Table of Contents GBI Research Report Guidance 2 Executive Summary 3 Table of Contents 4 List of Tables 5 List of Figures 9 Introduction 10 Skeletal Disease Report Coverage 10 Osteoarthritis - Overview 10 Osteoporosis - Overview 10 Post Menopausal Osteoporosis - Overview 10 Therapeutics Development 11 Osteoarthritis 11 Osteoporosis 21 Post Menopausal Osteoporosis 31 Therapeutics Assessment 34 Osteoarthritis 34 Osteoporosis 44 Post Menopausal Osteoporosis 54 Companies Involved in Therapeutics Development 62 Osteoarthritis 62 Osteoporosis 96 Post Menopausal Osteoporosis 124 Dormant Projects 129 Osteoarthritis 129 Osteoporosis 133 Post Menopausal Osteoporosis 138 Discontinued Products 139 Osteoarthritis 139 Osteoporosis 140 Post Menopausal Osteoporosis 141 Product Development Milestones 142 Osteoarthritis 142 Osteoporosis 154 Post Menopausal Osteoporosis 164 Appendix 175 Methodology 175 Coverage 175 Secondary Research 175 Primary Research 175 Expert Panel Validation 175 Contact Us 175 Disclaimer 176

List of Tables Number of Products under Development for Osteoarthritis 11 Number of Products under Development by Companies, Osteoarthritis 13 Number of Products under Development by Universities/Institutes, Osteoarthritis 15 Products under Development by Companies, Osteoarthritis 16 Products under Development by Universities/Institutes, Osteoarthritis 20 Number of Products under Development for Osteoporosis 21 Number of Products under Development by Companies, Osteoporosis 23 Number of Products under Development by Universities/Institutes, Osteoporosis 25 Products under Development by Companies, Osteoporosis 26 Products under Development by Universities/Institutes, Osteoporosis 30 Number of Products under Development for Post Menopausal Osteoporosis 31 Number of Products under Development by Companies, Post Menopausal Osteoporosis 32 Products under Development by Companies, Post Menopausal Osteoporosis 33 Number of Products by Stage and Target, Osteoarthritis 35 Number of Products by Stage and Mechanism of Action, Osteoarthritis 38 Number of Products by Stage and Route of Administration, Osteoarthritis 41 Number of Products by Stage and Molecule Type, Osteoarthritis 43 Number of Products by Stage and Target, Osteoporosis 45 Number of Products by Stage and Mechanism of Action, Osteoporosis 48 Number of Products by Stage and Route of Administration, Osteoporosis 51 Number of Products by Stage and Molecule Type, Osteoporosis 53 Number of Products by Stage and Target, Post Menopausal Osteoporosis 55 Number of Products by Stage and Mechanism of Action, Post Menopausal Osteoporosis 57 Number of Products by Stage and Route of Administration, Post Menopausal Osteoporosis 59 Number of Products by Stage and Molecule Type, Post Menopausal Osteoporosis 61 Osteoarthritis - Pipeline by A. Menarini Industrie Farmaceutiche Riunite Srl 62 Osteoarthritis - Pipeline by AbbVie Inc 62 Osteoarthritis - Pipeline by Abiogen Pharma SpA 63 Osteoarthritis - Pipeline by Ablynx NV 63 Osteoarthritis - Pipeline by Achelios Therapeutics Inc 64 Osteoarthritis - Pipeline by Addex