1 Table of Contents 1 Table of Contents 4 1.1 List of Tables 5 1.2 List of Figures 6 2 Epidemiology 7 2.1 Disease Background 7 2.2 Risk Factors and Comorbidities 8 2.3 Global Trends 10 2.4 Forecast Methodology 11 2.4.1 Sources Used 11 2.4.2 Forecast Assumptions and Methods 17 2.4.3 Sources Not Used 33 2.5 Epidemiological Forecast for VTE (2015-2025) 34 2.5.1 Pulmonary Embolism 34 2.5.2 Deep Vein Thrombosis 37 2.5.3 VTE 40 2.5.4 Number of Hospital Discharges Meeting Criteria for Medically Ill and Those at Risk for VTE 50 2.5.5 Number of Primary Total Knee Replacements and Revisions 51 2.5.6 Number of Hip Replacements 53 2.6 Discussion 55 2.6.1 Epidemiological Forecast Insight 55 2.6.2 Limitations of the Analysis 56 2.6.3 Strengths of the Analysis 57 3 Appendix 58 3.1 Bibliography 58 3.2 Physicians and Specialists Included in this Study 61 3.3 About the Authors 64 3.3.1 Epidemiologists 64 3.3.2 Reviewers 64 3.3.3 Global Director of Therapy Analysis and Epidemiology 65 3.3.4 Global Head of Healthcare 66 3.4 About GlobalData 67 3.5 About EpiCast 67 3.6 Disclaimer 68

1.1 List of Tables Table 1: Risk Factors and Comorbidities for VTE 9 Table 2: 8MM, Sources Used to Forecast the Diagnosed Incident Cases of PE 12 Table 3: 8MM, Sources Used to Forecast the Diagnosed Incident Cases of DVT 13 Table 4: 8MM, Sources Used to Forecast the Number of Hospital Discharges that Meet the Criteria for Medically Ill 14 Table 5: 6MM, Sources Used to Forecast Primary Total Knee Replacements 15 Table 6: 6MM, Sources Used to Forecast the Rate of Primary Total Knee Replacement Requiring Revisions 15 Table 7: Japan and China, Sources Used to Forecast Primary Total Knee Replacements and Revisions 16 Table 8: 8MM, Sources Used to Forecast Hip Replacements 16 Table 9: 8MM, Diagnosed Incident Cases of PE, All Ages, Both Sexes, Select Years 2015-2025 35 Table 10: 8MM, Diagnosed Incident Cases of DVT, All Ages, Both Sexes, Select Years 2015-2025 38 Table 11: 8MM, Diagnosed Incident Cases of VTE, All Ages, Both Sexes, Select Years 2015-2025 41 Table 12: 8MM, Age-Specific Diagnosed Incident Cases of VTE, Both Sexes, N (Row %), 2015 43 Table 13: 8MM, Sex-Specific Diagnosed Incident Cases of VTE, Both Sexes, N (Row %), 2015 45 Table 14: 8MM, Number of Recurrent VTE Cases One and 10 Years After Incident VTE Event, Both Sexes, All Ages, N, 2015 47 Table 15: 8MM, Number of VTE Cases With Cancer Comorbidity, Both Sexes, All Ages, N, 2015 and 2025 48 Table 16: 8MM, Number of VTE Attacks, Both Sexes, All Ages, N, 2015-2025 49 Table 17: 8MM, Number of Hospital Discharges Meeting Criteria for Medically Ill; Those at risk for VTE, Both Sexes, Ages ≥40 Years, N, 2015 51 Table 18: 8MM, Number of Primary Total Knee Replacements and Revisions, Both Sexes, Ages ≥15 Years 52 Table 19: 8MM, Number of Hip Replacements, Both Sexes, Ages ≥15 Years 54 1.2 List of Figures Figure 1: 8MM, Diagnosed Incident Cases of PE, All Ages, Both Sexes, Select Years 2015-2025 36 Figure 2: Age-Standardized Diagnosed Incidence of PE, All Ages, Cases Per 100,000, 2015 37 Figure 3: 8MM, Diagnosed Incident Cases of DVT, All Ages, Both Sexes, Select Years 2015-2025 39 Figure 4: Age-Standardized Diagnosed Incidence of DVT, All Ages, Cases Per 100,000 Population, 2015 40 Figure 5: 8MM, Diagnosed Incident Cases of VTE, All Ages, Both Sexes, Select Years 2015-2025 42 Figure 6: 8MM, Age-Specific Diagnosed Incident Cases of VTE, Both Sexes, N (Row %), 2015 44 Figure 7: 8MM, Sex-Specific Diagnosed Incident Cases of VTE, Both Sexes, N, 2015 46 Figure 8: 8MM, Number of VTE Attacks, Both Sexes, All Ages, N, 2015-2025 50 Figure 9: 8MM, Number of Primary Total Knee Replacements and Revisions, Both Sexes, Ages ≥15 Years 53 Figure 10: 8MM, Number Hip Replacements, Both Sexes, Ages ≥15 Years 55