1 Table of Contents 1 Table of Contents 4 1.1 List of Tables 5 1.2 List of Figures 7 2 Introduction 8 2.1 Cancer Supportive Care Report Coverage 8 2.2 Cancer Anorexia-Cachexia Syndrome – Overview 8 2.3 Bone Metastasis – Overview 8 2.4 Cancer Pain – Overview 8 3 Therapeutics Development 9 3.1 Cancer Anorexia-Cachexia Syndrome 9 3.2 Bone Metastasis 15 3.3 Cancer Pain 21 4 Therapeutics Assessment 27 4.1 Cancer Anorexia-Cachexia Syndrome 27 4.2 Bone Metastasis 34 4.3 Cancer Pain 41 5 Companies Involved in Therapeutics Development 49 5.1 Cancer Anorexia-Cachexia Syndrome 49 5.2 Bone Metastasis 54 5.3 Cancer Pain 63 6 Dormant Projects 80 6.1 Cancer Anorexia-Cachexia Syndrome 80 6.2 Bone Metastasis 82 6.3 Cancer Pain 84 7 Discontinued Products 87 7.1 Cancer Anorexia-Cachexia Syndrome 87 7.2 Bone Metastasis 87 7.3 Cancer Pain 88 8 Product Development Milestones 89 8.1 Cancer Anorexia-Cachexia Syndrome 89 8.2 Bone Metastasis 105 8.3 Cancer Pain 118 9 Appendix 127 9.1 Methodology 127 9.2 Coverage 127 9.3 Secondary Research 127 9.4 Primary Research 127 9.5 Expert Panel Validation 127 9.6 Contact Us 128 9.7 Disclaimer 128

1.1 List of Tables Table 1: Number of Products under Development for Cancer Anorexia-Cachexia Syndrome 9 Table 2: Number of Products under Development by Companies, Cancer Anorexia-Cachexia Syndrome 11 Table 3: Number of Products under Development by Universities/Institutes, Cancer Anorexia-Cachexia Syndrome 12 Table 4: Products under Development by Companies, Cancer Anorexia-Cachexia Syndrome 13 Table 5: Products under Development by Universities/Institutes, Cancer Anorexia-Cachexia Syndrome 14 Table 6: Number of Products under Development for Bone Metastasis 15 Table 7: Number of Products under Development by Companies, Bone Metastasis 17 Table 8: Number of Products under Development by Universities/Institutes, Bone Metastasis 18 Table 9: Products under Development by Companies, Bone Metastasis 19 Table 10: Products under Development by Universities/Institutes, Bone Metastasis 20 Table 11: Number of Products under Development for Cancer Pain 21 Table 12: Number of Products under Development by Companies, Cancer Pain 22 Table 13: Number of Products under Development by Universities/Institutes, Cancer Pain 24 Table 14: Products under Development by Companies, Cancer Pain 24 Table 15: Products under Development by Universities/Institutes, Cancer Pain 26 Table 16: Number of Products by Stage and Target, Cancer Anorexia-Cachexia Syndrome 28 Table 17: Number of Products by Stage and Mechanism of Action, Cancer Anorexia-Cachexia Syndrome 30 Table 18: Number of Products by Stage and Route of Administration, Cancer Anorexia-Cachexia Syndrome 32 Table 19: Number of Products by Stage and Molecule Type, Cancer Anorexia-Cachexia Syndrome 33 Table 20: Number of Products by Stage and Target, Bone Metastasis 35 Table 21: Number of Products by Stage and Mechanism of Action, Bone Metastasis 37 Table 22: Number of Products by Stage and Route of Administration, Bone Metastasis 39 Table 23: Number of Products by Stage and Molecule Type, Bone Metastasis 40 Table 24: Number of Products by Stage and Target, Cancer Pain 42 Table 25: Number of Products by Stage and Mechanism of Action, Cancer Pain 44 Table 26: Number of Products by Stage and Route of Administration, Cancer Pain 47 Table 27: Number of Products by Stage and Molecule Type, Cancer Pain 48 Table 28: Cancer Anorexia-Cachexia Syndrome – Pipeline by Abreos