Table of Contents Table of Contents 2 List of Tables 4 List of Figures 4 Introduction 5 Global Markets Direct Report Coverage 5 Intermittent Claudication Overview 6 Therapeutics Development 7 Pipeline Products for Intermittent Claudication - Overview 7 Intermittent Claudication - Therapeutics under Development by Companies 8 Intermittent Claudication - Pipeline Products Glance 9 Clinical Stage Products 9 Early Stage Products 10 Intermittent Claudication - Products under Development by Companies 11 Intermittent Claudication - Companies Involved in Therapeutics Development 12 ID Pharma Co., Ltd. 12 Kowa Company, Ltd. 13 Nuo Therapeutics, Inc. 14 Pluristem Therapeutics Inc. 15 Intermittent Claudication - Therapeutics Assessment 16 Assessment by Monotherapy Products 16 Assessment by Target 17 Assessment by Mechanism of Action 19 Assessment by Route of Administration 21 Assessment by Molecule Type 23 Drug Profiles 25 ALD-301 - Drug Profile 25 Product Description 25 Mechanism Of Action 25 R&D Progress 25 DVC-10101 - Drug Profile 28 Product Description 28 Mechanism Of Action 28 R&D Progress 28 K-134 - Drug Profile 29 Product Description 29 Mechanism Of Action 29 R&D Progress 29 LT-0101 - Drug Profile 31 Product Description 31 Mechanism Of Action 31 R&D Progress 31 PLX-PAD - Drug Profile 32 Product Description 32 Mechanism Of Action 32 R&D Progress 32 Intermittent Claudication - Dormant Projects 41 Intermittent Claudication - Discontinued Products 42 Intermittent Claudication - Product Development Milestones 43 Featured News & Press Releases 43 May 16, 2016: Pluristem Completes Enrollment of 150 Patients in Phase II Intermittent Claudication Trial 43 Aug 17, 2015: Pluristem Granted U.S. Patent for Production Methods and Use of Placental Cell Therapy in a Range of Indications 43 Nov 13, 2013: Pluristem Receives Regulatory Approval to Extend Its Phase II Study of PLX-PAD Cells in the Treatment of Intermittent Claudication to South Korea 44 Oct 02, 2013: Pluristem Receives Israeli Ministry of Health Approval to Expand Its Phase II Clinical Trial in Intermittent Claudication to Israel 44 Sep 16, 2013: FDA Lifts Clinical Hold of Pluristem's Phase II Intermittent Claudication Study 44 Jul 08, 2013: Pluristem's South Korean Partner Files IND With Korean FDA for PLX Cells 45 Jun 04, 2013: Pluristem To Receive Clinical-hold Notice From FDA For US Phase II Intermittent Claudication Study 45 Jan 15, 2013: Pluristem Receives Approval To Expand Phase II Clinical Trial In Intermittent Claudication To Germany 45 Aug 23, 2012: Pluristem Commences Phase II Clinical Trial For Intermittent Claudication Using PLX Cells 46 Aug 13, 2012: Pluristem Moves Intermittent Claudication Indication Forward in Germany Through Collaboration With Cato Research 46 Jul 18, 2012: Pluristem Partners With CPC Clinical Research For Peripheral Artery Disease Study 47 Apr 17, 2012: Pluristem Receives FDA Clearance For Phase II Clinical Trial In Intermittent Claudication 47 Jan 11, 2012: Kowa Initiates Japan Phase IIb Clinical Trials Of Anti-Platelet Agent K-134 48 Dec 02, 2011: Kowa Releases Japan Phase IIb Clinical Trials Data Of Anti-Platelet Agent, K-134 48 Nov 10, 2011: Kowa Announces Efficacy And Safety Of K-134 For Treatment Of Intermittent Claudication In AHA 2011 48 Appendix 50 Methodology 50 Coverage 50 Secondary Research 50 Primary Research 50 Expert Panel Validation 50 Contact Us 50 Disclaimer 51

List of Tables Number of Products under Development for Intermittent Claudication, H2 2016 7 Number of Products under Development by Companies, H2 2016 8 Comparative Analysis by Clinical Stage Development, H2 2016 9 Comparative Analysis by Early Stage Development, H2 2016 10 Products under Development by Companies, H2 2016 11 Intermittent Claudication - Pipeline by ID Pharma Co., Ltd., H2 2016 12 Intermittent Claudication - Pipeline by Kowa Company, Ltd., H2 2016 13 Intermittent Claudication - Pipeline by Nuo Therapeutics, Inc., H2 2016 14 Intermittent Claudication - Pipeline by Pluristem Therapeutics Inc., H2 2016 15 Assessment by Monotherapy Products, H2 2016 16 Number of Products by Stage and Target, H2 2016 18 Number of Products by Stage and Mechanism of Action, H2 2016 20 Number of Products by Stage and Route of Administration, H2 2016 22 Number of Products by Stage and Molecule Type, H2 2016 24 Intermittent Claudication - Dormant Projects, H2 2016 41 Intermittent Claudication - Discontinued Products, H2 2016 42 List of Figures Number of Products under Development for Intermittent Claudication, H2 2016 7 Number of Products under Development by Companies, H2 2016 8 Assessment by Monotherapy Products, H2 2016 16 Number of Products by Targets, H2 2016 17 Number of Products by Stage and Targets, H2 2016 17 Number of Products by Mechanism of Actions, H2 2016 19 Number of Products by Stage and Mechanism of Actions, H2 2016 19 Number of Products by Routes of Administration, H2 2016 21 Number of Products by Stage and Routes of Administration, H2 2016 21 Number of Products by Molecule Types, H2 2016 23 Number of Products by Stage and Molecule Types, H2 2016 23

ID Pharma Co., Ltd. Kowa Company, Ltd. Nuo Therapeutics, Inc. Pluristem Therapeutics Inc.