Table of Contents Table of Contents 2 List of Tables 5 List of Figures 5 Introduction 6 Global Markets Direct Report Coverage 6 Polycythemia Vera Overview 7 Therapeutics Development 8 Pipeline Products for Polycythemia Vera - Overview 8 Polycythemia Vera - Therapeutics under Development by Companies 9 Polycythemia Vera - Pipeline Products Glance 10 Late Stage Products 10 Clinical Stage Products 11 Early Stage Products 12 Polycythemia Vera - Products under Development by Companies 13 Polycythemia Vera - Companies Involved in Therapeutics Development 14 ANP Technologies, Inc. 14 Bristol-Myers Squibb Company 15 F. Hoffmann-La Roche Ltd. 16 Galena Biopharma, Inc. 17 Gilead Sciences, Inc. 18 Italfarmaco S.p.A. 19 Karus Therapeutics Limited 20 miRagen Therapeutics, Inc. 21 Nerviano Medical Sciences S.r.l. 22 Novartis AG 23 PharmaEssentia Corporation 24 Teva Pharmaceutical Industries Ltd. 25 Polycythemia Vera - Therapeutics Assessment 26 Assessment by Monotherapy Products 26 Assessment by Target 27 Assessment by Mechanism of Action 29 Assessment by Route of Administration 31 Assessment by Molecule Type 33 Drug Profiles 35 anagrelide hydrochloride CR - Drug Profile 35 Product Description 35 Mechanism Of Action 35 R&D Progress 35 arsenic trioxide - Drug Profile 38 Product Description 38 Mechanism Of Action 38 R&D Progress 38 dasatinib - Drug Profile 41 Product Description 41 Mechanism Of Action 41 R&D Progress 41 Drug to Inhibit Ribonucleotide Reductase for Polycythemia Vera and Essential Thrombocythemia - Drug Profile 44 Product Description 44 Mechanism Of Action 44 R&D Progress 44 givinostat - Drug Profile 45 Product Description 45 Mechanism Of Action 45 R&D Progress 45 idelalisib - Drug Profile 47 Product Description 47 Mechanism Of Action 47 R&D Progress 47 KA-1463 - Drug Profile 55 Product Description 55 Mechanism Of Action 55 R&D Progress 55 M-009 - Drug Profile 56 Product Description 56 Mechanism Of Action 56 R&D Progress 56 M-012 - Drug Profile 57 Product Description 57 Mechanism Of Action 57 R&D Progress 57 MGN-4893 - Drug Profile 59 Product Description 59 Mechanism Of Action 59 R&D Progress 59 momelotinib dihydrochloride - Drug Profile 60 Product Description 60 Mechanism Of Action 60 R&D Progress 60 NMSP-113 - Drug Profile 65 Product Description 65 Mechanism Of Action 65 R&D Progress 65 peginterferon alfa-2a - Drug Profile 66 Product Description 66 Mechanism Of Action 66 R&D Progress 66 ropeginterferon alfa-2b - Drug Profile 68 Product Description 68 Mechanism Of Action 68 R&D Progress 68 sonidegib phosphate - Drug Profile 71 Product Description 71 Mechanism Of Action 71 R&D Progress 71 Polycythemia Vera - Dormant Projects 76 Polycythemia Vera - Discontinued Products 77 Polycythemia Vera - Product Development Milestones 78 Featured News & Press Releases 78 May 09, 2016: Merganser Biotech Announces Issuance of U.S. Patent 9,315,545 Covering Development Compound M012 78 May 06, 2016: Drug-like Compound Shows Promise in Treating Two Blood Diseases 78 Dec 08, 2015: Galena Biopharma Presents Final GALE-401 Phase 2 Clinical Data at the 57th American Society of Hematology (ASH) Annual Meeting and Exposition 79 Nov 06, 2015: Galena Biopharma to Present Final GALE-401 Phase 2 Clinical Data at the 57th American Society of Hematology Annual Meeting and Exposition 80 Mar 05, 2015: AOP Orphan Pharmaceuticals announces progress of pivotal phase III trial PROUD-PV applying Ropeginterferon