Table of Contents GBI Research Report Guidance 2 Executive Summary 3 Table of Contents 4 List of Tables 5 List of Figures 11 Introduction 12 GBI Research Report Coverage 12 Osteoarthritis Pain - Overview 12 Migraine - Overview 12 Neuropathic Pain - Overview 12 Therapeutics Development 13 Osteoarthritis Pain 13 Migraine 20 Neuropathic Pain 28 Therapeutics Assessment 45 Osteoarthritis Pain 45 Migraine 55 Neuropathic Pain 65 Companies Involved in Therapeutics Development 78 Osteoarthritis Pain 78 Migraine 98 Neuropathic Pain 117 Dormant Projects 177 Osteoarthritis Pain 177 Migraine 179 Neuropathic Pain 182 Discontinued Products 191 Osteoarthritis Pain 191 Migraine 192 Neuropathic Pain 193 Product Development Milestones 196 Osteoarthritis Pain 196 Migraine 206 Neuropathic Pain 217 Appendix 228 Methodology 228 Coverage 228 Secondary Research 228 Primary Research 228 Expert Panel Validation 228 Contact Us 228 Disclaimer 229

List of Tables Number of Products under Development for Osteoarthritis Pain 13 Number of Products under Development by Companies, Osteoarthritis Pain 15 Number of Products under Development by Universities/Institutes, Osteoarthritis Pain 17 Products under Development by Companies, Osteoarthritis Pain 18 Products under Development by Universities/Institutes, Osteoarthritis Pain 19 Number of Products under Development for Migraine 20 Number of Products under Development by Companies, Migraine 22 Number of Products under Development by Universities/Institutes, Migraine 24 Products under Development by Companies, Migraine 25 Products under Development by Universities/Institutes, Migraine 27 Number of Products under Development for Neuropathic Pain 28 Number of Products under Development by Companies, Neuropathic Pain 30 Number of Products under Development by Universities/Institutes, Neuropathic Pain 35 Products under Development by Companies, Neuropathic Pain 36 Products under Development by Universities/Institutes, Neuropathic Pain 43 Number of Products by Stage and Target, Osteoarthritis Pain 46 Number of Products by Stage and Mechanism of Action, Osteoarthritis Pain 49 Number of Products by Stage and Route of Administration, Osteoarthritis Pain 52 Number of Products by Stage and Molecule Type, Osteoarthritis Pain 54 Number of Products by Stage and Target, Migraine 56 Number of Products by Stage and Mechanism of Action, Migraine 59 Number of Products by Stage and Route of Administration, Migraine 62 Number of Products by Stage and Molecule Type, Migraine 64 Number of Products by Stage and Target, Neuropathic Pain 66 Number of Products by Stage and Mechanism of Action, Neuropathic Pain 70 Number of Products by Stage and Route of Administration, Neuropathic Pain 75 Number of Products by Stage and Molecule Type, Neuropathic Pain 77 Osteoarthritis Pain - Pipeline by AbbVie Inc 78 Osteoarthritis Pain - Pipeline by Addex Therapeutics Ltd 78 Osteoarthritis Pain - Pipeline by Allergan Plc 79 Osteoarthritis Pain - Pipeline by Ampio Pharmaceuticals Inc 79 Osteoarthritis Pain - Pipeline by Antibe Therapeutics Inc 80 Osteoarthritis Pain - Pipeline by Aralez Pharmaceuticals Inc 80 Osteoarthritis Pain - Pipeline by Arena Pharmaceuticals Inc 81 Osteoarthritis Pain - Pipeline by