Table of Contents Table of Contents 2 Introduction 10 Multiple Sclerosis Overview 11 Therapeutics Development 12 Multiple Sclerosis - Therapeutics under Development by Companies 14 Multiple Sclerosis - Therapeutics under Investigation by Universities/Institutes 30 Multiple Sclerosis - Pipeline Products Glance 32 Multiple Sclerosis - Products under Development by Companies 36 Multiple Sclerosis - Products under Investigation by Universities/Institutes 56 Multiple Sclerosis - Companies Involved in Therapeutics Development 59 Multiple Sclerosis - Therapeutics Assessment 237 Drug Profiles 290 Multiple Sclerosis - Dormant Projects 828 Multiple Sclerosis - Discontinued Products 852 Multiple Sclerosis - Product Development Milestones 857 Appendix 868

List of Tables Number of Products under Development for Multiple Sclerosis, H1 2016 46 Number of Products under Development for Multiple Sclerosis - Comparative Analysis, H1 2016 47 Number of Products under Development by Companies, H1 2016 49 Number of Products under Development by Companies, H1 2016 (Contd..1) 50 Number of Products under Development by Companies, H1 2016 (Contd..2) 51 Number of Products under Development by Companies, H1 2016 (Contd..3) 52 Number of Products under Development by Companies, H1 2016 (Contd..4) 53 Number of Products under Development by Companies, H1 2016 (Contd..5) 54 Number of Products under Development by Companies, H1 2016 (Contd..6) 55 Number of Products under Development by Companies, H1 2016 (Contd..7) 56 Number of Products under Development by Companies, H1 2016 (Contd..8) 57 Number of Products under Development by Companies, H1 2016 (Contd..9) 58 Number of Products under Development by Companies, H1 2016 (Contd..10) 59 Number of Products under Development by Companies, H1 2016 (Contd..11) 60 Number of Products under Development by Companies, H1 2016 (Contd..12) 61 Number of Products under Development by Companies, H1 2016 (Contd..13) 62 Number of Products under Development by Companies, H1 2016 (Contd..14) 63 Number of Products under Investigation by Universities/Institutes, H1 2016 64 Number of Products under Investigation by Universities/Institutes, H1 2016 (Contd..1) 65 Comparative Analysis by Late Stage Development, H1 2016 66 Comparative Analysis by Clinical Stage Development, H1 2016 67 Comparative Analysis by Early Stage Development, H1 2016 68 Comparative Analysis by Unknown Stage Development, H1 2016 69 Products under Development by Companies, H1 2016 70 Products under Development by Companies, H1 2016 (Contd..1) 71 Products under Development by Companies, H1 2016 (Contd..2) 72 Products under Development by Companies, H1 2016 (Contd..3) 73 Products under Development by Companies, H1 2016 (Contd..4) 74 Products under Development by Companies, H1 2016 (Contd..5) 75 Products under Development by Companies, H1 2016 (Contd..6) 76 Products under Development by Companies, H1 2016 (Contd..7) 77 Products under Development by Companies, H1 2016 (Contd..8) 78 Products under Development by Companies, H1 2016 (Contd..9) 79 Products under Development by Companies, H1 2016 (Contd..10) 80 Products under Development by Companies, H1 2016 (Contd..11) 81 Products under Development by Companies, H1 2016 (Contd..12) 82 Products under Development by Companies, H1 2016 (Contd..13) 83 Products under Development by Companies, H1 2016 (Contd..14) 84 Products under Development by Companies, H1 2016 (Contd..15) 85 Products under Development by Companies, H1 2016 (Contd..16) 86 Products under Development by Companies, H1 2016 (Contd..17) 87 Products under Development by Companies, H1 2016 (Contd..18) 88 Products under Development by Companies, H1 2016 (Contd..19) 89 Products under Investigation by Universities/Institutes, H1 2016 90 Products under Investigation by Universities/Institutes, H1 2016 (Contd..1) 91 Products under Investigation by Universities/Institutes, H1 2016 (Contd..2) 92 Multiple Sclerosis - Pipeline by 4D Pharma Plc, H1 2016 93 Multiple Sclerosis - Pipeline by 4SC AG, H1 2016 94 Multiple Sclerosis - Pipeline by AB Science SA, H1 2016 95 Multiple Sclerosis - Pipeline by AbbVie Inc., H1 2016 96 Multiple Sclerosis - Pipeline by Ablynx NV, H1 2016 97 Multiple Sclerosis - Pipeline by Acorda Therapeutics, Inc., H1 2016 98 Multiple Sclerosis - Pipeline by Actelion Ltd, H1 2016 99 Multiple Sclerosis - Pipeline by Addex Therapeutics Ltd, H1 2016 100 Multiple Sclerosis - Pipeline by Adhaere Pharmaceuticals, Inc., H1 2016 101 Multiple Sclerosis - Pipeline by Aegis Therapeutics, LLC, H1 2016 102 Multiple Sclerosis - Pipeline by Affectis Pharmaceuticals AG, H1 2016 103 Multiple Sclerosis - Pipeline by AiCuris GmbH & Co. KG, H1 2016 104 Multiple Sclerosis - Pipeline by Alkermes Plc, H1 2016 105 Multiple Sclerosis - Pipeline by Alpha Cancer Technologies Inc., H1 2016 106 Multiple Sclerosis - Pipeline by Amarna Therapeutics B.V., H1 2016 107 Multiple Sclerosis - Pipeline by Anavex Life Sciences Corp., H1 2016 108 Multiple Sclerosis - Pipeline by Antisense Therapeutics Limited, H1 2016 109 Multiple Sclerosis - Pipeline by Antitope Limited, H1 2016 110 Multiple Sclerosis - Pipeline by Aphios Corporation, H1 2016 111 Multiple Sclerosis - Pipeline by Apitope International NV, H1 2016 112 Multiple Sclerosis - Pipeline by Arena Pharmaceuticals, Inc., H1 2016 113 Multiple Sclerosis - Pipeline by Argos Therapeutics, Inc., H1 2016 114 Multiple Sclerosis - Pipeline by Arrien Pharmaceuticals, LLC, H1 2016 115 Multiple Sclerosis - Pipeline by Artielle ImmunoTherapeutics, Inc., H1 2016 116 Multiple Sclerosis - Pipeline by Astellas Pharma Inc., H1 2016 117 Multiple Sclerosis - Pipeline by Asterias Biotherapeutics, Inc., H1 2016 118 Multiple Sclerosis - Pipeline by Atara Biotherapeutics, Inc., H1 2016 119 Multiple Sclerosis - Pipeline by Athersys, Inc., H1 2016 120 Multiple Sclerosis - Pipeline by Axxam SpA, H1 2016 121 Multiple Sclerosis - Pipeline by Baliopharm AG, H1 2016 122 Multiple Sclerosis - Pipeline by Bio-Cancer Treatment International Limited, H1 2016 123 Multiple Sclerosis - Pipeline by BioAegis Therapeutics, Inc., H1 2016 124 Multiple Sclerosis - Pipeline by BIOCAD, H1 2016 125 Multiple Sclerosis - Pipeline by Biocon Limited, H1 2016 126 Multiple Sclerosis - Pipeline by Biogen, Inc., H1 2016 127 Multiple Sclerosis - Pipeline by Biogenomics Limited, H1 2016 128 Multiple Sclerosis - Pipeline by Biokine Therapeutics Ltd., H1 2016 129 Multiple Sclerosis - Pipeline by Biomar Microbial Technologies, H1 2016 130 Multiple Sclerosis - Pipeline by Bionature E.A. Ltd., H1 2016 131 Multiple Sclerosis - Pipeline by Bioncotech