Table of Contents Table of Contents 2 List of Tables 6 List of Figures 6 Introduction 7 Global Markets Direct Report Coverage 7 CD40 Ligand (T Cell Antigen Gp39 or TNF Related Activation Protein or Tumor Necrosis Factor Ligand Superfamily Member 5 or CD154 or CD40LG) Overview 8 Therapeutics Development 9 CD40 Ligand (T Cell Antigen Gp39 or TNF Related Activation Protein or Tumor Necrosis Factor Ligand Superfamily Member 5 or CD154 or CD40LG) - Products under Development by Stage of Development 9 CD40 Ligand (T Cell Antigen Gp39 or TNF Related Activation Protein or Tumor Necrosis Factor Ligand Superfamily Member 5 or CD154 or CD40LG) - Products under Development by Therapy Area 10 CD40 Ligand (T Cell Antigen Gp39 or TNF Related Activation Protein or Tumor Necrosis Factor Ligand Superfamily Member 5 or CD154 or CD40LG) - Products under Development by Indication 11 CD40 Ligand (T Cell Antigen Gp39 or TNF Related Activation Protein or Tumor Necrosis Factor Ligand Superfamily Member 5 or CD154 or CD40LG) - Pipeline Products Glance 13 Late Stage Products 13 Early Stage Products 14 CD40 Ligand (T Cell Antigen Gp39 or TNF Related Activation Protein or Tumor Necrosis Factor Ligand Superfamily Member 5 or CD154 or CD40LG) - Products under Development by Companies 15 CD40 Ligand (T Cell Antigen Gp39 or TNF Related Activation Protein or Tumor Necrosis Factor Ligand Superfamily Member 5 or CD154 or CD40LG) - Products under Development by Universities/Institutes 18 CD40 Ligand (T Cell Antigen Gp39 or TNF Related Activation Protein or Tumor Necrosis Factor Ligand Superfamily Member 5 or CD154 or CD40LG) - Therapeutics Assessment 20 Assessment by Monotherapy/Combination Products 20 Assessment by Mechanism of Action 21 Assessment by Route of Administration 23 Assessment by Molecule Type 25 CD40 Ligand (T Cell Antigen Gp39 or TNF Related Activation Protein or Tumor Necrosis Factor Ligand Superfamily Member 5 or CD154 or CD40LG) - Companies Involved in Therapeutics Development 27 Biogen, Inc. 27 Bristol-Myers Squibb Company 28 eTheRNA Immunotherapies NV 29 ImmuNext, Inc. 30 Juno Therapeutics Inc. 31 MedImmune, LLC 32 Targovax AS 33 XL-protein GmbH 34 CD40 Ligand (T Cell Antigen Gp39 or TNF Related Activation Protein or Tumor Necrosis Factor Ligand Superfamily Member 5 or CD154 or CD40LG) - Drug Profiles 35 Antibodies to Antagonize CD40L for Autoimmune Diseases and GVHD - Drug Profile 35 Product Description 35 Mechanism Of Action 35 R&D Progress 35 Antibody to Target CD40 Ligand for Immunology - Drug Profile 36 Product Description 36 Mechanism Of Action 36 R&D Progress 36 BIIB-063 - Drug Profile 37 Product Description 37 Mechanism Of Action 37 R&D Progress 37 BMS-986004 - Drug Profile 38 Product Description 38 Mechanism Of Action 38 R&D Progress 38 Cellular Immunotherapy to Activate CD40L and to Target CD19 for B-Cell Malignancies - Drug Profile 39 Product Description 39 Mechanism Of Action 39 R&D Progress 39 FFP-102 - Drug Profile 41 Product Description 41 Mechanism Of Action 41 R&D Progress 41 hepatitis B vaccine - Drug Profile 42 Product Description 42 Mechanism Of Action 42 R&D Progress 42 ISF-35 - Drug Profile 43 Product Description 43 Mechanism Of Action 43 R&D Progress 43 LOAd-700 - Drug Profile 45 Product Description 45 Mechanism Of Action 45 R&D Progress 45 MEDI-4920 - Drug Profile 46 Product Description 46 Mechanism Of Action 46 R&D Progress 46 MegaCD40L - Drug Profile 47 Product Description 47 Mechanism Of Action 47 R&D Progress 47 Oligonucleotide to Activate CD40L, CD70 and TLR-4 for Oncology and Infectious Diseases - Drug Profile 48 Product Description 48 Mechanism Of Action 48 R&D Progress 48 ONCOS-402 - Drug Profile 49 Product Description 49 Mechanism Of Action 49 R&D Progress 49 TDI-28 - Drug Profile 50 Product Description 50 Mechanism Of Action 50 R&D Progress 50 TDI-846 - Drug Profile 51 Product Description 51 Mechanism Of Action 51 R&D Progress 51 UltraCD40L - Drug Profile 52 Product Description 52 Mechanism