1 Table of Contents 1 Table of Contents 2 1.1 List of Tables 4 1.2 List of Figures 5 2 Introduction 6 2.1 Nucleus Replacement Overview 6 3 Products under Development 7 3.1 Nucleus Replacement - Pipeline Products by Stage of Development 7 3.2 Nucleus Replacement - Pipeline Products by Territory 8 3.3 Nucleus Replacement - Pipeline Products by Regulatory Path 9 3.4 Nucleus Replacement - Pipeline Products by Estimated Approval Date 10 3.5 Nucleus Replacement - Ongoing Clinical Trials 11 4 Nucleus Replacement - Pipeline Products under Development by Companies 12 4.1 Nucleus Replacement Companies - Pipeline Products by Stage of Development 12 4.2 Nucleus Replacement - Pipeline Products by Stage of Development 13 5 Nucleus Replacement Companies and Product Overview 14 5.1 Arthro Kinetics AG Company Overview 14 5.1.1 Arthro Kinetics AG Pipeline Products & Ongoing Clinical Trials Overview 14 5.2 Chi2Gel Ltd. Company Overview 15 5.2.1 Chi2Gel Ltd. Pipeline Products & Ongoing Clinical Trials Overview 15 5.3 Clariance SAS Company Overview 16 5.3.1 Clariance SAS Pipeline Products & Ongoing Clinical Trials Overview 16 5.4 CryoLife, Inc. Company Overview 17 5.4.1 CryoLife, Inc. Pipeline Products & Ongoing Clinical Trials Overview 17 5.5 Gentis Inc. Company Overview 19 5.5.1 Gentis Inc. Pipeline Products & Ongoing Clinical Trials Overview 19 5.6 Hydrospine, Inc. Company Overview 22 5.6.1 Hydrospine, Inc. Pipeline Products & Ongoing Clinical Trials Overview 22 5.7 Raymedica, LLC Company Overview 23 5.7.1 Raymedica, LLC Pipeline Products & Ongoing Clinical Trials Overview 23 5.8 Replication Medical, Inc. Company Overview 25 5.8.1 Replication Medical, Inc. Pipeline Products & Ongoing Clinical Trials Overview 25 5.9 Spinalcyte Llc Company Overview 26 5.9.1 Spinalcyte Llc Pipeline Products & Ongoing Clinical Trials Overview 26 5.10 Spine Wave, Inc. Company Overview 27 5.10.1 Spine Wave, Inc. Pipeline Products & Ongoing Clinical Trials Overview 27 5.11 Stryker Corporation Company Overview 29 5.11.1 Stryker Corporation Pipeline Products & Ongoing Clinical Trials Overview 29 5.12 Synthes, Inc. Company Overview 31 5.12.1 Synthes, Inc. Pipeline Products & Ongoing Clinical Trials Overview 31 5.13 TranS1 Inc Company Overview 32 5.13.1 TranS1 Inc Pipeline Products & Ongoing Clinical Trials Overview 32 5.14 Vertebral Technologies, Inc. Company Overview 35 5.14.1 Vertebral Technologies, Inc. Pipeline Products & Ongoing Clinical Trials Overview 35 5.15 Zimmer Biomet Holdings, Inc. Company Overview 38 5.15.1 Zimmer Biomet Holdings, Inc. Pipeline Products & Ongoing Clinical Trials Overview 38 6 Nucleus Replacement- Recent Developments 40 6.1 May 04, 2016: SpinalCyte Receives New United States Patent for Spinal Disc Tissue Engineering 40 6.2 Apr 22, 2016: SpinalCyte Receives New Canadian Patent for Spinal Disc Tissue Engineering 40 6.3 Apr 19, 2016: SpinalCyte Announces Final Results From Phase II Animal Trials Using Human Dermal Fibroblast Transplantation for Intervertebral Disc Degeneration 40 6.4 Mar 29, 2016: SpinalCyte Announces New Results from Phase II Animal Trials of Cell Therapy to Regenerate the Spinal Disc 41 7 Appendix 42 7.1 Methodology 42 7.2 About GlobalData 45 7.3 Contact Us 45 7.4 Disclaimer 45

1.1 List of Tables Table 1: Nucleus Replacement - Pipeline Products by Stage of Development 7 Table 2: Nucleus Replacement - Pipeline Products by Territory 8 Table 3: Nucleus Replacement - Pipeline Products by Regulatory Path 9 Table 4: Nucleus Replacement - Pipeline Products by Estimated Approval Date 10 Table 5: Nucleus Replacement - Ongoing Clinical Trials 11 Table 6: Nucleus Replacement Companies - Pipeline Products by Stage of Development 12 Table 7: Nucleus Replacement - Pipeline Products by Stage of Development 13 Table 8: Arthro Kinetics AG Pipeline Products & Ongoing Clinical Trials Overview 14 Table 9: NuReS - Product Status 14 Table 10: NuReS - Product Description 14 Table 11: Chi2Gel Ltd. Pipeline Products & Ongoing Clinical Trials Overview 15 Table 12: Chi2Disc - Product Status 15 Table 13: Chi2Disc - Product Description 15 Table 14: Clariance SAS