Therapeutics S.L., H1 2016 132 Multiple Sclerosis - Pipeline by Bionovis SA, H1 2016 133 Multiple Sclerosis - Pipeline by Bionure Farma, S.L., H1 2016 134 Multiple Sclerosis - Pipeline by Biovista Inc., H1 2016 135 Multiple Sclerosis - Pipeline by Bird Rock Bio, Inc., H1 2016 136 Multiple Sclerosis - Pipeline by Bolder Biotechnology, Inc., H1 2016 137 Multiple Sclerosis - Pipeline by BrainStorm Cell Therapeutics Inc., H1 2016 138 Multiple Sclerosis - Pipeline by C4X Discovery Holdings PLC, H1 2016 139 Multiple Sclerosis - Pipeline by Caladrius Biosciences, Inc. , H1 2016 140 Multiple Sclerosis - Pipeline by CASI Pharmaceuticals Inc., H1 2016 141 Multiple Sclerosis - Pipeline by Catalyst Pharmaceuticals, Inc., H1 2016 142 Multiple Sclerosis - Pipeline by Celgene Corporation, H1 2016 143 Multiple Sclerosis - Pipeline by Cell Cure Neurosciences, Ltd., H1 2016 144 Multiple Sclerosis - Pipeline by Cell2B S.A. , H1 2016 145 Multiple Sclerosis - Pipeline by Cellceutix Corporation, H1 2016 146 Multiple Sclerosis - Pipeline by Chong Kun Dang Pharmaceutical Corp., H1 2016 147 Multiple Sclerosis - Pipeline by Cognosci, Inc., H1 2016 148 Multiple Sclerosis - Pipeline by Coherus BioSciences, Inc., H1 2016 149 Multiple Sclerosis - Pipeline by Commence Bio, Inc., H1 2016 150 Multiple Sclerosis - Pipeline by Compugen Ltd., H1 2016 151 Multiple Sclerosis - Pipeline by Connexios Life Sciences Pvt. Ltd., H1 2016 152 Multiple Sclerosis - Pipeline by Critical Outcome Technologies Inc., H1 2016 153 Multiple Sclerosis - Pipeline by CuraVac, Inc., H1 2016 154 Multiple Sclerosis - Pipeline by Cyxone AB, H1 2016 155 Multiple Sclerosis - Pipeline by Dimerix Bioscience Pty Ltd, H1 2016 156 Multiple Sclerosis - Pipeline by Eisai Co., Ltd., H1 2016 157 Multiple Sclerosis - Pipeline by Endece, LLC, H1 2016 158 Multiple Sclerosis - Pipeline by Euroscreen S.A., H1 2016 159 Multiple Sclerosis - Pipeline by Evgen Pharma Plc, H1 2016 160 Multiple Sclerosis - Pipeline by Evotec AG, H1 2016 161 Multiple Sclerosis - Pipeline by F. Hoffmann-La Roche Ltd., H1 2016 162 Multiple Sclerosis - Pipeline by Flex Pharma, Inc., H1 2016 163 Multiple Sclerosis - Pipeline by Forward Pharma A/S, H1 2016 164 Multiple Sclerosis - Pipeline by FPRT Bio Inc., H1 2016 165 Multiple Sclerosis - Pipeline by Gemac, H1 2016 166 Multiple Sclerosis - Pipeline by Genervon Biopharmaceuticals, LLC, H1 2016 167 Multiple Sclerosis - Pipeline by GeNeuro SA, H1 2016 168 Multiple Sclerosis - Pipeline by Genzyme Corporation, H1 2016 169 Multiple Sclerosis - Pipeline by GlaxoSmithKline Plc, H1 2016 170 Multiple Sclerosis - Pipeline by Glialogix, Inc., H1 2016 171 Multiple Sclerosis - Pipeline by Hansa Medical AB, H1 2016 172 Multiple Sclerosis - Pipeline by Hanwha Chemical Corporation, H1 2016 173 Multiple Sclerosis - Pipeline by Harbor Therapeutics, Inc., H1 2016 174 Multiple Sclerosis - Pipeline by HitGen LTD, H1 2016 175 Multiple Sclerosis - Pipeline by Hutchison MediPharma Limited, H1 2016 176 Multiple Sclerosis - Pipeline by Iltoo Pharma, H1 2016 177 Multiple Sclerosis - Pipeline by Immune Response BioPharma, Inc., H1 2016 178 Multiple Sclerosis - Pipeline by ImmuNext, Inc., H1 2016 179 Multiple Sclerosis - Pipeline by Immungenetics AG, H1 2016 180 Multiple Sclerosis - Pipeline by InDex Pharmaceuticals