65: Esophageal Cancer – Pipeline by Omeros Corp 101 Table 66: Esophageal Cancer – Pipeline by Omnitura Therapeutics Inc 101 Table 67: Esophageal Cancer – Pipeline by Oncolys BioPharma Inc 102 Table 68: Esophageal Cancer – Pipeline by Ono Pharmaceutical Co Ltd 103 Table 69: Esophageal Cancer – Pipeline by Puma Biotechnology Inc 103 Table 70: Esophageal Cancer – Pipeline by Rhizen Pharmaceuticals SA 103 Table 71: Esophageal Cancer – Pipeline by Shionogi & Co Ltd 104 Table 72: Esophageal Cancer – Pipeline by Spectrum Pharmaceuticals Inc 104 Table 73: Esophageal Cancer – Pipeline by Steba Biotech SA 105 Table 74: Esophageal Cancer – Pipeline by Stelic Institute & Co Inc 105 Table 75: Esophageal Cancer – Pipeline by Supratek Pharma Inc 106 Table 76: Esophageal Cancer – Pipeline by Symphogen A/S 106 Table 77: Esophageal Cancer – Pipeline by Taiho Pharmaceutical Co Ltd 106 Table 78: Esophageal Cancer – Pipeline by Taiwan Liposome Company Ltd 107 Table 79: Esophageal Cancer – Pipeline by Takara Bio Inc 107 Table 80: Esophageal Cancer – Pipeline by Transgene Biotek Ltd 108 Table 81: Esophageal Cancer – Pipeline by XuanZhu Pharma Co Ltd 108 Table 82: Gastric Cancer – Pipeline by 3SBio Inc 109 Table 83: Gastric Cancer – Pipeline by AbbVie Inc 110 Table 84: Gastric Cancer – Pipeline by AbGenomics International Inc 110 Table 85: Gastric Cancer – Pipeline by Abion Inc 111 Table 86: Gastric Cancer – Pipeline by Adaptimmune Therapeutics Plc 111 Table 87: Gastric Cancer – Pipeline by ADC Therapeutics Sarl 111 Table 88: Gastric Cancer – Pipeline by Aduro BioTech Inc 112 Table 89: Gastric Cancer – Pipeline by Advenchen Laboratories LLC 112 Table 90: Gastric Cancer – Pipeline by Allist Shanghai Pharmaceutical Technology Co Ltd 113 Table 91: Gastric Cancer – Pipeline by Almac Discovery Ltd 113 Table 92: Gastric Cancer – Pipeline by Alteogen Inc 114 Table 93: Gastric Cancer – Pipeline by Ambrx Inc 114 Table 94: Gastric Cancer – Pipeline by amcure GmbH 115 Table 95: Gastric Cancer – Pipeline by Amgen Inc 115 Table 96: Gastric Cancer – Pipeline by ANP Technologies Inc 116 Table 97: Gastric Cancer – Pipeline by Antikor Biopharma Ltd 116 Table 98: Gastric Cancer – Pipeline by arGEN-X BV 117 Table 99: Gastric Cancer – Pipeline by Array BioPharma Inc 117 Table 100: Gastric Cancer – Pipeline by Asana BioSciences LLC 118 Table 101: Gastric Cancer – Pipeline by Aslan Pharmaceuticals Pte Ltd 118 Table 102: Gastric Cancer – Pipeline by Astellas Pharma Inc 119 Table 103: Gastric Cancer – Pipeline by AstraZeneca Plc 120 Table 104: Gastric Cancer – Pipeline by Athenex Inc 120 Table 105: Gastric Cancer – Pipeline by Basilea Pharmaceutica Ltd 120 Table 106: Gastric Cancer – Pipeline by Bayer AG 121 Table 107: Gastric Cancer – Pipeline by BeiGene Ltd 122 Table 108: Gastric Cancer – Pipeline by Beijing Hanmi Pharmaceutical Co Ltd 122 Table 109: Gastric Cancer – Pipeline by Betta Pharmaceuticals Co Ltd 123 Table 110: Gastric Cancer – Pipeline by Biocon Ltd 123 Table 111: Gastric Cancer – Pipeline by Bioleaders Corp 123 Table 112: Gastric Cancer – Pipeline by Bionovis SA 124 Table 113: Gastric Cancer – Pipeline by Boehringer Ingelheim GmbH 124 Table 114: Gastric Cancer – Pipeline by Bristol-Myers Squibb Co 125 Table 115: Gastric Cancer – Pipeline by Camel-IDS