1 Table of Contents 1 Table of Contents 2 1.1 List of Tables 7 1.2 List of Figures 12 2 Pharmaceutical & Healthcare, Global, Deals Summary 18 2.1 Pharmaceutical & Healthcare, Global, Deals Analysis, 2015 18 2.1.1 Pharmaceuticals & Healthcare, Global, Deals Analysis, 2015 by Quarter 20 2.2 Pharmaceuticals & Healthcare, Global, by Type, Number of Deals, 2015 22 2.3 Pharmaceuticals & Healthcare, Global, by Type, Deal Values, 2015 23 2.4 Pharmaceuticals & Healthcare, Global, Top Deals, 2015 24 2.5 Pharmaceuticals & Healthcare, Top Deals, Global, Summaries, 2015 25 2.5.1 Allergan and Pfizer to Combine in USD160 Billion Deal 25 2.5.2 Teva Pharma to Acquire Generics Drug Business from Allergan for USD40.5 Billion 26 2.5.3 Actavis Raises USD21 Billion in Public Offering of Senior Notes 27 2.5.4 AbbVie Acquires Pharmacyclics 28 2.5.5 Pfizer Acquires Hospira for USD17 Billion 29 2.5.6 Danaher Acquires Pall for USD13.8 Billion 30 2.5.7 CVS Health Acquires Omnicare for USD12.9 Billion 31 2.5.8 UnitedHealth Acquires Catamaran for USD12.8 Billion 32 2.5.9 Valeant Pharma Acquires Salix Pharma for USD10.9 Billion 32 2.5.10 AbbVie Raises USD16.7 Billion in Public Offering of Notes 34 3 Pharmaceuticals & Healthcare, Global, Top Deal Makers, 2015 35 4 Pharmaceuticals & Healthcare, Global, Deal Summary, by Type 36 4.1 Pharmaceuticals & Healthcare, Global, M&A, 2015 36 4.1.1 Pharmaceuticals & Healthcare, Global, M&A, 2015 by Quarter 37 4.1.2 Top M&A Deals in 2015 38 4.1.3 Pharmaceuticals & Healthcare, Global, M&A Deals, by Therapy Area, 2015 39 4.2 Pharmaceuticals & Healthcare, Global, Equity Offering Deals, 2015 40 4.2.1 Pharmaceuticals & Healthcare, Global, Equity Offering Deals, 2015 by Quarter 41 4.2.2 Pharmaceuticals & Healthcare, Global, IPO Deals, 2015 42 4.2.3 Top IPOs in 2015 43 4.2.4 Pharmaceuticals & Healthcare, Global, Secondary Offerings Deals, 2015 44 4.2.5 Top Secondary Offerings in 2015 45 4.2.6 Pharmaceuticals & Healthcare, Global, PIPE Deals, 2015 45 4.2.7 Top PIPE Deals in 2015 46 4.2.8 Pharmaceuticals & Healthcare, Global, Equity Offering Deals, by Therapy Area, 2015 47 4.3 Pharmaceuticals & Healthcare, Global, Debt Offering Deals, 2015 48 4.3.1 Pharmaceuticals & Healthcare, Global Debt Offerings, 2015 by Quarter 49 4.3.2 Pharmaceuticals & Healthcare, Global, Public Debt Offerings, 2015 50 4.3.3 Top Public Debt Offerings in 2015 51 4.3.4 Pharmaceuticals & Healthcare, Global, Private Debt Placements, 2015 51 4.3.5 Top Private Debt Placements in 2015 52 4.3.6 Pharmaceuticals & Healthcare, Global, Debt Offering Deals, by Therapy Area, 2015 53 4.4 Pharmaceuticals & Healthcare, Global, Partnership Deals, 2015 54 4.4.1 Pharmaceuticals & Healthcare, Global, Partnership Deals, 2015 by Quarter 55 4.4.2 Pharmaceuticals & Healthcare, Global, Partnership Deals, by Therapy Area, 2015 57 4.4.3 Pharmaceuticals & Healthcare, Global, Partnership Deals, by Upfront & Milestone Payments and Deal Value (US$ m), 2015 58 4.4.4 Pharmaceuticals & Healthcare, Global, Partnership Deals, by Therapy Area, by Upfront & Milestone Payments and Deal Values (US$ m), 2015 59 4.4.5 Pharmaceuticals & Healthcare, Global, Partnership Deals, by Phase, Number Of Deals, 2015 60 4.4.6 Pharmaceuticals & Healthcare, Global, Partnership Deals, by Phase, Deal Values (US$ m), 2015 61 4.4.7 