Array BioPharma Inc 81 Osteoarthritis Pain - Pipeline by Astellas Pharma Inc 82 Osteoarthritis Pain - Pipeline by Axsome Therapeutics Inc 82 Osteoarthritis Pain - Pipeline by BELLUS Health Inc 83 Osteoarthritis Pain - Pipeline by Boehringer Ingelheim GmbH 83 Osteoarthritis Pain - Pipeline by Cara Therapeutics Inc 84 Osteoarthritis Pain - Pipeline by Chromocell Corp 84 Osteoarthritis Pain - Pipeline by Eli Lilly and Company 85 Osteoarthritis Pain - Pipeline by Elite Pharmaceuticals Inc 85 Osteoarthritis Pain - Pipeline by Eupraxia Pharmaceuticals Inc 86 Osteoarthritis Pain - Pipeline by Flexion Therapeutics Inc 86 Osteoarthritis Pain - Pipeline by Genzyme Corp 87 Osteoarthritis Pain - Pipeline by GlaxoSmithKline Plc 87 Osteoarthritis Pain - Pipeline by Grunenthal GmbH 88 Osteoarthritis Pain - Pipeline by Iroko Pharmaceuticals LLC 88 Osteoarthritis Pain - Pipeline by Marina Biotech Inc 89 Osteoarthritis Pain - Pipeline by Medestea Research & Production SpA 89 Osteoarthritis Pain - Pipeline by MedImmune LLC 90 Osteoarthritis Pain - Pipeline by Merck & Co Inc 90 Osteoarthritis Pain - Pipeline by Nuvo Pharmaceuticals Inc 91 Osteoarthritis Pain - Pipeline by Ono Pharmaceutical Co Ltd 91 Osteoarthritis Pain - Pipeline by Pfizer Inc 92 Osteoarthritis Pain - Pipeline by Phosphagenics Ltd 92 Osteoarthritis Pain - Pipeline by ProteoThera Inc 93 Osteoarthritis Pain - Pipeline by pSivida Corp 93 Osteoarthritis Pain - Pipeline by Purdue Pharma LP 94 Osteoarthritis Pain - Pipeline by Regeneron Pharmaceuticals Inc 94 Osteoarthritis Pain - Pipeline by Rottapharm Biotech Srl 95 Osteoarthritis Pain - Pipeline by Shionogi & Co Ltd 95 Osteoarthritis Pain - Pipeline by Symic Biomedical Inc 96 Osteoarthritis Pain - Pipeline by Taiwan Liposome Company Ltd 96 Osteoarthritis Pain - Pipeline by Vertex Pharmaceuticals Inc 97 Osteoarthritis Pain - Pipeline by Zynerba Pharmaceuticals Inc 97 Migraine - Pipeline by 4P Therapeutics LLC 98 Migraine - Pipeline by Achelios Therapeutics Inc 98 Migraine - Pipeline by Acorda Therapeutics Inc 99 Migraine - Pipeline by Alder Biopharmaceuticals Inc 99 Migraine - Pipeline by Allergan Plc 100 Migraine - Pipeline by Amgen Inc 100 Migraine - Pipeline by Aralez Pharmaceuticals Inc 101 Migraine - Pipeline by Astellas Pharma Inc 101 Migraine - Pipeline by Avanir Pharmaceuticals Inc 102 Migraine - Pipeline by Biofrontera AG 102 Migraine - Pipeline by BioHealthonomics Inc 103 Migraine - Pipeline by Charleston Laboratories Inc 103 Migraine - Pipeline by Corium International Inc 104 Migraine - Pipeline by Eli Lilly and Company 104 Migraine - Pipeline by Impel NeuroPharma Inc 105 Migraine - Pipeline by InKemia IUCT Group SA 105 Migraine - Pipeline by InStar Technologies AS 106 Migraine - Pipeline by Ionis Pharmaceuticals Inc 106 Migraine - Pipeline by Klaria Pharma Holding AB 107 Migraine - Pipeline by Medestea Research & Production SpA 107 Migraine - Pipeline by Merck & Co Inc 108 Migraine - Pipeline by Monosol Rx LLC 108 Migraine - Pipeline by NAL Pharmaceuticals Ltd 109 Migraine - Pipeline by Promius Pharma LLC 109 Migraine - Pipeline by RedHill Biopharma Ltd 110 Migraine - Pipeline by Revance Therapeutics Inc 110 Migraine - Pipeline by Shin Nippon Biomedical Laboratories Ltd 111 