1 Table of Contents 1 Table of Contents 2 1.1 List of Tables 4 1.2 List of Figures 6 2 Introduction 7 2.1 Intracranial Pressure Monitoring Devices Overview 7 3 Products under Development 8 3.1 Intracranial Pressure Monitoring Devices - Pipeline Products by Stage of Development 8 3.2 Intracranial Pressure Monitoring Devices - Pipeline Products by Territory 9 3.3 Intracranial Pressure Monitoring Devices - Pipeline Products by Regulatory Path 10 3.4 Intracranial Pressure Monitoring Devices - Pipeline Products by Estimated Approval Date 11 3.5 Intracranial Pressure Monitoring Devices - Ongoing Clinical Trials 12 4 Intracranial Pressure Monitoring Devices - Pipeline Products under Development by Companies 13 4.1 Intracranial Pressure Monitoring Devices Companies - Pipeline Products by Stage of Development 13 4.2 Intracranial Pressure Monitoring Devices - Pipeline Products by Stage of Development 14 5 Intracranial Pressure Monitoring Devices Companies and Product Overview 15 5.1 Ad-Tech Medical Instrument Corporation Company Overview 15 5.1.1 Ad-Tech Medical Instrument Corporation Pipeline Products & Ongoing Clinical Trials Overview 15 5.2 HeadSense Medical Ltd. Company Overview 16 5.2.1 HeadSense Medical Ltd. Pipeline Products & Ongoing Clinical Trials Overview 16 5.3 Integrated Sensing Systems, Inc. Company Overview 24 5.3.1 Integrated Sensing Systems, Inc. Pipeline Products & Ongoing Clinical Trials Overview 24 5.4 Koronis Biomedical Technologies Corporation Company Overview 26 5.4.1 Koronis Biomedical Technologies Corporation Pipeline Products & Ongoing Clinical Trials Overview 26 5.5 Neural Analytics, Inc. Company Overview 27 5.5.1 Neural Analytics, Inc. Pipeline Products & Ongoing Clinical Trials Overview 27 5.6 NeuroDx Development LLC Company Overview 28 5.6.1 NeuroDx Development LLC Pipeline Products & Ongoing Clinical Trials Overview 28 5.7 Northwestern University Company Overview 29 5.7.1 Northwestern University Pipeline Products & Ongoing Clinical Trials Overview 29 5.8 Orsan Medical Technologies Ltd. Company Overview 30 5.8.1 Orsan Medical Technologies Ltd. Pipeline Products & Ongoing Clinical Trials Overview 30 5.9 The Feinstein Institute for Medical Research Company Overview 31 5.9.1 The Feinstein Institute for Medical Research Pipeline Products & Ongoing Clinical Trials Overview 31 5.10 Third Eye Diagnostics, Inc. Company Overview 32 5.10.1 Third Eye Diagnostics, Inc. Pipeline Products & Ongoing Clinical Trials Overview 32 5.11 University of Illinois Company Overview 33 5.11.1 University of Illinois Pipeline Products & Ongoing Clinical Trials Overview 33 5.12 Vittamed Corporation Company Overview 34 5.12.1 Vittamed Corporation Pipeline Products & Ongoing Clinical Trials Overview 34 5.13 Vivonics, Inc. Company Overview 36 5.13.1 Vivonics, Inc. Pipeline Products & Ongoing Clinical Trials Overview 36 5.14 Washington University in St. Louis Company Overview 37 5.14.1 Washington University in St. Louis Pipeline Products & Ongoing Clinical Trials Overview 37 5.15 Wisconsin Institute of Nuclear Systems Company Overview 38 5.15.1 Wisconsin Institute of Nuclear Systems Pipeline Products & Ongoing Clinical Trials Overview 38 6 Intracranial Pressure Monitoring Devices- Recent Developments 40 6.1 May 09, 2016: Penumbra Reports First Quarter 2016 Financial Results 40 6.2 May 04, 2016: Nihon Kohden Awarded New Equipment, Supplies Contract with Premier 40 6.3 Mar 21, 2016: Neural Analytics Awarded National Science Foundation Grant of $743,756 for Non-Invasive Monitoring of Intracranial Pressure for Traumatic Brain