1 Table of Contents 1 Table of Contents 2 1.1 List of Tables 5 1.2 List of Figures 8 2 Introduction 9 2.1 Artificial Pancreas Overview 9 3 Products under Development 10 3.1 Artificial Pancreas - Pipeline Products by Stage of Development 10 3.2 Artificial Pancreas - Pipeline Products by Territory 11 3.3 Artificial Pancreas - Pipeline Products by Regulatory Path 12 3.4 Artificial Pancreas - Pipeline Products by Estimated Approval Date 13 3.5 Artificial Pancreas - Ongoing Clinical Trials 14 4 Artificial Pancreas - Pipeline Products under Development by Companies 15 4.1 Artificial Pancreas Companies - Pipeline Products by Stage of Development 15 4.2 Artificial Pancreas - Pipeline Products by Stage of Development 17 5 Artificial Pancreas Companies and Product Overview 19 5.1 Admetsys Corporation Company Overview 19 5.1.1 Admetsys Corporation Pipeline Products & Ongoing Clinical Trials Overview 19 5.2 Advanced Biosensors-Ohio, Llc Company Overview 20 5.2.1 Advanced Biosensors-Ohio, Llc Pipeline Products & Ongoing Clinical Trials Overview 20 5.3 Animas Corporation Company Overview 21 5.3.1 Animas Corporation Pipeline Products & Ongoing Clinical Trials Overview 21 5.4 Beta-O2 Technologies Ltd. Company Overview 22 5.4.1 Beta-O2 Technologies Ltd. Pipeline Products & Ongoing Clinical Trials Overview 22 5.5 Bigfoot Biomedical, Inc. Company Overview 26 5.5.1 Bigfoot Biomedical, Inc. Pipeline Products & Ongoing Clinical Trials Overview 26 5.6 BioTex, Inc. Company Overview 27 5.6.1 BioTex, Inc. Pipeline Products & Ongoing Clinical Trials Overview 27 5.7 Boston University Company Overview 28 5.7.1 Boston University Pipeline Products & Ongoing Clinical Trials Overview 28 5.8 Cerco Medical LLC Company Overview 29 5.8.1 Cerco Medical LLC Pipeline Products & Ongoing Clinical Trials Overview 29 5.9 Converge Biotech, Inc. Company Overview 30 5.9.1 Converge Biotech, Inc. Pipeline Products & Ongoing Clinical Trials Overview 30 5.10 Covalor Medical, LLC Company Overview 31 5.10.1 Covalor Medical, LLC Pipeline Products & Ongoing Clinical Trials Overview 31 5.11 De Montfort University Company Overview 32 5.11.1 De Montfort University Pipeline Products & Ongoing Clinical Trials Overview 32 5.12 Debiotech S.A. Company Overview 33 5.12.1 Debiotech S.A. Pipeline Products & Ongoing Clinical Trials Overview 33 5.13 Defymed, Inc. Company Overview 34 5.13.1 Defymed, Inc. Pipeline Products & Ongoing Clinical Trials Overview 34 5.14 Diabeloop Company Overview 36 5.14.1 Diabeloop Pipeline Products & Ongoing Clinical Trials Overview 36 5.15 Giner, Inc. Company Overview 39 5.15.1 Giner, Inc. Pipeline Products & Ongoing Clinical Trials Overview 39 5.16 Imperial College London Company Overview 41 5.16.1 Imperial College London Pipeline Products & Ongoing Clinical Trials Overview 41 5.17 Inreda Diabetic BV Company Overview 46 5.17.1 Inreda Diabetic BV Pipeline Products & Ongoing Clinical Trials Overview 46 5.18 Kencak LLC Company Overview 47 5.18.1 Kencak LLC Pipeline Products & Ongoing Clinical Trials Overview 47 5.19 Medtronic plc Company Overview 48 5.19.1 Medtronic plc Pipeline Products & Ongoing Clinical Trials Overview 48 5.20 Miromatrix Medical Inc. Company Overview 56 5.20.1 Miromatrix Medical Inc. Pipeline Products & Ongoing Clinical Trials Overview 56 5.21 Pacific Diabetes Technologies, Inc. Company Overview 58 5.21.1 Pacific Diabetes Technologies, Inc. Pipeline Products & Ongoing Clinical Trials Overview 58 5.22 Pancreum, LLC Company Overview 59 5.22.1 Pancreum, LLC Pipeline Products & Ongoing Clinical Trials Overview 59 5.23 PharmaCyte Biotech, Inc. Company Overview 61 5.23.1 PharmaCyte Biotech, Inc. Pipeline