Table of Contents Table of Contents 2 List of Tables 5 List of Figures 5 Introduction 6 Global Markets Direct Report Coverage 6 Ocular Pain Overview 7 Therapeutics Development 8 Pipeline Products for Ocular Pain - Overview 8 Ocular Pain - Therapeutics under Development by Companies 9 Ocular Pain - Pipeline Products Glance 10 Late Stage Products 10 Clinical Stage Products 11 Early Stage Products 12 Ocular Pain - Products under Development by Companies 13 Ocular Pain - Companies Involved in Therapeutics Development 14 InSite Vision Incorporated 14 Kala Pharmaceuticals, Inc. 15 Ocular Therapeutix, Inc. 16 Reata Pharmaceuticals, Inc. 17 Sylentis S.A.U. 18 Valeant Pharmaceuticals International, Inc. 19 Ocular Pain - Therapeutics Assessment 20 Assessment by Monotherapy Products 20 Assessment by Combination Products 21 Assessment by Target 22 Assessment by Mechanism of Action 24 Assessment by Route of Administration 26 Assessment by Molecule Type 28 Drug Profiles 30 (bromfenac sodium + dexamethasone acetate) - Drug Profile 30 Product Description 30 Mechanism of Action 30 R&D Progress 30 dexamethasone acetate SR - Drug Profile 31 Product Description 31 Mechanism of Action 31 R&D Progress 31 difluprednate XR - Drug Profile 32 Product Description 32 Mechanism of Action 32 R&D Progress 32 ISV-303 - Drug Profile 33 Product Description 33 Mechanism of Action 33 R&D Progress 33 ketorolac tromethamine - Drug Profile 35 Product Description 35 Mechanism of Action 35 R&D Progress 35 loteprednol etabonate - Drug Profile 36 Product Description 36 Mechanism of Action 36 R&D Progress 36 loteprednol etabonate next generation - Drug Profile 38 Product Description 38 Mechanism of Action 38 R&D Progress 38 NT-71 - Drug Profile 39 Product Description 39 Mechanism of Action 39 R&D Progress 39 NT-72 - Drug Profile 40 Product Description 40 Mechanism of Action 40 R&D Progress 40 omaveloxolone - Drug Profile 41 Product Description 41 Mechanism of Action 41 R&D Progress 41 RX-10045 - Drug Profile 44 Product Description 44 Mechanism of Action 44 R&D Progress 44 Small Molecules to Block NaV1.7 Channel for Pain and Pruritus - Drug Profile 46 Product Description 46 Mechanism of Action 46 R&D Progress 46 SYL-1001 - Drug Profile 47 Product Description 47 Mechanism of Action 47 R&D Progress 47 Ocular Pain - Recent Pipeline Updates 48 Ocular Pain - Dormant Projects 61 Ocular Pain - Product Development Milestones 62 Featured News & Press Releases 62 Mar 14, 2016: Sylentis Reports Positive Phase II Results With SYL1001 in Treating Ocular Pain Related to Dry Eye Syndrome 62 Jan 11, 2016: Ocular Therapeutix Strengthens Executive Management Team with the Appointment of Highly Regarded Ophthalmologist Jonathan H. Talamo, M.D., as Chief Medical Officer 62 Dec 09, 2015: Ocular Therapeutix Announces FDA Acceptance of NDA Filing for DEXTENZA for the Treatment of Post-Surgical Ocular Pain 63 Oct 14, 2015: Ocular Therapeutix Begins Enrollment in Third Phase 3 Clinical Trial for DEXTENZA for the Treatment of Post-Surgical Ocular Inflammation and Pain 64 Sep 02, 2015: InSite Vision Named in BromSite Patent Lawsuit; Company Believes Lawsuit Is Without Merit 64 Aug 17, 2015: InSite Vision Announces FDA Acceptance of NDA Filing for BromSite 65 May 15, 2015: Ocular Therapeutix Announces Plans to Proceed with an NDA Submission for OTX-DP for Treatment of Post-Surgical Ocular Pain Indication 65 Oct 01, 2013: Ocular Therapeutix Announces Phase 2 Study Results for Sustained Release Dexamethasone 67 Oct 01, 2013: InSite Vision Completes Enrollment of Confirmatory Phase 3 Clinical Study of BromSite for the Reduction of Inflammation and Pain after Cataract Surgery 67 May 09, 2013: InSite Vision Initiates Confirmatory Phase III Clinical Study Of BromSite For Reduction Of Inflammation And Pain After Cataract Surgery 68 Appendix 69 Methodology 69 Coverage 69 Secondary Research 69 Primary Research 69 Expert Panel Validation 69 Contact Us 69 Disclaimer 70

List of Tables Number of Products under Development for Ocular Pain, H1 2016 8 Number of Products under Development by Companies, H1 2016 9 Comparative Analysis by Late Stage Development, H1 2016 10 Comparative Analysis by Clinical Stage Development, H1 2016 11 Comparative Analysis by Early Stage Development, H1 2016 12 Products under Development by Companies, H1 2016 13 Ocular Pain - Pipeline by InSite Vision Incorporated, H1 2016 14 Ocular Pain - Pipeline by Kala Pharmaceuticals, Inc., H1 2016 15 Ocular Pain - Pipeline by Ocular Therapeutix, Inc., H1 2016 16 Ocular Pain - Pipeline by Reata Pharmaceuticals, Inc., H1 2016 17 Ocular Pain - Pipeline by Sylentis S.A.U., H1 2016 18 Ocular Pain - Pipeline by Valeant Pharmaceuticals International, Inc., H1 2016 19 Assessment by Monotherapy Products, H1 2016 20 Assessment by Combination Products, H1 2016 21 Number of Products by Stage and Target, H1 2016 23 Number of Products by Stage and Mechanism of Action, H1 2016 25 Number of Products by Stage and Route of Administration, H1 2016 27 Number of Products by Stage and Molecule Type, H1 2016 29 Ocular Pain Therapeutics - Recent Pipeline Updates, H1 2016 48 Ocular Pain - Dormant Projects, H1 2016 61 List of Figures Number of Products under Development for Ocular Pain, H1 2016 8 Number of Products under Development by Companies, H1 2016 9 Comparative Analysis by Late Stage Development, H1 2016 10 Comparative Analysis by Early Stage Products, H1 2016 12 Assessment by Monotherapy Products, H1 2016 20 Number of Products by Top 10 Targets, H1 2016 22 Number of Products by Stage and Top 10 Targets, H1 2016 22 Number of Products by Mechanism of Actions, H1 2016 24 Number of Products by Stage and Mechanism of Actions, H1 2016 24 Number of Products by Routes of Administration, H1 2016 26 Number of Products by Stage and Routes of Administration, H1 2016 26 Number of Products by Molecule Types, H1 2016 28 Number of Products by Stage and Molecule Types, H1 2016 28

InSite Vision Incorporated Kala Pharmaceuticals, Inc. Ocular Therapeutix, Inc. Reata Pharmaceuticals, Inc. Sylentis S.A.U. Valeant Pharmaceuticals International, Inc.