Table of Contents Table of Contents 2 List of Tables 5 List of Figures 5 Introduction 6 Global Markets Direct Report Coverage 6 Choroidal Neovascularization Overview 7 Therapeutics Development 8 Pipeline Products for Choroidal Neovascularization - Overview 8 Pipeline Products for Choroidal Neovascularization - Comparative Analysis 9 Choroidal Neovascularization - Therapeutics under Development by Companies 10 Choroidal Neovascularization - Therapeutics under Investigation by Universities/Institutes 11 Choroidal Neovascularization - Pipeline Products Glance 12 Late Stage Products 12 Clinical Stage Products 13 Early Stage Products 14 Choroidal Neovascularization - Products under Development by Companies 15 Choroidal Neovascularization - Products under Investigation by Universities/Institutes 16 Choroidal Neovascularization - Companies Involved in Therapeutics Development 17 Affitech A/S 17 F. Hoffmann-La Roche Ltd. 18 Genentech, Inc. 19 Iconic Therapeutics, Inc. 20 Mabion SA 21 Navigen Pharmaceuticals, Inc. 22 Noxxon Pharma AG 23 Promedior, Inc. 24 Sanwa Kagaku Kenkyusho Co., Ltd. 25 Choroidal Neovascularization - Therapeutics Assessment 26 Assessment by Monotherapy Products 26 Assessment by Target 27 Assessment by Mechanism of Action 29 Assessment by Route of Administration 31 Assessment by Molecule Type 33 Drug Profiles 35 Antisense Oligonucleotides for Ophthalmology and Oncology - Drug Profile 35 Product Description 35 Mechanism of Action 35 R&D Progress 35 AP-202 - Drug Profile 37 Product Description 37 Mechanism of Action 37 R&D Progress 37 Doxarubicin Pegylated - Drug Profile 38 Product Description 38 Mechanism of Action 38 R&D Progress 38 hI-con1 - Drug Profile 39 Product Description 39 Mechanism of Action 39 R&D Progress 39 MAb-30D8 - Drug Profile 41 Product Description 41 Mechanism of Action 41 R&D Progress 41 NAV-2729 - Drug Profile 42 Product Description 42 Mechanism of Action 42 R&D Progress 42 Netrin-4 - Drug Profile 45 Product Description 45 Mechanism of Action 45 R&D Progress 45 NM-9405 - Drug Profile 46 Product Description 46 Mechanism of Action 46 R&D Progress 46 NOXD-20 - Drug Profile 48 Product Description 48 Mechanism of Action 48 R&D Progress 48 PGN-635 - Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 PRM-167 - Drug Profile 50 Product Description 50 Mechanism of Action 50 R&D Progress 50 ranibizumab - Drug Profile 51 Product Description 51 Mechanism of Action 51 R&D Progress 51 ranibizumab biosimilar - Drug Profile 55 Product Description 55 Mechanism of Action 55 R&D Progress 55 RG-7716 - Drug Profile 56 Product Description 56 Mechanism of Action 56 R&D Progress 56 SK-1011 - Drug Profile 57 Product Description 57 Mechanism of Action 57 R&D Progress 57 Small Molecule for Inflammation and Choroidal Neovascularization - Drug Profile 58 Product Description 58 Mechanism of Action 58 R&D Progress 58 Synthetic Peptides for Age Related Macular Degeneration and Choroidal Neovascularization - Drug Profile 59 Product Description 59 Mechanism of Action 59 R&D Progress 59 Synthetic Peptides to Target VEGF for Choroidal Neovascularization - Drug Profile 60 Product Description 60 Mechanism of Action 60 R&D Progress 60 Choroidal Neovascularization - Recent Pipeline Updates 62 Choroidal Neovascularization - Dormant Projects 68 Choroidal Neovascularization - Discontinued Products 69 Choroidal Neovascularization - Product Development Milestones 70 Featured News & Press Releases 70 Nov 26, 2013: NICE gives green light to ranibizumab for eye condition in final guidance 70 Jul 05, 2013: Novartis drug Lucentis approved in EU as first effective anti-VEGF treatment for myopic choroidal neovascularization 70 May 31, 2013: Novartis Receives Positive CHMP Opinion For Lucentis To Treat Myopic Choroidal Neovascularization Showing Vision Gains With Only Two Injections 71 Appendix 73 Methodology 73 Coverage 73 Secondary Research 73 Primary Research 73 Expert Panel Validation 73 Contact Us 73 Disclaimer 74

List of Tables Number of Products under Development for Choroidal Neovascularization, H1 2016 8 Number of Products under Development for Choroidal Neovascularization - Comparative Analysis, H1 2016 9 Number of Products under Development by Companies, H1 2016 10 Number of Products under Investigation by Universities/Institutes, H1 2016 11 Comparative Analysis by Late Stage Development, H1 2016 12 Comparative Analysis by Clinical Stage Development, H1 2016 13 Comparative Analysis by Early Stage Development, H1 2016 14 Products under Development by Companies, H1 2016 15 Products under Investigation by Universities/Institutes, H1 2016 16 Choroidal Neovascularization - Pipeline by Affitech A/S, H1 2016 17 Choroidal Neovascularization - Pipeline by F. Hoffmann-La Roche Ltd., H1 2016 18 Choroidal Neovascularization - Pipeline by Genentech, Inc., H1 2016 19 Choroidal Neovascularization - Pipeline by Iconic Therapeutics, Inc., H1 2016 20 Choroidal Neovascularization - Pipeline by Mabion SA, H1 2016 21 Choroidal Neovascularization - Pipeline by Navigen Pharmaceuticals, Inc., H1 2016 22 Choroidal Neovascularization - Pipeline by Noxxon Pharma AG, H1 2016 23 Choroidal Neovascularization - Pipeline by Promedior, Inc., H1 2016 24 Choroidal Neovascularization - Pipeline by Sanwa Kagaku Kenkyusho Co., Ltd., H1 2016 25 Assessment by Monotherapy Products, H1 2016 26 Number of Products by Stage and Target, H1 2016 28 Number of Products by Stage and Mechanism of Action, H1 2016 30 Number of Products by Stage and Route of Administration, H1 2016 32 Number of Products by Stage and Molecule Type, H1 2016 34 Choroidal Neovascularization Therapeutics - Recent Pipeline Updates, H1 2016 62 Choroidal Neovascularization - Dormant Projects, H1 2016 68 Choroidal Neovascularization - Discontinued Products, H1 2016 69 List of Figures Number of Products under Development for Choroidal Neovascularization, H1 2016 8 Number of Products under Development for Choroidal Neovascularization - Comparative Analysis, H1 2016 9 Number of Products under Development by Companies, H1 2016 10 Comparative Analysis by Early Stage Products, H1 2016 14 Assessment by Monotherapy Products, H1 2016 26 Number of Products by Targets, H1 2016 27 Number of Products by Stage and Targets, H1 2016 27 Number of Products by Mechanism of Actions, H1 2016 29 Number of Products by Stage and Mechanism of Actions, H1 2016 29 Number of Products by Routes of Administration, H1 2016 31 Number of Products by Stage and Routes of Administration, H1 2016 31 Number of Products by Molecule Types, H1 2016 33 Number of Products by Stage and Molecule Types, H1 2016 33

Affitech A/S F. Hoffmann-La Roche Ltd. Genentech, Inc. Iconic Therapeutics, Inc. Mabion SA Navigen Pharmaceuticals, Inc. Noxxon Pharma AG Promedior, Inc. Sanwa Kagaku Kenkyusho Co., Ltd.