Table of Contents Table of Contents 2 List of Tables 6 List of Figures 7 Introduction 8 Global Markets Direct Report Coverage 8 Traumatic Brain Injury Overview 9 Therapeutics Development 10 Pipeline Products for Traumatic Brain Injury - Overview 10 Pipeline Products for Traumatic Brain Injury - Comparative Analysis 11 Traumatic Brain Injury - Therapeutics under Development by Companies 12 Traumatic Brain Injury - Therapeutics under Investigation by Universities/Institutes 16 Traumatic Brain Injury - Pipeline Products Glance 17 Late Stage Products 17 Clinical Stage Products 18 Early Stage Products 19 Traumatic Brain Injury - Products under Development by Companies 20 Traumatic Brain Injury - Products under Investigation by Universities/Institutes 24 Traumatic Brain Injury - Companies Involved in Therapeutics Development 25 ALSP, Inc. 25 Amarantus Bioscience Holdings, Inc. 26 Athersys, Inc. 27 BHR Pharma, LLC 28 Cognosci, Inc. 29 Euroscreen S.A. 30 Grupo Ferrer Internacional, S.A. 31 Karyopharm Therapeutics, Inc. 32 Kyorin Pharmaceutical Co., Ltd. 33 Levolta Pharmaceuticals, Inc. 34 Lixte Biotechnology Holdings, Inc. 35 Lpath, Inc. 36 Luc Therapeutics, Inc. 37 MandalMed, Inc. 38 Mapreg S.A.S. 39 Neuralstem, Inc. 40 Neuren Pharmaceuticals Limited 41 NeuroHealing Pharmaceuticals Inc. 42 NeuroNascent, Inc. 43 Neuronax SAS 44 NeuroVive Pharmaceutical AB 45 New World Laboratories, Inc. 46 Novogen Limited 47 Omeros Corporation 48 PharmatrophiX, Inc. 49 Phylogica Limited 50 Premier Biomedical Inc. 51 Prevacus, Inc. 52 QR Pharma, Inc. 53 RegeneRx Biopharmaceuticals, Inc. 54 Remedy Pharmaceuticals, Inc. 55 Sage Therapeutics, Inc. 56 SanBio, Inc. 57 STATegics, Inc. 58 Tetra Discovery Partners LLC 59 vasopharm GmbH 60 VG Life Sciences, Inc. 61 Traumatic Brain Injury - Therapeutics Assessment 62 Assessment by Monotherapy Products 62 Assessment by Combination Products 63 Assessment by Target 64 Assessment by Mechanism of Action 67 Assessment by Route of Administration 70 Assessment by Molecule Type 72 Drug Profiles 74 (levocetirizine dihydrochloride + montelukast sodium) - Drug Profile 74 2-DG - Drug Profile 75 ALP-496 - Drug Profile 77 AMRS-001 - Drug Profile 79 apomorphine hydrochloride - Drug Profile 82 AST-001 - Drug Profile 84 AST-002 - Drug Profile 85 AVL-8168 - Drug Profile 86 Cell Therapy to Activate hNT-3 for Spinal Cord and Traumatic Brain Injury - Drug Profile 87 CHEC-7 - Drug Profile 89 CHEC-9 - Drug Profile 90 CNB-001 - Drug Profile 92 coenzyme Q10+ cyanocobalamin + cyclobenzaprine hydrochloride + naltrexone + pyridoxine - Drug Profile 94 COG-1410 - Drug Profile 95 cyclosporine - Drug Profile 97 dexamethasone acetate + melatonin - Drug Profile 100 EPO-Variant - Drug Profile 101 ESN-502 - Drug Profile 102 felbamate - Drug Profile 103 FIB-117 - Drug Profile 104 glyburide - Drug Profile 105 HBI-002 - Drug Profile 108 HBI-137 - Drug Profile 109 HBN-1 - Drug Profile 110 HBN-2 - Drug Profile 111 HPI-201 - Drug Profile 112 HPI-363 - Drug Profile 114 ibudilast - Drug Profile 115 ICCN-100 - Drug Profile 117 JM-4 - Drug Profile 118 KPT-350 - Drug Profile 119 LB-201 - Drug Profile 120 LB-205 - Drug Profile 121 LM11A-31BHS - Drug Profile 122 LM22A-4 - Drug Profile 124 Lpathomab - Drug Profile 125 MAP-4343 - Drug Profile 127 Neu-2000- Drug Profile 128 ND-478 - Drug Profile 130 NNI-370 - Drug Profile 131 NNZ-2591 - Drug Profile 132 NSI-189 - Drug Profile 133 NSI-566 - Drug Profile 135 NVP-019 - Drug Profile 137 NVX-428 - Drug Profile 138 NWL-53 - Drug Profile 139 NX-210 - Drug Profile 140 PF-05285401 - Drug Profile 141 Posiphen - Drug Profile 145 progesterone - Drug Profile 147 PRV-002 - Drug Profile 148 PYC-35 - Drug Profile 149 PYC-36 - Drug Profile 150 PYC-38 - Drug Profile 151 PYC-98 - Drug Profile 152 R-503 - Drug Profile 153 RGN-352 - Drug Profile 155 SB-623 - Drug Profile 157 