Pharmaceuticals & Healthcare, Global, Partnership Deals, by Phase, by Upfront & Milestone Payments and Deal Values (US$ m), 2015 63 4.4.8 Pharmaceuticals & Healthcare, Global, Top Partnership Deals, by Deal Values, 2015 64 4.4.9 Pharmaceuticals & Healthcare, Global, Top Partnership Deals, by Upfront Payment, 2015 65 4.4.10 Pharmaceuticals & Healthcare, Global, Top Partnership Deals, by Milestone Payment, 2015 65 4.5 Pharmaceuticals & Healthcare, Global, Licensing Agreements, 2015 66 4.5.1 Pharmaceuticals & Healthcare, Global, Licensing Agreements, 2015 by Quarter 67 4.5.2 Pharmaceuticals & Healthcare, Global, Licensing Agreements, by Therapy Area, 2015 68 4.5.3 Pharmaceuticals & Healthcare, Global, Licensing Agreements, by Upfront & Milestone Payments and Deal Value (US$ m), 2015 69 4.5.4 Pharmaceuticals & Healthcare, Global, Licensing Agreements, by Therapy Area, by Upfront & Milestone Payments and Deal Values (US$ m), 2015 70 4.5.5 Pharmaceuticals & Healthcare, Global, Licensing Agreement Deals, by Phase, Total Deal Values (US$ m), 2015 71 4.5.6 Pharmaceuticals & Healthcare, Global, Licensing Agreement Deals, by Phase, Total Deal Values (US$ m), 2015 72 4.5.7 Pharmaceuticals & Healthcare, Global, Licensing Agreements, by Phase, by Upfront & Milestone Payments and Deal Values (US$ m), 2015 74 4.5.8 Pharmaceuticals & Healthcare, Global, Top Licensing Agreements, by Deal Values, 2015 75 4.5.9 Pharmaceuticals & Healthcare, Global, Top Licensing Agreements, by Upfront Payment, 2015 76 4.5.10 Pharmaceuticals & Healthcare, Global, Top Licensing Agreements, by Milestone Payment, 2015 77 4.6 Pharmaceuticals & Healthcare, Global, Private Equity Deals, 2015 78 4.6.1 Pharmaceuticals & Healthcare, Global, Private Equity Deals, 2015 by Quarter 79 4.6.2 Top Private Equity Deals in 2015 80 4.6.3 Pharmaceuticals & Healthcare, Global, Private Equity Deals, by Therapy Area, 2015 81 4.7 Pharmaceuticals & Healthcare, Global, Venture Capital Deals, 2015 82 4.7.1 Pharmaceuticals & Healthcare, Global, Venture Financing Deals, 2015 by Quarter 83 4.7.2 Pharmaceuticals & Healthcare, Global, Venture Capital Deals, by Stage of Financing, 2015 84 4.7.3 Pharmaceuticals & Healthcare, Global, Venture Capital Deals, by Stage of Financing, 2015 85 4.7.4 Pharmaceuticals & Healthcare, Global, Venture Capital, by Therapy Area, 2015 86 4.7.5 Pharmaceuticals & Healthcare, Global, Top VC Backed Companies, Last One Year 87 4.7.6 Pharmaceuticals & Healthcare, Global, Top Venture Financing Firms, 2015 88 4.7.7 Top Venture Financing Deals in 2015 90 5 Pharmaceuticals & Healthcare, Global, Deal Summary, By Market 91 5.1 Pharmaceuticals & Healthcare, Global, Oncology Deals, 2015 91 5.1.1 Pharmaceuticals & Healthcare, Global, Oncology Deals, 2015 by Quarter 93 5.1.2 Oncology - Deals of the Year 94 5.2 Pharmaceuticals & Healthcare, Global, Central Nervous System Deals, 2015 98 5.2.1 Pharmaceuticals & Healthcare, Global, Central Nervous System Deals, 2015 by Quarter 100 5.2.2 Central Nervous System - Deals of the Year 101 5.3 Pharmaceuticals & Healthcare, Global, Infectious Disease Deals, 2015 106 5.3.1 Pharmaceuticals & Healthcare, Global, Infectious Disease Deals, 2015 by Quarter 108 5.3.2 Infectious Disease - Deals of the Year 109 5.4 Pharmaceuticals & Healthcare, Global, Immunology Deals, 