Table of Contents Table of Contents 2 List of Tables 7 List of Figures 8 Introduction 9 Global Markets Direct Report Coverage 9 Chikungunya Overview 10 Therapeutics Development 11 Pipeline Products for Chikungunya – Overview 11 Pipeline Products for Chikungunya – Comparative Analysis 12 Chikungunya – Therapeutics under Development by Companies 13 Chikungunya – Therapeutics under Investigation by Universities/Institutes 15 Chikungunya – Pipeline Products Glance 16 Clinical Stage Products 16 Early Stage Products 17 Chikungunya – Products under Development by Companies 18 Chikungunya – Products under Investigation by Universities/Institutes 19 Chikungunya – Companies Involved in Therapeutics Development 20 Abivax S.A. 20 Arbovax, Inc. 21 Arno Therapeutics, Inc. 22 Bharat Biotech International Limited 23 Etubics Corporation 24 Indian Immunologicals Limited 25 Inovio Pharmaceuticals, Inc. 26 Integral Molecular, Inc. 27 Integrated BioTherapeutics, Inc. 28 Merck & Co., Inc. 29 Nanotherapeutics, Inc. 30 PaxVax, Inc. 31 Profectus BioSciences, Inc. 32 Takeda Pharmaceutical Company Limited 33 Themis Bioscience GmbH 34 Valneva SE 35 Chikungunya – Therapeutics Assessment 36 Assessment by Monotherapy Products 36 Assessment by Target 37 Assessment by Mechanism of Action 39 Assessment by Route of Administration 41 Assessment by Molecule Type 43 Drug Profiles 45 ABX-309 - Drug Profile 45 Product Description 45 Mechanism of Action 45 R&D Progress 45 Antibody for Chikungunya - Drug Profile 46 Product Description 46 Mechanism of Action 46 R&D Progress 46 AR-12 - Drug Profile 47 Product Description 47 Mechanism of Action 47 R&D Progress 47 chikungunya (viral like particles) vaccine - Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 chikungunya vaccine - Drug Profile 50 Product Description 50 Mechanism of Action 50 R&D Progress 50 chikungunya vaccine - Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 chikungunya vaccine - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 chikungunya vaccine - Drug Profile 53 Product Description 53 Mechanism of Action 53 R&D Progress 53 chikungunya vaccine - Drug Profile 54 Product Description 54 Mechanism of Action 54 R&D Progress 54 chikungunya vaccine - Drug Profile 55 Product Description 55 Mechanism of Action 55 R&D Progress 55 chikungunya vaccine - Drug Profile 56 Product Description 56 Mechanism of Action 56 R&D Progress 56 chikungunya vaccine - Drug Profile 57 Product Description 57 Mechanism of Action 57 R&D Progress 57 chikungunya vaccine - Drug Profile 58 Product Description 58 Mechanism of Action 58 R&D Progress 58 chikungunya vaccine - Drug Profile 59 Product Description 59 Mechanism of Action 59 R&D Progress 59 chikungunya vaccine - Drug Profile 60 Product Description 60 Mechanism of Action 60 R&D Progress 60 chikungunya vaccine - Drug Profile 61 Product Description 61 Mechanism of Action 61 R&D Progress 61 chikungunya vaccine - Drug Profile 62 Product Description 62 Mechanism of Action 62 R&D Progress 62 chikungunya vaccine - Drug Profile 63 Product Description 63 Mechanism of Action 63 R&D Progress 63 chikungunya vaccine - Drug Profile 64 Product Description 64 Mechanism of Action 64 R&D Progress 64 DEF-201 - Drug Profile 65 Product Description 65 Mechanism of Action 65 R&D Progress 65 IMCKV-063 - Drug Profile 67 Product Description 67 Mechanism of Action 67 R&D Progress 67 Monoclonal Antibodies for Chikungunya - Drug Profile 68 Product Description 68 Mechanism of Action 68 R&D Progress 68 Monoclonal Antibodies for Equine Encephalitis and Chikungunya - Drug Profile 69 Product Description 69 Mechanism of Action 69 R&D Progress 69 Monoclonal Antibodies to Inhibit CHIKV E2 for Chikungunya - Drug Profile 70 Product Description 70 Mechanism of Action 70 R&D Progress 70 Monoclonal Antibodies to Inhibit Viral E1/E2 Proteins for Chikungunya - Drug Profile 71 Product Description 71 Mechanism of Action 71 R&D Progress 71 Monoclonal Antibody for Chikungunya - Drug Profile 72 Product Description 72 Mechanism of Action 72 R&D Progress 72 MV-CHIK - Drug Profile 73 Product Description 73 Mechanism of Action 73 R&D Progress 73 Small Molecule to Inhibit NS2 and NS3 for Chikungunya - Drug Profile 74 Product Description 74 Mechanism of Action 74 R&D Progress 74 Small Molecules to Inhibit Viral RNA for Chikungunya Virus Infections - Drug Profile 75 Product Description 75 Mechanism of Action 75 R&D Progress 75 Chikungunya – Recent Pipeline Updates 76 Chikungunya - Dormant Projects 80 Chikungunya – Product Development Milestones 81 Featured News & Press Releases 81 Mar 22, 2016: Inovio’s DNA-based Monoclonal