sepranolone - Drug Profile 159 Small Molecule to Activate Epsilon PKC for Traumatic Brain Injury - Drug Profile 162 Small Molecule to Antagonize GPR17 for CNS Disorders - Drug Profile 163 Small Molecules for Stroke and Traumatic Brain Injury - Drug Profile 164 Small Molecules for Traumatic Brain Injury - Drug Profile 165 Small Molecules to Antagonize NMDA2A for Central Nervous System Disorders - Drug Profile 166 Small Molecules to Antagonize TLR-4 for CNS Disorders - Drug Profile 167 Small Molecules to Inhibit PBR for Traumatic Brain Injury and Neurodegenerative Diseases - Drug Profile 168 Stem Cell Therapy for Central Nervous System Disorder - Drug Profile 169 Stem Cell Therapy for CNS Disorders - Drug Profile 170 STSE-15 - Drug Profile 171 T-094 - Drug Profile 173 TBI-121 - Drug Profile 174 TBI-122 - Drug Profile 175 TBI-123 - Drug Profile 176 trofinetide - Drug Profile 177 UH-0113 - Drug Profile 180 UH-0213 - Drug Profile 181 VAS-203 - Drug Profile 182 VG-1177 - Drug Profile 184 VitalHeme - Drug Profile 186 VOLT-02 - Drug Profile 187 Traumatic Brain Injury - Recent Pipeline Updates 188 Traumatic Brain Injury - Dormant Projects 237 Traumatic Brain Injury - Discontinued Products 241 Traumatic Brain Injury - Product Development Milestones 242 Featured News & Press Releases 242 Appendix 248 Methodology 248 Coverage 248 Secondary Research 248 Primary Research 248 Expert Panel Validation 248 Contact Us 248 Disclaimer 249

List of Tables Number of Products under Development for Traumatic Brain Injury, H1 2016 16 Number of Products under Development for Traumatic Brain Injury - Comparative Analysis, H1 2016 17 Number of Products under Development by Companies, H1 2016 18 Number of Products under Development by Companies, H1 2016 (Contd..1) 19 Number of Products under Development by Companies, H1 2016 (Contd..2) 20 Number of Products under Development by Companies, H1 2016 (Contd..3) 21 Number of Products under Investigation by Universities/Institutes, H1 2016 22 Comparative Analysis by Late Stage Development, H1 2016 23 Comparative Analysis by Clinical Stage Development, H1 2016 24 Comparative Analysis by Early Stage Development, H1 2016 25 Products under Development by Companies, H1 2016 26 Products under Development by Companies, H1 2016 (Contd..1) 27 Products under Development by Companies, H1 2016 (Contd..2) 28 Products under Development by Companies, H1 2016 (Contd..3) 29 Products under Investigation by Universities/Institutes, H1 2016 30 Traumatic Brain Injury - Pipeline by ALSP, Inc., H1 2016 31 Traumatic Brain Injury - Pipeline by Amarantus Bioscience Holdings, Inc., H1 2016 32 Traumatic Brain Injury - Pipeline by Athersys, Inc., H1 2016 33 Traumatic Brain Injury - Pipeline by BHR Pharma, LLC, H1 2016 34 Traumatic Brain Injury - Pipeline by Cognosci, Inc., H1 2016 35 Traumatic Brain Injury - Pipeline by Euroscreen S.A., H1 2016 36 Traumatic Brain Injury - Pipeline by Grupo Ferrer Internacional, S.A., H1 2016 37 Traumatic Brain Injury - Pipeline by Karyopharm Therapeutics, Inc., H1 2016 38 Traumatic Brain Injury - Pipeline by Kyorin Pharmaceutical Co., Ltd., H1 2016 39 Traumatic Brain Injury - Pipeline by Levolta Pharmaceuticals, Inc., H1 2016 40 Traumatic Brain Injury - Pipeline by Lixte Biotechnology Holdings, Inc., H1 2016 41 Traumatic Brain Injury - Pipeline by Lpath, Inc., H1 2016 42 Traumatic Brain Injury - Pipeline by Luc Therapeutics, Inc., H1 2016 43 Traumatic Brain Injury - Pipeline by MandalMed, Inc., H1 2016 44 Traumatic Brain Injury - Pipeline by Mapreg S.A.S., H1 2016 45 Traumatic Brain Injury - Pipeline by Neuralstem, Inc., H1 2016 46 Traumatic Brain Injury - Pipeline by Neuren Pharmaceuticals Limited, H1 2016 47 Traumatic Brain Injury - Pipeline by NeuroHealing Pharmaceuticals Inc., H1 2016 48 Traumatic Brain Injury - Pipeline by NeuroNascent, Inc., H1 2016 