Biosciences Inc 49 Table 29: Cancer Anorexia-Cachexia Syndrome – Pipeline by Acacia Pharma Ltd 49 Table 30: Cancer Anorexia-Cachexia Syndrome – Pipeline by Aeterna Zentaris Inc 50 Table 31: Cancer Anorexia-Cachexia Syndrome – Pipeline by Incyte Corp 50 Table 32: Cancer Anorexia-Cachexia Syndrome – Pipeline by Lakewood-Amedex Inc 51 Table 33: Cancer Anorexia-Cachexia Syndrome – Pipeline by Novartis AG 51 Table 34: Cancer Anorexia-Cachexia Syndrome – Pipeline by Paradigm Biopharmaceuticals Ltd 52 Table 35: Cancer Anorexia-Cachexia Syndrome – Pipeline by RaQualia Pharma Inc 52 Table 36: Cancer Anorexia-Cachexia Syndrome – Pipeline by Viking Therapeutics Inc 53 Table 37: Cancer Anorexia-Cachexia Syndrome – Pipeline by Zeria Pharmaceutical Co Ltd 53 Table 38: Bone Metastasis – Pipeline by Ablynx NV 54 Table 39: Bone Metastasis – Pipeline by Amgen Inc 54 Table 40: Bone Metastasis – Pipeline by Amura Holdings Ltd 55 Table 41: Bone Metastasis – Pipeline by BiologicsMD Inc 55 Table 42: Bone Metastasis – Pipeline by ChemoCentryx Inc 56 Table 43: Bone Metastasis – Pipeline by CSPC Pharmaceutical Group Limited 56 Table 44: Bone Metastasis – Pipeline by Deciphera Pharmaceuticals LLC 57 Table 45: Bone Metastasis – Pipeline by Eli Lilly and Co 57 Table 46: Bone Metastasis – Pipeline by Lupin Ltd 58 Table 47: Bone Metastasis – Pipeline by Mirati Therapeutics Inc 58 Table 48: Bone Metastasis – Pipeline by Oncobiologics Inc 59 Table 49: Bone Metastasis – Pipeline by Oncodrone BV 59 Table 50: Bone Metastasis – Pipeline by OPKO Health Inc 60 Table 51: Bone Metastasis – Pipeline by R Pharm 60 Table 52: Bone Metastasis – Pipeline by Redx Pharma Plc 61 Table 53: Bone Metastasis – Pipeline by Serene LLC 61 Table 54: Bone Metastasis – Pipeline by Taiho Pharmaceutical Co Ltd 62 Table 55: Bone Metastasis – Pipeline by Terpenoid Therapeutics Inc 62 Table 56: Cancer Pain – Pipeline by Alexza Pharmaceuticals Inc 63 Table 57: Cancer Pain – Pipeline by AngioChem Inc 63 Table 58: Cancer Pain – Pipeline by Aoxing Pharmaceutical Company Inc 64 Table 59: Cancer Pain – Pipeline by Aphios Corp 64 Table 60: Cancer Pain – Pipeline by AstraZeneca Plc 65 Table 61: Cancer Pain – Pipeline by ChironWells GmbH 65 Table 62: Cancer Pain – Pipeline by Colby Pharmaceutical Co 66 Table 63: Cancer Pain – Pipeline by ConSynance Therapeutics Inc 66 Table 64: Cancer Pain – Pipeline by Daewoong Pharmaceutical Co Ltd 67 Table 65: Cancer Pain – Pipeline by Daiichi Sankyo Co Ltd 67 Table 66: Cancer Pain – Pipeline by Dompe Farmaceutici SpA 68 Table 67: Cancer Pain – Pipeline by Fujimoto Pharmaceutical Corp 68 Table 68: Cancer Pain – Pipeline by Grunenthal GmbH 69 Table 69: Cancer Pain – Pipeline by Hisamitsu Pharmaceutical Co Inc 69 Table 70: Cancer Pain – Pipeline by Immupharma Plc 70 Table 71: Cancer Pain – Pipeline by Insys Therapeutics Inc 70 Table 72: Cancer Pain – Pipeline by IntelGenx Corp 71 Table 73: Cancer Pain – Pipeline by iX Biopharma Ltd 71 Table 74: Cancer Pain – Pipeline by Klaria Pharma Holding AB 72 Table 75: Cancer Pain – Pipeline by Komipharm International Co Ltd 72 Table 76: Cancer Pain – Pipeline by KPI Therapeutics Inc 73 Table 77: Cancer Pain – Pipeline by Medlab Clinical Ltd 73 Table 78: Cancer Pain – Pipeline by Nanomerics Ltd 74 Table 79: Cancer Pain – Pipeline by Neurocentrx Pharma Ltd 74 Table 80: Cancer Pain – Pipeline by Nippon Kayaku Co Ltd 75 Table 81: Cancer Pain – Pipeline by Orion Corporation 75 Table 82: Cancer Pain – Pipeline by Pain Therapeutics Inc 76 Table 83: Cancer Pain – Pipeline by Pfizer Inc 76 Table 84: Cancer Pain – Pipeline by Pharmaleads SA 77 Table 85: Cancer Pain – Pipeline by Recordati SpA 77 Table 86: Cancer Pain – Pipeline by Ribomic Inc 78 Table 87: Cancer Pain – Pipeline by Trillium Therapeutics Inc 78 Table 88: Cancer Pain – Pipeline by Virobay Inc 79 Table 89: Cancer Pain – Pipeline by WEX Pharmaceuticals Inc 79 Table 90: Cancer Anorexia-Cachexia Syndrome – Dormant Projects 80 Table 91: Bone Metastasis – Dormant Projects 82 Table 92: Cancer Pain – Dormant Projects 84 Table 93: Cancer Anorexia-Cachexia Syndrome – Discontinued Products 87 Table 94: Bone Metastasis – Discontinued Products 87 Table 95: Cancer Pain – Discontinued Products 88 1.2 List of Figures Figure 1: Number of Products under Development for Cancer Anorexia-Cachexia Syndrome 9 Figure 2: Number of Products under Development by Companies, Cancer Anorexia-Cachexia Syndrome 10 Figure 3: Number of Products under Development by Universities/Institutes, Cancer Anorexia-Cachexia Syndrome 12 Figure 4: Number of Products under Development for Bone Metastasis 15 Figure 5: Number of Products under Development by Companies, Bone Metastasis 16 Figure 6: Number of Products under Development by Universities/Institutes, Bone Metastasis 18 Figure 7: Number of Products under Development for Cancer Pain 21 Figure 8: Number of Products under Development by Companies, Cancer Pain 22 Figure 9: Number of Products by Top 10 Targets, Cancer Anorexia-Cachexia Syndrome 27 Figure 10: Number of Products by Stage and Top 10 Targets, Cancer Anorexia-Cachexia Syndrome 27 Figure 11: Number of Products by Top 10 Mechanism of Actions, Cancer Anorexia-Cachexia Syndrome 29 Figure 12: Number of Products by Stage and Top 10 Mechanism of Actions, Cancer Anorexia-Cachexia Syndrome 29 Figure 13: Number of Products by Routes of Administration, Cancer Anorexia-Cachexia Syndrome 31 Figure 14: Number of Products by Stage and Routes of Administration, Cancer Anorexia-Cachexia Syndrome 31 Figure 15: Number of Products by Molecule Types, Cancer Anorexia-Cachexia Syndrome 32 Figure 16: Number of Products by Stage and Molecule Types, Cancer Anorexia-Cachexia Syndrome 33 Figure 17: Number of Products by Top 10 Targets, Bone Metastasis 34 Figure 18: Number of Products by Stage and Top 10 Targets, Bone Metastasis 34 Figure 19: Number of Products by Top 10 Mechanism of Actions, Bone Metastasis 36 Figure 20: Number of Products by Stage and Top 10 Mechanism of Actions, Bone Metastasis 36 Figure 21: Number of Products by Routes of Administration, Bone Metastasis 38 Figure 22: Number of Products by Stage and Routes of Administration, Bone Metastasis 38 Figure 23: Number of Products by Molecule Types, Bone Metastasis 39 Figure 24: Number of Products by Stage and Molecule Types, Bone Metastasis 40 Figure 25: Number of Products by Top 10 Targets, Cancer Pain 41 Figure 26: Number of Products by Stage and Top 10 Targets, Cancer Pain 41 Figure 27: Number of Products by Top 10 Mechanism of Actions, Cancer Pain 43 Figure 28: Number of Products by Stage and Top 10 Mechanism of Actions, Cancer Pain 44 Figure 29: Number of Products by Routes of Administration, Cancer Pain 46 Figure 30: Number of Products by Stage and Routes of Administration, Cancer Pain 46 Figure 31: Number of Products by Molecule Types, Cancer Pain 47 Figure 32: Number of Products by Stage and Molecule Types, Cancer Pain 48