1 Table of Contents 1 Table of Contents 2 1.1 List of Tables 3 1.2 List of Figures 4 2 Introduction 5 2.1 Cardiopulmonary Bypass Equipment Overview 5 3 Products under Development 6 3.1 Cardiopulmonary Bypass Equipment - Pipeline Products by Stage of Development 6 3.2 Cardiopulmonary Bypass Equipment - Pipeline Products by Territory 7 3.3 Cardiopulmonary Bypass Equipment - Pipeline Products by Regulatory Path 8 3.4 Cardiopulmonary Bypass Equipment - Pipeline Products by Estimated Approval Date 9 4 Cardiopulmonary Bypass Equipment - Pipeline Products under Development by Companies 10 4.1 Cardiopulmonary Bypass Equipment Companies - Pipeline Products by Stage of Development 10 4.2 Cardiopulmonary Bypass Equipment - Pipeline Products by Stage of Development 11 5 Cardiopulmonary Bypass Equipment Companies and Product Overview 12 5.1 AngioDynamics, Inc. Company Overview 12 5.1.1 AngioDynamics, Inc. Pipeline Products & Ongoing Clinical Trials Overview 12 5.2 Circulatory Technology Inc. Company Overview 14 5.2.1 Circulatory Technology Inc. Pipeline Products & Ongoing Clinical Trials Overview 14 5.3 Design Mentor, Inc. Company Overview 15 5.3.1 Design Mentor, Inc. Pipeline Products & Ongoing Clinical Trials Overview 15 5.4 Emory University Company Overview 16 5.4.1 Emory University Pipeline Products & Ongoing Clinical Trials Overview 16 5.5 LivaNova PLC Company Overview 18 5.5.1 LivaNova PLC Pipeline Products & Ongoing Clinical Trials Overview 18 5.6 Mayo Clinic US Company Overview 21 5.6.1 Mayo Clinic US Pipeline Products & Ongoing Clinical Trials Overview 21 5.7 Michigan Critical Care Consultants, Inc. Company Overview 22 5.7.1 Michigan Critical Care Consultants, Inc. Pipeline Products & Ongoing Clinical Trials Overview 22 5.8 Sree Chitra Tirunal Institute for Medical Sciences & Technology Company Overview 23 5.8.1 Sree Chitra Tirunal Institute for Medical Sciences & Technology Pipeline Products & Ongoing Clinical Trials Overview 23 5.9 University of Pittsburgh Company Overview 25 5.9.1 University of Pittsburgh Pipeline Products & Ongoing Clinical Trials Overview 25 5.10 University of Strathclyde Company Overview 27 5.10.1 University of Strathclyde Pipeline Products & Ongoing Clinical Trials Overview 27 6 Cardiopulmonary Bypass Equipment- Recent Developments 28 6.1 Mar 14, 2016: CardiacAssist Receives 510(k) Clearance for its TandemLung Oxygenator 28 6.2 Feb 11, 2016: Terumo Cardiovascular Group Introduces the CAPIOX FX Advance Oxygenator 28 6.3 Nov 17, 2015: Study Shows Sorin XTRA Autotransfusion System Achieves High Fat Removal Rate 29 6.4 Aug 06, 2015: AngioDynamics Begins Patient Enrollment In RAPID Study 29 6.5 Jul 10, 2015: Global Launch Of Flextherm, Sorins Latest Generation Of Heating And Cooling Systems 30 6.6 May 15, 2015: UPMC Continues Strong Financial Performance Through First Nine Months of Fiscal Year 2015 30 7 Appendix 32 7.1 Methodology 32 7.2 About GlobalData 34 7.3 Contact Us 35 7.4 Disclaimer 35

1.1 List of Tables Table 1: Cardiopulmonary Bypass Equipment - Pipeline Products by Stage of Development 6 Table 2: Cardiopulmonary Bypass Equipment - Pipeline Products by Territory 7 Table 3: Cardiopulmonary Bypass Equipment - Pipeline Products by Regulatory Path 8 Table 4: Cardiopulmonary Bypass Equipment - Pipeline Products by Estimated Approval Date 9 Table 5: Cardiopulmonary Bypass Equipment Companies - Pipeline Products by Stage of Development 10 Table 6: Cardiopulmonary Bypass Equipment - Pipeline Products by Stage of Development 11 Table 7: AngioDynamics, Inc. Pipeline Products & Ongoing Clinical Trials Overview 12 Table 8: AngioVac Line Extension - Product Status 13 Table 9: AngioVac Line Extension - Product Description 13 Table 10: Circulatory Technology Inc. Pipeline Products & Ongoing Clinical Trials Overview 14 Table 11: Heart Lung Machine - Product Status 14 Table 12: Heart Lung Machine - Product Description 14 Table 13: Design Mentor, Inc. Pipeline Products & Ongoing Clinical Trials Overview 15 Table 14: VentriFlo Pump - Product Status 15 Table 15: VentriFlo Pump - Product Description 15 Table 16: Emory University Pipeline Products & Ongoing Clinical Trials Overview 16 Table 17: Antegrade Catheter - Product Status 17 Table 18: Antegrade Catheter - Product Description 17 Table 19: LivaNova PLC Pipeline Products & Ongoing Clinical Trials Overview 18 Table 20: Heartlink System - Product Status 19 Table 21: Heartlink System - Product Description 19 Table 22: LBATS - Product Status 20 Table 23: LBATS - Product Description 20 Table 24: Mayo Clinic US Pipeline Products & Ongoing Clinical Trials Overview 21 Table 25: Heart-Lung Machine Reservoir Sensor - Product Status 21 Table 26: Heart-Lung Machine Reservoir Sensor - Product Description 21 Table 27: Michigan Critical Care Consultants, Inc. Pipeline Products & Ongoing Clinical Trials Overview 22 Table 28: Blood Pump - Product Status 22 Table 29: Blood Pump - Product Description 22 Table 30: Sree Chitra Tirunal Institute for Medical Sciences & Technology Pipeline Products & Ongoing Clinical Trials Overview 23 Table 31: Centrifugal Blood Pump - Product Status 23 Table 32: Centrifugal Blood Pump - Product Description 23 Table 33: Paediatric And Neonatal Arterial Filter - Product Status 24 Table 34: Paediatric And Neonatal Arterial Filter - Product Description 24 Table 35: University of Pittsburgh Pipeline Products & Ongoing Clinical Trials Overview 25 Table 36: Portable Emergency Cardiopulmonary Bypass Device - Product Status 26 Table 37: Portable Emergency Cardiopulmonary Bypass Device - Product Description 26 Table 38: University of Strathclyde Pipeline Products & Ongoing Clinical Trials Overview 27 Table 39: Neonatal Life Support System - Product Status 27 Table 40: Neonatal Life Support System - Product Description 27 Table 41: Glossary 33 1.2 List of Figures Figure 1: Cardiopulmonary Bypass Equipment - Pipeline Products by Stage of Development 6 Figure 2: Cardiopulmonary Bypass Equipment - Pipeline Products by Territory 7 Figure 3: Cardiopulmonary Bypass Equipment - Pipeline Products by Regulatory Path 8 Figure 4: Cardiopulmonary Bypass Equipment - Pipeline Products by Estimated Approval Date 9

AngioDynamics, Inc. Circulatory Technology Inc. Design Mentor, Inc. Emory University LivaNova PLC Mayo Clinic US Michigan Critical Care Consultants, Inc. Sree Chitra Tirunal Institute for Medical Sciences & Technology University of Pittsburgh University of Strathclyde