Products & Ongoing Clinical Trials Overview 61 5.24 Rensselaer Polytechnic Institute Company Overview 63 5.24.1 Rensselaer Polytechnic Institute Pipeline Products & Ongoing Clinical Trials Overview 63 5.25 Schneider Children's Medical Center of Israel Company Overview 65 5.25.1 Schneider Children's Medical Center of Israel Pipeline Products & Ongoing Clinical Trials Overview 65 5.26 TecMed, Inc. Company Overview 69 5.26.1 TecMed, Inc. Pipeline Products & Ongoing Clinical Trials Overview 69 5.27 The University of Newcastle Company Overview 70 5.27.1 The University of Newcastle Pipeline Products & Ongoing Clinical Trials Overview 70 5.28 TypeZero Technologies LLC Company Overview 71 5.28.1 TypeZero Technologies LLC Pipeline Products & Ongoing Clinical Trials Overview 71 5.29 Ultradian Diagnostics LLC Company Overview 75 5.29.1 Ultradian Diagnostics LLC Pipeline Products & Ongoing Clinical Trials Overview 75 5.30 Universidad Autonoma de Madrid Company Overview 76 5.30.1 Universidad Autonoma de Madrid Pipeline Products & Ongoing Clinical Trials Overview 76 5.31 Universitat Politecnica de Valencia Company Overview 77 5.31.1 Universitat Politecnica de Valencia Pipeline Products & Ongoing Clinical Trials Overview 77 5.32 University of California, San Francisco Company Overview 78 5.32.1 University of California, San Francisco Pipeline Products & Ongoing Clinical Trials Overview 78 5.33 University of California, Santa Barbara Company Overview 79 5.33.1 University of California, Santa Barbara Pipeline Products & Ongoing Clinical Trials Overview 79 5.34 University of Cambridge Company Overview 82 5.34.1 University of Cambridge Pipeline Products & Ongoing Clinical Trials Overview 82 5.35 University of Florida Company Overview 84 5.35.1 University of Florida Pipeline Products & Ongoing Clinical Trials Overview 84 5.36 XERIS Pharmaceuticals, Inc. Company Overview 85 5.36.1 XERIS Pharmaceuticals, Inc. Pipeline Products & Ongoing Clinical Trials Overview 85 6 Artificial Pancreas - Recent Developments 86 7 Appendix 95 7.1 Methodology 95 7.2 About GlobalData 97 7.3 Contact Us 98 7.4 Disclaimer 98

1.1 List of Tables Table 1: Artificial Pancreas - Pipeline Products by Stage of Development 10 Table 2: Artificial Pancreas - Pipeline Products by Territory 11 Table 3: Artificial Pancreas - Pipeline Products by Regulatory Path 12 Table 4: Artificial Pancreas - Pipeline Products by Estimated Approval Date 13 Table 5: Artificial Pancreas - Ongoing Clinical Trials 14 Table 6: Artificial Pancreas Companies - Pipeline Products by Stage of Development 15 Table 7: Artificial Pancreas - Pipeline Products by Stage of Development 17 Table 8: Admetsys Corporation Pipeline Products & Ongoing Clinical Trials Overview 19 Table 9: Admetsys Smart Pancreas - Product Status 19 Table 10: Admetsys Smart Pancreas - Product Description 19 Table 11: Advanced Biosensors-Ohio, Llc Pipeline Products & Ongoing Clinical Trials Overview 20 Table 12: Artificial Pancreas - Product Status 20 Table 13: Artificial Pancreas - Product Description 20 Table 14: Animas Corporation Pipeline Products & Ongoing Clinical Trials Overview 21 Table 15: Hypoglycemia-Hyperglycemia Minimizer System - Product Status 21 Table 16: Hypoglycemia-Hyperglycemia Minimizer System - Product Description 21 Table 17: Beta-O2 Technologies Ltd. Pipeline Products & Ongoing Clinical Trials Overview 22 Table 18: ßAir Bio-artificial Pancreas - Product Status 23 Table 19: ßAir Bio-artificial Pancreas - Product Description 23 Table 20: Beta-O2 Technologies Ltd. - Ongoing Clinical Trials Overview 24 Table 21: ßAir Bio-artificial Pancreas - An Open Label, Pilot Investigation, to