Antibody and DNA Vaccine Provide 100% Protection Against Lethal Chikungunya Virus Challenge in Preclinical Study 81 Sep 19, 2015: Arno Therapeutics Data Demonstrates Novel Antimicrobial Activity of AR-12, Identified it as Lead Compound of New Class of Drugs 82 Mar 02, 2015: Themis Bioscience’s Chikungunya Vaccine Study Results Published in The Lancet Infectious Diseases 84 Dec 10, 2014: Integral Molecular identifies potent inhibitory antibodies against Chikungunya virus 84 Nov 20, 2014: Themis Bioscience’s Vaccine Against Chikunguya Successful In Phase 1 85 Jun 12, 2014: Threat of Emerging Virus can be Stopped: Interim results of First Clinical Trial of Themis Bioscience's Vaccine Candidate Against Chikungunya Fever Prove Successful 86 Mar 27, 2013: Themis Bioscience Plans To Initiate Phase I Study Of Chikungunya Fever Vaccine Candidate 87 Aug 15, 2011: Inviragen And University of Texas Medical Branch Receive Funding For Development Of Chikungunya Virus Vaccine 87 Nov 04, 2010: Novel Recombinant Chikungunya Virus Vaccine Shown To Be Safe And Effective In Multiple Animal Models 88 Nov 02, 2010: Inviragen Receives Two Therapeutic Discovery Project Grants For Vaccine Development 88 Appendix 89 Methodology 89 Coverage 89 Secondary Research 89 Primary Research 89 Expert Panel Validation 89 Contact Us 89 Disclaimer 90

List of Tables Number of Products under Development for Chikungunya, H1 2016 11 Number of Products under Development for Chikungunya – Comparative Analysis, H1 2016 12 Number of Products under Development by Companies, H1 2016 14 Number of Products under Investigation by Universities/Institutes, H1 2016 15 Comparative Analysis by Clinical Stage Development, H1 2016 16 Comparative Analysis by Early Stage Development, H1 2016 17 Products under Development by Companies, H1 2016 18 Products under Investigation by Universities/Institutes, H1 2016 19 Chikungunya – Pipeline by Abivax S.A., H1 2016 20 Chikungunya – Pipeline by Arbovax, Inc., H1 2016 21 Chikungunya – Pipeline by Arno Therapeutics, Inc., H1 2016 22 Chikungunya – Pipeline by Bharat Biotech International Limited, H1 2016 23 Chikungunya – Pipeline by Etubics Corporation, H1 2016 24 Chikungunya – Pipeline by Indian Immunologicals Limited, H1 2016 25 Chikungunya – Pipeline by Inovio Pharmaceuticals, Inc., H1 2016 26 Chikungunya – Pipeline by Integral Molecular, Inc., H1 2016 27 Chikungunya – Pipeline by Integrated BioTherapeutics, Inc., H1 2016 28 Chikungunya – Pipeline by Merck & Co., Inc., H1 2016 29 Chikungunya – Pipeline by Nanotherapeutics, Inc., H1 2016 30 Chikungunya – Pipeline by PaxVax, Inc., H1 2016 31 Chikungunya – Pipeline by Profectus BioSciences, Inc., H1 2016 32 Chikungunya – Pipeline by Takeda Pharmaceutical Company Limited, H1 2016 33 Chikungunya – Pipeline by Themis Bioscience GmbH, H1 2016 34 Chikungunya – Pipeline by Valneva SE, H1 2016 35 Assessment by Monotherapy Products, H1 2016 36 Number of Products by Stage and Target, H1 2016 38 Number of Products by Stage and Mechanism of Action, H1 2016 40 Number of Products by Stage and Route of Administration, H1 2016 42 Number of Products by Stage and Molecule Type, H1 2016 44 Chikungunya Therapeutics – Recent Pipeline Updates, H1 2016 76 Chikungunya – Dormant Projects, H1 2016 80 List of Figures Number of Products under Development for Chikungunya, H1 2016 11 Number of Products under Development for Chikungunya – Comparative Analysis, H1 2016 12 Number of Products under Development by Companies, H1 2016 13 Number of Products under Investigation by Universities/Institutes, H1 2016 15 Comparative Analysis by Clinical Stage Development, H1 2016 16 Comparative Analysis by Early Stage Products, H1 2016 17 Assessment by Monotherapy Products, H1 2016 36 Number of Products by Top 10 Targets, H1 2016 37 Number of Products by Stage and Top 10 Targets, H1 2016 37 Number of Products by Top 10 Mechanism of Actions, H1 2016 39 Number of Products by Stage and Top 10 Mechanism of Actions, H1 2016 39 Number of Products by Routes of Administration, H1 2016 41 Number of Products by Stage and Routes of Administration, H1 2016 41 Number of Products by Top 10 Molecule Types, H1 2016 43 Number of Products by Stage and Top 10 Molecule Types, H1 2016 43

Abivax S.A. Arbovax, Inc. Arno Therapeutics, Inc. Bharat Biotech International Limited Etubics Corporation Indian Immunologicals Limited Inovio Pharmaceuticals, Inc. Integral Molecular, Inc. Integrated BioTherapeutics, Inc. Merck & Co., Inc. Nanotherapeutics, Inc. PaxVax, Inc. Profectus BioSciences, Inc. Takeda Pharmaceutical Company Limited Themis Bioscience GmbH Valneva SE