NV 126 Table 116: Gastric Cancer – Pipeline by Cancer Prevention Pharmaceuticals Inc 126 Table 117: Gastric Cancer – Pipeline by Cascadian Therapeutics Inc 126 Table 118: Gastric Cancer – Pipeline by CBT Pharmaceuticals Inc 127 Table 119: Gastric Cancer – Pipeline by Celgene Corp 127 Table 120: Gastric Cancer – Pipeline by Celldex Therapeutics Inc 128 Table 121: Gastric Cancer – Pipeline by Cellectar Biosciences Inc 129 Table 122: Gastric Cancer – Pipeline by Celltrion Inc 129 Table 123: Gastric Cancer – Pipeline by Celon Pharma SA 130 Table 124: Gastric Cancer – Pipeline by Chipscreen Biosciences Ltd 130 Table 125: Gastric Cancer – Pipeline by Chugai Pharmaceutical Co Ltd 131 Table 126: Gastric Cancer – Pipeline by Curaxys SL 131 Table 127: Gastric Cancer – Pipeline by Cytori Therapeutics Inc 132 Table 128: Gastric Cancer – Pipeline by Daiichi Sankyo Co Ltd 132 Table 129: Gastric Cancer – Pipeline by Debiopharm International SA 133 Table 130: Gastric Cancer – Pipeline by Deciphera Pharmaceuticals LLC 133 Table 131: Gastric Cancer – Pipeline by Dr. Reddy's Laboratories Ltd 134 Table 132: Gastric Cancer – Pipeline by Eddingpharm Inc 134 Table 133: Gastric Cancer – Pipeline by Eli Lilly and Co 135 Table 134: Gastric Cancer – Pipeline by EOS Biosciences Inc 136 Table 135: Gastric Cancer – Pipeline by Erytech Pharma SA 136 Table 136: Gastric Cancer – Pipeline by Esperance Pharmaceuticals Inc 136 Table 137: Gastric Cancer – Pipeline by Exelixis Inc 137 Table 138: Gastric Cancer – Pipeline by F-star Biotechnology Ltd 137 Table 139: Gastric Cancer – Pipeline by F. Hoffmann-La Roche Ltd 138 Table 140: Gastric Cancer – Pipeline by Five Prime Therapeutics Inc 139 Table 141: Gastric Cancer – Pipeline by Frost Biologic Inc 139 Table 142: Gastric Cancer – Pipeline by Galena Biopharma Inc 140 Table 143: Gastric Cancer – Pipeline by Genelux Corp 140 Table 144: Gastric Cancer – Pipeline by Genentech Inc 140 Table 145: Gastric Cancer – Pipeline by Gilead Sciences Inc 141 Table 146: Gastric Cancer – Pipeline by GlaxoSmithKline Plc 142 Table 147: Gastric Cancer – Pipeline by Glenmark Pharmaceuticals Ltd 142 Table 148: Gastric Cancer – Pipeline by GlycoNex Inc 143 Table 149: Gastric Cancer – Pipeline by Glycotope GmbH 143 Table 150: Gastric Cancer – Pipeline by Green Cross Corp 144 Table 151: Gastric Cancer – Pipeline by Halozyme Therapeutics Inc 144 Table 152: Gastric Cancer – Pipeline by Hanmi Pharmaceuticals Co Ltd 145 Table 153: Gastric Cancer – Pipeline by Horizon Pharma Plc 145 Table 154: Gastric Cancer – Pipeline by Humanigen Inc 146 Table 155: Gastric Cancer – Pipeline by Hummingbird Bioscience Pte Ltd 146 Table 156: Gastric Cancer – Pipeline by Hutchison MediPharma Ltd 147 Table 157: Gastric Cancer – Pipeline by Ignyta Inc 147 Table 158: Gastric Cancer – Pipeline by Ildong Pharmaceutical Co Ltd 148 Table 159: Gastric Cancer – Pipeline by Immunomedics Inc 149 Table 160: Gastric Cancer – Pipeline by Incyte Corp 149 Table 161: Gastric Cancer – Pipeline by Inovio Pharmaceuticals Inc 150 Table 162: Gastric Cancer – Pipeline by Inspyr Therapeutics Inc 150 Table 163: Gastric Cancer – Pipeline by Insys Therapeutics Inc 151 Table 164: Gastric Cancer – Pipeline by Ipsen SA 151 Table 165: Gastric Cancer – Pipeline by Jiangsu Hengrui