TABLE OF CONTENTS COMPANY OVERVIEW AND KEY FACTS PARTNERSHIP --Partnership – Overview --Partnership – Deal reports CAPITAL RAISING --Capital Raising – Overview --Capital Raising – Deal reports APPENDIX --About Datamonitor Financial Deals Database --Deal Definition and Methodology --About Datamonitor --Datamonitor Professional Services Knowledge Center LIST OF TABLES --Regulus Therapeutics activity by deal type – volume (2011 -YTD2015) --Regulus Therapeutics legal advisor ranking by value ($m) --Regulus Therapeutics financial advisor ranking by value ($m) --Top Deals(2011 -YTD2015) --Regulus Therapeutics targets and partners (2011 -YTD2015) --Regulus Therapeutics partnership volume and value trend (2011-YTD2015) --Regulus Therapeutics partnership trend by key deal type (2011-YTD2015) --Regulus Therapeutics capital raising volume and value trend (2011-YTD2015) --Regulus Therapeutics capital raising by deal type (2011-YTD2015) LIST OF FIGURES --Regulus Therapeutics activity by deal type - volume (2011-YTD2015) --Regulus Therapeutics partnership volume and value trend (2011-YTD2015) --Regulus Therapeutics partnership trend by key deal type (2011-YTD2015) --Regulus Therapeutics capital raising volume and value trend (2011-YTD2015) --Regulus Therapeutics capital raising by deal type (2011-YTD2015)

Regulus Therapeutics, Inc.