Pipeline Products & Ongoing Clinical Trials Overview 16 Table 15: NucleoFill - Product Status 16 Table 16: NucleoFill - Product Description 16 Table 17: CryoLife, Inc. Pipeline Products & Ongoing Clinical Trials Overview 17 Table 18: Biodisc Nucleus Pulposus Replacement - Product Status 17 Table 19: Biodisc Nucleus Pulposus Replacement - Product Description 18 Table 20: Gentis Inc. Pipeline Products & Ongoing Clinical Trials Overview 19 Table 21: DiscCell - Product Status 19 Table 22: DiscCell - Product Description 19 Table 23: Gentis Inc. - Ongoing Clinical Trials Overview 20 Table 24: DiscCell - Pivotal Clinical Study Of DiscCell Augmentation Versus Microdiscectomy 21 Table 25: Hydrospine, Inc. Pipeline Products & Ongoing Clinical Trials Overview 22 Table 26: Intervertebral Disc Repair System - Product Status 22 Table 27: Intervertebral Disc Repair System - Product Description 22 Table 28: Raymedica, LLC Pipeline Products & Ongoing Clinical Trials Overview 23 Table 29: HydraFlex Nucleus Arthroplasty System - Product Status 23 Table 30: HydraFlex Nucleus Arthroplasty System - Product Description 24 Table 31: PDN-SOLO XL - Product Status 24 Table 32: PDN-SOLO XL - Product Description 24 Table 33: Replication Medical, Inc. Pipeline Products & Ongoing Clinical Trials Overview 25 Table 34: NeuDisc - Product Status 25 Table 35: NeuDisc - Product Description 25 Table 36: Spinalcyte Llc Pipeline Products & Ongoing Clinical Trials Overview 26 Table 37: Spinal Disc Tissue Regenerator - Product Status 26 Table 38: Spinal Disc Tissue Regenerator - Product Description 26 Table 39: Spine Wave, Inc. Pipeline Products & Ongoing Clinical Trials Overview 27 Table 40: NuCore Injectable Nucleus - Product Status 27 Table 41: NuCore Injectable Nucleus - Product Description 28 Table 42: NuCore RPXL Injectable Nucleus - Product Status 28 Table 43: NuCore RPXL Injectable Nucleus - Product Description 28 Table 44: Stryker Corporation Pipeline Products & Ongoing Clinical Trials Overview 29 Table 45: Aquarelle - Product Status 29 Table 46: Aquarelle - Product Description 30 Table 47: Synthes, Inc. Pipeline Products & Ongoing Clinical Trials Overview 31 Table 48: Hydrafil - Product Status 31 Table 49: Hydrafil - Product Description 31 Table 50: TranS1 Inc Pipeline Products & Ongoing Clinical Trials Overview 32 Table 51: Percutaneous Nucleus Replacement - Product Status 32 Table 52: Percutaneous Nucleus Replacement - Product Description 32 Table 53: TranS1 Inc - Ongoing Clinical Trials Overview 33 Table 54: Percutaneous Nucleus Replacement - Feasibility Study To Assess The Safety And Effectiveness Of The PNR 34 Table 55: Vertebral Technologies, Inc. Pipeline Products & Ongoing Clinical Trials Overview 35 Table 56: InterCushion Disc Nucleus Replacement System - Product Status 35 Table 57: InterCushion Disc Nucleus Replacement System - Product Description 35 Table 58: Vertebral Technologies, Inc. - Ongoing Clinical Trials Overview 36 Table 59: InterCushion Disc Nucleus Replacement System - A Pilot Clinical Study to Assess the Safety and Effectiveness of the InterCushion Disc Nucleus Prosthesis in Patients Receiving Discectomy 37 Table 60: Zimmer Biomet Holdings, Inc. Pipeline Products & Ongoing Clinical Trials Overview 38 Table 61: Newcleus - Product Status 38 Table 62: Newcleus - Product Description 38 Table 63: Regain Lumbar Artificial Disc - Product Status 39 Table 64: Regain Lumbar Artificial Disc - Product Description 39 Table 65: Glossary 43 1.2 List of Figures Figure 1: Nucleus Replacement - Pipeline Products by Stage of Development 7 Figure 2: Nucleus Replacement - Pipeline Products by Territory 8 Figure 3: Nucleus Replacement - Pipeline Products by Regulatory Path 9 Figure 4: Nucleus Replacement - Pipeline Products by Estimated Approval Date 10 Figure 5: Nucleus Replacement - Ongoing Clinical Trials 11

Arthro Kinetics AG Chi2Gel Ltd. Clariance SAS CryoLife, Inc. Gentis Inc. Hydrospine, Inc. Raymedica, LLC Replication Medical, Inc. Spinalcyte Llc Spine Wave, Inc. Stryker Corporation Synthes, Inc. TranS1 Inc Vertebral Technologies, Inc. Zimmer Biomet Holdings, Inc.