Table of Contents Table of Contents 2 Introduction 8 Colon Cancer Overview 9 Therapeutics Development 10 Colon Cancer - Therapeutics under Development by Companies 12 Colon Cancer - Therapeutics under Investigation by Universities/Institutes 23 Colon Cancer - Pipeline Products Glance 26 Colon Cancer - Products under Development by Companies 29 Colon Cancer - Products under Investigation by Universities/Institutes 42 Colon Cancer - Companies Involved in Therapeutics Development 46 Colon Cancer - Therapeutics Assessment 179 Drug Profiles 203 Colon Cancer - Dormant Projects 660 Colon Cancer - Discontinued Products 680 Colon Cancer - Product Development Milestones 681 Appendix 692

List of Tables Number of Products under Development for Colon Cancer, H2 2016 39 Number of Products under Development for Colon Cancer - Comparative Analysis, H2 2016 40 Number of Products under Development by Companies, H2 2016 41 Number of Products under Development by Companies, H2 2016 (Contd..1) 42 Number of Products under Development by Companies, H2 2016 (Contd..2) 43 Number of Products under Development by Companies, H2 2016 (Contd..3) 44 Number of Products under Development by Companies, H2 2016 (Contd..4) 45 Number of Products under Development by Companies, H2 2016 (Contd..5) 46 Number of Products under Development by Companies, H2 2016 (Contd..6) 47 Number of Products under Development by Companies, H2 2016 (Contd..7) 48 Number of Products under Development by Companies, H2 2016 (Contd..8) 49 Number of Products under Development by Companies, H2 2016 (Contd..9) 50 Number of Products under Development by Companies, H2 2016 (Contd..10) 51 Number of Products under Investigation by Universities/Institutes, H2 2016 52 Number of Products under Investigation by Universities/Institutes, H2 2016 (Contd..1) 53 Number of Products under Investigation by Universities/Institutes, H2 2016 (Contd..2) 54 Comparative Analysis by Late Stage Development, H2 2016 55 Comparative Analysis by Clinical Stage Development, H2 2016 56 Comparative Analysis by Early Stage Development, H2 2016 57 Products under Development by Companies, H2 2016 58 Products under Development by Companies, H2 2016 (Contd..1) 59 Products under Development by Companies, H2 2016 (Contd..2) 60 Products under Development by Companies, H2 2016 (Contd..3) 61 Products under Development by Companies, H2 2016 (Contd..4) 62 Products under Development by Companies, H2 2016 (Contd..5) 63 Products under Development by Companies, H2 2016 (Contd..6) 64 Products under Development by Companies, H2 2016 (Contd..7) 65 Products under Development by Companies, H2 2016 (Contd..8) 66 Products under Development by Companies, H2 2016 (Contd..9) 67 Products under Development by Companies, H2 2016 (Contd..10) 68 Products under Development by Companies, H2 2016 (Contd..11) 69 Products under Development by Companies, H2 2016 (Contd..12) 70 Products under Investigation by Universities/Institutes, H2 2016 71 Products under Investigation by Universities/Institutes, H2 2016 (Contd..1) 72 Products under Investigation by Universities/Institutes, H2 2016 (Contd..2) 73 Products under Investigation by Universities/Institutes, H2 2016 (Contd..3) 74 Colon Cancer - Pipeline by Actinium Pharmaceuticals Inc, H2 2016 75 Colon Cancer - Pipeline