Table of Contents Table of Contents 2 Introduction 12 Rheumatoid Arthritis Overview 13 Therapeutics Development 14 Rheumatoid Arthritis - Therapeutics under Development by Companies 16 Rheumatoid Arthritis - Therapeutics under Investigation by Universities/Institutes 34 Rheumatoid Arthritis - Pipeline Products Glance 37 Rheumatoid Arthritis - Products under Development by Companies 41 Rheumatoid Arthritis - Products under Investigation by Universities/Institutes 69 Rheumatoid Arthritis - Companies Involved in Therapeutics Development 72 Rheumatoid Arthritis - Therapeutics Assessment 294 Drug Profiles 328 Rheumatoid Arthritis - Dormant Projects 1016 Rheumatoid Arthritis - Discontinued Products 1064 Rheumatoid Arthritis - Product Development Milestones 1075 Appendix 1093

List of Tables Number of Products under Development for Rheumatoid Arthritis, H1 2016 63 Number of Products under Development for Rheumatoid Arthritis - Comparative Analysis, H1 2016 64 Number of Products under Development by Companies, H1 2016 65 Number of Products under Development by Companies, H1 2016 (Contd..1) 66 Number of Products under Development by Companies, H1 2016 (Contd..2) 67 Number of Products under Development by Companies, H1 2016 (Contd..3) 68 Number of Products under Development by Companies, H1 2016 (Contd..4) 69 Number of Products under Development by Companies, H1 2016 (Contd..5) 70 Number of Products under Development by Companies, H1 2016 (Contd..6) 71 Number of Products under Development by Companies, H1 2016 (Contd..7) 72 Number of Products under Development by Companies, H1 2016 (Contd..8) 73 Number of Products under Development by Companies, H1 2016 (Contd..9) 74 Number of Products under Development by Companies, H1 2016 (Contd..10) 75 Number of Products under Development by Companies, H1 2016 (Contd..11) 76 Number of Products under Development by Companies, H1 2016 (Contd..12) 77 Number of Products under Development by Companies, H1 2016 (Contd..13) 78 Number of Products under Development by Companies, H1 2016 (Contd..14) 79 Number of Products under Development by Companies, H1 2016 (Contd..15) 80 Number of Products under Development by Companies, H1 2016 (Contd..16) 81 Number of Products under Development by Companies, H1 2016 (Contd..17) 82 Number of Products under Investigation by Universities/Institutes, H1 2016 83 Number of Products under Investigation by Universities/Institutes, H1 2016 (Contd..1) 84 Number of Products under Investigation by Universities/Institutes, H1 2016 (Contd..2) 85 Comparative Analysis by Late Stage Development, H1 2016 86 Comparative Analysis by Clinical Stage Development, H1 2016 87 Comparative Analysis by Early Stage Development, H1 2016 88 Comparative Analysis by Unknown Stage Development, H1 2016 89 Products under Development by Companies, H1 2016 90 Products under Development by Companies, H1 2016 (Contd..1) 91 Products under Development by Companies, H1 2016 (Contd..2) 92 Products under Development by Companies, H1 2016 (Contd..3) 93 Products under Development by Companies, H1 2016 (Contd..4) 94 Products under Development by