Medicine Co Ltd 152 Table 166: Gastric Cancer – Pipeline by Jiangsu Kanion Pharmaceutical Co Ltd 153 Table 167: Gastric Cancer – Pipeline by Johnson & Johnson 153 Table 168: Gastric Cancer – Pipeline by Jounce Therapeutics Inc 154 Table 169: Gastric Cancer – Pipeline by Konruns Pharmaceutical Co Ltd 154 Table 170: Gastric Cancer – Pipeline by Kringle Pharma Inc 155 Table 171: Gastric Cancer – Pipeline by Kuhnil Pharmaceutical Co Ltd 155 Table 172: Gastric Cancer – Pipeline by Kyowa Hakko Kirin Co Ltd 156 Table 173: Gastric Cancer – Pipeline by LATITUDE Pharmaceuticals Inc 156 Table 174: Gastric Cancer – Pipeline by LegoChem Biosciences Inc 157 Table 175: Gastric Cancer – Pipeline by LinXis BV 157 Table 176: Gastric Cancer – Pipeline by MacroGenics Inc 158 Table 177: Gastric Cancer – Pipeline by Madrigal Pharmaceuticals Inc. 158 Table 178: Gastric Cancer – Pipeline by MaxiVAX SA 158 Table 179: Gastric Cancer – Pipeline by Mebiopharm Co Ltd 159 Table 180: Gastric Cancer – Pipeline by MedImmune LLC 159 Table 181: Gastric Cancer – Pipeline by Merck & Co Inc 160 Table 182: Gastric Cancer – Pipeline by Merck KGaA 160 Table 183: Gastric Cancer – Pipeline by Merrimack Pharmaceuticals Inc 161 Table 184: Gastric Cancer – Pipeline by Mersana Therapeutics Inc 161 Table 185: Gastric Cancer – Pipeline by Merus NV 162 Table 186: Gastric Cancer – Pipeline by Mirati Therapeutics Inc 162 Table 187: Gastric Cancer – Pipeline by Molecular Partners AG 163 Table 188: Gastric Cancer – Pipeline by Molecular Targeting Technologies Inc 163 Table 189: Gastric Cancer – Pipeline by Moleculin Biotech Inc 164 Table 190: Gastric Cancer – Pipeline by MolMed SpA 164 Table 191: Gastric Cancer – Pipeline by NanoCarrier Co Ltd 165 Table 192: Gastric Cancer – Pipeline by Novartis AG 166 Table 193: Gastric Cancer – Pipeline by Novogen Ltd 166 Table 194: Gastric Cancer – Pipeline by OBI Pharma Inc 167 Table 195: Gastric Cancer – Pipeline by Oncobiologics Inc 167 Table 196: Gastric Cancer – Pipeline by Oncolys BioPharma Inc 168 Table 197: Gastric Cancer – Pipeline by OncoMed Pharmaceuticals Inc 168 Table 198: Gastric Cancer – Pipeline by OncoResponse Inc 169 Table 199: Gastric Cancer – Pipeline by Ono Pharmaceutical Co Ltd 169 Table 200: Gastric Cancer – Pipeline by Opsona Therapeutics Ltd 170 Table 201: Gastric Cancer – Pipeline by Patrys Ltd 170 Table 202: Gastric Cancer – Pipeline by Pfizer Inc 171 Table 203: Gastric Cancer – Pipeline by Pharma Mar SA 171 Table 204: Gastric Cancer – Pipeline by Pieris Pharmaceuticals Inc 172 Table 205: Gastric Cancer – Pipeline by Plexxikon Inc 172 Table 206: Gastric Cancer – Pipeline by Prescient Therapeutics Ltd 173 Table 207: Gastric Cancer – Pipeline by Puma Biotechnology Inc 173 Table 208: Gastric Cancer – Pipeline by Redx Pharma Plc 173 Table 209: Gastric Cancer – Pipeline by Rhizen Pharmaceuticals SA 174 Table 210: Gastric Cancer – Pipeline by Richter Gedeon Nyrt 174 Table 211: Gastric Cancer – Pipeline by Samumed LLC 175 Table 212: Gastric Cancer – Pipeline by Sanofi 175 Table 213: Gastric Cancer – Pipeline by Selecta Biosciences Inc 176 Table 214: Gastric Cancer – Pipeline by Sequella Inc 176 Table 215: Gastric Cancer – Pipeline by Shionogi & Co Ltd 177 Table 216: Gastric Cancer – Pipeline by Simcere Pharmaceutical