2015 113 5.4.1 Pharmaceuticals & Healthcare, Global, Immunology Deals, 2015 by Quarter 115 5.4.2 Immunology - Deals of the Year 116 5.5 Pharmaceuticals & Healthcare, Global, Cardiovascular Deals, 2015 119 5.5.1 Pharmaceuticals & Healthcare, Global, Cardiovascular Deals, 2015 by Quarter 121 5.5.2 Cardiovascular - Deals of the Year 122 5.6 Pharmaceuticals & Healthcare, Global, Metabolic Disorders Deals, 2015 125 5.6.1 Pharmaceuticals & Healthcare, Global, Metabolic Disorders Deals, 2015 by Quarter 127 5.6.2 Metabolic Disorders - Deals of the Year 128 5.7 Pharmaceuticals & Healthcare, Global, Gastrointestinal Deals, 2015 131 5.7.1 Pharmaceuticals & Healthcare, Global, Gastrointestinal Deals, 2015 by Quarter 133 5.7.2 Gastrointestinal - Deals of the Year 134 6 Pharmaceuticals & Healthcare, Deal Summary, By Geography 137 6.1 Pharmaceuticals & Healthcare, North America Region, Deals, 2015 137 6.1.1 Pharmaceuticals & Healthcare, North America Region, Deals, 2015 by Quarter 139 6.1.2 North America - Deals of the Year 140 6.2 Pharmaceuticals & Healthcare, European Region Deals, 2015 146 6.2.1 Pharmaceuticals & Healthcare, Europe, Deals, 2015 by Quarter 148 6.2.2 Europe - Deals of the Year 149 6.3 Pharmaceuticals & Healthcare, Asia-Pacific Region, Deals, 2015 154 6.3.1 Pharmaceuticals & Healthcare, Asia-Pacific Region Deals, 2015 by Quarter 156 6.3.2 Asia-Pacific - Deals of the Year 157 6.4 Pharmaceuticals & Healthcare, Rest of the World (ROW) Deals, 2015 160 6.4.1 Pharmaceuticals & Healthcare, Rest of the World Deals, 2015 by Quarter 162 6.4.2 Rest of the World - Deals of the Year 163 7 Pharmaceuticals & Healthcare, Global, Top Financial Advisors 166 7.1 Pharmaceuticals & Healthcare, Global, Top Financial Advisors, M&A, 2015 166 7.2 Pharmaceuticals & Healthcare, Global, Top Financial Advisors, Equity Offerings, 2015 168 8 Further Information 170 8.1 Methodology 170 8.2 About GlobalData 171 8.3 Disclosure information 171 8.4 Disclaimer 172

1.1 List of Tables Table 1: Pharmaceutical & Healthcare, Global, Deals Summary, Number of Deals and Deal Value (US$ m), 2011 - 2015 19 Table 2: Pharmaceuticals & Healthcare, Deals Summary, Global, Number of Deals and Deal Value (US$ m), Q1 2015-Q4 2015 21 Table 3: Pharmaceuticals & Healthcare, Global, Number Of Deals and Deal Values (%), 2015 23 Table 4: Pharmaceuticals & Healthcare, Top Deals, Global, 2015 24 Table 5: Pharmaceuticals & Healthcare, Global, Top Deal Makers, Number of Deals and Deal Value (US$ m), 2015 35 Table 6: Pharmaceuticals & Healthcare, Global, M&A, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 37 Table 7: Pharmaceuticals & Healthcare, Global, M&A, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 38 Table 8: Pharmaceuticals & Healthcare, Global, Top M&A Deals, 2015 38 Table 9: Pharmaceuticals & Healthcare, Global, M&A, Deals Summary, Number of Deals and Deal Values (US$ m), by Therapy Area, 2015 39 Table 10: Pharmaceuticals & Healthcare, Global, Equity Offerings, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 41 Table 11: Pharmaceuticals & Healthcare, Global, Equity Offerings, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 42 Table 12: Pharmaceuticals & Healthcare, Global, IPO Deals, Deals Summary, Number of Deals and Deal Value (US$ m), 2011 - 2015 43 Table 13: Pharmaceuticals & Healthcare, Global, Top IPOs, 2015 43 Table 14: Pharmaceuticals & Healthcare, Global, Secondary Offerings, Deals Summary, Number of Deals and Deal Value (US$ m), 2011 - 2015 44 Table 15: Pharmaceuticals & Healthcare, Global, Top Secondary Offerings, 2015 45 Table 16: Pharmaceuticals & Healthcare, Global, PIPEs, Deals Summary, Number of Deals and Deal Value (US$ m), 2011 - 2015 46 Table 17: Pharmaceuticals & Healthcare, Global, Top PIPE Deals, 2015 46 Table 18: Pharmaceuticals & Healthcare, Global, Equity Offering Deals, Deals Summary, Number of Deals and Deal Values (US$ m), 2015 47 Table 19: Pharmaceuticals & Healthcare, Global, Debt Offering, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 48 Table 20: Pharmaceuticals & Healthcare, Global, Debt Offering, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 49 Table 21: Pharmaceuticals & Healthcare, Global, Public Debt Offerings, Deals Summary, Number of Deals and Deal Value (US$ m), 2011 - 2015 50 Table 22: Pharmaceuticals & Healthcare, Global, Top Public Debt Offerings, 2015 51 Table 23: Pharmaceuticals & Healthcare, Global, Private Debt Placements, Deals Summary, Number of Deals and Deal Value (US$ m), 2011 - 2015 52 Table 24: Pharmaceuticals & Healthcare, Global, Top Private Debt Placements, 2015 52 Table 25: Pharmaceuticals & Healthcare, Global, Debt Offering Deals, Summary, Number of Deals and Deal Values (US$ m), 2015 53 Table 26: Pharmaceuticals & Healthcare, Global, Partnerships, Number of Deals and Deal Values (US$ m), 2011 - 2015 55 Table 27: Pharmaceuticals & Healthcare, Global, Partnerships, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 56 Table 28: Pharmaceuticals & Healthcare, Global, Partnership Deals, by Therapy Area, Number of Deals and Deal Values (US$ m), 2015 57 Table 29: Pharmaceuticals & Healthcare, Partnership Deals, Upfront & Milestone Payment and Deal Values (US$ m), 2015 58 Table 30: Pharmaceuticals & Healthcare, Global, Partnership Deals, by Therapy Area, Upfront & Milestone Payment and Deal Values (US$ m), 2015 60 Table 31: Pharmaceuticals & Healthcare, Global, Partnership Deals, by Phase, 2015 62 Table 32: Pharmaceuticals & Healthcare, Global, Partnership Deals, by Upfront & Milestone Payment and Deal Values (US$ m), 2015 64 Table 33: Pharmaceuticals & Healthcare, Global, Partnerships, Upfront & Milestone Payment and Deal Values (US$ m), 2015 64 Table 34: Pharmaceuticals & Healthcare, Global, Top Partnership Deals, by Upfront Payment, 2015 65 Table 35: Pharmaceuticals & Healthcare, Global, Top Partnership Deals, by Milestone Payment, 2015 65 Table 36: Pharmaceuticals & Healthcare, Global, Licensing Agreement Deals, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 67 Table 37: Pharmaceuticals & Healthcare, Global, Licensing Agreement Deals, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 68 Table 38: Pharmaceuticals & Healthcare, Global, Licensing Agreements, by Therapy Area, Number of Deals and Deal Values (US$ m), 2015 69 Table 39: Pharmaceuticals & Healthcare, Licensing Agreements, Upfront & Milestone Payments and Deal Values (US$ m), 2015 70 Table 40: Pharmaceuticals & Healthcare, Global, Licensing Agreements, by Therapy Area, Upfront & Milestone Payments and Deal Values (US$ m), 2015 71 Table 41: Pharmaceuticals & Healthcare, Global, Partnership Deals, by Phase, Q4 2014 - Q4 2015 73 Table 42: Pharmaceuticals & Healthcare, Global, Licensing Agreements, by Upfront & Milestone Payments and Deal Values (US$ m), 2015 75 Table 43: Pharmaceuticals & Healthcare, Global, Partnerships, Upfront & Milestone Payment and Deal Values (US$ m), 2015 75 Table 44: Pharmaceuticals & Healthcare, Global, Top Licensing Agreements, by Upfront Payment, 2015 76 Table 45: Pharmaceutical & Healthcare, Global, Top Licensing Agreements, by Milestone Payment, 2015 77 Table 46: Pharmaceuticals & Healthcare, Global, Private Equity, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 79 Table 47: Pharmaceuticals & Healthcare, Global, Private Equity, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 80 Table 48: Pharmaceuticals & Healthcare, Global, Top Private Equity Deals, 2015 80 Table 49: Pharmaceuticals & Healthcare, Global, Private Equity Deals, by Therapy Area, Deals Summary, Number of Deals and Deal Values (US$ m), 2015 81 Table 50: Pharmaceuticals & Healthcare, Global, Venture Capital, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 83 Table 51: Pharmaceuticals & Healthcare, Global, Venture Capital, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 84 Table 52: Pharmaceuticals & Healthcare, Global, Venture Capital Deals, by Stage of Financing, Number Of Deals and Deal Values (%), 2015 85 Table 53: Pharmaceuticals & Healthcare, Global, Venture Capital Deals, by Therapy Area, Deals Summary, Number of Deals and Deal Values (US$ m), 2015 86 Table 54: Pharmaceutical & Healthcare, Global, Top VC Backed Companies, 2015 87 Table 55: Pharmaceuticals & Healthcare, Top Venture Financing Firms, Global, Number of Deals and Deal Value (US$ m), 2015 89 Table 56: Pharmaceuticals & Healthcare, Top Venture Financing Deals, Global, 2015 90 Table 57: Pharmaceuticals & Healthcare, Global, Oncology, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 92 Table 58: Pharmaceuticals & Healthcare, Global, Oncology, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 94 Table 59: Pharmaceuticals & Healthcare, Global, Central Nervous System, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 99 Table 60: Pharmaceuticals & Healthcare, Global, Central Nervous System, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 101 Table 61: Pharmaceuticals & Healthcare, Global, Infectious Disease, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 107 Table 62: Pharmaceuticals & Healthcare, Global, Infectious Disease, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 109 Table 63: Pharmaceuticals & Healthcare, Global, Immunology, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 114 Table 64: Pharmaceuticals & Healthcare, Global, Immunology, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 116 Table 65: Pharmaceuticals & Healthcare, Global, Cardiovascular, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 120 Table 66: Pharmaceuticals & Healthcare, Global, Cardiovascular, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 122 Table 67: Pharmaceuticals & Healthcare, Global, Metabolic Disorders, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 126 Table 68: Pharmaceuticals & Healthcare, Global, Metabolic Disorders, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 128 Table 69: Pharmaceuticals & Healthcare, Global, Gastrointestinal, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 132 Table 70: Pharmaceuticals & Healthcare, Global, Gastrointestinal, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 134 Table 71: Pharmaceuticals & Healthcare, North America, Deals Summary, Number of Deals and Deal Value (US$ m), 2011 - 2015 138 Table 72: Pharmaceuticals & Healthcare, North America, Deals Summary, Number of Deals and Deal Value (US$ m), Q1 2015-Q4 2015 140 Table 73: Pharmaceuticals & Healthcare, Europe, Deals Summary, Number of Deals and Deal Value (US$ m), 2011 - 2015 147 Table 74: Pharmaceuticals & Healthcare, European Region Deals, Deals Summary, Global, Number of Deals and Deal Value (US$ m), Q1 2015-Q4 2015 149 Table 75: Pharmaceuticals & Healthcare, Asia-Pacific, Deals Summary, Number of Deals and Deal Value (US$ m), 2011 - 2015 155 Table 76: Pharmaceuticals & Healthcare, Asia-Pacific Region Deals, Deals Summary, Global, Number of Deals and Deal Value (US$ m), Q1 2015-Q4 2015 157 Table 77: Pharmaceuticals & Healthcare, Rest of the World Deals, Deals Summary, Number of Deals and Deal Value (US$ m), 2011 - 2015 161 Table 78: Pharmaceuticals & Healthcare, Rest of the World Deals, Deals Summary, Number of Deals and Deal Value (US$ m), Q1 2015-Q4 2015 163 Table 79: Pharmaceuticals & Healthcare, Global,, Top Financial Advisors, M&A, Number of Deals and Deal Value (US$ m), 2015 167 Table 80: Pharmaceuticals & Healthcare, Global Top Financial Advisors, Equity Offerings, Number of Deals and Deal Value (US$ m), 2015 169 1.2 List of Figures Figure 1: Pharmaceutical & Healthcare, Global, Number of Deals and Deal Value (US$ m), 2011- 2015 18 Figure 2: Pharmaceuticals & Healthcare, Global, Number of Deals and Deal Value (US$ m), Q1 2015-Q4 2015 20 Figure 3: Pharmaceuticals & Healthcare, Global, Number Of Deals (%), 2015 22 Figure 4: Pharmaceuticals & Healthcare, Global, Deal Values (%), 2015 23 Figure 5: Pharmaceuticals & Healthcare, Global, M&A, Number of Deals and Deal Values (US$ m), 2011 - 2015 36 Figure 6: Pharmaceuticals & Healthcare, Global, M&A, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 37 Figure 7: Pharmaceuticals & Healthcare, Global, M&As, by Therapy Area, Number of Deals and Deal Values (US$ m), by Therapy Area, 2015 39 Figure 8: Pharmaceuticals & Healthcare, Global, Equity Offering Deals, Number of Deals and Deal Values (US$ m), 2011 - 2015 40 Figure 9: Pharmaceuticals & Healthcare, Global, Equity Offering Deals, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 41 Figure 10: Pharmaceuticals & Healthcare, Global, IPO Deals, Number of Deals and Deal Value (US$ m), 2011 - 2015 42 Figure 11: Pharmaceuticals & Healthcare, Global, Secondary Offerings Deals, Number of Deals and Deal Value (US$ m), 2011 - 2015 44 Figure 12: Pharmaceuticals & Healthcare, Global, PIPE Deals, Number of Deals and Deal Value (US$ m), 2011 - 2015 45 Figure 13: Pharmaceuticals & Healthcare, Global, Equity Offering Deals, by Therapy Area, Number of Deals and Deal Values (US$ m), 2015 47 Figure 14: Pharmaceuticals & Healthcare, Global, Debt Offering Deals, Number of Deals and Deal Values (US$ m), 2011 - 2015 48 Figure 15: Pharmaceuticals & Healthcare, Global, Debt Offering Deals, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 49 Figure 