AB, H1 2016 181 Multiple Sclerosis - Pipeline by Innate Immunotherapeutics Ltd, H1 2016 182 Multiple Sclerosis - Pipeline by Inovio Pharmaceuticals, Inc., H1 2016 183 Multiple Sclerosis - Pipeline by Io Therapeutics, Inc., H1 2016 184 Multiple Sclerosis - Pipeline by Jyant Technologies, Inc., H1 2016 185 Multiple Sclerosis - Pipeline by Kadimastem Ltd., H1 2016 186 Multiple Sclerosis - Pipeline by Kadmon Corporation, LLC, H1 2016 187 Multiple Sclerosis - Pipeline by KAHR medical Ltd., H1 2016 188 Multiple Sclerosis - Pipeline by KaloBios Pharmaceuticals, Inc., H1 2016 189 Multiple Sclerosis - Pipeline by Kareus Therapeutics, SA, H1 2016 190 Multiple Sclerosis - Pipeline by Karo Pharma AB, H1 2016 191 Multiple Sclerosis - Pipeline by Karyopharm Therapeutics, Inc., H1 2016 192 Multiple Sclerosis - Pipeline by Kezar Life Sciences, Inc., H1 2016 193 Multiple Sclerosis - Pipeline by Kineta, Inc., H1 2016 194 Multiple Sclerosis - Pipeline by Kyorin Pharmaceutical Co., Ltd., H1 2016 195 Multiple Sclerosis - Pipeline by Lead Discovery Center GmbH, H1 2016 196 Multiple Sclerosis - Pipeline by LFB S.A., H1 2016 197 Multiple Sclerosis - Pipeline by Lipocure Ltd., H1 2016 198 Multiple Sclerosis - Pipeline by MacroGenics, Inc., H1 2016 199 Multiple Sclerosis - Pipeline by MAKScientific, LLC, H1 2016 200 Multiple Sclerosis - Pipeline by Mallinckrodt Plc, H1 2016 201 Multiple Sclerosis - Pipeline by Mapi Pharma Ltd., H1 2016 202 Multiple Sclerosis - Pipeline by Marathon Pharmaceuticals, LLC, H1 2016 203 Multiple Sclerosis - Pipeline by MedAnnex Ltd, H1 2016 204 Multiple Sclerosis - Pipeline by MedDay SA, H1 2016 205 Multiple Sclerosis - Pipeline by Medestea Research & Production S.p.A., H1 2016 206 Multiple Sclerosis - Pipeline by MedImmune, LLC, H1 2016 207 Multiple Sclerosis - Pipeline by Meiji Seika Pharma Co., Ltd., H1 2016 208 Multiple Sclerosis - Pipeline by Merck KGaA, H1 2016 209 Multiple Sclerosis - Pipeline by Meta-IQ ApS, H1 2016 210 Multiple Sclerosis - Pipeline by Mitochon Pharmaceuticals, Inc., H1 2016 211 Multiple Sclerosis - Pipeline by Mitsubishi Tanabe Pharma Corporation, H1 2016 212 Multiple Sclerosis - Pipeline by MorphoSys AG, H1 2016 213 Multiple Sclerosis - Pipeline by Neuralstem, Inc., H1 2016 214 Multiple Sclerosis - Pipeline by Neuren Pharmaceuticals Limited, H1 2016 215 Multiple Sclerosis - Pipeline by Neurotec Pharma SL, H1 2016 216 Multiple Sclerosis - Pipeline by New World Laboratories, Inc., H1 2016 217 Multiple Sclerosis - Pipeline by Novartis AG, H1 2016 218 Multiple Sclerosis - Pipeline by NovImmune SA, H1 2016 219 Multiple Sclerosis - Pipeline by Nuevolution AB, H1 2016 220 Multiple Sclerosis - Pipeline by Octapharma AG, H1 2016 221 Multiple Sclerosis - Pipeline by Omeros Corporation, H1 2016 222 Multiple Sclerosis - Pipeline by OncoImmune, Inc., H1 2016 223 Multiple Sclerosis - Pipeline by Opexa Therapeutics, Inc., H1 2016 224 Multiple Sclerosis - Pipeline by OPKO Health, Inc., H1 2016 225 Multiple Sclerosis - Pipeline by OSE Immunotherapeutics, H1 2016 226 Multiple Sclerosis - Pipeline by Parvus Therapeutics, Inc., H1 2016 227 Multiple Sclerosis - Pipeline by Peptinov SAS, H1 2016 228 Multiple Sclerosis - Pipeline by Pfenex Inc., H1 2016 229 Multiple Sclerosis - Pipeline by Pfizer Inc., H1 2016 230 Multiple Sclerosis - Pipeline by PharmaEssentia Corporation, H1 2016 231 Multiple Sclerosis - Pipeline by PharmatrophiX, Inc., H1 2016 232 Multiple Sclerosis - Pipeline by Pharmaxis Limited, H1 2016 233 Multiple Sclerosis - Pipeline by Pieris Pharmaceuticals, Inc., H1 2016 234 Multiple Sclerosis - Pipeline by Plexxikon Inc., H1 2016 235 Multiple Sclerosis - Pipeline by ProNoxis AB, H1 2016 236 Multiple Sclerosis - Pipeline by Prothena Corporation Plc, H1 2016 237 Multiple Sclerosis - Pipeline by Q Therapeutics, Inc., H1 2016 238 Multiple Sclerosis - Pipeline by ReceptoPharm, Inc., H1 2016 239 Multiple Sclerosis - Pipeline by RedHill Biopharma Ltd., H1 2016 240 Multiple Sclerosis - Pipeline by RegeneRx Biopharmaceuticals, Inc., H1 2016 241 Multiple Sclerosis - Pipeline by Regenesance BV, H1 2016 242 Multiple Sclerosis - Pipeline by Resverlogix Corp., H1 2016 243 Multiple Sclerosis - Pipeline by ReveraGen BioPharma, Inc., H1 2016 244 Multiple Sclerosis - Pipeline by Rigel Pharmaceuticals, Inc., H1 2016 245 Multiple Sclerosis - Pipeline by SanBio, Inc., H1 2016 246 Multiple Sclerosis - Pipeline by Santhera Pharmaceuticals Holding AG, H1 2016 247 Multiple Sclerosis - Pipeline by Sareum Holdings Plc, H1 2016 248 Multiple Sclerosis - Pipeline by SK Biopharmaceuticals Co., Ltd., H1 2016 249 Multiple Sclerosis - Pipeline by Sorrento Therapeutics, Inc., H1 2016 250 Multiple Sclerosis - Pipeline by Symic Biomedical, Inc., H1 2016 251 Multiple Sclerosis - Pipeline by Synthon Holdings BV, H1 2016 252 Multiple Sclerosis - Pipeline by Targazyme, Inc., H1 2016 253 Multiple Sclerosis - Pipeline by Teikoku Pharma USA, Inc., H1 2016 254 Multiple Sclerosis - Pipeline by Teva Pharmaceutical Industries Ltd., H1 2016 255 Multiple Sclerosis - Pipeline by Therapix Biosciences Ltd, H1 2016 256 Multiple Sclerosis - Pipeline by TikoMed AB, H1 2016 257 Multiple Sclerosis - Pipeline by Toleranzia AB, H1 2016 258 Multiple Sclerosis - Pipeline by Topas Therapeutics GmbH, H1 2016 259 Multiple Sclerosis - Pipeline by TxCell SA, H1 2016 260 Multiple Sclerosis - Pipeline by Vaccinex, Inc., H1 2016 261 Multiple Sclerosis - Pipeline by Vakzine Projekt Management GmbH, H1 2016 262 Multiple Sclerosis - Pipeline by Vertex Pharmaceuticals Incorporated, H1 2016 263 Multiple Sclerosis - Pipeline by Virogenomics BioDevelopment, Inc., H1 2016 264 Multiple Sclerosis - Pipeline by Vitae Pharmaceuticals, Inc., H1 2016 265 Multiple Sclerosis - Pipeline by VivaCell Biotechnology Espana S.L., H1 2016 266 Multiple Sclerosis - Pipeline by Xenetic Biosciences (UK) Limited, H1 2016 267 Multiple Sclerosis - Pipeline by XL-protein GmbH, H1 2016 268 Multiple Sclerosis - Pipeline by Yungjin Pharm. Co., Ltd., H1 2016 269 Multiple Sclerosis - Pipeline by Zydus Cadila Healthcare Limited, H1 2016 270 Assessment by Monotherapy Products, H1 2016 271 Assessment by Combination Products, H1 2016 272 Number of Products by Stage and Target, H1 2016 274 Number of Products by Stage and Mechanism of Action, H1 2016 303 Number of Products by Stage and Route of Administration, H1 2016 321 Number of Products by Stage and Molecule Type, H1 2016 323 Multiple Sclerosis - Dormant Projects, H1 2016 862 Multiple Sclerosis - Dormant Projects (Contd..1), H1 2016 863 Multiple Sclerosis - Dormant Projects (Contd..2), H1 2016 864 Multiple