Therapeutics Ltd 64 Osteoarthritis - Pipeline by Amgen Inc 65 Osteoarthritis - Pipeline by Amura Holdings Ltd 65 Osteoarthritis - Pipeline by Arcarios BV 66 Osteoarthritis - Pipeline by Asahi Kasei Pharma Corp 66 Osteoarthritis - Pipeline by Asklepios BioPharmaceutical Inc 67 Osteoarthritis - Pipeline by Astellas Pharma Inc 67 Osteoarthritis - Pipeline by Biopharm GmbH 68 Osteoarthritis - Pipeline by Bone Therapeutics SA 68 Osteoarthritis - Pipeline by Can-Fite BioPharma Ltd 69 Osteoarthritis - Pipeline by Cardax Inc 69 Osteoarthritis - Pipeline by Cellular Biomedicine Group Inc 70 Osteoarthritis - Pipeline by Cipla Ltd 70 Osteoarthritis - Pipeline by Corestem Inc 71 Osteoarthritis - Pipeline by Dong-A Socio Holdings Co Ltd 71 Osteoarthritis - Pipeline by Evgen Pharma Plc 72 Osteoarthritis - Pipeline by F. Hoffmann-La Roche Ltd 72 Osteoarthritis - Pipeline by Galapagos NV 73 Osteoarthritis - Pipeline by Gemphire Therapeutics Inc 73 Osteoarthritis - Pipeline by GeneFrontier Corp 74 Osteoarthritis - Pipeline by Genequine Biotherapeutics GmbH 74 Osteoarthritis - Pipeline by GlaxoSmithKline Plc 75 Osteoarthritis - Pipeline by HSRx Group 75 Osteoarthritis - Pipeline by InKemia IUCT Group SA 76 Osteoarthritis - Pipeline by International Stem Cell Corp 76 Osteoarthritis - Pipeline by Jeil Pharmaceutical Co Ltd 77 Osteoarthritis - Pipeline by Jenrin Discovery Inc 77 Osteoarthritis - Pipeline by K-Stemcell Co Ltd 78 Osteoarthritis - Pipeline by Kang Stem Biotech Co Ltd 78 Osteoarthritis - Pipeline by Levolta Pharmaceuticals Inc 79 Osteoarthritis - Pipeline by LG Chem, Ltd. 79 Osteoarthritis - Pipeline by Marina Biotech Inc 80 Osteoarthritis - Pipeline by Medivir AB 80 Osteoarthritis - Pipeline by Merck KGaA 81 Osteoarthritis - Pipeline by Mesoblast Ltd 81 Osteoarthritis - Pipeline by Mor Research Application Ltd 82 Osteoarthritis - Pipeline by NicOx SA 82 Osteoarthritis - Pipeline by Nordic Bioscience A/S 83 Osteoarthritis - Pipeline by Novartis AG 83 Osteoarthritis - Pipeline by NovelMed Therapeutics Inc 84 Osteoarthritis - Pipeline by Omeros Corp 84 Osteoarthritis - Pipeline by Ono Pharmaceutical Co Ltd 85 Osteoarthritis - Pipeline by OrthoCyte Corp 85 Osteoarthritis - Pipeline by Osteologix Holdings Plc 86 Osteoarthritis - Pipeline by Pfizer Inc 86 Osteoarthritis - Pipeline by Pharmalink AB 87 Osteoarthritis - Pipeline by Philogen SpA 87 Osteoarthritis - Pipeline by PhytoHealth Corp 88 Osteoarthritis - Pipeline by PLx Pharma Inc 88 Osteoarthritis - Pipeline by ProteoThera Inc 89 Osteoarthritis - Pipeline by Regeneus Ltd 89 Osteoarthritis - Pipeline by Regulaxis SAS 90 Osteoarthritis - Pipeline by Rottapharm Biotech Srl 90 Osteoarthritis - Pipeline by Samumed LLC 91 Osteoarthritis - Pipeline by Seikagaku Corp 91 Osteoarthritis - Pipeline by Stelis Biopharma Pvt Ltd 92 Osteoarthritis - Pipeline by Takeda Pharmaceutical Company Ltd 92 Osteoarthritis - Pipeline by TissueGene Inc 93 Osteoarthritis - Pipeline by Yooyoung Pharmaceutical Co Ltd 93 Osteoarthritis - Pipeline by Yuhan Corp 94 Osteoarthritis - Pipeline by Yungjin Pharm Co Ltd 94 Osteoarthritis - Pipeline by Zimmer Biomet Holdings Inc 95 Osteoporosis - Pipeline by Addex Therapeutics Ltd 96 Osteoporosis - Pipeline by Alize Pharma SAS 96 Osteoporosis - Pipeline by Alvogen Korea Co Ltd 97 Osteoporosis - Pipeline by Amgen Inc 97 Osteoporosis - Pipeline by Amura Holdings Ltd 98 Osteoporosis - Pipeline by BiologicsMD Inc 98 Osteoporosis - Pipeline by Bone Biologics Corp 99 Osteoporosis - Pipeline by Bristol-Myers Squibb Company 99 Osteoporosis - Pipeline by Cellmid Ltd 100 Osteoporosis - Pipeline by ChoDang Pharm Co Ltd 100 Osteoporosis - Pipeline by Chugai Pharmaceutical Co Ltd 101 Osteoporosis - Pipeline by Corium International Inc 101 Osteoporosis - Pipeline by Critical Pharmaceuticals Ltd 102 Osteoporosis - Pipeline by Daiichi Sankyo Company Ltd 102 Osteoporosis - Pipeline by ElexoPharm GmbH 103 Osteoporosis - Pipeline by EndoCeutics Inc 103 Osteoporosis - Pipeline by Entera Bio Ltd 104 Osteoporosis - Pipeline by Enteris BioPharma Inc 104 Osteoporosis - Pipeline by Enzo Biochem Inc 105 Osteoporosis - Pipeline by F. Hoffmann-La Roche Ltd 105 Osteoporosis - Pipeline by Gador SA 106 Osteoporosis - Pipeline by GL Pharm Tech Corp 106 Osteoporosis - Pipeline by Glide Pharmaceutical Technologies Ltd 107 Osteoporosis - Pipeline by Hanmi Pharmaceuticals Co Ltd 107 Osteoporosis - Pipeline by Haoma Medica Ltd 108 Osteoporosis - Pipeline by Immunovo BV 108 Osteoporosis - Pipeline by Immunwork Inc 109 Osteoporosis - Pipeline by Intas Pharmaceuticals Ltd 109 Osteoporosis - Pipeline by Ipsen SA 110 Osteoporosis - Pipeline by Kaken Pharmaceutical Co Ltd 110 Osteoporosis - Pipeline by Lead Discovery Center GmbH 111 Osteoporosis - Pipeline by Ligand Pharmaceuticals Inc 111 Osteoporosis - Pipeline by Lotus Pharmaceutical Co Ltd 112 Osteoporosis - Pipeline by Lupin Ltd 112 Osteoporosis - Pipeline by Merck & Co Inc 113 Osteoporosis - Pipeline by Mereo Biopharma Group Plc 113 Osteoporosis - Pipeline by NIBEC 114 Osteoporosis - Pipeline by Omeros Corp 114 Osteoporosis - Pipeline by Oncobiologics Inc 115 Osteoporosis - Pipeline by Osteologix Holdings Plc 115 Osteoporosis - Pipeline by Paras Biopharmaceuticals Finland Oy 116 Osteoporosis - Pipeline by Pfenex Inc 116 Osteoporosis - Pipeline by PhytoHealth Corp 117 Osteoporosis - Pipeline by R Pharm 117 Osteoporosis - Pipeline by Ribomic Inc 118 Osteoporosis - Pipeline by Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd 118 Osteoporosis - Pipeline by Shin Poong PharmCo Ltd 119 Osteoporosis - Pipeline by Sinil Pharmaceutical Co Ltd 119 Osteoporosis - Pipeline by Stelis Biopharma Pvt Ltd 120 Osteoporosis - Pipeline by Sumitomo Dainippon Pharma Co Ltd 120 Osteoporosis - Pipeline by Terpenoid Therapeutics Inc 121 Osteoporosis - Pipeline by TSH Biopharm Corporation Ltd 121 Osteoporosis - Pipeline by Uni-Bio Science Group Ltd 122 Osteoporosis - Pipeline by Viking Therapeutics Inc 122 Osteoporosis - Pipeline by Wroclawskie Centrum Badan EIT+ Sp z oo 123 Osteoporosis - Pipeline by Yooyoung Pharm Co Ltd 123 Osteoporosis - Pipeline by Zydus Cadila Healthcare Ltd 124 Post Menopausal Osteoporosis - Pipeline by Amgen Inc 