49 Traumatic Brain Injury - Pipeline by Neuronax SAS, H1 2016 50 Traumatic Brain Injury - Pipeline by NeuroVive Pharmaceutical AB, H1 2016 51 Traumatic Brain Injury - Pipeline by New World Laboratories, Inc., H1 2016 52 Traumatic Brain Injury - Pipeline by Novogen Limited, H1 2016 53 Traumatic Brain Injury - Pipeline by Omeros Corporation, H1 2016 54 Traumatic Brain Injury - Pipeline by PharmatrophiX, Inc., H1 2016 55 Traumatic Brain Injury - Pipeline by Phylogica Limited, H1 2016 56 Traumatic Brain Injury - Pipeline by Premier Biomedical Inc., H1 2016 57 Traumatic Brain Injury - Pipeline by Prevacus, Inc., H1 2016 58 Traumatic Brain Injury - Pipeline by QR Pharma, Inc., H1 2016 59 Traumatic Brain Injury - Pipeline by RegeneRx Biopharmaceuticals, Inc., H1 2016 60 Traumatic Brain Injury - Pipeline by Remedy Pharmaceuticals, Inc., H1 2016 61 Traumatic Brain Injury - Pipeline by Sage Therapeutics, Inc., H1 2016 62 Traumatic Brain Injury - Pipeline by SanBio, Inc., H1 2016 63 Traumatic Brain Injury - Pipeline by STATegics, Inc., H1 2016 64 Traumatic Brain Injury - Pipeline by Tetra Discovery Partners LLC, H1 2016 65 Traumatic Brain Injury - Pipeline by vasopharm GmbH, H1 2016 66 Traumatic Brain Injury - Pipeline by VG Life Sciences, Inc., H1 2016 67 Assessment by Monotherapy Products, H1 2016 68 Assessment by Combination Products, H1 2016 69 Number of Products by Stage and Target, H1 2016 71 Number of Products by Stage and Mechanism of Action, H1 2016 74 Number of Products by Stage and Route of Administration, H1 2016 77 Number of Products by Stage and Molecule Type, H1 2016 79 Traumatic Brain Injury Therapeutics - Recent Pipeline Updates, H1 2016 194 Traumatic Brain Injury - Dormant Projects, H1 2016 243 Traumatic Brain Injury - Dormant Projects (Contd..1), H1 2016 244 Traumatic Brain Injury - Dormant Projects (Contd..2), H1 2016 245 Traumatic Brain Injury - Dormant Projects (Contd..3), H1 2016 246 Traumatic Brain Injury - Discontinued Products, H1 2016 247 List of Figures Number of Products under Development for Traumatic Brain Injury, H1 2016 16 Number of Products under Development for Traumatic Brain Injury - Comparative Analysis, H1 2016 17 Number of Products under Development by Companies, H1 2016 18 Number of Products under Investigation by Universities/Institutes, H1 2016 22 Comparative Analysis by Clinical Stage Development, H1 2016 24 Comparative Analysis by Early Stage Products, H1 2016 25 Assessment by Monotherapy Products, H1 2016 68 Assessment by Combination Products, H1 2016 69 Number of Products by Top 10 Targets, H1 2016 70 Number of Products by Stage and Top 10 Targets, H1 2016 70 Number of Products by Top 10 Mechanism of Actions, H1 2016 73 Number of Products by Stage and Top 10 Mechanism of Actions, H1 2016 73 Number of Products by Routes of Administration, H1 2016 76 Number of Products by Stage and Routes of Administration, H1 2016 76 Number of Products by Top 10 Molecule Types, H1 2016 78 Number of Products by Stage and Top 10 Molecule Types, H1 2016 78

ALSP, Inc. Amarantus Bioscience Holdings, Inc. Athersys, Inc. BHR Pharma, LLC Cognosci, Inc. Euroscreen S.A. Grupo Ferrer Internacional, S.A. Karyopharm Therapeutics, Inc. Kyorin Pharmaceutical Co., Ltd. Levolta Pharmaceuticals, Inc. Lixte Biotechnology Holdings, Inc. Lpath, Inc. Luc Therapeutics, Inc. MandalMed, Inc. Mapreg S.A.S. Neuralstem, Inc. Neuren Pharmaceuticals Limited NeuroHealing Pharmaceuticals Inc. NeuroNascent, Inc. Neuronax SAS NeuroVive Pharmaceutical AB New World Laboratories, Inc. Novogen Limited Omeros Corporation PharmatrophiX, Inc. Phylogica Limited Premier Biomedical Inc. Prevacus, Inc. QR Pharma, Inc. RegeneRx Biopharmaceuticals, Inc. Remedy Pharmaceuticals, Inc. Sage Therapeutics, Inc. SanBio, Inc. STATegics, Inc. Tetra Discovery Partners LLC vasopharm GmbH VG Life Sciences, Inc.