by Adamed Sp z oo, H2 2016 76 Colon Cancer - Pipeline by Adgero Biopharmaceuticals Inc, H2 2016 77 Colon Cancer - Pipeline by Advanced Cancer Therapeutics, H2 2016 78 Colon Cancer - Pipeline by Advanced Proteome Therapeutics Corp, H2 2016 79 Colon Cancer - Pipeline by Advenchen Laboratories LLC, H2 2016 80 Colon Cancer - Pipeline by Aeglea BioTherapeutics Inc, H2 2016 81 Colon Cancer - Pipeline by Affimed GmbH, H2 2016 82 Colon Cancer - Pipeline by Agenus Inc, H2 2016 83 Colon Cancer - Pipeline by AGV Discovery SAS, H2 2016 84 Colon Cancer - Pipeline by AIMM Therapeutics BV, H2 2016 85 Colon Cancer - Pipeline by Almac Discovery Ltd, H2 2016 86 Colon Cancer - Pipeline by Ambrx Inc, H2 2016 87 Colon Cancer - Pipeline by Anavex Life Sciences Corp, H2 2016 88 Colon Cancer - Pipeline by AndroScience Corp, H2 2016 89 Colon Cancer - Pipeline by Aphios Corp, H2 2016 90 Colon Cancer - Pipeline by Aposense Ltd, H2 2016 91 Colon Cancer - Pipeline by Aptose Biosciences Inc, H2 2016 92 Colon Cancer - Pipeline by AstraZeneca Plc, H2 2016 93 Colon Cancer - Pipeline by Aurigene Discovery Technologies Ltd, H2 2016 94 Colon Cancer - Pipeline by BCN Biosciences LLC, H2 2016 95 Colon Cancer - Pipeline by Bio-Path Holdings Inc, H2 2016 96 Colon Cancer - Pipeline by BioCancell Ltd, H2 2016 97 Colon Cancer - Pipeline by Biogazelle NV, H2 2016 98 Colon Cancer - Pipeline by Bioncotech Therapeutics SL, H2 2016 99 Colon Cancer - Pipeline by Blirt SA, H2 2016 100 Colon Cancer - Pipeline by Boehringer Ingelheim GmbH, H2 2016 101 Colon Cancer - Pipeline by Can-Fite BioPharma Ltd, H2 2016 102 Colon Cancer - Pipeline by Celprogen Inc, H2 2016 103 Colon Cancer - Pipeline by Chiome Bioscience Inc, H2 2016 104 Colon Cancer - Pipeline by Cyclacel Pharmaceuticals Inc, H2 2016 105 Colon Cancer - Pipeline by CytomX Therapeutics Inc, H2 2016 106 Colon Cancer - Pipeline by Cytune Pharma SAS, H2 2016 107 Colon Cancer - Pipeline by CZ BioMed Corp, H2 2016 108 Colon Cancer - Pipeline by Daiichi Sankyo Company Ltd, H2 2016 109 Colon Cancer - Pipeline by DEKK-TEC Inc, H2 2016 110 Colon Cancer - Pipeline by Eli Lilly and Company, H2 2016 111 Colon Cancer - Pipeline by EntreChem SL, H2 2016 112 Colon Cancer - Pipeline by EnzymeBioSystems, H2 2016 113 Colon Cancer - Pipeline by F. Hoffmann-La Roche Ltd, H2 2016 114 Colon Cancer - Pipeline by GlaxoSmithKline Plc, H2 2016 115 Colon Cancer - Pipeline by GlycaNova Norway AS, H2 2016 116 Colon Cancer - Pipeline by GlycoMimetics Inc, H2 2016 117 Colon Cancer - Pipeline by Grunenthal GmbH, H2 2016 118 Colon Cancer - Pipeline by Halozyme Therapeutics Inc, H2 2016 119 Colon Cancer - Pipeline by Hamlet Pharma AB, H2 2016 120 Colon Cancer - Pipeline by Hanmi Pharmaceuticals Co Ltd, H2 2016 121 Colon Cancer - Pipeline by Helix BioPharma Corp, H2 2016 122 Colon Cancer - Pipeline by Histogen Inc, H2 2016 123 Colon Cancer - Pipeline by Horizon Pharma Plc, H2 2016 124 Colon Cancer - Pipeline by Idera Pharmaceuticals Inc, H2 2016 125 Colon Cancer - Pipeline by Immune Pharmaceuticals Inc, H2 2016 126 Colon Cancer - Pipeline by Immunome Inc, H2 2016 127 Colon Cancer - Pipeline by Immunomedics Inc, H2 2016 128 Colon Cancer - Pipeline by Immunotope Inc, H2 2016 129 Colon Cancer - Pipeline by Immupharma Plc, H2 2016 130 Colon Cancer - Pipeline by IMPACT