Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Pipeline Review, H2 2016
SKU ID :GMD-10263255 | Published Date: 30-Jul-2016 | No. of pages: 93Description
TOC
Table of Contents
Table of Contents 2
List of Tables 6
List of Figures 7
Introduction 8
Global Markets Direct Report Coverage 8
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) Overview 9
Therapeutics Development 10
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Products under Development by Stage of Development 10
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Products under Development by Therapy Area 11
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Products under Development by Indication 12
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Pipeline Products Glance 14
Late Stage Products 14
Early Stage Products 15
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Products under Development by Companies 16
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Products under Development by Universities/Institutes 19
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Therapeutics Assessment 21
Assessment by Monotherapy/Combination Products 21
Assessment by Mechanism of Action 22
Assessment by Route of Administration 24
Assessment by Molecule Type 26
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Companies Involved in Therapeutics Development 28
Aileron Therapeutics, Inc. 28
CASI Pharmaceuticals Inc. 29
Cerulean Pharma, Inc. 30
Daiichi Sankyo Company, Limited 31
F. Hoffmann-La Roche Ltd. 32
InterMed Discovery GmbH 33
OncoImmune, Inc. 34
Peloton Therapeutics, Inc. 35
RXi Pharmaceuticals Corporation 36
Sorrento Therapeutics, Inc. 37
Transcriptogen Ltd 38
Vascular Biogenics Ltd. 39
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Drug Profiles 40
A-503451A - Drug Profile 40
Product Description 40
Mechanism Of Action 40
R&D Progress 40
Antisense RNAi Oligonucleotide to Inhibit HIF-1 Alpha for Retinal Disease and Oncology - Drug Profile 41
Product Description 41
Mechanism Of Action 41
R&D Progress 41
Antisense RNAi Oligonucleotide to Inhibit SOX4 and HIF-1 Alpha for Metastatic Ovarian Cancer - Drug Profile 42
Product Description 42
Mechanism Of Action 42
R&D Progress 42
ATSP-9172 - Drug Profile 43
Product Description 43
Mechanism Of Action 43
R&D Progress 43
BC-001 - Drug Profile 44
Product Description 44
Mechanism Of Action 44
R&D Progress 44
CASI-2ME2 - Drug Profile 45
Product Description 45
Mechanism Of Action 45
R&D Progress 45
CRLX-101 - Drug Profile 48
Product Description 48
Mechanism Of Action 48
R&D Progress 48
Echinomycin - Drug Profile 59
Product Description 59
Mechanism Of Action 59
R&D Progress 59
Gene Therapy to Activate HIF-1 Alpha for Wound and Ulcers - Drug Profile 60
Product Description 60
Mechanism Of Action 60
R&D Progress 60
HS-1793 - Drug Profile 61
Product Description 61
Mechanism Of Action 61
R&D Progress 61
IMD-026259 - Drug Profile 62
Product Description 62
Mechanism Of Action 62
R&D Progress 62
KCN-1 - Drug Profile 63
Product Description 63
Mechanism Of Action 63
R&D Progress 63
MPT-0B098 - Drug Profile 65
Product Description 65
Mechanism Of Action 65
R&D Progress 65
RG-6061 - Drug Profile 66
Product Description 66
Mechanism Of Action 66
R&D Progress 66
Small Molecule to Inhibit HIF-1 Alpha for Oncology - Drug Profile 68
Product Description 68
Mechanism Of Action 68
R&D Progress 68
SR-16388 - Drug Profile 69
Product Description 69
Mechanism Of Action 69
R&D Progress 69
TR-764 - Drug Profile 70
Product Description 70
Mechanism Of Action 70
R&D Progress 70
TSG-1900 - Drug Profile 71
Product Description 71
Mechanism Of Action 71
R&D Progress 71
VB-411 - Drug Profile 72
Product Description 72
Mechanism Of Action 72
R&D Progress 72
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Dormant Projects 73
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Discontinued Products 77
Hypoxia Inducible Factor 1 Alpha (ARNT Interacting Protein or Basic Helix Loop Helix PAS Protein MOP1 or Class E Basic Helix Loop Helix Protein 78 or Member Of PAS Protein 1 or PAS Domain Containing Protein 8 or HIF1A) - Featured News & Press Releases 78
Jul 19, 2016: Cerulean Receives FDA Fast Track Designation for CRLX101 for the Treatment of Platinum-Resistant Ovarian Cancer 78
Jun 22, 2016: Cerulean Announces Publication in Cancer Research 78
Jun 09, 2016: Cerulean Announces Manuscript Published in Annals of Oncology 79