124 Post Menopausal Osteoporosis - Pipeline by Enteris BioPharma Inc 125 Post Menopausal Osteoporosis - Pipeline by Intas Pharmaceuticals Ltd 125 Post Menopausal Osteoporosis - Pipeline by Ipsen SA 126 Post Menopausal Osteoporosis - Pipeline by Ligand Pharmaceuticals Inc 126 Post Menopausal Osteoporosis - Pipeline by Lupin Ltd 127 Post Menopausal Osteoporosis - Pipeline by NIBEC 127 Post Menopausal Osteoporosis - Pipeline by Oncobiologics Inc 128 Post Menopausal Osteoporosis - Pipeline by Paras Biopharmaceuticals Finland Oy 128 Osteoarthritis - Dormant Projects 129 Osteoporosis - Dormant Projects 133 Post Menopausal Osteoporosis - Dormant Projects 138 Osteoarthritis - Discontinued Products 139 Osteoporosis - Discontinued Products 140 Post Menopausal Osteoporosis - Discontinued Products 141 List of Figures Number of Products under Development for Osteoarthritis 11 Number of Products under Development by Companies, Osteoarthritis 12 Number of Products under Development by Universities/Institutes, Osteoarthritis 15 Number of Products under Development for Osteoporosis 21 Number of Products under Development by Companies, Osteoporosis 22 Number of Products under Development by Universities/Institutes, Osteoporosis 25 Number of Products under Development for Post Menopausal Osteoporosis 31 Number of Products under Development by Companies, Post Menopausal Osteoporosis 32 Number of Products by Top 10 Targets, Osteoarthritis 34 Number of Products by Stage and Top 10 Targets, Osteoarthritis 34 Number of Products by Top 10 Mechanism of Actions, Osteoarthritis 37 Number of Products by Stage and Top 10 Mechanism of Actions, Osteoarthritis 37 Number of Products by Routes of Administration, Osteoarthritis 40 Number of Products by Stage and Routes of Administration, Osteoarthritis 40 Number of Products by Top 10 Molecule Types, Osteoarthritis 42 Number of Products by Stage and Top 10 Molecule Types, Osteoarthritis 42 Number of Products by Top 10 Targets, Osteoporosis 44 Number of Products by Stage and Top 10 Targets, Osteoporosis 44 Number of Products by Top 10 Mechanism of Actions, Osteoporosis 47 Number of Products by Stage and Top 10 Mechanism of Actions, Osteoporosis 47 Number of Products by Top 10 Routes of Administration, Osteoporosis 50 Number of Products by Stage and Top 10 Routes of Administration, Osteoporosis 50 Number of Products by Top 10 Molecule Types, Osteoporosis 52 Number of Products by Stage and Top 10 Molecule Types, Osteoporosis 52 Number of Products by Targets, Post Menopausal Osteoporosis 54 Number of Products by Stage and Targets, Post Menopausal Osteoporosis 54 Number of Products by Mechanism of Actions, Post Menopausal Osteoporosis 56 Number of Products by Stage and Mechanism of Actions, Post Menopausal Osteoporosis 56 Number of Products by Routes of Administration, Post Menopausal Osteoporosis 58 Number of Products by Stage and Routes of Administration, Post Menopausal Osteoporosis 58 Number of Products by Molecule Types, Post Menopausal Osteoporosis 60 Number of Products by Stage and Molecule Types, Post Menopausal Osteoporosis 60