Companies, H1 2016 (Contd..5) 95 Products under Development by Companies, H1 2016 (Contd..6) 96 Products under Development by Companies, H1 2016 (Contd..7) 97 Products under Development by Companies, H1 2016 (Contd..8) 98 Products under Development by Companies, H1 2016 (Contd..9) 99 Products under Development by Companies, H1 2016 (Contd..10) 100 Products under Development by Companies, H1 2016 (Contd..11) 101 Products under Development by Companies, H1 2016 (Contd..12) 102 Products under Development by Companies, H1 2016 (Contd..13) 103 Products under Development by Companies, H1 2016 (Contd..14) 104 Products under Development by Companies, H1 2016 (Contd..15) 105 Products under Development by Companies, H1 2016 (Contd..16) 106 Products under Development by Companies, H1 2016 (Contd..17) 107 Products under Development by Companies, H1 2016 (Contd..18) 108 Products under Development by Companies, H1 2016 (Contd..19) 109 Products under Development by Companies, H1 2016 (Contd..20) 110 Products under Development by Companies, H1 2016 (Contd..21) 111 Products under Development by Companies, H1 2016 (Contd..22) 112 Products under Development by Companies, H1 2016 (Contd..23) 113 Products under Development by Companies, H1 2016 (Contd..24) 114 Products under Development by Companies, H1 2016 (Contd..25) 115 Products under Development by Companies, H1 2016 (Contd..26) 116 Products under Development by Companies, H1 2016 (Contd..27) 117 Products under Investigation by Universities/Institutes, H1 2016 118 Products under Investigation by Universities/Institutes, H1 2016 (Contd..1) 119 Products under Investigation by Universities/Institutes, H1 2016 (Contd..2) 120 Rheumatoid Arthritis - Pipeline by 3SBio Inc., H1 2016 121 Rheumatoid Arthritis - Pipeline by 4D Pharma Plc, H1 2016 122 Rheumatoid Arthritis - Pipeline by 4SC AG, H1 2016 123 Rheumatoid Arthritis - Pipeline by AB Science SA, H1 2016 124 Rheumatoid Arthritis - Pipeline by AB2 Bio Ltd., H1 2016 125 Rheumatoid Arthritis - Pipeline by AbbVie Inc., H1 2016 126 Rheumatoid Arthritis - Pipeline by Ablynx NV, H1 2016 127 Rheumatoid Arthritis - Pipeline by ACEA Biosciences, Inc., H1 2016 128 Rheumatoid Arthritis - Pipeline by Addex Therapeutics Ltd, H1 2016 129 Rheumatoid Arthritis - Pipeline by Advinus Therapeutics Ltd, H1 2016 130 Rheumatoid Arthritis - Pipeline by AlphaMab Co., Ltd, H1 2016 131 Rheumatoid Arthritis - Pipeline by Alteogen Inc., H1 2016 132 Rheumatoid Arthritis - Pipeline by Amgen Inc., H1 2016 133 Rheumatoid Arthritis - Pipeline by Amura Holdings Limited, H1 2016 134 Rheumatoid Arthritis - Pipeline by Anacor Pharmaceuticals, Inc., H1 2016 135 Rheumatoid Arthritis - Pipeline by Applied Genetic Technologies Corporation, H1 2016 136 Rheumatoid Arthritis - Pipeline by ARA Healthcare Pvt. Ltd., H1 2016 137 Rheumatoid Arthritis - Pipeline by Arena Pharmaceuticals, Inc., H1 2016 138 Rheumatoid Arthritis - Pipeline by Arrien Pharmaceuticals, LLC, H1 2016 139 Rheumatoid Arthritis - Pipeline by Arthrogen BV, H1 2016 140 Rheumatoid Arthritis - Pipeline by Asahi Kasei Pharma Corp., H1 2016 141 Rheumatoid Arthritis - Pipeline