Table of Contents COMPANY OVERVIEW AND KEY FACTS --Mergers and Acquisitions – Deal reports --Corporate Venturing – Deal reports PARTNERSHIP --Partnership – Overview --Partnership – Deal reports CAPITAL RAISING --Capital Raising – Overview --Capital Raising – Deal reports DIVESTMENTS --Divestments – Overview --Divestments – Deal reports APPENDIX --About MarketLine Financial Deals Database --Deal Definition and Methodology --About MarketLine --MarketLine Professional Services Knowledge Center List of Tables --Ionis Pharmaceuticals activity by deal type – volume (2015-TTM2016) --Ionis Pharmaceuticals activity by deal type – volume (2012 -YTD2016) --Ionis Pharmaceuticals legal advisor ranking by value ($m) --Ionis Pharmaceuticals financial advisor ranking by value ($m) --Top Deals(2012 -YTD2016) --Ionis Pharmaceuticals targets and partners (2012 -YTD2016) --Ionis Pharmaceuticals partnership volume and value trend (2012-YTD2016) --Ionis Pharmaceuticals partnership trend by key deal type (2012-YTD2016) --Ionis Pharmaceuticals capital raising volume and value trend (2012-YTD2016) --Ionis Pharmaceuticals capital raising by deal type (2012-YTD2016) --Ionis Pharmaceuticals divestments volume and value trend (2012-YTD2016) --Ionis Pharmaceuticals divestments activity by geography (2012-YTD2016) List of Figures --Ionis Pharmaceuticals activity by deal type - volume (trailing twelve months (TTM)) --Ionis Pharmaceuticals activity by deal type - volume (2012-YTD2016) --Ionis Pharmaceuticals partnership volume and value trend (2012-YTD2016) --Ionis Pharmaceuticals partnership trend by key deal type (2012-YTD2016) --Ionis Pharmaceuticals capital raising volume and value trend (2012-YTD2016) --Ionis Pharmaceuticals capital raising by deal type (2012-YTD2016) --Ionis Pharmaceuticals divestments volume and value trend (2012-YTD2016) --Ionis Pharmaceuticals divestments by geography (2012-YTD2016)