Therapeutics Inc, H2 2016 131 Colon Cancer - Pipeline by Incuron LLC, H2 2016 132 Colon Cancer - Pipeline by Infinity Pharmaceuticals Inc, H2 2016 133 Colon Cancer - Pipeline by Inflection Biosciences Ltd, H2 2016 134 Colon Cancer - Pipeline by Innopharmax Inc, H2 2016 135 Colon Cancer - Pipeline by Intezyne Technologies Inc, H2 2016 136 Colon Cancer - Pipeline by Ironwood Pharmaceuticals Inc, H2 2016 137 Colon Cancer - Pipeline by Jasco Pharmaceuticals LLC, H2 2016 138 Colon Cancer - Pipeline by Jiangsu Kanion Pharmaceutical Co Ltd, H2 2016 139 Colon Cancer - Pipeline by JW Pharmaceutical Corp, H2 2016 140 Colon Cancer - Pipeline by Karyopharm Therapeutics Inc, H2 2016 141 Colon Cancer - Pipeline by Kyowa Hakko Kirin Co Ltd, H2 2016 142 Colon Cancer - Pipeline by Les Laboratoires Servier SAS, H2 2016 143 Colon Cancer - Pipeline by Lipocure Ltd, H2 2016 144 Colon Cancer - Pipeline by Lupin Ltd, H2 2016 145 Colon Cancer - Pipeline by Lymphocyte Activation Technologies SA, H2 2016 146 Colon Cancer - Pipeline by MabVax Therapeutics Holdings Inc, H2 2016 147 Colon Cancer - Pipeline by MacroGenics Inc, H2 2016 148 Colon Cancer - Pipeline by MaxiVAX SA, H2 2016 149 Colon Cancer - Pipeline by Meabco A/S, H2 2016 150 Colon Cancer - Pipeline by Medicenna Therapeutics Inc, H2 2016 151 Colon Cancer - Pipeline by Microlin Bio, Inc., H2 2016 152 Colon Cancer - Pipeline by Molecular Targeting Technologies Inc, H2 2016 153 Colon Cancer - Pipeline by MolMed SpA, H2 2016 154 Colon Cancer - Pipeline by Monopar Therapeutics LLC, H2 2016 155 Colon Cancer - Pipeline by Multimmune GmbH, H2 2016 156 Colon Cancer - Pipeline by NormOxys Inc, H2 2016 157 Colon Cancer - Pipeline by Northwest Biotherapeutics Inc, H2 2016 158 Colon Cancer - Pipeline by Novartis AG, H2 2016 159 Colon Cancer - Pipeline by Omeros Corp, H2 2016 160 Colon Cancer - Pipeline by Omnitura Therapeutics Inc, H2 2016 161 Colon Cancer - Pipeline by Oncovir Inc, H2 2016 162 Colon Cancer - Pipeline by Ono Pharmaceutical Co Ltd, H2 2016 163 Colon Cancer - Pipeline by Orega Biotech SAS, H2 2016 164 Colon Cancer - Pipeline by OSE Immunotherapeutics, H2 2016 165 Colon Cancer - Pipeline by Panacea Pharmaceuticals Inc, H2 2016 166 Colon Cancer - Pipeline by Patrys Ltd, H2 2016 167 Colon Cancer - Pipeline by PharmaCyte Biotech Inc, H2 2016 168 Colon Cancer - Pipeline by Pharminox Ltd, H2 2016 169 Colon Cancer - Pipeline by Philogen SpA, H2 2016 170 Colon Cancer - Pipeline by Pique Therapeutics, H2 2016 171 Colon Cancer - Pipeline by Plexxikon Inc, H2 2016 172 Colon Cancer - Pipeline by ProNAi Therapeutics Inc, H2 2016 173 Colon Cancer - Pipeline by Provecs Medical GmbH, H2 2016 174 Colon Cancer - Pipeline by Provectus Biopharmaceuticals Inc, H2 2016 175 Colon Cancer - Pipeline by Qu Biologics Inc, H2 2016 176 Colon Cancer - Pipeline by Recce Pty Ltd, H2 2016 177 Colon Cancer - Pipeline by Rexahn Pharmaceuticals Inc, H2 2016 178 Colon Cancer - Pipeline by Rgenix Inc, H2 2016 179 Colon Cancer - Pipeline by Sareum Holdings Plc, H2 2016 180 Colon Cancer - Pipeline by Savoy Pharmaceuticals Inc, H2 2016 181 Colon Cancer - Pipeline by Sellas Inc, H2 2016 182 Colon Cancer - Pipeline by Sigma-Tau SpA, H2 2016 183 Colon Cancer - Pipeline by Sirnaomics Inc, H2 2016 184 Colon Cancer - Pipeline by SOM Biotech