by Asana BioSciences, LLC, H1 2016 142 Rheumatoid Arthritis - Pipeline by Astellas Pharma Inc., H1 2016 143 Rheumatoid Arthritis - Pipeline by AstraZeneca Plc, H1 2016 144 Rheumatoid Arthritis - Pipeline by Avexxin AS, H1 2016 145 Rheumatoid Arthritis - Pipeline by Axxam SpA, H1 2016 146 Rheumatoid Arthritis - Pipeline by BCN Peptides, S.A., H1 2016 147 Rheumatoid Arthritis - Pipeline by Bio-Cancer Treatment International Limited, H1 2016 148 Rheumatoid Arthritis - Pipeline by BIOCAD, H1 2016 149 Rheumatoid Arthritis - Pipeline by Biocon Limited, H1 2016 150 Rheumatoid Arthritis - Pipeline by Biokine Therapeutics Ltd., H1 2016 151 Rheumatoid Arthritis - Pipeline by BioLingus AG, H1 2016 152 Rheumatoid Arthritis - Pipeline by BioLite, Inc., H1 2016 153 Rheumatoid Arthritis - Pipeline by Bionovis SA, H1 2016 154 Rheumatoid Arthritis - Pipeline by BioTherapeutics Inc., H1 2016 155 Rheumatoid Arthritis - Pipeline by Bird Rock Bio, Inc., H1 2016 156 Rheumatoid Arthritis - Pipeline by Boehringer Ingelheim GmbH, H1 2016 157 Rheumatoid Arthritis - Pipeline by Bone Medical Limited, H1 2016 158 Rheumatoid Arthritis - Pipeline by Boryung Pharmaceutical Co., Ltd., H1 2016 159 Rheumatoid Arthritis - Pipeline by Bristol-Myers Squibb Company, H1 2016 160 Rheumatoid Arthritis - Pipeline by Can-Fite BioPharma Ltd., H1 2016 161 Rheumatoid Arthritis - Pipeline by Cardax Pharmaceuticals, Inc., H1 2016 162 Rheumatoid Arthritis - Pipeline by CASI Pharmaceuticals Inc., H1 2016 163 Rheumatoid Arthritis - Pipeline by CEL-SCI Corporation, H1 2016 164 Rheumatoid Arthritis - Pipeline by Celgene Corporation, H1 2016 165 Rheumatoid Arthritis - Pipeline by Cellceutix Corporation, H1 2016 166 Rheumatoid Arthritis - Pipeline by Celltrion, Inc., H1 2016 167 Rheumatoid Arthritis - Pipeline by ChemoCentryx, Inc., H1 2016 168 Rheumatoid Arthritis - Pipeline by Chipscreen Biosciences Ltd, H1 2016 169 Rheumatoid Arthritis - Pipeline by ChironWells GmbH, H1 2016 170 Rheumatoid Arthritis - Pipeline by Chong Kun Dang Pharmaceutical Corp., H1 2016 171 Rheumatoid Arthritis - Pipeline by CJ HealthCare Corp., H1 2016 172 Rheumatoid Arthritis - Pipeline by CLL Pharma, H1 2016 173 Rheumatoid Arthritis - Pipeline by Clonz Biotech Private Limited, H1 2016 174 Rheumatoid Arthritis - Pipeline by Coherus BioSciences, Inc., H1 2016 175 Rheumatoid Arthritis - Pipeline by Commence Bio, Inc., H1 2016 176 Rheumatoid Arthritis - Pipeline by Compugen Ltd., H1 2016 177 Rheumatoid Arthritis - Pipeline by Confluence Life Sciences, Inc., H1 2016 178 Rheumatoid Arthritis - Pipeline by CSL Limited, H1 2016 179 Rheumatoid Arthritis - Pipeline by Cyclacel Pharmaceuticals, Inc., H1 2016 180 Rheumatoid Arthritis - Pipeline by Daiichi Sankyo Company, Limited, H1 2016 181 Rheumatoid Arthritis - Pipeline by Diamyd Medical AB, H1 2016 182 Rheumatoid Arthritis - Pipeline by Domainex Limited, H1 2016 183 Rheumatoid Arthritis - Pipeline by Dr. Reddy's Laboratories Limited, H1 2016 184 Rheumatoid Arthritis - Pipeline by Eisai Co., Ltd., H1 2016 185 Rheumatoid Arthritis - Pipeline by Eli Lilly and Company, H1 2016 186 Rheumatoid Arthritis - Pipeline by Enceladus Pharmaceuticals BV, H1 2016 187 Rheumatoid Arthritis - Pipeline by Endocyte, Inc., H1 2016 188 Rheumatoid Arthritis - Pipeline by Enzene Biosciences Ltd., H1 2016 189 Rheumatoid Arthritis - Pipeline by Epirus Biopharmaceuticals, Inc., H1 2016 190 Rheumatoid Arthritis - Pipeline by F. Hoffmann-La Roche Ltd., H1 2016 191 Rheumatoid Arthritis - Pipeline by Five Prime Therapeutics, Inc., H1 2016 192 Rheumatoid Arthritis - Pipeline by Fountain Biopharma Inc., H1 2016 193 Rheumatoid Arthritis - Pipeline by Galapagos NV, H1 2016 194 Rheumatoid Arthritis - Pipeline by Gene Techno Science Co., Ltd., H1 2016 195 Rheumatoid Arthritis - Pipeline by Genentech, Inc., H1 2016 196 Rheumatoid Arthritis - Pipeline by Genor BioPharma Co., Ltd., H1 2016 197 Rheumatoid Arthritis - Pipeline by Genosco, H1 2016 198 Rheumatoid Arthritis - Pipeline by Gilead Sciences, Inc., H1 2016 199 Rheumatoid Arthritis - Pipeline by GlaxoSmithKline Plc, H1 2016 200 Rheumatoid Arthritis - Pipeline by Griffin Discoveries BV, H1 2016 201 Rheumatoid Arthritis - Pipeline by Han Wha Pharma Co., Ltd., H1 2016 202 Rheumatoid Arthritis - Pipeline by Handok Inc., H1 2016 203 Rheumatoid Arthritis - Pipeline by Hanmi Pharmaceuticals, Co. Ltd., H1 2016 204 Rheumatoid Arthritis - Pipeline by Hansa Medical AB, H1 2016 205 Rheumatoid Arthritis - Pipeline by Hanwha Chemical Corporation, H1 2016 206 Rheumatoid Arthritis - Pipeline by HEC Pharm Co., Ltd., H1 2016 207 Rheumatoid Arthritis - Pipeline by Hetero Drugs Limited, H1 2016 208 Rheumatoid Arthritis - Pipeline by HitGen LTD, H1 2016 209 Rheumatoid Arthritis - Pipeline by Huabo Biopharm Co., Ltd., H1 2016 210 Rheumatoid Arthritis - Pipeline by Hutchison MediPharma Limited, H1 2016 211 Rheumatoid Arthritis - Pipeline by Idera Pharmaceuticals, Inc., H1 2016 212 Rheumatoid Arthritis - Pipeline by Idogen AB, H1 2016 213 Rheumatoid Arthritis - Pipeline by Immune Response BioPharma, Inc., H1 2016 214 Rheumatoid Arthritis - Pipeline by Immungenetics AG, H1 2016 215 Rheumatoid Arthritis - Pipeline by ImmunoFrontier, Inc., H1 2016 216 Rheumatoid Arthritis - Pipeline by Innate Pharma S.A., H1 2016 217 Rheumatoid Arthritis - Pipeline by Innovent Biologics, Inc., H1 2016 218 Rheumatoid Arthritis - Pipeline by Intas Pharmaceuticals Ltd., H1 2016 219 Rheumatoid Arthritis - Pipeline by ISU ABXIS Co.,Ltd., H1 2016 220 Rheumatoid Arthritis - Pipeline by JHL Biotech, Inc., H1 2016 221 Rheumatoid Arthritis - Pipeline by Jiangsu Hengrui Medicine Co., Ltd., H1 2016 222 Rheumatoid Arthritis - Pipeline by Johnson & Johnson, H1 2016 223 Rheumatoid Arthritis - Pipeline by Jyant Technologies, Inc., H1 2016 224 Rheumatoid Arthritis - Pipeline by Kadmon Corporation, LLC, H1 2016 225 Rheumatoid Arthritis - Pipeline by KAHR medical Ltd., H1 2016 226 Rheumatoid Arthritis - Pipeline by Kang Stem Biotech Co., Ltd., H1 2016 227 Rheumatoid Arthritis - Pipeline by Karus Therapeutics Limited, H1 2016 228 Rheumatoid Arthritis - Pipeline by Karyopharm Therapeutics, Inc., H1 2016 229 Rheumatoid Arthritis - Pipeline by Kezar Life Sciences, Inc., H1 2016 230 Rheumatoid Arthritis - Pipeline by Kineta, Inc., H1 2016 231 Rheumatoid Arthritis - Pipeline by Kolltan Pharmaceuticals, Inc., H1 2016 232 Rheumatoid Arthritis - Pipeline by Lead Pharma Holding B.V., H1 2016 233 Rheumatoid Arthritis - Pipeline by Lexicon Pharmaceuticals, Inc., H1 2016 234 Rheumatoid Arthritis - Pipeline by LG Life Science LTD., H1 2016 235 List of Figures Number of Products under Development for Rheumatoid Arthritis, H1 2016 63 Number of Products under Development for Rheumatoid Arthritis - Comparative Analysis, H1 2016 64 Number of Products under Development by Companies, H1 2016 65 Number of Products under Investigation by Universities/Institutes, H1 2016 83 Comparative Analysis by Late Stage Development, H1 2016 86 Comparative Analysis by Clinical Stage Development, H1 2016 87 Comparative Analysis by Early Stage Products, H1 2016 88 Assessment by Monotherapy Products, H1 2016 343 Number of Products by Top 10 Targets, H1 2016 345 Number of Products by Stage and Top 10 Targets, H1 2016 345 Number of Products by Top 10 Mechanism of Actions, H1 2016 358 Number of Products by Stage and Top 10 Mechanism of Actions, H1 2016 358 Number of Products by Top 10 Routes of Administration, H1 2016 373 Number of Products by Stage and Top 10 Routes of Administration, H1 2016 373 Number of Products by Top 10 Molecule Types, H1 2016 375 Number of Products by Stage and Top 10 Molecule Types, H1 2016 375

3SBio Inc. 4D Pharma Plc 4SC AG AB Science SA AB2 Bio Ltd. AbbVie Inc. Ablynx NV ACEA Biosciences, Inc. Addex Therapeutics Ltd Advinus Therapeutics Ltd AlphaMab Co., Ltd Alteogen Inc. Amgen Inc. Amura Holdings Limited Anacor Pharmaceuticals, Inc. Applied Genetic Technologies Corporation ARA Healthcare Pvt. Ltd. Arena Pharmaceuticals, Inc. Arrien Pharmaceuticals, LLC Arthrogen BV Asahi Kasei Pharma Corp. Asana BioSciences, LLC Astellas Pharma Inc. AstraZeneca Plc Avexxin AS Axxam SpA BCN Peptides, S.A. Bio-Cancer Treatment International Limited BIOCAD Biocon Limited Biokine Therapeutics Ltd. BioLingus AG BioLite, Inc. Bionovis SA BioTherapeutics Inc. Bird Rock Bio, Inc. Boehringer Ingelheim GmbH Bone Medical Limited Boryung Pharmaceutical Co., Ltd. Bristol-Myers Squibb Company Can-Fite BioPharma Ltd. Cardax Pharmaceuticals, Inc. CASI Pharmaceuticals Inc. CEL-SCI Corporation Celgene Corporation Cellceutix Corporation Celltrion, Inc. ChemoCentryx, Inc. Chipscreen Biosciences Ltd ChironWells GmbH Chong Kun Dang Pharmaceutical Corp. CJ HealthCare Corp. CLL Pharma Clonz Biotech Private Limited Coherus BioSciences, Inc. Commence Bio, Inc. Compugen Ltd. Confluence Life Sciences, Inc. CSL Limited Cyclacel Pharmaceuticals, Inc. Daiichi Sankyo Company, Limited Diamyd Medical AB Domainex Limited Dr. Reddy's Laboratories Limited Eisai Co., Ltd. Eli Lilly and Company Enceladus Pharmaceuticals BV Endocyte, Inc. Enzene Biosciences Ltd. Epirus Biopharmaceuticals, Inc. F. Hoffmann-La Roche Ltd. Five Prime Therapeutics, Inc. Fountain Biopharma Inc. Galapagos NV Gene Techno Science Co., Ltd. Genentech, Inc. Genor BioPharma Co., Ltd. Genosco Gilead Sciences, Inc. GlaxoSmithKline Plc Griffin Discoveries