May 19, 2016: Cerulean Announces Oral Presentation on Phase 1b results of CRLX101 at Gynecologic Oncology 2016 Conference 80
May 10, 2016: Cerulean Announces First Patient Dosed in Phase 1/2 Trial Evaluating CRLX101 in Combination with LYNPARZA 80
Apr 25, 2016: Cerulean Announces Oral Presentation of CRLX101 Clinical Data at Gynecologic Oncology 2016 Conference 81
Apr 19, 2016: Cerulean Announces Presentation at 2016 American Association for Cancer Research Annual Meeting of Stage 1 Data from Phase 2 Trial in Platinum-Resistant Ovarian Cancer 82
Mar 23, 2016: Cerulean Announces Publication Showing CRLX101 Localizes Selectively in Human Tumors, Sparing Adjacent Healthy Tissue 84
Mar 16, 2016: Cerulean Announces Data Presentation at the 2016 American Association for Cancer Research Annual Meeting 85
Nov 09, 2015: Cerulean Announces Data at the 2015 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 87
Oct 27, 2015: Cerulean Announces Poster Presentations at the 2015 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 88
Oct 19, 2015: Cerulean Announces First Patient Dosed in Clinical Trial to Evaluate Weekly Dosing Schedule with CRLX101 89
Oct 15, 2015: Cerulean Announces Completion of Enrollment of Randomized Phase 2 Trial of CRLX101 in Combination with Avastin in Relapsed Renal Cell Carcinoma 89
Sep 30, 2015: Cerulean Announces CRLX101 Advances to Second Stage of Phase 2 Clinical Trial of CRLX101 in Combination with Avastin in Relapsed Ovarian Cancer 90
Jul 21, 2015: Cerulean Announces First Patient Dosed in Phase 1b Trial of CRLX101 in Combination with Weekly Paclitaxel in Relapsed Ovarian Cancer 90
Appendix 92
Methodology 92
Coverage 92
Secondary Research 92
Primary Research 92
Expert Panel Validation 92
Contact Us 92
Disclaimer 93
Tables & Figures
List of Tables
Number of Products under Development for, H2 2016 10
Number of Products under Development by Therapy Area, H2 2016 11
Number of Products under Development by Indication, H2 2016 12
Comparative Analysis by Late Stage Development, H2 2016 14
Comparative Analysis by Early Stage Products, H2 2016 15
Number of Products under Development by Companies, H2 2016 16
Products under Development by Companies, H2 2016 17
Products under Development by Companies, H2 2016 (Contd..1) 18
Number of Products under Investigation by Universities/Institutes, H2 2016 19
Products under Investigation by Universities/Institutes, H2 2016 20
Assessment by Monotherapy/Combination Products, H2 2016 21
Number of Products by Stage and Mechanism of Action, H2 2016 23
Number of Products by Stage and Route of Administration, H2 2016 25
Number of Products by Stage and Molecule Type, H2 2016 27
Pipeline by Aileron Therapeutics, Inc., H2 2016 28
Pipeline by CASI Pharmaceuticals Inc., H2 2016 29
Pipeline by Cerulean Pharma, Inc., H2 2016 30
Pipeline by Daiichi Sankyo Company, Limited, H2 2016 31
Pipeline by F. Hoffmann-La Roche Ltd., H2 2016 32
Pipeline by InterMed Discovery GmbH, H2 2016 33
Pipeline by OncoImmune, Inc., H2 2016 34
Pipeline by Peloton Therapeutics, Inc., H2 2016 35
Pipeline by RXi Pharmaceuticals Corporation, H2 2016 36
Pipeline by Sorrento Therapeutics, Inc., H2 2016 37
Pipeline by Transcriptogen Ltd, H2 2016 38
Pipeline by Vascular Biogenics Ltd., H2 2016 39
Dormant Projects, H2 2016 73
Dormant Projects (Contd..1), H2 2016 74
Dormant Projects (Contd..2), H2 2016 75
Dormant Projects (Contd..3), H2 2016 76
Discontinued Products, H2 2016 77
List of Figures
Number of Products under Development for, H2 2016 10
Number of Products under Development by Therapy Area, H2 2016 11
Number of Products under Development by Top 10 Indication, H2 2016 12
Comparative Analysis by Early Stage Products, H2 2016 15
Assessment by Monotherapy/Combination Products, H2 2016 21
Number of Products by Mechanism of Actions, H2 2016 22
Number of Products by Stage and Mechanism of Actions, H2 2016 22
Number of Products by Routes of Administration, H2 2016 24
Number of Products by Stage and Routes of Administration, H2 2016 24
Number of Products by Molecule Types, H2 2016 26
Number of Products by Stage and Molecule Type, H2 2016 26
Companies
Aileron Therapeutics, Inc.
CASI Pharmaceuticals Inc.
Cerulean Pharma, Inc.
Daiichi Sankyo Company, Limited
F. Hoffmann-La Roche Ltd.
InterMed Discovery GmbH
OncoImmune, Inc.
Peloton Therapeutics, Inc.
RXi Pharmaceuticals Corporation
Sorrento Therapeutics, Inc.
Transcriptogen Ltd
Vascular Biogenics Ltd.
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