Assess the Safety and Efficacy of Transplantation of Macro-encapsulated Human Islets within the Bioartificial Pancreas Beta-Air in Patients with Type 1 Diabetes Mellitus 25 Table 22: Bigfoot Biomedical, Inc. Pipeline Products & Ongoing Clinical Trials Overview 26 Table 23: Artificial Pancreas - Product Status 26 Table 24: Artificial Pancreas - Product Description 26 Table 25: BioTex, Inc. Pipeline Products & Ongoing Clinical Trials Overview 27 Table 26: Artificial Pancreas - Product Status 27 Table 27: Artificial Pancreas - Product Description 27 Table 28: Boston University Pipeline Products & Ongoing Clinical Trials Overview 28 Table 29: iLet - Product Status 28 Table 30: iLet - Product Description 28 Table 31: Cerco Medical LLC Pipeline Products & Ongoing Clinical Trials Overview 29 Table 32: Islet Sheet - Product Status 29 Table 33: Islet Sheet - Product Description 29 Table 34: Converge Biotech, Inc. Pipeline Products & Ongoing Clinical Trials Overview 30 Table 35: Bioartificial Pancreas System - Product Status 30 Table 36: Bioartificial Pancreas System - Product Description 30 Table 37: Covalor Medical, LLC Pipeline Products & Ongoing Clinical Trials Overview 31 Table 38: Artificial Pancreas - Product Status 31 Table 39: Artificial Pancreas - Product Description 31 Table 40: De Montfort University Pipeline Products & Ongoing Clinical Trials Overview 32 Table 41: InSmart Artificial Pancreas - Product Status 32 Table 42: InSmart Artificial Pancreas - Product Description 32 Table 43: Debiotech S.A. Pipeline Products & Ongoing Clinical Trials Overview 33 Table 44: Next Generation Artificial Pancreas - Product Status 33 Table 45: Next Generation Artificial Pancreas - Product Description 33 Table 46: Defymed, Inc. Pipeline Products & Ongoing Clinical Trials Overview 34 Table 47: MAILPAN - Product Status 35 Table 48: MAILPAN - Product Description 35 Table 49: Diabeloop Pipeline Products & Ongoing Clinical Trials Overview 36 Table 50: Diabeloop - Product Status 36 Table 51: Diabeloop - Product Description 36 Table 52: Diabeloop - Ongoing Clinical Trials Overview 37 Table 53: Diabeloop - Crossover Evaluation of Glycemic Control Provided for Three Days by the Artificial Pancreas Diabeloop Compared to Conventional Treatment by External Insulin Pump in Patients with Type 1 Diabetes in Sedentary Position, Outstanding Meals and Physical Activity: DIABELOOP WP6.2 38 Table 54: Giner, Inc. Pipeline Products & Ongoing Clinical Trials Overview 39 Table 55: BAPIOS System - Product Status 40 Table 56: BAPIOS System - Product Description 40 Table 57: Imperial College London Pipeline Products & Ongoing Clinical Trials Overview 41 Table 58: Bio-inspired Artificial Pancreas - Product Status 42 Table 59: Bio-inspired Artificial Pancreas - Product Description 42 Table 60: Imperial College London - Ongoing Clinical Trials Overview 43 Table 61: Bio-inspired Artificial Pancreas - A Multicenter Study of Outpatient Automated Blood Glucose Control With a Bihormonal Bionic Pancreas 44 Table 62: Bio-inspired Artificial Pancreas - Closed-Loop Glucagon Administration for the Automated Prevention and Treatment of Hypoglycemia 44 Table 63: Bio-inspired Artificial Pancreas - The Summer Camp Study 2: Outpatient Automated Blood Glucose Control With a Bi-Hormonal Bionic Endocrine Pancreas in a Pediatric Population Ages 6-11 at the Clara Barton Diabetes Camps 45 Table 64: Inreda Diabetic BV Pipeline Products & Ongoing Clinical Trials Overview 46 Table 65: Bi-Hormonal Artificial Pancreas - Product Status 46 Table 66: Bi-Hormonal Artificial Pancreas - Product Description 46 Table 67: Kencak LLC Pipeline Products & Ongoing Clinical Trials Overview 47 Table 68: BioArtificial Pancreas - Product Status 47 Table 69: BioArtificial Pancreas - Product Description 47 Table 70: Medtronic plc Pipeline Products & Ongoing Clinical Trials Overview 48 Table 71: Hybrid Closed Loop System - Product Status 49 Table 72: Hybrid Closed Loop System - Product Description 49 Table 73: MiniMed 640G System - Product Status 50 Table 74: MiniMed 640G System - Product Description 50 Table 75: Third-Generation Artificial Pancreas System - Product Status 51 Table 76: Third-Generation Artificial Pancreas System - Product Description 51 Table 77: Medtronic plc - Ongoing Clinical Trials Overview 52 Table 78: Hybrid Closed Loop System - Feasibility Study to Evaluate the Hybrid-logic Closed Loop System in Type 1 Diabetes -Single-arm, Single-center, in Clinic Study-The DREMED Trial 53 Table 79: Hybrid Closed Loop System - Preventing Hypoglycemia During Exercise With Proactive Snacking on Closed Loop 53 Table 80: MiniMed 640G System - A Performance Evaluation of the Enlite 3 Sensor 54 Table 81: MiniMed 640G System - Prevention of Hypoglycaemia Using the Minimed 640G System 54 Table 82: MiniMed 640G System - Standardized Evaluation of Subcutaneous Glucose Monitoring Systems under Routine Environmental Conditions 55 Table 83: MiniMed 640G System - Study of Minimed 640G Insulin Pump with SmartGuard in Prevention of Low Glucose Events in Adults with Type 1 Diabetes at Risk of Severe Hypoglycemia 55 Table 84: Miromatrix Medical Inc. Pipeline Products & Ongoing Clinical Trials Overview 56 Table 85: Miro Pancreas - Product Status 57 Table 86: Miro Pancreas - Product Description 57 Table 87: Pacific Diabetes Technologies, Inc. Pipeline Products & Ongoing Clinical Trials Overview 58 Table 88: Single Indicating electrode Sensing Catheter - Product Status 58 Table 89: Single Indicating electrode Sensing Catheter - Product Description 58 Table 90: Pancreum, LLC Pipeline Products & Ongoing Clinical Trials Overview 59 Table 91: Genesis Artificial Pancreas - Product Status 60 Table 92: Genesis Artificial Pancreas - Product Description 60 Table 93: PharmaCyte Biotech, Inc. Pipeline Products & Ongoing Clinical Trials Overview 61 Table 94: Bio-Artificial Pancreas - Product Status 62 Table 95: Bio-Artificial Pancreas - Product Description 62 Table 96: Rensselaer Polytechnic Institute Pipeline Products & Ongoing Clinical Trials Overview 63 Table 97: Closed-Loop Artificial Pancreas System - Product Status 64 Table 98: Closed-Loop Artificial Pancreas System - Product Description 64 Table 99: Schneider Children's Medical Center of Israel Pipeline Products & Ongoing Clinical Trials Overview 65 Table 100: MD-Logic Artificial Pancreas - Product Status 66 Table 101: MD-Logic Artificial Pancreas - Product Description 66 Table 102: Schneider Children's Medical Center of Israel - Ongoing Clinical Trials Overview 67 Table 103: MD-Logic Artificial Pancreas - Open-label, 3 Center, Randomized, Cross-over Study to Evaluate the Safety and Efficacy of 60 Hours Closed-loop Control Using the MD-Logic Automated Insulin Delivery System Compared to Sensor Augmented Pump Therapy at T1D Patients at Home 68 Table 104: TecMed, Inc. Pipeline Products & Ongoing Clinical Trials Overview 69 Table 105: TecMed Artificial Pancreas - Product Status 69 Table 106: TecMed Artificial Pancreas - Product Description 69 Table 107: The University of Newcastle Pipeline Products & Ongoing Clinical Trials Overview 70 Table 108: Closed Glucose-Sensing Insulin-Delivery System - Product Status 70 Table 109: Closed Glucose-Sensing Insulin-Delivery System - Product Description 70 Table 110: TypeZero