BV Han Wha Pharma Co., Ltd. Handok Inc. Hanmi Pharmaceuticals, Co. Ltd. Hansa Medical AB Hanwha Chemical Corporation HEC Pharm Co., Ltd. Hetero Drugs Limited HitGen LTD Huabo Biopharm Co., Ltd. Hutchison MediPharma Limited Idera Pharmaceuticals, Inc. Idogen AB Immune Response BioPharma, Inc. Immungenetics AG ImmunoFrontier, Inc. Innate Pharma S.A. Innovent Biologics, Inc. Intas Pharmaceuticals Ltd. ISU ABXIS Co.,Ltd. JHL Biotech, Inc. Jiangsu Hengrui Medicine Co., Ltd. Johnson & Johnson Jyant Technologies, Inc. Kadmon Corporation, LLC KAHR medical Ltd. Kang Stem Biotech Co., Ltd. Karus Therapeutics Limited Karyopharm Therapeutics, Inc. Kezar Life Sciences, Inc. Kineta, Inc. Kolltan Pharmaceuticals, Inc. Lead Pharma Holding B.V. Lexicon Pharmaceuticals, Inc. LG Life Science LTD. Lipocure Ltd. LSK BioPartners, Inc. Lupin Limited Mabion SA Mabtech Limited mAbxience S.A. MacroGenics, Inc. Mebiopharm Co., Ltd. MedAnnex Ltd Medestea Research & Production S.p.A. MediGene AG MedImmune, LLC Mesoblast Limited Millennium Pharmaceuticals, Inc. Mitsubishi Tanabe Pharma Corporation Modern Biosciences Plc ModiQuest Group Momenta Pharmaceuticals, Inc. Morphotek, Inc. Mycenax Biotech Inc. MYOS RENS Technology Inc. Myungmoon pharmaceutical Co., Ltd. NanoSmart Pharmaceuticals, Inc. Navigen Pharmaceuticals, Inc. Neovacs SA Nimbus Therapeutics, LLC Nissan Chemical Industries, Ltd. Novartis AG NovImmune SA Nuevolution AB Omeros Corporation Oncobiologics, Inc. Oncodesign SA OncoImmune, Inc. Ono Pharmaceutical Co., Ltd. OPKO Health, Inc. Opsona Therapeutics Limited Oscotec Inc. OSE Immunotherapeutics Panacea Biotec Limited Paras Biopharmaceuticals Finland Oy Parvus Therapeutics, Inc. Peptinov SAS Pfenex Inc. Pfizer Inc. Pharmacyclics, Inc. Pharmedartis GmbH Phenex Pharmaceuticals AG Philogen S.p.A. PLx Pharma Inc. Principia Biopharma Inc. Progenra, Inc. ProNoxis AB ProtAb Ltd Protagonist Therapeutics Inc. Protalex, Inc. Protalix BioTherapeutics, Inc. Qu Biologics Inc. R-Pharm Re-Pharm Limited ReceptoPharm, Inc. RedHill Biopharma Ltd. Redx Pharma Plc Regeneron Pharmaceuticals, Inc. Resverlogix Corp. ReveraGen BioPharma, Inc. Rhizen Pharmaceuticals S.A. Richter Gedeon Nyrt. Saje Pharma, LLC Sandoz International GmbH Sareum Holdings Plc SBI Biotech Co., Ltd. Selvita S.A. Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. Shanghai Henlius Biotech Co., Ltd. Shanghai Pharmaceutical Co., Ltd. Swedish Orphan Biovitrum AB Synovo GmbH Syntrix Biosystems, Inc. TaiwanJ Pharmaceuticals Co., Ltd. Takeda Pharmaceutical Company Limited TechnoPhage SA Teijin Pharma Limited The International Biotechnology Center (IBC) Generium TheraMAB LLC Therapeutic Proteins International, LLC TiGenix NV Toleranzia AB Tumorend, LLC TxCell SA U.S. Stem Cell, Inc. UCB S.A. United BioPharma, Inc. Vaccinex, Inc. Valeant Pharmaceuticals International, Inc. Vichem Chemie Research Ltd. Vicore Pharma AB Vida Therapeutics Inc. Vitae Pharmaceuticals, Inc. Vitaeris Inc Xbrane Biopharma AB Xencor, Inc. XTL Biopharmaceuticals Ltd. Yungjin Pharm. Co., Ltd. Yuyu Pharma, Inc. Zenyaku Kogyo Co., Ltd. Zydus Cadila Healthcare Limited