Group 177 Table 217: Gastric Cancer – Pipeline by Sorrento Therapeutics Inc 178 Table 218: Gastric Cancer – Pipeline by Spectrum Pharmaceuticals Inc 178 Table 219: Gastric Cancer – Pipeline by Stelic Institute & Co Inc 179 Table 220: Gastric Cancer – Pipeline by Supratek Pharma Inc 179 Table 221: Gastric Cancer – Pipeline by SynCore Biotechnology Co Ltd 180 Table 222: Gastric Cancer – Pipeline by Synovo GmbH 180 Table 223: Gastric Cancer – Pipeline by Synthon Holdings BV 180 Table 224: Gastric Cancer – Pipeline by Taiho Pharmaceutical Co Ltd 181 Table 225: Gastric Cancer – Pipeline by Taiwan Liposome Company Ltd 182 Table 226: Gastric Cancer – Pipeline by Takis Srl 182 Table 227: Gastric Cancer – Pipeline by Tessa Therapeutics Pte Ltd 182 Table 228: Gastric Cancer – Pipeline by Transgene SA 183 Table 229: Gastric Cancer – Pipeline by Tyrogenex Inc 183 Table 230: Gastric Cancer – Pipeline by United BioPharma Inc 184 Table 231: Gastric Cancer – Pipeline by Vaxon Biotech 184 Table 232: Gastric Cancer – Pipeline by ViiV Healthcare Ltd 184 Table 233: Gastric Cancer – Pipeline by Viracta Therapeutics Inc 185 Table 234: Gastric Cancer – Pipeline by XuanZhu Pharma Co Ltd 185 Table 235: Gastric Cancer – Pipeline by Zymeworks Inc 186 Table 236: Esophageal Cancer – Dormant Projects 187 Table 237: Gastric Cancer – Dormant Projects 190 Table 238: Esophageal Cancer – Discontinued Products 198 Table 239: Gastric Cancer – Discontinued Products 199 1.2 List of Figures Figure 1: Number of Products under Development for Esophageal Cancer 11 Figure 2: Number of Products under Development by Companies, Esophageal Cancer 12 Figure 3: Number of Products under Development by Universities/Institutes, Esophageal Cancer 15 Figure 4: Number of Products under Development for Gastric Cancer 21 Figure 5: Number of Products under Development by Companies, Gastric Cancer 22 Figure 6: Number of Products under Development by Universities/Institutes, Gastric Cancer 29 Figure 7: Number of Products by Top 10 Targets, Esophageal Cancer 45 Figure 8: Number of Products by Stage and Top 10 Targets, Esophageal Cancer 45 Figure 9: Number of Products by Top 10 Mechanism of Actions, Esophageal Cancer 49 Figure 10: Number of Products by Stage and Top 10 Mechanism of Actions, Esophageal Cancer 49 Figure 11: Number of Products by Top 10 Routes of Administration, Esophageal Cancer 53 Figure 12: Number of Products by Stage and Top 10 Routes of Administration, Esophageal Cancer 53 Figure 13: Number of Products by Top 10 Molecule Types, Esophageal Cancer 55 Figure 14: Number of Products by Stage and Top 10 Molecule Types, Esophageal Cancer 55 Figure 15: Number of Products by Top 10 Targets, Gastric Cancer 56 Figure 16: Number of Products by Stage and Top 10 Targets, Gastric Cancer 57 Figure 17: Number of Products by Top 10 Mechanism of Actions, Gastric Cancer 64 Figure 18: Number of Products by Stage and Top 10 Mechanism of Actions, Gastric Cancer 65 Figure 19: Number of Products by Routes of Administration, Gastric Cancer 74 Figure 20: Number of Products by Stage and Routes of Administration, Gastric Cancer 75 Figure 21: Number of Products by Top 10 Molecule Types, Gastric Cancer 76 Figure 22: Number of Products by Stage and Top 10 Molecule Types, Gastric Cancer 76