SL, H2 2016 185 Colon Cancer - Pipeline by Somantix BV, H2 2016 186 Colon Cancer - Pipeline by Sorrento Therapeutics Inc, H2 2016 187 Colon Cancer - Pipeline by Sphaera Pharma Pvt Ltd, H2 2016 188 Colon Cancer - Pipeline by Starpharma Holdings Ltd, H2 2016 189 Colon Cancer - Pipeline by Sunshine Biopharma Inc, H2 2016 190 Colon Cancer - Pipeline by Synergys Biotherapeutics Inc, H2 2016 191 Colon Cancer - Pipeline by TaiRx Inc, H2 2016 192 Colon Cancer - Pipeline by Taiwan Liposome Company Ltd, H2 2016 193 Colon Cancer - Pipeline by Takis Srl, H2 2016 194 Colon Cancer - Pipeline by Targovax ASA, H2 2016 195 Colon Cancer - Pipeline by Transgene Biotek Ltd, H2 2016 196 Colon Cancer - Pipeline by TVAX Biomedical Inc, H2 2016 197 Colon Cancer - Pipeline by Tyg Oncology Ltd, H2 2016 198 Colon Cancer - Pipeline by TyrNovo Ltd, H2 2016 199 Colon Cancer - Pipeline by Vaccinogen Inc, H2 2016 200 Colon Cancer - Pipeline by Vault Pharma Inc, H2 2016 201 Colon Cancer - Pipeline by Vaxenta Biotechnologies, H2 2016 202 Colon Cancer - Pipeline by Vaximm AG, H2 2016 203 Colon Cancer - Pipeline by VG Life Sciences Inc, H2 2016 204 Colon Cancer - Pipeline by Yakult Honsha Co Ltd, H2 2016 205 Colon Cancer - Pipeline by Zensun (Shanghai) Sci & Tech Co Ltd, H2 2016 206 Colon Cancer - Pipeline by ZIOPHARM Oncology Inc, H2 2016 207 Assessment by Monotherapy Products, H2 2016 208 Assessment by Combination Products, H2 2016 209 Number of Products by Stage and Target, H2 2016 211 Number of Products by Stage and Mechanism of Action, H2 2016 220 Number of Products by Stage and Route of Administration, H2 2016 229 Number of Products by Stage and Molecule Type, H2 2016 231 Colon Cancer - Dormant Projects, H2 2016 689 Colon Cancer - Dormant Projects (Contd..1), H2 2016 690 Colon Cancer - Dormant Projects (Contd..2), H2 2016 691 Colon Cancer - Dormant Projects (Contd..3), H2 2016 692 Colon Cancer - Dormant Projects (Contd..4), H2 2016 693 Colon Cancer - Dormant Projects (Contd..5), H2 2016 694 Colon Cancer - Dormant Projects (Contd..6), H2 2016 695 Colon Cancer - Dormant Projects (Contd..7), H2 2016 696 Colon Cancer - Dormant Projects (Contd..8), H2 2016 697 Colon Cancer - Dormant Projects (Contd..9), H2 2016 698 Colon Cancer - Dormant Projects (Contd..10), H2 2016 699 Colon Cancer - Dormant Projects (Contd..11), H2 2016 700 Colon Cancer - Dormant Projects (Contd..12), H2 2016 701 Colon Cancer - Dormant Projects (Contd..13), H2 2016 702 Colon Cancer - Dormant Projects (Contd..14), H2 2016 703 Colon Cancer - Dormant Projects (Contd..15), H2 2016 704 Colon Cancer - Dormant Projects (Contd..16), H2 2016 705 Colon Cancer - Dormant Projects (Contd..17), H2 2016 706 Colon Cancer - Dormant Projects (Contd..18), H2 2016 707 Colon Cancer - Dormant Projects (Contd..19), H2 2016 708 Colon Cancer - Discontinued Products, H2 2016 709 List of Figures Number of Products under Development for Colon Cancer, H2 2016 39 Number of Products under Development for Colon Cancer - Comparative Analysis, H2 2016 40 Number of Products under Development by Companies, H2 2016 41 Number of Products under Investigation by Universities/Institutes, H2 2016 52 Comparative Analysis by Clinical Stage Development, H2 2016 56 Comparative Analysis by Early Stage Products, H2 2016 57 Assessment by Monotherapy