Technologies LLC Pipeline Products & Ongoing Clinical Trials Overview 71 Table 111: inControl AP - Product Status 71 Table 112: inControl AP - Product Description 71 Table 113: TypeZero Technologies LLC - Ongoing Clinical Trials Overview 72 Table 114: inControl AP - A Trial on Artificial Pancreas to Manage Type 1 diabetes By Automatically Regulating Insulin and Blood Sugar Levels 73 Table 115: inControl AP - Examination of New Control Algorithm of inControl AP 73 Table 116: inControl AP - International Diabetes Closed Loop Trial ("IDCL") 74 Table 117: Ultradian Diagnostics LLC Pipeline Products & Ongoing Clinical Trials Overview 75 Table 118: Artificial Pancreas - Product Status 75 Table 119: Artificial Pancreas - Product Description 75 Table 120: Universidad Autonoma de Madrid Pipeline Products & Ongoing Clinical Trials Overview 76 Table 121: Predictive Rule-Based Algorithm - Product Status 76 Table 122: Predictive Rule-Based Algorithm - Product Description 76 Table 123: Universitat Politecnica de Valencia Pipeline Products & Ongoing Clinical Trials Overview 77 Table 124: ClosedLoop 4Meal Control - Product Status 77 Table 125: ClosedLoop 4Meal Control - Product Description 77 Table 126: University of California, San Francisco Pipeline Products & Ongoing Clinical Trials Overview 78 Table 127: Bioartificial Pancreas - Product Status 78 Table 128: Bioartificial Pancreas - Product Description 78 Table 129: University of California, Santa Barbara Pipeline Products & Ongoing Clinical Trials Overview 79 Table 130: Closed-Loop Artificial Pancreas - Product Status 80 Table 131: Closed-Loop Artificial Pancreas - Product Description 80 Table 132: Pediatric Artificial Pancreas - Product Status 81 Table 133: Pediatric Artificial Pancreas - Product Description 81 Table 134: University of Cambridge Pipeline Products & Ongoing Clinical Trials Overview 82 Table 135: Florence D2A System - Product Status 83 Table 136: Florence D2A System - Product Description 83 Table 137: University of Florida Pipeline Products & Ongoing Clinical Trials Overview 84 Table 138: Bioartificial Pancreas - Type 1 Diabetes - Product Status 84 Table 139: Bioartificial Pancreas - Type 1 Diabetes - Product Description 84 Table 140: XERIS Pharmaceuticals, Inc. Pipeline Products & Ongoing Clinical Trials Overview 85 Table 141: G-Pump - BP - Product Status 85 Table 142: G-Pump - BP - Product Description 85 Table 143: Glossary 96 1.2 List of Figures Figure 1: Artificial Pancreas - Pipeline Products by Stage of Development 10 Figure 2: Artificial Pancreas - Pipeline Products by Territory 11 Figure 3: Artificial Pancreas - Pipeline Products by Regulatory Path 12 Figure 4: Artificial Pancreas - Pipeline Products by Estimated Approval Date 13 Figure 5: Artificial Pancreas - Ongoing Clinical Trials 14

Admetsys Corporation Advanced Biosensors-Ohio, Llc Animas Corporation Beta-O2 Technologies Ltd. Bigfoot Biomedical, Inc. BioTex, Inc. Boston University Cerco Medical LLC Converge Biotech, Inc. Covalor Medical, LLC De Montfort University Debiotech S.A. Defymed, Inc. Diabeloop Giner, Inc. Imperial College London Inreda Diabetic BV Kencak LLC Medtronic plc Miromatrix Medical Inc. Pacific Diabetes Technologies, Inc. Pancreum, LLC PharmaCyte Biotech, Inc. Rensselaer Polytechnic Institute Schneider Children's Medical Center of Israel TecMed, Inc. The University of Newcastle TypeZero Technologies LLC Ultradian Diagnostics LLC Universidad Autonoma de Madrid Universitat Politecnica de Valencia University of California, San Francisco University of California, Santa Barbara University of Cambridge University of Florida XERIS Pharmaceuticals, Inc.