alfa 2b, a novel, long-acting, mono-pegylated Interferon for treatment of Polycythemia Vera 81 Nov 18, 2014: Galena Biopharma Completes Enrollment In GALE-401 (Anagrelide Controlled Release) Phase 2 Clinical Trial 82 Oct 10, 2013: AOP Orphan Pharmaceuticals Announces Progress of Pivotal Phase III Trial PROUD-PV of Novel Mono-Pegylated Interferon Alpha 2b for the Treatment of Polycythemia Vera 82 Dec 10, 2012: AOP Orphan Pharma Reports Positive Phase II Data Of New Mono-pegylated Interferon Alpha 2b For Treatment Of Polycythemia Vera 83 Feb 17, 2011: miRagen Therapeutics Receives Orphan Drug Designation for MGN-4893 for Treatment of Polycythemia Vera 84 Appendix 85 Methodology 85 Coverage 85 Secondary Research 85 Primary Research 85 Expert Panel Validation 85 Contact Us 85 Disclaimer 86

List of Tables Number of Products under Development for Polycythemia Vera, H2 2016 8 Number of Products under Development by Companies, H2 2016 9 Comparative Analysis by Late Stage Development, H2 2016 10 Comparative Analysis by Clinical Stage Development, H2 2016 11 Comparative Analysis by Early Stage Development, H2 2016 12 Products under Development by Companies, H2 2016 13 Polycythemia Vera - Pipeline by ANP Technologies, Inc., H2 2016 14 Polycythemia Vera - Pipeline by Bristol-Myers Squibb Company, H2 2016 15 Polycythemia Vera - Pipeline by F. Hoffmann-La Roche Ltd., H2 2016 16 Polycythemia Vera - Pipeline by Galena Biopharma, Inc., H2 2016 17 Polycythemia Vera - Pipeline by Gilead Sciences, Inc., H2 2016 18 Polycythemia Vera - Pipeline by Italfarmaco S.p.A., H2 2016 19 Polycythemia Vera - Pipeline by Karus Therapeutics Limited, H2 2016 20 Polycythemia Vera - Pipeline by miRagen Therapeutics, Inc., H2 2016 21 Polycythemia Vera - Pipeline by Nerviano Medical Sciences S.r.l., H2 2016 22 Polycythemia Vera - Pipeline by Novartis AG, H2 2016 23 Polycythemia Vera - Pipeline by PharmaEssentia Corporation, H2 2016 24 Polycythemia Vera - Pipeline by Teva Pharmaceutical Industries Ltd., H2 2016 25 Assessment by Monotherapy Products, H2 2016 26 Number of Products by Stage and Target, H2 2016 28 Number of Products by Stage and Mechanism of Action, H2 2016 30 Number of Products by Stage and Route of Administration, H2 2016 32 Number of Products by Stage and Molecule Type, H2 2016 34 Polycythemia Vera - Dormant Projects, H2 2016 76 Polycythemia Vera - Discontinued Products, H2 2016 77 List of Figures Number of Products under Development for Polycythemia Vera, H2 2016 8 Number of Products under Development by Companies, H2 2016 9 Comparative Analysis by Clinical Stage Development, H2 2016 11 Assessment by Monotherapy Products, H2 2016 26 Number of Products by Top 10 Targets, H2 2016 27 Number of Products by Stage and Top 10 Targets, H2 2016 27 Number of Products by Top 10 Mechanism of Actions, H2 2016 29 Number of Products by Stage and Top 10 Mechanism of Actions, H2 2016 29 Number of Products by Routes of Administration, H2 2016 31 Number of Products by Stage and Routes of Administration, H2 2016 31 Number of Products by Molecule Types, H2 2016 33 Number of Products by Stage and Molecule Types, H2 2016 33

ANP Technologies, Inc. Bristol-Myers Squibb Company F. Hoffmann-La Roche Ltd. Galena Biopharma, Inc. Gilead Sciences, Inc. Italfarmaco S.p.A. Karus Therapeutics Limited miRagen Therapeutics, Inc. Nerviano Medical Sciences S.r.l. Novartis AG PharmaEssentia Corporation Teva Pharmaceutical Industries Ltd.