Products, H2 2016 208 Assessment by Combination Products, H2 2016 209 Number of Products by Top 10 Targets, H2 2016 210 Number of Products by Stage and Top 10 Targets, H2 2016 210 Number of Products by Top 10 Mechanism of Actions, H2 2016 219 Number of Products by Stage and Top 10 Mechanism of Actions, H2 2016 219 Number of Products by Top 10 Routes of Administration, H2 2016 228 Number of Products by Stage and Top 10 Routes of Administration, H2 2016 228 Number of Products by Top 10 Molecule Types, H2 2016 230 Number of Products by Stage and Top 10 Molecule Types, H2 2016 230

Actinium Pharmaceuticals Inc Adamed Sp z oo Adgero Biopharmaceuticals Inc Advanced Cancer Therapeutics Advanced Proteome Therapeutics Corp Advenchen Laboratories LLC Aeglea BioTherapeutics Inc Affimed GmbH Agenus Inc AGV Discovery SAS AIMM Therapeutics BV Almac Discovery Ltd Ambrx Inc Anavex Life Sciences Corp AndroScience Corp Aphios Corp Aposense Ltd Aptose Biosciences Inc AstraZeneca Plc Aurigene Discovery Technologies Ltd BCN Biosciences LLC Bio-Path Holdings Inc BioCancell Ltd Biogazelle NV Bioncotech Therapeutics SL Blirt SA Boehringer Ingelheim GmbH Can-Fite BioPharma Ltd Celprogen Inc Chiome Bioscience Inc Cyclacel Pharmaceuticals Inc CytomX Therapeutics Inc Cytune Pharma SAS CZ BioMed Corp Daiichi Sankyo Company Ltd DEKK-TEC Inc Eli Lilly and Company EntreChem SL EnzymeBioSystems F. Hoffmann-La Roche Ltd GlaxoSmithKline Plc GlycaNova Norway AS GlycoMimetics Inc Grunenthal GmbH Halozyme Therapeutics Inc Hamlet Pharma AB Hanmi Pharmaceuticals Co Ltd Helix BioPharma Corp Histogen Inc Horizon Pharma Plc Idera Pharmaceuticals Inc Immune Pharmaceuticals Inc Immunome Inc Immunomedics Inc Immunotope Inc Immupharma Plc IMPACT Therapeutics Inc Incuron LLC Infinity Pharmaceuticals Inc Inflection Biosciences Ltd Innopharmax Inc Intezyne Technologies Inc Ironwood Pharmaceuticals Inc Jasco Pharmaceuticals LLC Jiangsu Kanion Pharmaceutical Co Ltd JW Pharmaceutical Corp Karyopharm Therapeutics Inc Kyowa Hakko Kirin Co Ltd Les Laboratoires Servier SAS Lipocure Ltd Lupin Ltd Lymphocyte Activation Technologies SA MabVax Therapeutics Holdings Inc MacroGenics Inc MaxiVAX SA Meabco A/S Medicenna Therapeutics Inc Microlin Bio, Inc. Molecular Targeting Technologies Inc MolMed SpA Monopar Therapeutics LLC Multimmune GmbH NormOxys Inc Northwest Biotherapeutics Inc Novartis AG Omeros Corp Omnitura Therapeutics Inc Oncovir Inc Ono Pharmaceutical Co Ltd Orega Biotech SAS OSE Immunotherapeutics Panacea Pharmaceuticals Inc Patrys Ltd PharmaCyte Biotech Inc Pharminox Ltd Philogen SpA Pique Therapeutics Plexxikon Inc ProNAi Therapeutics Inc Provecs Medical GmbH Provectus Biopharmaceuticals Inc Qu Biologics Inc Recce Pty Ltd Rexahn Pharmaceuticals Inc Rgenix Inc Sareum Holdings Plc Savoy Pharmaceuticals Inc Sellas Inc Sigma-Tau SpA Sirnaomics Inc SOM Biotech SL Somantix BV Sorrento Therapeutics Inc Sphaera Pharma Pvt Ltd Starpharma Holdings Ltd Sunshine Biopharma Inc Synergys Biotherapeutics Inc TaiRx Inc Taiwan Liposome Company Ltd Takis Srl Targovax ASA Transgene Biotek Ltd TVAX Biomedical Inc Tyg Oncology Ltd TyrNovo Ltd Vaccinogen Inc Vault Pharma Inc Vaxenta Biotechnologies Vaximm AG VG Life Sciences Inc Yakult Honsha Co Ltd Zensun (Shanghai) Sci & Tech Co Ltd ZIOPHARM Oncology Inc