1 Table of Contents 1 Table of Contents 2 1.1 List of Tables 4 1.2 List of Figures 4 2 Introduction 5 2.1 Ankle Replacement Overview 5 3 Products under Development 6 3.1 Ankle Replacement - Pipeline Products by Stage of Development 6 3.2 Ankle Replacement - Pipeline Products by Segment 7 3.3 Ankle Replacement - Pipeline Products by Territory 8 3.4 Ankle Replacement - Pipeline Products by Regulatory Path 9 3.5 Ankle Replacement - Pipeline Products by Estimated Approval Date 10 4 Ankle Replacement - Pipeline Products under Development by Companies 11 4.1 Ankle Replacement Companies - Pipeline Products by Stage of Development 11 4.2 Ankle Replacement - Pipeline Products by Stage of Development 12 5 Ankle Replacement Companies and Product Overview 13 5.1 Exactech, Inc. Company Overview 13 5.1.1 Exactech, Inc. Pipeline Products & Ongoing Clinical Trials Overview 13 5.2 Implants International Limited Company Overview 15 5.2.1 Implants International Limited Pipeline Products & Ongoing Clinical Trials Overview 15 5.3 Integra LifeSciences Holdings Corporation Company Overview 16 5.3.1 Integra LifeSciences Holdings Corporation Pipeline Products & Ongoing Clinical Trials Overview 16 5.4 NDSU Research Foundation Company Overview 18 5.4.1 NDSU Research Foundation Pipeline Products & Ongoing Clinical Trials Overview 18 5.5 Wright Medical Group N.V. Company Overview 19 5.5.1 Wright Medical Group N.V. Pipeline Products & Ongoing Clinical Trials Overview 19 5.6 Zimmer Biomet Holdings, Inc. Company Overview 21 5.6.1 Zimmer Biomet Holdings, Inc. Pipeline Products & Ongoing Clinical Trials Overview 21 6 Ankle Replacement- Recent Developments 23 6.1 Apr 28, 2016: Orthofix International Reports First Quarter 2016 Financial Results 23 6.2 Apr 27, 2016: Integra LifeSciences Reports First Quarter 2016 Financial Results 24 6.3 Apr 26, 2016: Integra LifeSciences Announces Initial Clinical Use of the Cadence Total Ankle System in the United States 25 6.4 Apr 21, 2016: Exactech Receives FDA 510(k) Clearance for Vantage Total Ankle 25 6.5 Mar 02, 2016: Wright Medical Group Highlights Recent Innovation INFINITY Total Ankle Replacement System at the American Academy of Orthopaedic Surgeons 2016 Annual Meeting 26 6.6 Feb 29, 2016: Orthofix International Reports Fourth Quarter and Fiscal 2015 Financial Results 26 6.7 Feb 25, 2016: Integra LifeSciences Reports Fourth Quarter and Full Year 2015 Financial Results and Issues 2016 Full Year Guidance 28 6.8 Jan 12, 2016: Orthofix Announces Preliminary Fourth Quarter 2015 and Full Year Net Sales Results 29 6.9 Nov 03, 2015: Orthofix International Reports Third Quarter 2015 Financial Results 30 6.10 Nov 03, 2015: Integra LifeSciences Reports Third Quarter 2015 Financial Results 32 6.11 Oct 01, 2015: Novadaq Technologies Enters into Co-Marketing Agreement with Arthrex 32 6.12 Sep 03, 2015: Integra LifeSciences Acquires Ankle and Toe Replacement Products from Tornier for USD6 Million 33 6.13 Sep 03, 2015: Integra LifeSciences Acquires Ankle Replacement and Silastic Toe Replacement Products from Tornier 33 6.14 Aug 31, 2015: Integra LifeSciences Raises USD220 Million in Public Offering of Shares 33 6.15 Aug 04, 2015: Integra LifeSciences Prices Public Offering of Shares for USD201.3 Million 33 6.16 Aug 04, 2015: Orthofix International Reports Second Quarter 2015 Financial Results 34 6.17 Jul 30, 2015: Integra LifeSciences Reports Second Quarter 2015 Financial Results 35 6.18 Jul 15, 2015: Wright Medical Group Highlights Recent Innovations at the American Orthopaedic Foot and Ankle Society 2015 Annual Meeting 36 6.19 Jul 01, 2015: Integra LifeSciences Completes Spin-Off of SeaSpine 36 6.20 May 18, 2015: Orthofix International Reports First Quarter 2015 Financial Results 37 7 Appendix 39 7.1 Methodology 39 7.2 About GlobalData 41 7.3 Contact Us 42 7.4 Disclaimer 42

1.1 List of Tables Table 1: Ankle Replacement - Pipeline Products by Stage of Development 6 Table 2: Ankle Replacement - Pipeline Products by Segment 7 Table 3: Ankle Replacement - Pipeline Products by Territory 8 Table 4: Ankle Replacement - Pipeline Products by Regulatory Path 9 Table 5: Ankle Replacement - Pipeline Products by Estimated Approval Date 10 Table 6: Ankle Replacement Companies - Pipeline Products by Stage of Development 11 Table 7: Ankle Replacement - Pipeline Products by Stage of Development 12 Table 8: Exactech, Inc. Pipeline Products & Ongoing Clinical Trials Overview 13 Table 9: Vantage Total Ankle System - Product Status 14 Table 10: Vantage Total Ankle System - Product Description 14 Table 11: Implants International Limited Pipeline Products & Ongoing Clinical Trials Overview 15 Table 12: Akilos Total Ankle System - Product Status 15 Table 13: Akilos Total Ankle System - Product Description 15 Table 14: Integra LifeSciences Holdings Corporation Pipeline Products & Ongoing Clinical Trials Overview 16 Table 15: 2-Piece Total Ankle Replacement System - Product Status 17 Table 16: 2-Piece Total Ankle Replacement System - Product Description 17 Table 17: NDSU Research Foundation Pipeline Products & Ongoing Clinical Trials Overview 18 Table 18: Total Ankle Replacement Device - Product Status 18 Table 19: Total Ankle Replacement Device - Product Description 18 Table 20: Wright Medical Group N.V. Pipeline Products & Ongoing Clinical Trials Overview 19 Table 21: INVISION Revision Ankle System - Product Status 20 Table 22: INVISION Revision Ankle System - Product Description 20 Table 23: Zimmer Biomet Holdings, Inc. Pipeline Products & Ongoing Clinical Trials Overview 21 Table 24: Two-part Semiconstrained Ankle Prosthesis Device - Product Status 22 Table 25: Two-part Semiconstrained Ankle Prosthesis Device - Product Description 22 Table 26: Glossary 40 1.2 List of Figures Figure 1: Ankle Replacement - Pipeline Products by Stage of Development 6 Figure 2: Ankle Replacement - Pipeline Products by Segment 7 Figure 3: Ankle Replacement - Pipeline Products by Territory 8 Figure 4: Ankle Replacement - Pipeline Products by Regulatory Path 9 Figure 5: Ankle Replacement - Pipeline Products by Estimated Approval Date 10

Exactech, Inc. Implants International Limited Integra LifeSciences Holdings Corporation NDSU Research Foundation Wright Medical Group N.V. Zimmer Biomet Holdings, Inc.