Sclerosis - Dormant Projects (Contd..3), H1 2016 865 Multiple Sclerosis - Dormant Projects (Contd..4), H1 2016 866 Multiple Sclerosis - Dormant Projects (Contd..5), H1 2016 867 Multiple Sclerosis - Dormant Projects (Contd..6), H1 2016 868 Multiple Sclerosis - Dormant Projects (Contd..7), H1 2016 869 Multiple Sclerosis - Dormant Projects (Contd..8), H1 2016 870 Multiple Sclerosis - Dormant Projects (Contd..9), H1 2016 871 Multiple Sclerosis - Dormant Projects (Contd..10), H1 2016 872 Multiple Sclerosis - Dormant Projects (Contd..11), H1 2016 873 Multiple Sclerosis - Dormant Projects (Contd..12), H1 2016 874 Multiple Sclerosis - Dormant Projects (Contd..13), H1 2016 875 Multiple Sclerosis - Dormant Projects (Contd..14), H1 2016 876 Multiple Sclerosis - Dormant Projects (Contd..15), H1 2016 877 Multiple Sclerosis - Dormant Projects (Contd..16), H1 2016 878 Multiple Sclerosis - Dormant Projects (Contd..17), H1 2016 879 Multiple Sclerosis - Dormant Projects (Contd..18), H1 2016 880 Multiple Sclerosis - Dormant Projects (Contd..19), H1 2016 881 Multiple Sclerosis - Dormant Projects (Contd..20), H1 2016 882 Multiple Sclerosis - Dormant Projects (Contd..21), H1 2016 883 Multiple Sclerosis - Dormant Projects (Contd..22), H1 2016 884 Multiple Sclerosis - Dormant Projects (Contd..23), H1 2016 885 Multiple Sclerosis - Discontinued Products, H1 2016 886 Multiple Sclerosis - Discontinued Products (Contd..1), H1 2016 887 Multiple Sclerosis - Discontinued Products (Contd..2), H1 2016 888 Multiple Sclerosis - Discontinued Products (Contd..3), H1 2016 889 Multiple Sclerosis - Discontinued Products (Contd..4), H1 2016 890 List of Figures Number of Products under Development for Multiple Sclerosis, H1 2016 46 Number of Products under Development for Multiple Sclerosis - Comparative Analysis, H1 2016 47 Number of Products under Development by Companies, H1 2016 48 Number of Products under Investigation by Universities/Institutes, H1 2016 64 Comparative Analysis by Late Stage Development, H1 2016 66 Comparative Analysis by Clinical Stage Development, H1 2016 67 Comparative Analysis by Early Stage Products, H1 2016 68 Assessment by Monotherapy Products, H1 2016 271 Assessment by Combination Products, H1 2016 272 Number of Products by Top 10 Targets, H1 2016 273 Number of Products by Stage and Top 10 Targets, H1 2016 273 Number of Products by Top 10 Mechanism of Actions, H1 2016 302 Number of Products by Stage and Top 10 Mechanism of Actions, H1 2016 302 Number of Products by Top 10 Routes of Administration, H1 2016 320 Number of Products by Stage and Top 10 Routes of Administration, H1 2016 320 Number of Products by Top 10 Molecule Types, H1 2016 322 Number of Products by Stage and Top 10 Molecule Types, H1 2016 322

4D Pharma Plc 4SC AG AB Science SA AbbVie Inc. Ablynx NV Acorda Therapeutics, Inc. Actelion Ltd Addex Therapeutics Ltd Adhaere Pharmaceuticals, Inc. Aegis Therapeutics, LLC Affectis Pharmaceuticals AG AiCuris GmbH & Co. KG Alkermes Plc Alpha Cancer Technologies Inc. Amarna Therapeutics B.V. Anavex Life Sciences Corp. Antisense Therapeutics Limited Antitope Limited Aphios Corporation Apitope International NV Arena Pharmaceuticals, Inc. Argos Therapeutics, Inc. Arrien Pharmaceuticals, LLC Artielle ImmunoTherapeutics, Inc. Astellas Pharma Inc. Asterias