Table of Contents Table of Contents 2 Introduction 8 Age Related Macular Degeneration Overview 9 Therapeutics Development 10 Age Related Macular Degeneration - Therapeutics under Development by Companies 12 Age Related Macular Degeneration - Therapeutics under Investigation by Universities/Institutes 23 Age Related Macular Degeneration - Pipeline Products Glance 24 Age Related Macular Degeneration - Products under Development by Companies 28 Age Related Macular Degeneration - Products under Investigation by Universities/Institutes 40 Age Related Macular Degeneration - Companies Involved in Therapeutics Development 41 Age Related Macular Degeneration - Therapeutics Assessment 157 Drug Profiles 172 Age Related Macular Degeneration - Recent Pipeline Updates 436 Age Related Macular Degeneration - Dormant Projects 535 Age Related Macular Degeneration - Discontinued Products 549 Age Related Macular Degeneration - Product Development Milestones 550 Appendix 557

AC Immune SA Achillion Pharmaceuticals, Inc. Aciont Inc. AdAlta Pty Ltd. Adverum Biotechnologies, Inc. Aerie Pharmaceuticals, Inc. Aerpio Therapeutics, Inc. Alimera Sciences, Inc. Alkeus Pharmaceuticals, Inc. Allergan Plc Allinky Biopharma Alteogen Inc. Amakem NV Amarna Therapeutics B.V. Ampio Pharmaceuticals, Inc. Amyndas Pharmaceuticals LLC Apellis Pharmaceuticals, Inc. Apexigen, Inc. Applied Genetic Technologies Corporation Astellas Pharma Inc. Benitec Biopharma Limited BIOCAD Biokine Therapeutics Ltd. BioMAS Ltd. Biomics Biotechnologies Co., Ltd. Biophytis SAS Boehringer Ingelheim GmbH Caladrius Biosciences, Inc. Catalyst Biosciences, Inc. Cell Cure Neurosciences, Ltd. Charlesson LLC. Cipla Ltd. Clanotech AB Clearside BioMedical, Inc. Clonz Biotech Private Limited Coherus BioSciences, Inc. Colby Pharmaceutical Company Crinetics Pharmaceuticals, Inc. Critical Pharmaceuticals Limited Daiichi Sankyo Company, Limited Delenex Therapeutics AG Diffusion Pharmaceuticals Inc. Digna Biotech, S.L. Eleven Biotherapeutics Inc. Elsalys Biotech SAS Exonate Limited F. Hoffmann-La Roche Ltd. Foamix Pharmaceuticals Ltd. Formycon AG Gene Techno Science Co., Ltd. Genentech, Inc. GenSight Biologics S.A. GlaxoSmithKline Plc Grupo Ferrer Internacional, S.A. GTx, Inc. HanAll Biopharma Co., Ltd. Huabo Biopharm Co., Ltd. iCo Therapeutics Inc. Icon Bioscience, Inc. Iconic Therapeutics, Inc. Innovent Biologics, Inc. Intellect Neurosciences, Inc. International Stem Cell Corporation Ionis Pharmaceuticals, Inc. Jeil Pharmaceutical Co., Ltd. Johnson & Johnson Kadmon Corporation, LLC Kala Pharmaceuticals, Inc. Kodiak Sciences, Inc. LeadArtis S.L. M's Science Corporation Mabion SA MacuCLEAR, Inc. Mitotech S.A. Mitsubishi Tanabe Pharma Corporation Navigen Pharmaceuticals, Inc. Navya Biologicals Pvt Ltd Neovacs SA Neumedicines Inc. Neuroptis Biotech Neurotech Pharmaceuticals, Inc. Novartis AG Ocular Therapeutix, Inc. Ohr Pharmaceutical Inc. Omeros Corporation Ophthotech Corp. Orphagen Pharmaceuticals, Inc. Oxford BioMedica Plc PanOptica, Inc. Pfenex Inc. Pfizer Inc. Precision Ocular Ltd Promedior, Inc. pSivida Corp. QLT Inc. Quark Pharmaceuticals, Inc. Ra Pharmaceuticals, Inc. Regeneron Pharmaceuticals, Inc. RegenxBio Inc. Ribomic Inc. RXi Pharmaceuticals Corporation SanBio, Inc. Santen Pharmaceutical Co., Ltd. Sanwa Kagaku Kenkyusho Co., Ltd. SciFluor Life Sciences, LLC Sirnaomics, Inc. Stealth BioTherapeutics Inc. Sucampo Pharmaceuticals, Inc. Sumitomo Dainippon Pharma Co., Ltd. Sun Pharma Advanced Research Company Ltd. TRACON Pharmaceuticals, Inc. TWi Pharmaceuticals, Inc. Tyrogenex, Inc. VasGene Therapeutics, Inc. Wellstat Ophthalmics Corporation Xbrane Biopharma AB