16: Pharmaceuticals & Healthcare, Global, Public Debt Offering Deals, Number of Deals and Deal Value (US$ m), 2011 - 2015 50 Figure 17: Pharmaceuticals & Healthcare, Global, Private Debt Placements, Number of Deals and Deal Value (US$ m), 2011 - 2015 51 Figure 18: Pharmaceuticals & Healthcare, Global, Debt Offering Deals, by Therapy Area, Number of Deals and Deal Values (US$ m), 2015 53 Figure 19: Pharmaceuticals & Healthcare, Global, Partnerships, Number of Deals and Deal Values (US$ m), 2011 - 2015 54 Figure 20: Pharmaceuticals & Healthcare, Global, Partnerships, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 55 Figure 21: Pharmaceuticals & Healthcare, Global, Partnership Deals Break down (%), 2015 56 Figure 22: Pharmaceuticals & Healthcare, Global, Partnership Deals, by Therapy Area, Number of Deals and Deal Values (US$ m), 2015 57 Figure 23: Pharmaceuticals & Healthcare, Global, Partnership Deals, Upfront & Milestone Payments and Deal Values (US$ m), 2015 58 Figure 24: Pharmaceuticals & Healthcare, Global, Partnership Deals, by Therapy Area, Upfront & Milestone Payment and Deal Values (US$ m), 2015 59 Figure 25: Pharmaceuticals & Healthcare, Global, Partnership Deals, by Phase, 2015 60 Figure 26: Pharmaceuticals & Healthcare, Global, Partnership Deals, by Phase, 2015 61 Figure 27: Pharmaceuticals & Healthcare, Global, Partnership Deals, by Phase, by Upfront & Milestone Payments and Deal Values (US$ m), 2015 63 Figure 28: Pharmaceuticals & Healthcare, Global, Licensing Agreements, Number of Deals and Deal Values (US$ m), 2011 - 2015 66 Figure 29: Pharmaceuticals & Healthcare, Global, Licensing Agreements, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 67 Figure 30: Pharmaceuticals & Healthcare, Global, Licensing Agreements, by Therapy Area, Number of Deals and Deal Values (US$ m), 2015 68 Figure 31: Pharmaceuticals & Healthcare, Global, Licensing Agreements, Upfront & Milestone Payments and Deal Values (US$ m), 2015 69 Figure 32: Pharmaceuticals & Healthcare, Global, Licensing Agreements, by Therapy Area, Upfront & Milestone Payment and Deal Values (US$ m), 2015 70 Figure 33: Pharmaceuticals & Healthcare, Global, Licensing Agreement Deals, by Phase, Number Of Deals, 2015 71 Figure 34: Pharmaceuticals & Healthcare, Global, Licensing Agreement Deals, by Phase, Deal Values (US$ m), 2015 72 Figure 35: Pharmaceuticals & Healthcare, Global, Licensing Agreements, by Phase, by Upfront & Milestone Payment and Deal Values (US$ m), 2015 74 Figure 36: Pharmaceuticals & Healthcare, Global, Private Equity, Number of Deals and Deal Values (US$ m), 2011 - 2015 78 Figure 37: Pharmaceuticals & Healthcare, Global, Private Equity, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 79 Figure 38: Pharmaceuticals & Healthcare, Global, Private Equity Deals, by Therapy Area, Number of Deals and Deal Values (US$ m), by Therapy Area, 2015 81 Figure 39: Pharmaceuticals & Healthcare, Global, Venture Capital, Number of Deals and Deal Values (US$ m), 2011 - 2015 82 Figure 40: Pharmaceuticals & Healthcare, Global, Venture Capital, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 83 Figure 41: Pharmaceuticals & Healthcare, Global, Venture Capital Deals, by Stage of Financing, Number Of Deals (%), 2015 84 Figure 42: Pharmaceuticals & Healthcare, Global, Venture