Injury 41 6.4 Mar 08, 2016: Penumbra Reports Fourth Quarter and Full Year 2015 Financial Results 41 6.5 Feb 23, 2016: Penumbra Appoints Kevin Sullivan to its Board of Directors 42 6.6 Nov 12, 2015: Penumbra Reports Third Quarter 2015 Financial Results 43 6.7 Oct 16, 2015: Vittamed Raises USD10 Million in Series A Financing 43 6.8 Sep 08, 2015: Penumbra Raises USD138 Million in IPO 43 6.9 Jul 01, 2015: The National Space Biomedical Research Institute Has Selected Ornim Medical's c-FLOW Cerebral Blood Flow Monitor to Explore the Impact of Spaceflight Conditions on Brain Physiology 44 7 Appendix 45 7.1 Methodology 45 7.2 About GlobalData 48 7.3 Contact Us 48 7.4 Disclaimer 48

1.1 List of Tables Table 1: Intracranial Pressure Monitoring Devices - Pipeline Products by Stage of Development 8 Table 2: Intracranial Pressure Monitoring Devices - Pipeline Products by Territory 9 Table 3: Intracranial Pressure Monitoring Devices - Pipeline Products by Regulatory Path 10 Table 4: Intracranial Pressure Monitoring Devices - Pipeline Products by Estimated Approval Date 11 Table 5: Intracranial Pressure Monitoring Devices - Ongoing Clinical Trials 12 Table 6: Intracranial Pressure Monitoring Devices Companies - Pipeline Products by Stage of Development 13 Table 7: Intracranial Pressure Monitoring Devices - Pipeline Products by Stage of Development 14 Table 8: Ad-Tech Medical Instrument Corporation Pipeline Products & Ongoing Clinical Trials Overview 15 Table 9: ICP Monitor - Product Status 15 Table 10: ICP Monitor - Product Description 15 Table 11: HeadSense Medical Ltd. Pipeline Products & Ongoing Clinical Trials Overview 16 Table 12: HeadSense - Cerebral Vasospasm - Product Status 16 Table 13: HeadSense - Cerebral Vasospasm - Product Description 16 Table 14: HeadSense - Concussion - Product Status 17 Table 15: HeadSense - Concussion - Product Description 17 Table 16: HS-1000 - Product Status 18 Table 17: HS-1000 - Product Description 18 Table 18: HeadSense Medical Ltd. - Ongoing Clinical Trials Overview 19 Table 19: HS-1000 - A Prospective, Open-label, Non-randomized, Comparative Study Designed to Evaluate the Accuracy and Safety of HS-1000 Device, a Non-Invasive Intracranial Pressure (ICP) Monitor, in Patients Undergoing Invasive Intracranial Pressure Monitoring Procedure for Various Clinical Conditions 20 Table 20: HeadSense - Cerebral Vasospasm - An Evaluation of Non-invasive Acoustic Approach to Detect and Monitor Cerebral Vasospasm 21 Table 21: HeadSense - Cerebral Vasospasm - An Evaluation of Non-invasive Intracranial Pressure Monitoring in Patients Undergoing Invasive Intracranial Pressure Monitoring via an Intraparenchymal Pressure Monitoring Device 21 Table 22: HeadSense - Cerebral Vasospasm - An Open-label, Non-randomized, Comparative Study Designed to Evaluate the Accuracy and Safety of HS-1000 Device, a Non-invasive Brain Monitor 21 Table 23: HeadSense - Cerebral Vasospasm - Comparison of the Non-invasive ICP Headsense Monitor Verses Lumbar CSF Pressure Measurement 22 Table 24: HeadSense - Concussion - An Open-Label, Non-Randomized Study Designed to Evaluate the Correlation of HS-1000 Device Capabilities in the Diagnosis and Assessment of Patients After Concussion with Clinical Evaluation 23 Table 25: HeadSense - Concussion - Indirect Intracranial Pressure Measurement in Patients with Suspected or Documented Concussion 23 Table 26: Integrated Sensing Systems, Inc. Pipeline Products & Ongoing Clinical Trials Overview 24 Table 27: Intracranial Wireless Pressure Monitoring Sensor - Product Status 24 Table 28: Intracranial Wireless Pressure Monitoring Sensor - Product Description 25 Table 29: Koronis Biomedical Technologies Corporation Pipeline Products & Ongoing Clinical Trials Overview 26 Table 30: Non-Invasive Intracranial Pressure Monitor - Product Status 26 Table 31: Non-Invasive Intracranial Pressure Monitor - Product Description 26 Table 32: Neural Analytics, Inc. Pipeline Products & Ongoing Clinical Trials Overview 27 Table 33: RapidICP - Product Status 27 Table 34: RapidICP - Product Description 27 Table 35: NeuroDx Development LLC Pipeline Products & Ongoing Clinical Trials Overview 28 Table 36: ICPCheck - Product Status 28 Table 37: ICPCheck - Product Description 28 Table 38: Northwestern University Pipeline Products & Ongoing Clinical Trials Overview 29 Table 39: Intracranial Pressure Control System - Product Status 29 Table 40: Intracranial Pressure Control System - Product Description 29 Table 41: Orsan Medical Technologies Ltd. Pipeline Products & Ongoing Clinical Trials Overview 30 Table 42: Non-Invasive Intracranial Pressure Monitor - Product Status 30 Table 43: Non-Invasive Intracranial Pressure Monitor - Product Description 30 Table 44: The Feinstein Institute for Medical Research Pipeline Products & Ongoing Clinical Trials Overview 31 Table 45: Flexible Spirally-rolled Polymer Tube - Product Status 31 Table 46: Flexible Spirally-rolled Polymer Tube - Product Description 31 Table 47: Third Eye Diagnostics, Inc. Pipeline Products & Ongoing Clinical Trials Overview 32 Table 48: Cerepress - Product Status 32 Table 49: Cerepress - Product Description 32 Table 50: University of Illinois Pipeline Products & Ongoing Clinical Trials Overview 33 Table 51: Intracranial Pressure Monitor - Product Status 33 Table 52: Intracranial Pressure Monitor - Product Description 34 Table 53: Vittamed Corporation Pipeline Products & Ongoing Clinical Trials Overview 34 Table 54: Vittamed 205 - Product Status 34 Table 55: Vittamed 205 - Product Description 35 Table 56: Vivonics, Inc. Pipeline Products & Ongoing Clinical Trials Overview 36 Table 57: Vivonics IPASS - Product Status 36 Table 58: Vivonics IPASS - Product Description 36 Table 59: Washington University in St. Louis Pipeline Products & Ongoing Clinical Trials Overview 37 Table 60: Wireless Dissolvable Sensor - Product Status 37 Table 61: Wireless Dissolvable Sensor - Product Description 37 Table 62: Wisconsin Institute of Nuclear Systems Pipeline Products & Ongoing Clinical Trials Overview 38 Table 63: Implantable Intracranial Pressure Monitor - Product Status 38 Table 64: Implantable Intracranial Pressure Monitor - Product Description 39 Table 65: Glossary 46 1.2 List of Figures Figure 1: Intracranial Pressure Monitoring Devices - Pipeline Products by Stage of Development 8 Figure 2: Intracranial Pressure Monitoring Devices - Pipeline Products by Territory 9 Figure 3: Intracranial Pressure Monitoring Devices - Pipeline Products by Regulatory Path 10 Figure 4: Intracranial Pressure Monitoring Devices - Pipeline Products by Estimated Approval Date 11 Figure 5: Intracranial Pressure Monitoring Devices - Ongoing Clinical Trials 12

Ad-Tech Medical Instrument Corporation HeadSense Medical Ltd. Integrated Sensing Systems, Inc. Koronis Biomedical Technologies Corporation Neural Analytics, Inc. NeuroDx Development LLC Northwestern University Orsan Medical Technologies Ltd. The Feinstein Institute for Medical Research Third Eye Diagnostics, Inc. University of Illinois Vittamed Corporation Vivonics, Inc. Washington University in St. Louis Wisconsin Institute of Nuclear Systems