Biotherapeutics, Inc. Atara Biotherapeutics, Inc. Athersys, Inc. Axxam SpA Baliopharm AG Bio-Cancer Treatment International Limited BioAegis Therapeutics, Inc. BIOCAD Biocon Limited Biogen, Inc. Biogenomics Limited Biokine Therapeutics Ltd. Biomar Microbial Technologies Bionature E.A. Ltd. Bioncotech Therapeutics S.L. Bionovis SA Bionure Farma, S.L. Biovista Inc. Bird Rock Bio, Inc. Bolder Biotechnology, Inc. BrainStorm Cell Therapeutics Inc. C4X Discovery Holdings PLC Caladrius Biosciences, Inc. CASI Pharmaceuticals Inc. Catalyst Pharmaceuticals, Inc. Celgene Corporation Cell Cure Neurosciences, Ltd. Cell2B S.A. Cellceutix Corporation Chong Kun Dang Pharmaceutical Corp. Cognosci, Inc. Coherus BioSciences, Inc. Commence Bio, Inc. Compugen Ltd. Connexios Life Sciences Pvt. Ltd. Critical Outcome Technologies Inc. CuraVac, Inc. Cyxone AB Dimerix Bioscience Pty Ltd Eisai Co., Ltd. Endece, LLC Euroscreen S.A. Evgen Pharma Plc Evotec AG F. Hoffmann-La Roche Ltd. Flex Pharma, Inc. Forward Pharma A/S FPRT Bio Inc. Gemac Genervon Biopharmaceuticals, LLC GeNeuro SA Genzyme Corporation GlaxoSmithKline Plc Glialogix, Inc. Hansa Medical AB Hanwha Chemical Corporation Harbor Therapeutics, Inc. HitGen LTD Hutchison MediPharma Limited Iltoo Pharma Immune Response BioPharma, Inc. ImmuNext, Inc. Immungenetics AG InDex Pharmaceuticals AB Innate Immunotherapeutics Ltd Inovio Pharmaceuticals, Inc. Io Therapeutics, Inc. Jyant Technologies, Inc. Kadimastem Ltd. Kadmon Corporation, LLC KAHR medical Ltd. KaloBios Pharmaceuticals, Inc. Kareus Therapeutics, SA Karo Pharma AB Karyopharm Therapeutics, Inc. Kezar Life Sciences, Inc. Kineta, Inc. Kyorin Pharmaceutical Co., Ltd. Lead Discovery Center GmbH LFB S.A. Lipocure Ltd. MacroGenics, Inc. MAKScientific, LLC Mallinckrodt Plc Mapi Pharma Ltd. Marathon Pharmaceuticals, LLC MedAnnex Ltd MedDay SA Medestea Research & Production S.p.A. MedImmune, LLC Meiji Seika Pharma Co., Ltd. Merck KGaA Meta-IQ ApS Mitochon Pharmaceuticals, Inc. Mitsubishi Tanabe Pharma Corporation MorphoSys AG Neuralstem, Inc. Neuren Pharmaceuticals Limited Neurotec Pharma SL New World Laboratories, Inc. Novartis AG NovImmune SA Nuevolution AB Octapharma AG Omeros Corporation OncoImmune, Inc. Opexa Therapeutics, Inc. OPKO Health, Inc. OSE Immunotherapeutics Parvus Therapeutics, Inc. Peptinov SAS Pfenex Inc. Pfizer Inc. PharmaEssentia Corporation PharmatrophiX, Inc. Pharmaxis Limited Pieris Pharmaceuticals, Inc. Plexxikon Inc. ProNoxis AB Prothena Corporation Plc Q Therapeutics, Inc. ReceptoPharm, Inc. RedHill Biopharma Ltd. RegeneRx Biopharmaceuticals, Inc. Regenesance BV Resverlogix Corp. ReveraGen BioPharma, Inc. Rigel Pharmaceuticals, Inc. SanBio, Inc. Santhera Pharmaceuticals Holding AG Sareum Holdings Plc SK Biopharmaceuticals Co., Ltd. Sorrento Therapeutics, Inc. Symic Biomedical, Inc. Synthon Holdings BV Targazyme, Inc. Teikoku Pharma USA, Inc. Teva Pharmaceutical Industries Ltd. Therapix Biosciences Ltd TikoMed AB Toleranzia AB Topas Therapeutics GmbH TxCell SA Vaccinex, Inc. Vakzine Projekt Management GmbH Vertex Pharmaceuticals Incorporated Virogenomics BioDevelopment, Inc. Vitae Pharmaceuticals, Inc. VivaCell Biotechnology Espana S.L. Xenetic Biosciences (UK) Limited XL-protein GmbH Yungjin Pharm. Co., Ltd. Zydus Cadila Healthcare Limited