Capital Deals, by Stage of Financing, Deal Values (%), 2015 85 Figure 43: Pharmaceuticals & Healthcare, Global, Venture Capital Deals, by Therapy Area, Number of Deals and Deal Values (US$ m), by Therapy Area, 2015 86 Figure 44: Pharmaceuticals & Healthcare, Top Venture Financing Firms, Global, Number of Deals and Deal Value (US$ m), 2015 88 Figure 45: Pharmaceuticals & Healthcare, Global, Oncology, Number of Deals and Deal Values (US$ m), 2011 - 2015 91 Figure 46: Pharmaceuticals & Healthcare, Global, Oncology, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 93 Figure 47: Pharmaceuticals & Healthcare, Global, Central Nervous System, Number of Deals and Deal Values (US$ m), 2015, 2011 - 2015 98 Figure 48: Pharmaceuticals & Healthcare, Central Nervous System, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 100 Figure 49: Pharmaceuticals & Healthcare, Global, Infectious Disease, Number of Deals and Deal Value (US$ m), 2011 - 2015 106 Figure 50: Pharmaceuticals & Healthcare, Global, Infectious Disease, Number of Deals and Deal Value (US$ m), Q1 2015-Q4 2015 108 Figure 51: Pharmaceuticals & Healthcare, Global, Immunology, Number of Deals and Deal Values (US$ m), 2011 - 2015 113 Figure 52: Pharmaceuticals & Healthcare, Global, Immunology, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 115 Figure 53: Pharmaceuticals & Healthcare, Global, Cardiovascular, Number of Deals and Deal Values (US$ m), 2011 - 2015 119 Figure 54: Pharmaceuticals & Healthcare, Global, Cardiovascular, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 121 Figure 55: Pharmaceuticals & Healthcare, Global, Metabolic Disorders, Number of Deals and Deal Values (US$ m), 2011 - 2015 125 Figure 56: Pharmaceuticals & Healthcare, Global, Metabolic Disorders, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 127 Figure 57: Pharmaceuticals & Healthcare, Global, Gastrointestinal, Deals Summary, Number of Deals and Deal Values (US$ m), 2011 - 2015 131 Figure 58: Pharmaceuticals & Healthcare, Global, Gastrointestinal, Deals Summary, Number of Deals and Deal Values (US$ m), Q1 2015-Q4 2015 133 Figure 59: Pharmaceuticals & Healthcare, North America, Number of Deals and Deal Value (US$ m), 2011 - 2015 137 Figure 60: Pharmaceuticals & Healthcare, North America, Number of Deals and Deal Value (US$ m), Q1 2015-Q4 2015 139 Figure 61: Pharmaceuticals & Healthcare, Europe, Number of Deals and Deal Value (US$ m), 2011 - 2015 146 Figure 62: Pharmaceuticals & Healthcare, Europe, Number of Deals and Deal Value (US$ m), Q1 2015-Q4 2015 148 Figure 63: Pharmaceuticals & Healthcare, Asia-Pacific, Number of Deals and Deal Value (US$ m), 2011 - 2015 154 Figure 64: Pharmaceuticals & Healthcare, Asia-Pacific Region, Deals, Number of Deals and Deal Value (US$ m), Q1 2015-Q4 2015 156 Figure 65: Pharmaceuticals & Healthcare, Rest of the World Deals, Number of Deals and Deal Value (US$ m), 2011 - 2015 160 Figure 66: Pharmaceuticals & Healthcare, Rest of the World Deals, Number of Deals and Deal Value (US$ m), Q1 2015-Q4 2015 162 Figure 67: Pharmaceuticals & Healthcare, Global, Top Financial Advisors, M&A, Number of Deals and Deal Value (US$ m), 2015 166 Figure 68: Pharmaceuticals & Healthcare, Global, Top Financial Advisors, Equity Offerings, Number of Deals and Deal Value (US$ m), 2015 168