Migraine - Pipeline by Suda Ltd 111 Migraine - Pipeline by Teva Pharmaceutical Industries Ltd 112 Migraine - Pipeline by TheraJect Inc 112 Migraine - Pipeline by Tonix Pharmaceuticals Holding Corp 113 Migraine - Pipeline by Trevena Inc 113 Migraine - Pipeline by Trigemina Inc 114 Migraine - Pipeline by TrioxBio Inc 114 Migraine - Pipeline by Vertex Pharmaceuticals Inc 115 Migraine - Pipeline by Xenon Pharmaceuticals Inc 115 Migraine - Pipeline by Zosano Pharma Corp 116 Neuropathic Pain - Pipeline by 2-BBB Medicines BV 117 Neuropathic Pain - Pipeline by AbbVie Inc 117 Neuropathic Pain - Pipeline by Abide Therapeutics Inc 118 Neuropathic Pain - Pipeline by Acadia Pharmaceuticals Inc 118 Neuropathic Pain - Pipeline by Achelios Therapeutics Inc 119 Neuropathic Pain - Pipeline by Aevi Genomic Medicine Inc 119 Neuropathic Pain - Pipeline by Affectis Pharmaceuticals AG 120 Neuropathic Pain - Pipeline by Amura Holdings Ltd 120 Neuropathic Pain - Pipeline by AnaBios Corp 121 Neuropathic Pain - Pipeline by Anavex Life Sciences Corp 121 Neuropathic Pain - Pipeline by AngioChem Inc 122 Neuropathic Pain - Pipeline by Apollo Endosurgery Inc 122 Neuropathic Pain - Pipeline by Aptinyx Inc 123 Neuropathic Pain - Pipeline by Arena Pharmaceuticals Inc 123 Neuropathic Pain - Pipeline by Asahi Kasei Pharma Corp 124 Neuropathic Pain - Pipeline by Astellas Pharma Inc 124 Neuropathic Pain - Pipeline by AstraZeneca Plc 125 Neuropathic Pain - Pipeline by Aucta Pharmaceuticals LLC 125 Neuropathic Pain - Pipeline by BCI Pharma 126 Neuropathic Pain - Pipeline by BCN Peptides SA 126 Neuropathic Pain - Pipeline by Biogen Inc 127 Neuropathic Pain - Pipeline by Biomar Microbial Technologies 127 Neuropathic Pain - Pipeline by Bionomics Ltd 128 Neuropathic Pain - Pipeline by Bristol-Myers Squibb Company 128 Neuropathic Pain - Pipeline by Can-Fite BioPharma Ltd 129 Neuropathic Pain - Pipeline by Cara Therapeutics Inc 129 Neuropathic Pain - Pipeline by Cavion LLC 130 Neuropathic Pain - Pipeline by Celgene Corp 130 Neuropathic Pain - Pipeline by Cerecor Inc 131 Neuropathic Pain - Pipeline by Chromocell Corp 131 Neuropathic Pain - Pipeline by Circuit Therapeutics Inc 132 Neuropathic Pain - Pipeline by CLL Pharma SA 132 Neuropathic Pain - Pipeline by Colby Pharmaceutical Company 133 Neuropathic Pain - Pipeline by ConSynance Therapeutics Inc 133 Neuropathic Pain - Pipeline by ContraVir Pharmaceuticals Inc 134 Neuropathic Pain - Pipeline by Crinetics Pharmaceuticals Inc 134 Neuropathic Pain - Pipeline by Cytogel Pharma LLC 135 Neuropathic Pain - Pipeline by Daewoong Pharmaceutical Co Ltd 135 Neuropathic Pain - Pipeline by Daiichi Sankyo Company Ltd 136 Neuropathic Pain - Pipeline by Develco Pharma Schweiz AG 136 Neuropathic Pain - Pipeline by Dompe Farmaceutici SpA 137 Neuropathic Pain - Pipeline by Eisai Co Ltd 137 Neuropathic Pain - Pipeline by Eli Lilly and Company 138 Neuropathic Pain - Pipeline by Endece LLC 138 Neuropathic Pain - Pipeline by Evec Inc 139 Neuropathic Pain - Pipeline by Genecode AS 139 Neuropathic Pain - Pipeline by GL Pharm Tech Corp 140 Neuropathic Pain - Pipeline by Glenmark Pharmaceuticals Ltd 140 Neuropathic Pain - Pipeline by Glialogix Inc 141 Neuropathic Pain - Pipeline by Grunenthal GmbH 