1 Table of Contents
1 Table of Contents 3
1.1 List of Tables 4
1.2 List of Figures 4
2 Stem Cell Therapies Overview 5
2.1 Types of Stem Cells 6
2.2 Timeline of Key Events in Stem Cell Research 1900-2016 9
2.3 What are Stem Cell Therapies? 10
2.4 Autologous Versus Allogeneic Stem Cells 10
2.5 The Stem Cell Therapy Market and Potential Therapeutic Applications 11
3 Stem Cell Therapies: Key Marketed Products 13
3.1 Prochymal (Mesoblast) 13
3.2 Cellgram-AMI (Pharmicell) 14
3.3 CardioRel (Reliance Life Sciences) 16
3.4 Trinity Elite (Orthofix International) 16
3.5 Cartistem (Medipost) 17
3.6 Osteocel Plus (NuVasive) 18
3.7 Holoclar (Chiesi Farmaceutici) 19
4 Stem Cell Therapy Development: Drivers and Restraints 22
4.1 Stem Cell Industry Challenges 22
4.2 Stem Cell Therapies: Market Drivers and Opportunities 26
4.2.1 Steady Progress in Clinical Research and Increasing Evidence of Product Effectiveness 27
4.2.2 Increasing Government Funding and Regulatory Support 28
4.2.3 Advances in Scalable Manufacturing Strategies 28
4.2.4 Streamlining of Regulatory Frameworks in Key Geographical Markets. 29
5 Stem Cell Production Strategies: Overview, Challenges and Recent Technological Advances 30
5.1 Important Challenges in the Manufacturing Process Remain 32
5.2 Case Study: Cynata Therapeutics’ Cymerus Technology 33
6 Stem Cell Therapy Pipeline 35
6.1 Stem Cell Therapy Pipeline by Therapy Area and Stages of Development 35
6.2 Leading Companies’ Positioning in the Stem Cell Pipeline 38
6.3 Stem Cell Pipeline Companies by Therapy Area 38
6.4 Stem Cell Pipeline Companies by Stage of Development 39
7 Conclusion 40
8 Appendix 41
8.1 Industry Survey Results: Important Factors Contributing to Growth in the Stem Cell Therapy Market 41
8.2 Industry Survey Results: Important Factors Restraining Growth in the Stem Cell Therapy Market 41
8.3 Industry Survey Results: Factors Negatively Impacting Funding and Investment for Stem Cell Research 42
8.4 Industry Survey Results: Therapeutic Areas with Highest Commercial Prospects in the Stem Cell Therapy Market 42
8.5 Industry Survey Results: The Most Important Manufacturing Challenges in Stem Cell Production 43
8.6 Industry Survey Results: The Most Important Ethical Challenges in the Stem Cell Therapy Market 43
8.7 References 44
8.8 Contact Us 46
8.9 Disclaimer 46

1.1 List of Tables

Table 1: Defining Properties Of Stem Cells 5
Table 2: Mechanisms of Stem Cell Renewal 5
Table 3: Potency of Stem Cells, Description and Sources 6
Table 4: Stem Cell Classification 7
Table 5: Somatic Stem Cells, Description, Potency, Source 8
Table 6: Main Therapeutic Applications of Stem Cells 12
Table 7: Prochymal 14
Table 8: Cellgram-AMI 15
Table 9: CardioRel 16
Table 10: Trinity Elite 17
Table 11: Cartistem 18
Table 12: Osteocel Plus 19
Table 13: Holoclar 20
Table 14: Challenges to Successful Stem Cell Therapy Development and Commercialization 22

1.2 List of Figures

Figure 1: Selected Key Milestones in Stem Cell Research, 1900-2016 9
Figure 2: Industry Survey Results: Most Important Factors Restraining Stem Cell Therapy Market Growth 25
Figure 3: Industry Survey Results: Most Important Ethical Challenges in the Stem Cell Therapy Market 26
Figure 4: Industry Survey Results: Most Important Factors Contributing to Stem Cell Therapy Market Growth 27
Figure 5: Overview of Stem Cell Manufacturing Process 30
Figure 6: Key Elements and Associated Procedures in Stem Cell Manufacturing 31
Figure 7: Stem Cell Therapy Pipeline by Therapy Area and Stage of Development 35
Figure 8: Stem Cell Therapy Pipeline by Therapy Area and Stage of Development 36
Figure 9: Stem Cell Therapy R&D Companies by Type, and Volume of Pipeline Therapies by Company Type 38
Figure 10: Stem Cell Therapy Pipeline by Company and Therapy Area 39
Figure 11: Stem Cell Therapy Pipeline by Company and Stage of Development 39
Figure 12: Industry Survey Results: Most Important Factors Contributing to Stem Cell Therapy Market Growth 41
Figure 13: Industry Survey Results: Most Important Factors Restraining Stem Cell Therapy Market Growth 41
Figure 14: Industry Survey Results: Factors Negatively Impacting Funding and Investment for Stem Cell Research 42
Figure 15: Industry Survey Results: Therapeutic Areas with Greatest Commercial Prospects in the Stem Cell Therapies Market 42
Figure 16: Industry Survey Results: Most Important Manufacturing Challenges in Stem Cell Production 43
Figure 17: Industry Survey Results: Most Important Ethical Challenges in the Stem Cell Therapy Market 43