Of Action 52 R&D Progress 52 Vaccine to Target CD40L and GM-CSF for Oncology - Drug Profile 53 Product Description 53 Mechanism Of Action 53 R&D Progress 53 XL-050 - Drug Profile 55 Product Description 55 Mechanism Of Action 55 R&D Progress 55 CD40 Ligand (T Cell Antigen Gp39 or TNF Related Activation Protein or Tumor Necrosis Factor Ligand Superfamily Member 5 or CD154 or CD40LG) - Dormant Projects 56 CD40 Ligand (T Cell Antigen Gp39 or TNF Related Activation Protein or Tumor Necrosis Factor Ligand Superfamily Member 5 or CD154 or CD40LG) - Featured News & Press Releases 58 Nov 17, 2015: Memgen Announces Preclinical Results for ISF35 in Combination with Checkpoint Inhibitors in a Model of Metastatic Melanoma 58 Dec 07, 2011: Memgen Announces Upcoming Presentation For ISF35 In Chronic Lymphocytic Leukemia At 2011 ASH Annual Meeting 58 Jun 21, 2011: Memgen Presents Clinical Results For ISF35 In Chronic Lymphocytic Leukemia At ASCO 2011 59 Dec 09, 2010: Memgen Announces Clinical And Preclinical Results For ISF35 In Chronic Lymphocytic Leukemia And Non-Hodgkin's Lymphoma 59 Dec 08, 2009: Memgen Announces Positive Data Results Of ISF35 For Chronic Lymphocytic Leukemia 60 Dec 08, 2009: Memgen's ISF35 Sensitizes Cancer Cells To Chemotherapy 61 Dec 02, 2009: Memgen Selects Clinical Trial Results Of ISF35 For An Oral Presentation At ASH 2009 Annual Meeting 61 Dec 01, 2009: Memgen's Clinical Trial Results Of ISF35 For Chronic Lymphocytic Leukemia Selected For Presentation At ASH 2009 Annual Meeting 62 Jun 08, 2009: Memgen Reports Positive Results For ISF35 In High-Risk Chronic Lymphocytic Leukemia 62 Jun 04, 2009: Memgen Reports Positive Results For ISF35 In High-Risk Chronic Lymphocytic Leukemia 62 Appendix 64 Methodology 64 Coverage 64 Secondary Research 64 Primary Research 64 Expert Panel Validation 64 Contact Us 64 Disclaimer 65

List of Tables Number of Products under Development for, H1 2016 9 Number of Products under Development by Therapy Area, H1 2016 10 Number of Products under Development by Indication, H1 2016 11 Comparative Analysis by Late Stage Development, H1 2016 13 Comparative Analysis by Early Stage Products, H1 2016 14 Number of Products under Development by Companies, H1 2016 15 Products under Development by Companies, H1 2016 16 Products under Development by Companies, H1 2016 (Contd..1) 17 Number of Products under Investigation by Universities/Institutes, H1 2016 18 Products under Investigation by Universities/Institutes, H1 2016 19 Assessment by Monotherapy/Combination Products, H1 2016 20 Number of Products by Stage and Mechanism of Action, H1 2016 22 Number of Products by Stage and Route of Administration, H1 2016 24 Number of Products by Stage and Molecule Type, H1 2016 26 Pipeline by Biogen, Inc., H1 2016 27 Pipeline by Bristol-Myers Squibb Company, H1 2016 28 Pipeline by eTheRNA Immunotherapies NV, H1 2016 29 Pipeline by ImmuNext, Inc., H1 2016 30 Pipeline by Juno Therapeutics Inc., H1 2016 31 Pipeline by MedImmune, LLC, H1 2016 32 Pipeline by Targovax AS, H1 2016 33 Pipeline by XL-protein GmbH, H1 2016 34 Dormant Projects, H1 2016 56 Dormant Projects (Contd..1), H1 2016 57 List of Figures Number of Products under Development for, H1 2016 9 Number of Products under Development by Therapy Area, H1 2016 10 Number of Products under Development by Top 10 Indication, H1 2016 11 Comparative Analysis by Early Stage Products, H1 2016 14 Assessment by Monotherapy/Combination Products, H1 2016 20 Number of Products by Mechanism of Actions, H1 2016 21 Number of Products by Stage and Mechanism of Actions, H1 2016 21 Number of Products by Routes of Administration, H1 2016 23 Number of Products by Stage and Routes of Administration, H1 2016 23 Number of Products by Molecule Types, H1 2016 25 Number of Products by Stage and Molecule Type, H1 2016 25

Biogen, Inc. Bristol-Myers Squibb Company eTheRNA Immunotherapies NV ImmuNext, Inc. Juno Therapeutics Inc. MedImmune, LLC Targovax AS XL-protein GmbH