141 Neuropathic Pain - Pipeline by GW Pharmaceuticals Plc 142 Neuropathic Pain - Pipeline by Hydra Biosciences Inc 142 Neuropathic Pain - Pipeline by Immune Pharmaceuticals Inc 143 Neuropathic Pain - Pipeline by InMed Pharmaceuticals Inc 143 Neuropathic Pain - Pipeline by Intec Pharma ltd 144 Neuropathic Pain - Pipeline by Integral Molecular Inc 144 Neuropathic Pain - Pipeline by Intellipharmaceutics International Inc 145 Neuropathic Pain - Pipeline by Jeil Pharmaceutical Co Ltd 145 Neuropathic Pain - Pipeline by Jiangsu Hengrui Medicine Co Ltd 146 Neuropathic Pain - Pipeline by Jiangsu Nhwa Pharmaceutical Corp Ltd 146 Neuropathic Pain - Pipeline by Johnson & Johnson 147 Neuropathic Pain - Pipeline by JT Pharmaceuticals Inc 147 Neuropathic Pain - Pipeline by Knopp Biosciences LLC 148 Neuropathic Pain - Pipeline by Kolon Life Science Inc 148 Neuropathic Pain - Pipeline by KPI Therapeutics Inc 149 Neuropathic Pain - Pipeline by Lexicon Pharmaceuticals Inc 149 Neuropathic Pain - Pipeline by Lohocla Research Corp 150 Neuropathic Pain - Pipeline by Mapi Pharma Ltd 150 Neuropathic Pain - Pipeline by MD Biosciences GmbH 151 Neuropathic Pain - Pipeline by Medestea Research & Production SpA 151 Neuropathic Pain - Pipeline by Medifron DBT Co Ltd 152 Neuropathic Pain - Pipeline by MEDRx Co Ltd 152 Neuropathic Pain - Pipeline by Medy-Tox Inc 153 Neuropathic Pain - Pipeline by Merck & Co Inc 153 Neuropathic Pain - Pipeline by Mitsubishi Tanabe Pharma Corp 154 Neuropathic Pain - Pipeline by Mundipharma International Ltd 154 Neuropathic Pain - Pipeline by Nanomerics Ltd 155 Neuropathic Pain - Pipeline by Neurim Pharmaceuticals Ltd 155 Neuropathic Pain - Pipeline by Neurocentrx Pharma Ltd 156 Neuropathic Pain - Pipeline by NeuroCycle Therapeutics GmbH 156 Neuropathic Pain - Pipeline by NeurOp Inc 157 Neuropathic Pain - Pipeline by Newron Pharmaceuticals SpA 157 Neuropathic Pain - Pipeline by Nippon Chemiphar Co Ltd 158 Neuropathic Pain - Pipeline by NoNO Inc 158 Neuropathic Pain - Pipeline by Novaremed Ltd 159 Neuropathic Pain - Pipeline by Novartis AG 159 Neuropathic Pain - Pipeline by Omeros Corp 160 Neuropathic Pain - Pipeline by Orion Oyj 160 Neuropathic Pain - Pipeline by Patagonia Pharmaceuticals LLC 161 Neuropathic Pain - Pipeline by PeriphaGen Inc 161 Neuropathic Pain - Pipeline by Pfizer Inc 162 Neuropathic Pain - Pipeline by Pharmaleads SA 162 Neuropathic Pain - Pipeline by Phosphagenics Ltd 163 Neuropathic Pain - Pipeline by Prismic Pharmaceuticals Inc 163 Neuropathic Pain - Pipeline by RaQualia Pharma Inc 164 Neuropathic Pain - Pipeline by Re-Pharm Ltd 164 Neuropathic Pain - Pipeline by Reata Pharmaceuticals Inc 165 Neuropathic Pain - Pipeline by Relmada Therapeutics Inc 165 Neuropathic Pain - Pipeline by Revance Therapeutics Inc 166 Neuropathic Pain - Pipeline by Rottapharm Biotech Srl 166 Neuropathic Pain - Pipeline by Saniona AB 167 Neuropathic Pain - Pipeline by Scilex Pharmaceuticals Inc 167 Neuropathic Pain - Pipeline by Shionogi & Co Ltd 168 Neuropathic Pain - Pipeline by SK Biopharmaceuticals Co Ltd 168 Neuropathic Pain - Pipeline by Sunovion Pharmaceuticals Inc 169 Neuropathic Pain - Pipeline by Syntrix Biosystems Inc 169 Neuropathic Pain - Pipeline by Takeda Pharmaceutical Company Ltd 170 Neuropathic Pain - Pipeline by Teva Pharmaceutical Industries Ltd 170 Neuropathic Pain - Pipeline by Theranexus SAS 171 Neuropathic Pain - Pipeline by Toray Industries Inc 171 Neuropathic Pain - Pipeline by Torrent Pharmaceuticals Ltd 172 Neuropathic Pain - Pipeline by Trevena Inc 172 Neuropathic Pain - Pipeline by Virobay Inc 173 Neuropathic Pain - Pipeline by VistaGen Therapeutics Inc 173 Neuropathic Pain - Pipeline by Vitality Biopharma Inc 174 Neuropathic Pain - Pipeline by Yooyoung Pharm Co Ltd 174 Neuropathic Pain - Pipeline by Yuhan Corp 175 Neuropathic Pain - Pipeline by Yungjin Pharm Co Ltd 175 Neuropathic Pain - Pipeline by Zynerba Pharmaceuticals Inc 176 Osteoarthritis Pain - Dormant Projects 177 Migraine - Dormant Projects 179 Neuropathic Pain - Dormant Projects 182 Osteoarthritis Pain - Discontinued Products 191 Migraine - Discontinued Products 192 Neuropathic Pain - Discontinued Products 193 List of Figures Number of Products under Development for Osteoarthritis Pain 13 Number of Products under Development by Companies, Osteoarthritis Pain 14 Number of Products under Development by Universities/Institutes, Osteoarthritis Pain 17 Number of Products under Development for Migraine 20 Number of Products under Development by Companies, Migraine 21 Number of Products under Development by Universities/Institutes, Migraine 24 Number of Products under Development for Neuropathic Pain 28 Number of Products under Development by Companies, Neuropathic Pain 29 Number of Products under Development by Universities/Institutes, Neuropathic Pain 34 Number of Products by Top 10 Targets, Osteoarthritis Pain 45 Number of Products by Stage and Top 10 Targets, Osteoarthritis Pain 45 Number of Products by Top 10 Mechanism of Actions, Osteoarthritis Pain 48 Number of Products by Stage and Top 10 Mechanism of Actions, Osteoarthritis Pain 48 Number of Products by Routes of Administration, Osteoarthritis Pain 51 Number of Products by Stage and Routes of Administration, Osteoarthritis Pain 51 Number of Products by Molecule Types, Osteoarthritis Pain 53 Number of Products by Stage and Molecule Types, Osteoarthritis Pain 53 Number of Products by Top 10 Targets, Migraine 55 Number of Products by Stage and Top 10 Targets, Migraine 55 Number of Products by Top 10 Mechanism of Actions, Migraine 58 Number of Products by Stage and Top 10 Mechanism of Actions, Migraine 58 Number of Products by Top 10 Routes of Administration, Migraine 61 Number of Products by Stage and Top 10 Routes of Administration, Migraine 61 Number of Products by Molecule Types, Migraine 63 Number of Products by Stage and Molecule Types, Migraine 63 Number of Products by Top 10 Targets, Neuropathic Pain 65 Number of Products by Stage and Top 10 Targets, Neuropathic Pain 65 Number of Products by Top 10 Mechanism of Actions, Neuropathic Pain 69 Number of Products by Stage and Top 10 Mechanism of Actions, Neuropathic Pain 69 Number of Products by Top 10 Routes of Administration, Neuropathic Pain 74 Number of Products by Stage and Top 10 Routes of Administration, Neuropathic Pain 74 Number of Products by Top 10 Molecule Types, Neuropathic Pain 76 Number of Products by Stage and Top 10 Molecule Types, Neuropathic Pain 76